Results 81 to 90 of about 16,636 (201)

Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis.

, 2006
Caspofungin inhibits synthesis of beta-1,3-glucan, an essential component of the Aspergillus cell wall. This echinocandin has demonstrated efficacy (45% success) as salvage monotherapy of invasive aspergillosis (IA).
Segal, Brahm H, Kartsonis, Nicholas, Caillot, Denis, Killar, John, Maertens, J., Cordonnier, Catherine, Patterson, Thomas F, Aoun, Michel, Glasmacher, Axel, Thiebaut, Anne, Taylor, Arlene, Caspofungin Combination Therapy Study Group, Sable, Carole, Herbrecht, R   +13 more
core   +1 more source

Caspofungin effects on electrocardiogram of mice : an evaluation of cardiac safety.

, 2021
Caspofungin is an echinocandin, exhibiting efcacy against most Candida species invasive infection. Its cardiotoxicity was reported in isolated rat heart and ventricular myocytes, but in vivo and clinical studies are insufcient.
Guimarães, Homero Nogueira, Paula, Danielle Cristiane Correa de, Araújo, Carolina Morais, Branquinho, Renata Tupinambá, Leite, Elaine Amaral, Guimarães, Andrea Grabe   +5 more
core   +1 more source

Efficacy and safety of caspofungin for the treatment of invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease

Journal of International Medical Research
Objectives We assessed the efficacy of a 3-week primary or salvage caspofungin regimen in patients with chronic obstructive pulmonary disease (COPD) and concomitant proven or suspected invasive pulmonary aspergillosis (IPA).
Shaoqiang Li, Zhengtu Li, Penglei Wang, Yangqing Zhan, Jiaxing Xie, Feng Ye   +5 more
doaj   +1 more source

The Effects of Holothurin and Caspofungin on the Vaginal Cell Inflammation Parameters of the Rattus norvegicus Strain Post Induction of Candida albicans

Infection and Drug Resistance, 2023
Sri Handayani,1,2 Nurdiana Nurdiana,3 Sri Winarsih,4 Agustina Tri Endharti5 1Doctoral Program of Medical Science Department, Faculty of Medicine, Brawijaya University, Malang, Indonesia; 2Department of Midwifery of Aisyiyah, Institution of Surakarta ...
Handayani S, Nurdiana N, Winarsih S, Tri Endharti A   +3 more
doaj  

A caspofungin ölő hatásának összehasonlító vizsgálata Candida parapsilosis, Candida orthopsilosis és Candida metapsilosis ellen

, 2009
A kisérletünk célja meghatározni a caspofungin in vitro hatását e három Candida faj klinikai izolátumai ellen, makro- és mikrodilúciós módszerekkel, RPMI-1640 és antibiotikum médium-3 (AM3) tápközegek használatával.
Bársony, Alexandra Lilla
core  

Effects of caspofungin on membrane efflux.

, 2015
Transporter-mediated efflux of rhodamine 123 was determined in absence (blue line) and presence of caspofungin (red line). The wild-type CEA10 strain was challenged with different caspofungin concentrations, while the mutant strains were analyzed using ...
Reinhard Guthke (51972), Vito Valiante (615656), Jörg Linde (402557), Olaf Kniemeyer (249966), Axel A. Brakhage (199110), Clara Baldin (793862), Robert Altwasser (793861), Jakob Weber (410403)   +7 more
core   +1 more source

Predictors of caspofungin exposure-response relationship: a retrospective cohort study on therapeutic drug monitoring parameters

Frontiers in Pharmacology
IntroductionThis study aimed to characterize the exposure-response relationship of caspofungin through analysis of trough serum concentration (Cmin) associated with clinical efficacy, while identifying clinically determinants of Cmin.MethodsA single ...
Mingwei Meng, Ruhua Wei, Yating Lu, Wen Cao, Kai Mo, Zheng Huang, Yane Qin, Xiaobu Lan   +7 more
doaj   +1 more source

[Clinical and juridical aspects of management of neonates with invasive fungal infections] [Article in Italian] • Aspetti clinici e giuridici della gestione del neonato con infezioni fungine invasive

Journal of Pediatric and Neonatal Individualized Medicine, 2012
Fungal infections are an important cause of morbidity and mortality in neonatology, especially in the case of neonates weighing ≤ 1500 grams (VLBW) at birth.
Vassilios Fanos, Angelica Dessì, Riccardo Fresa   +2 more
doaj   +1 more source

A caspofungin in vivo hatékonyságának vizsgálata Candida krusei által fertőzött BALB/c neutropéniás egérmodellben

, 2013
A 20. század végétől kezdődően jelentős epidemiológiai változások zajlanak azokban a Candida fajokban, amelyek az invazív candidosisokban szerepett játszanak. A diagnosztizált esetekben a vezető helyen még mindig a C. albicans található, de a szerzett
Sándor, Attila
core  

Pharmacokinetics of caspofungin in ICU patients

, 2014
OBJECTIVES: Caspofungin is used for treatment of invasive fungal infections. As the pharmacokinetics (PK) of antimicrobial agents in critically ill patients can be highly variable, we set out to explore caspofungin PK in ICU patients.
Burger, D.M., Leeuwen, H.J. van, Muilwijk, E.W., Zanten, A.R. van, Pickkers, P., Lange, D.W. de, Bruggemann, R.J.M., Schouten, J.A., Colbers, A., Verweij, P.E.   +9 more
core   +1 more source