Plant derived cyclic peptides [PDF]
Biochemical Society Transactions, 2021 Cyclic peptides are widespread throughout the plant kingdom, and display diverse sequences, structures and bioactivities. The potential applications attributed to these peptides and their unusual biosynthesis has captivated the attention of researchers for many years.
Norelle L. Daly, David T. Wilson
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Lessons for Oral Bioavailability: How Conformationally Flexible Cyclic Peptides Enter and Cross Lipid Membranes [PDF]
, 2022 Cyclic peptides are able to extend the druggable space of pharmaceutical targets, due to their size, conformational behavior, and high proportion of hydrogen bond donors and acceptors.
Sereina, Riniker +6 more
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Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Nigel J. Pyne +7 more
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A computational study of cyclic peptides with vibrational circular dichroism [PDF]
, 2022 Cyclic peptides are a class of molecules that has shown antimicrobial potential. These are complex compounds to investigate with their large conformational space and multiple chiral centers. A technique that can be used to investigate both conformational
Eikås, Karolina Di Remigio
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Improving In Vivo Brain Delivery of Monoclonal Antibody Using Novel Cyclic Peptides
Pharmaceutics, 2019 Many proteins can be used to treat brain diseases; however, the presence of the blood−brain barrier (BBB) creates an obstacle to delivering them into the brain.
Kavisha R. Ulapane +2 more
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Utilizing Copper-Mediated Deprotection of Selenazolidine for Cyclic Peptides Synthesis [PDF]
, 2019 Selenazoliline (Sez) was originally developed as a masking form of selenocysteine (Sec) for the chemical synthesis of challenging proteins. Here we utilize Sez and our recent reported copper(II)-mediated deprotection for the synthesis of cyclic peptides.
Zhenguang Zhao (7008461) +3 more
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Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides
Molecules, 2017 Cyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding ...
Xiaohan Wang +4 more
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Enhancing Cell Penetration Efficiency of Cyclic Oligoarginines Using Rigid Scaffolds
Pharmaceutics, 2023 Delivering therapeutic agents into cells has always been a major challenge. In recent years, cyclization emerged as a tool for designing CPPs to increase their internalization and stability.
Csaba Bató +2 more
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Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine [PDF]
, 2012 Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important ...
Schöllmann, C. +3 more
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Recent Progress in Understanding the Properties of Linseed Cyclic Peptides and the Mechanism Underlying Their Bitter Taste [PDF]
Shipin KexueLinseed cyclic peptides are important active ingredients in flaxseed, exhibiting antioxidant, anti-inflammatory and anti-cancer properties. However, linseed cyclic peptides undergo partial oxidation during processing and storage, leading to structural ...
ZHANG Qingyi, GUO Ruirui, JIA Caihua, ZHENG Yifu, TANG Lin, DENG Qianchun, CHENG Chen, HUANG Fenghong, ZHAO Siming, TANG Cui’e
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