Results 71 to 80 of about 2,011,052 (344)

Structure–activity relationships of cyclic and linear peptide T analogues

, 1993
Using the potent cyclic peptide T analog [formula: see text] as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides.
Spisani S, Reali E, Traniello S, SALVADORI, Severo, MARASTONI, Mauro, Tomatis R., Balboni G, Scaranari V   +7 more
core   +1 more source

Protozoan-induced regulation of cyclic lipopeptide biosynthesis Is an effective predation defense mechanism for Pseudomonas fluorescens [PDF]

, 2009
Environmental bacteria are exposed to a myriad of biotic interactions that influence their function and survival. The grazing activity of protozoan predators significantly impacts the dynamics, diversification, and evolution of bacterial communities in ...
de Bruijn, Irene, Mazzola, M., Mazzola, Mark, Bruijn, I., de, Cohen, Michael F, Cohen, M.F., Raaijmakers, Jos M, Raaijmakers, J.M., de Bruijn, I.   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Software-aided approach to investigate peptide structure and metabolic susceptibility of amide bonds in peptide drugs based on high resolution mass spectrometry. [PDF]

PLoS ONE, 2017
Interest in using peptide molecules as therapeutic agents due to high selectivity and efficacy is increasing within the pharmaceutical industry. However, most peptide-derived drugs cannot be administered orally because of low bioavailability and ...
Tatiana Radchenko, Andreas Brink, Yves Siegrist, Christopher Kochansky, Alison Bateman, Fabien Fontaine, Luca Morettoni, Ismael Zamora   +7 more
doaj   +1 more source

Site-Specific Protein Modifications by an Engineered Asparaginyl Endopeptidase from Viola canadensis

Frontiers in Chemistry, 2021
Asparaginyl endopeptidases (AEPs) or legumains are Asn/Asp (Asx)-specific proteases that break peptide bonds, but also function as peptide asparaginyl ligases (PALs) that make peptide bonds.
Yu Chen, Yu Chen, Dingpeng Zhang, Dingpeng Zhang, Xiaohong Zhang, Xiaohong Zhang, Zhen Wang, Zhen Wang, Chuan-Fa Liu, Chuan-Fa Liu, Chuan-Fa Liu, James P. Tam, James P. Tam, James P. Tam   +13 more
doaj   +1 more source

Cyclization and Self-Assembly of Cyclic Peptides

, 2021
Cyclic peptides are a fascinating class of molecules that can be programmed to fold or self-assemble into diverse mono- and multidimensional structures with potential applications in biomedicine, nanoelectronics, or catalysis. Herein we describe on-resin procedures to carry out head-to-tail peptide cyclization based on orthogonal protected linear ...
Méndez-Ardoy, Alejandro, Insua, Ignacio, Granja, Juan R., Montenegro, Javier   +3 more
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Anion Recognition Using a Simple Cyclic Peptide [PDF]

, 2020
The head-to-tail cyclic hexapeptide, [cyclo(Val-Thr)3], was found to bind to a range of anions in DMSO-d6 with higher affinity for tetrahedral oxo-anions than halides.
Jolliffe, Katrina, Sergeant, Genevieve
core   +2 more sources

Computational prediction of plasma protein binding of cyclic peptides from small molecule experimental data using sparse modeling techniques

BMC Bioinformatics, 2018
Background Cyclic peptide-based drug discovery is attracting increasing interest owing to its potential to avoid target protein depletion. In drug discovery, it is important to maintain the biostability of a drug within the proper range.
Takashi Tajimi, Naoki Wakui, Keisuke Yanagisawa, Yasushi Yoshikawa, Masahito Ohue, Yutaka Akiyama   +5 more
doaj   +1 more source

An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease

Journal of Biological Chemistry, 2017
Inflammatory bowel diseases (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory treatment. Recent studies have shown that small peptides show promise for reducing inflammation in models of IBD.
Claudia Cobos Caceres, P. Bansal, S. Navarro, David T. Wilson, Laurianne Don, P. Giacomin, A. Loukas, N. Daly   +7 more
semanticscholar   +1 more source