Improving In Vivo Brain Delivery of Monoclonal Antibody Using Novel Cyclic Peptides
Pharmaceutics, 2019 Many proteins can be used to treat brain diseases; however, the presence of the blood−brain barrier (BBB) creates an obstacle to delivering them into the brain.
Kavisha R. Ulapane +2 more
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Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides
Molecules, 2017 Cyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding ...
Xiaohan Wang +4 more
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Enhancing Cell Penetration Efficiency of Cyclic Oligoarginines Using Rigid Scaffolds
Pharmaceutics, 2023 Delivering therapeutic agents into cells has always been a major challenge. In recent years, cyclization emerged as a tool for designing CPPs to increase their internalization and stability.
Csaba Bató +2 more
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Recent Progress in Understanding the Properties of Linseed Cyclic Peptides and the Mechanism Underlying Their Bitter Taste [PDF]
Shipin KexueLinseed cyclic peptides are important active ingredients in flaxseed, exhibiting antioxidant, anti-inflammatory and anti-cancer properties. However, linseed cyclic peptides undergo partial oxidation during processing and storage, leading to structural ...
ZHANG Qingyi, GUO Ruirui, JIA Caihua, ZHENG Yifu, TANG Lin, DENG Qianchun, CHENG Chen, HUANG Fenghong, ZHAO Siming, TANG Cui’e
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Development of the force field for cyclosporine A
Biophysics and Physicobiology, 2022 Membrane permeability of cyclic peptides is an important factor in drug design. To investigate the membrane permeability of cyclic peptides using molecular dynamics (MD) simulations, the accurate force fields for unnatural amino acids present in the ...
Tsutomu Yamane +2 more
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Antimicrobial Cyclic Peptides for Plant Disease Control
The Plant Pathology Journal, 2015 Antimicrobial cyclic peptides derived from microbes bind stably with target sites, have a tolerance to hydrolysis by proteases, and a favorable degradability under field conditions, which make them an attractive proposition for use as agricultural ...
Dong Wan Lee, Beom Seok Kim
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Peptide oligomers from ultra-short peptides using sortase
Biochemistry and Biophysics Reports, 2017 Sortase A catalyzed ligation of ultra-short peptides leads to inter/intra-molecular transpeptidation to form either linear or cyclic oligomers dependent upon the peptide length.
Natalya Voloshchuk +3 more
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Anion recognition by cyclic peptides [PDF]
Chemical Communications, 2015 Cyclic peptides provide excellent scaffolds for anion recognition and improved binding affinity and selectivity has been achieved through peptide backbone rigidification and the introduction of side chains bearing anion recognition groups.
Elmes, Robert B. P. +1 more
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Anti-oxidative stress mechanism of cyclic dipeptide in distiller's grains of strong-flavor Baijiu [PDF]
Zhongguo niangzaoIn this study, the in vitro antioxidant activity of free peptides in distiller's grains of strong-flavor (Nongxiangxing) Baijiu was determined by measuring the free radical scavenging rate of 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH).
GUO Yan, LIAO Qinjian, ZHENG Jia, WANG Fang, YANG Hao, ZHOU Hanling, SU Jian
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Novel Cyclic Peptides from Lethal Amanita Mushrooms through a Genome-Guided Approach
Journal of Fungi, 2021 Most species in the genus Amanita are ectomycorrhizal fungi comprising both edible and poisonous mushrooms. Some species produce potent cyclic peptide toxins, such as α-amanitin, which places them among the deadliest organisms known to mankind.
Shengwen Zhou +8 more
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