Results 21 to 30 of about 100,338 (264)

Cyclic RGD-containing peptides: in silico exploration against BCL-X(L) [PDF]

The Ukrainian Biochemical Journal, 2023
Сyclic peptides attract attention for possible applications in cancer treatment. We examined the abili­ty of six cyclic RGD-containing peptides-based compounds to inhibit B-cell lymphoma-extra-large (Bcl-XL) (PDB ID: 3zk6) using the in silico method.
A. K. Oyebamiji, E. T. Akintayo, C. O. Akintayo, H. O. Aworinde, O. D. Adekunle, S. A. Akintelu   +5 more
doaj   +1 more source

Presence of short and cyclic peptides in Acacia and Ziziphus honeys may potentiate their medicinal values

Open Chemistry, 2021
Acacia honey is characterized by high nutritional, antioxidant, antibacterial and immuno-modulatory values. This work investigated the presence of short and cyclic peptides in Acacia and Ziziphus honey samples.
ALaerjani Wed Mohammed Ali, Abu-Melha Saraa Abdullah, Khan Khalid Ali, Ghramh Hamed A., Alalmie Ali Yahya A., Alshareef Rahaf Mohammed Hussein, AL-Shehri Badria M., Mohammed Mohammed Elimam Ahamed   +7 more
doaj   +1 more source

Genome sequences of Rhizopogon roseolus, Mariannaea elegans, Myrothecium verrucaria, and Sphaerostilbella broomeana and the identification of biosynthetic gene clusters for fungal peptide natural products

G3: Genes, Genomes, Genetics, 2022
In recent years, a variety of fungal cyclic peptides with interesting bioactivities have been discovered. For many of these peptides, the biosynthetic pathways are unknown and their elucidation often holds surprises.
Eva Vogt, Christopher M Field, Lukas Sonderegger, Markus Künzler   +3 more
doaj   +1 more source

Peptídeos cíclicos de biomassa vegetal: características, diversidade, biossíntese e atividades biológicas Cyclic peptide from plant biomass: chemical features and diversity, biosynthesis and biological activities

Química Nova, 2009
Natural peptides are outstanding as the most promising macromolecules in the search for new drugs, especially those of cyclic nature. The higher plants revealed a very peculiar composition of their cyclic peptides, which distinguish themselves by a "head-
Douglas Gatte Picchi, Wanessa Fernanda Altei, Mônica Sue Saito, Vanderlan da Silva Bolzani, Eduardo Maffud Cilli   +4 more
doaj   +1 more source

Investigation of cyclic peptides as drug delivery systems for the delivery of the anti-tuberculosis drug pyrazinamide [PDF]

Nanoscale Advances
One of the important goals of drug delivery in the treatment of diseases is to effectively deliver drugs to deep and inaccessible areas of tissues. In recent years, cyclic peptides (CPs) have been used as drug delivery systems due to their high affinity ...
Batoul Makiabadi, Fereshteh Naderi, Mohammad Zakarianezhad, Aria Raessi   +3 more
doaj   +1 more source

Directed Evolution of Bicyclic Peptides for Therapeutic Application

CHIMIA, 2013
Many naturally occurring cyclic peptides or derivatives thereof are used as therapeutics such as the human hormones vasopressin and oxytocin or the antibiotics vancomycin and daptomycin.
Philippe Diderich, Christian Heinis
doaj   +1 more source

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

Molecules, 2018
Peptides are important biomolecules which facilitate the understanding of complex biological processes, which in turn could be serendipitous biological targets for future drugs. They are classified as a unique therapeutic niche and will play an important
Muna Ali Abdalla, Lyndy J. McGaw
doaj   +1 more source

Macrocylases as synthetic tools for ligand synthesis: enzymatic synthesis of cyclic peptides containing metal-binding amino acids

Royal Society Open Science, 2021
Improving the sustainability of synthesis is a major goal in green chemistry, which has been greatly aided by the development of asymmetric transition metal catalysis.
Richard C. Brewster, Irati Colmenero Labeaga, Catriona E. Soden, Amanda G. Jarvis   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source