Development of the force field for cyclosporine A
Biophysics and Physicobiology, 2022 Membrane permeability of cyclic peptides is an important factor in drug design. To investigate the membrane permeability of cyclic peptides using molecular dynamics (MD) simulations, the accurate force fields for unnatural amino acids present in the ...
Tsutomu Yamane +2 more
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Antimicrobial Cyclic Peptides for Plant Disease Control
The Plant Pathology Journal, 2015 Antimicrobial cyclic peptides derived from microbes bind stably with target sites, have a tolerance to hydrolysis by proteases, and a favorable degradability under field conditions, which make them an attractive proposition for use as agricultural ...
Dong Wan Lee, Beom Seok Kim
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Simultaneous cyclization and derivatization of peptides using cyclopentenediones [PDF]
, 2017 Unprotected linear peptides containing N-terminal cysteines and another cysteine residue can be simultaneously cyclized and derivatized using 2,2-disubstituted cyclopentenediones. High yields of cyclic peptide conjugates may be obtained in short reaction
Agramunt, Jordi +4 more
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Anion recognition by cyclic peptides [PDF]
Chemical Communications, 2015 Cyclic peptides provide excellent scaffolds for anion recognition and improved binding affinity and selectivity has been achieved through peptide backbone rigidification and the introduction of side chains bearing anion recognition groups.
Elmes, Robert B. P. +1 more
openaire +5 more sources
Peptide oligomers from ultra-short peptides using sortase
Biochemistry and Biophysics Reports, 2017 Sortase A catalyzed ligation of ultra-short peptides leads to inter/intra-molecular transpeptidation to form either linear or cyclic oligomers dependent upon the peptide length.
Natalya Voloshchuk +3 more
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A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins [PDF]
, 2017 Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation.
Cavalcanti-Adam, Elisabetta Ada +12 more
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Anti-oxidative stress mechanism of cyclic dipeptide in distiller's grains of strong-flavor Baijiu [PDF]
Zhongguo niangzaoIn this study, the in vitro antioxidant activity of free peptides in distiller's grains of strong-flavor (Nongxiangxing) Baijiu was determined by measuring the free radical scavenging rate of 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH).
GUO Yan, LIAO Qinjian, ZHENG Jia, WANG Fang, YANG Hao, ZHOU Hanling, SU Jian
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Novel Cyclic Peptides from Lethal Amanita Mushrooms through a Genome-Guided Approach
Journal of Fungi, 2021 Most species in the genus Amanita are ectomycorrhizal fungi comprising both edible and poisonous mushrooms. Some species produce potent cyclic peptide toxins, such as α-amanitin, which places them among the deadliest organisms known to mankind.
Shengwen Zhou +8 more
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Cyclic RGD-containing peptides: in silico exploration against BCL-X(L) [PDF]
The Ukrainian Biochemical Journal, 2023 Сyclic peptides attract attention for possible applications in cancer treatment. We examined the ability of six cyclic RGD-containing peptides-based compounds to inhibit B-cell lymphoma-extra-large (Bcl-XL) (PDB ID: 3zk6) using the in silico method.
A. K. Oyebamiji +5 more
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Analytical Rebridging Monte Carlo: Application to cis/trans Isomerization in Proline-Containing, Cyclic Peptides [PDF]
, 1999 We present a new method, the analytical rebridging scheme, for Monte Carlo simulation of proline-containing, cyclic peptides. The cis/trans isomerization is accommodated by allowing for two states of the amide bond.
Higgins K. A. +4 more
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