Results 11 to 20 of about 109,234 (306)
Current Medicinal Chemistry, 2016 For decades the opioid receptors have been an attractive therapeutic target for the treatment of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have been known to produce opioid activity and analgesia, but their therapeutics have been limited mainly due to low blood brain barrier penetration and poor ...
Michael, Remesic +2 more
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Plant derived cyclic peptides [PDF]
Biochemical Society Transactions, 2021 Cyclic peptides are widespread throughout the plant kingdom, and display diverse sequences, structures and bioactivities. The potential applications attributed to these peptides and their unusual biosynthesis has captivated the attention of researchers for many years.
Norelle L. Daly, David T. Wilson
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Cyclic Peptides for Drug Development
Angewandte Chemie International Edition, 2023 AbstractCyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years through improved methods for synthesis and drug development have resulted in a steady ...
Ji, Xinjian +2 more
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Cyclic Peptides in Pipeline: What Future for These Great Molecules?
Pharmaceuticals, 2023 Cyclic peptides are molecules that are already used as drugs in therapies approved for various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and immunosuppressants.
Lia Costa +2 more
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Antimicrobial Cyclic Peptides for Plant Disease Control
The Plant Pathology Journal, 2015 Antimicrobial cyclic peptides derived from microbes bind stably with target sites, have a tolerance to hydrolysis by proteases, and a favorable degradability under field conditions, which make them an attractive proposition for use as agricultural ...
Dong Wan Lee, Beom Seok Kim
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CycloPepper: a machine learning platform for predicting cyclization outcomes and optimizing synthesis of therapeutic cyclopeptides [PDF]
Nature CommunicationsCyclic peptides exhibit remarkable stability, membrane permeability, and binding affinity, positioning them as promising therapeutics. However, their synthesis, particularly on-resin head-to-tail cyclization, remains challenging, with cyclization site ...
Yourong Pan +5 more
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Small Natural Cyclic Peptides from DBAASP Database
PharmaceuticalsAntimicrobial peptides (AMPs) are promising tools for combating microbial resistance. However, their therapeutic potential is hindered by two intrinsic drawbacks—low target affinity and poor in vivo stability.
Evgenia Alimbarashvili +3 more
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The Evolution ofMomordicaCyclic Peptides
Molecular Biology and Evolution, 2014 Cyclic proteins have evolved for millions of years across all kingdoms of life to confer structural stability over their acyclic counterparts while maintaining intrinsic functional properties. Here, we show that cyclic miniproteins (or peptides) from Momordica (Cucurbitaceae) seeds evolved in species that diverged from an African ancestor around 19 Ma.
Mahatmanto, Tunjung +6 more
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Pharmaceuticals, 2023 Fungal infections remain a significant concern for human health. The emergence of microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic antifungal treatments in immunocompromised patients have sparked substantial ...
Naiera M. Helmy, Keykavous Parang
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A computational study of cyclic peptides with vibrational circular dichroism [PDF]
, 2022 Cyclic peptides are a class of molecules that has shown antimicrobial potential. These are complex compounds to investigate with their large conformational space and multiple chiral centers. A technique that can be used to investigate both conformational
Eikås, Karolina Di Remigio
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