Results 81 to 90 of about 17,702 (177)

Low Caspofungin Exposure in Patients in Intensive Care Units [PDF]

, 2017
In critically ill patients, drug exposure may be influenced by altered drug distribution and clearance. Earlier studies showed that the variability in caspofungin exposure was high in Intensive Care Unit (ICU) patients.
Touw, Daan J.; id_orcid, Alffenaar, Jan-Willem C., Zijlstra, Jan G.; id_orcid, Uges, Donald R. A., Touw, Daan J., Beishuizen, Albertus, Kosterink, Jos G. W., Veringa, Anette, Elst , van der, Kim C. M., Kosterink, Jos G. W.; id_orcid, van der Werf, Tjip S., Brummelhuis-Visser, Petra, Zijlstra, Jan G., Klont, Rob   +13 more
core   +2 more sources

Predictors of caspofungin exposure-response relationship: a retrospective cohort study on therapeutic drug monitoring parameters

Frontiers in Pharmacology
IntroductionThis study aimed to characterize the exposure-response relationship of caspofungin through analysis of trough serum concentration (Cmin) associated with clinical efficacy, while identifying clinically determinants of Cmin.MethodsA single ...
Mingwei Meng, Ruhua Wei, Yating Lu, Wen Cao, Kai Mo, Zheng Huang, Yane Qin, Xiaobu Lan   +7 more
doaj   +1 more source

Effects of caspofungin on membrane efflux.

, 2015
Transporter-mediated efflux of rhodamine 123 was determined in absence (blue line) and presence of caspofungin (red line). The wild-type CEA10 strain was challenged with different caspofungin concentrations, while the mutant strains were analyzed using ...
Reinhard Guthke (51972), Vito Valiante (615656), Jörg Linde (402557), Olaf Kniemeyer (249966), Axel A. Brakhage (199110), Clara Baldin (793862), Robert Altwasser (793861), Jakob Weber (410403)   +7 more
core   +1 more source

Efficacy and safety of caspofungin for the treatment of invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease

Journal of International Medical Research
Objectives We assessed the efficacy of a 3-week primary or salvage caspofungin regimen in patients with chronic obstructive pulmonary disease (COPD) and concomitant proven or suspected invasive pulmonary aspergillosis (IPA).
Shaoqiang Li, Zhengtu Li, Penglei Wang, Yangqing Zhan, Jiaxing Xie, Feng Ye   +5 more
doaj   +1 more source

A caspofungin in vivo hatékonyságának vizsgálata Candida krusei által fertőzött BALB/c neutropéniás egérmodellben

, 2013
A 20. század végétől kezdődően jelentős epidemiológiai változások zajlanak azokban a Candida fajokban, amelyek az invazív candidosisokban szerepett játszanak. A diagnosztizált esetekben a vezető helyen még mindig a C. albicans található, de a szerzett
Sándor, Attila
core  

Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis.

, 2006
Caspofungin inhibits synthesis of beta-1,3-glucan, an essential component of the Aspergillus cell wall. This echinocandin has demonstrated efficacy (45% success) as salvage monotherapy of invasive aspergillosis (IA).
Segal, Brahm H, Kartsonis, Nicholas, Caillot, Denis, Killar, John, Maertens, J., Cordonnier, Catherine, Patterson, Thomas F, Aoun, Michel, Glasmacher, Axel, Thiebaut, Anne, Taylor, Arlene, Caspofungin Combination Therapy Study Group, Sable, Carole, Herbrecht, R   +13 more
core   +1 more source

Effects of cationic antimicrobial peptides on Candida and Saccharomyces species [PDF]

, 2010
Electronic version does not contain associated previously published materialAntimicrobial peptides (AMPs) are found throughout the animal kingdom and act as a natural defence against a broad spectrum of pathogens.
Harris, Mark R.
core   +2 more sources

In Vitro Assessment of Antifungal Caspofungin on Leishmania donovani Culture Isolation

Canadian Journal of Infectious Diseases and Medical Microbiology, 2017
Leishmania parasite isolation from the human aspirates is always challenging due to most probability of the fungal contamination and the use of antifungal drug which could support the selective growth of the Leishmania parasite. In this study, we examine
Narayan Raj Bhattarai, Keshav Rai, Suman Rijal, Basudha Khanal   +3 more
doaj   +1 more source

The Effects of Holothurin and Caspofungin on the Vaginal Cell Inflammation Parameters of the Rattus norvegicus Strain Post Induction of Candida albicans

Infection and Drug Resistance, 2023
Sri Handayani,1,2 Nurdiana Nurdiana,3 Sri Winarsih,4 Agustina Tri Endharti5 1Doctoral Program of Medical Science Department, Faculty of Medicine, Brawijaya University, Malang, Indonesia; 2Department of Midwifery of Aisyiyah, Institution of Surakarta ...
Handayani S, Nurdiana N, Winarsih S, Tri Endharti A   +3 more
doaj  

Caspofungin in pediatric patients

, 2008
Invasive fungal infections have emerged as one of the most significant complications in severely immunocompromised pediatric patients, such as children suffering from hematological malignancies or children undergoing hematopoietic stem cell ...
Andreas H Groll, Thomas Lehrnbecher
core   +1 more source