Anion recognition by cyclic peptides [PDF]
Chemical Communications, 2015 Cyclic peptides provide excellent scaffolds for anion recognition and improved binding affinity and selectivity has been achieved through peptide backbone rigidification and the introduction of side chains bearing anion recognition groups.
Elmes, Robert B. P. +1 more
openaire +7 more sources
Small Natural Cyclic Peptides from DBAASP Database
PharmaceuticalsAntimicrobial peptides (AMPs) are promising tools for combating microbial resistance. However, their therapeutic potential is hindered by two intrinsic drawbacks—low target affinity and poor in vivo stability.
Evgenia Alimbarashvili +3 more
doaj +2 more sources
A computational study of cyclic peptides with vibrational circular dichroism [PDF]
, 2022 Cyclic peptides are a class of molecules that has shown antimicrobial potential. These are complex compounds to investigate with their large conformational space and multiple chiral centers. A technique that can be used to investigate both conformational
Eikås, Karolina Di Remigio +2 more
core +1 more source
Lessons for Oral Bioavailability: How Conformationally Flexible Cyclic Peptides Enter and Cross Lipid Membranes [PDF]
, 2022 Cyclic peptides are able to extend the druggable space of pharmaceutical targets, due to their size, conformational behavior, and high proportion of hydrogen bond donors and acceptors.
Sereina, Riniker +6 more
core +1 more source
Plant derived cyclic peptides [PDF]
, 2021 Cyclic peptides are widespread throughout the plant kingdom, and display diverse sequences, structures and bioactivities. The potential applications attributed to these peptides and their unusual biosynthesis has captivated the attention of researchers ...
Wilson, David T. +3 more
core +1 more source
Marine Cyclic Peptides: Antimicrobial Activity and Synthetic Strategies
Marine Drugs, 2022 Oceans are a rich source of structurally unique bioactive compounds from the perspective of potential therapeutic agents. Marine peptides are a particularly interesting group of secondary metabolites because of their chemistry and wide range of ...
Ricardo Ribeiro +3 more
doaj +1 more source
Utilizing Copper-Mediated Deprotection of Selenazolidine for Cyclic Peptides Synthesis [PDF]
, 2019 Selenazoliline (Sez) was originally developed as a masking form of selenocysteine (Sec) for the chemical synthesis of challenging proteins. Here we utilize Sez and our recent reported copper(II)-mediated deprotection for the synthesis of cyclic peptides.
Zhenguang Zhao (7008461) +3 more
core +1 more source
Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides
Molecules, 2017 Cyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding ...
Xiaohan Wang +4 more
doaj +1 more source
Improving In Vivo Brain Delivery of Monoclonal Antibody Using Novel Cyclic Peptides
Pharmaceutics, 2019 Many proteins can be used to treat brain diseases; however, the presence of the blood−brain barrier (BBB) creates an obstacle to delivering them into the brain.
Kavisha R. Ulapane +2 more
doaj +1 more source
Enhancing Cell Penetration Efficiency of Cyclic Oligoarginines Using Rigid Scaffolds
Pharmaceutics, 2023 Delivering therapeutic agents into cells has always been a major challenge. In recent years, cyclization emerged as a tool for designing CPPs to increase their internalization and stability.
Csaba Bató +2 more
doaj +1 more source