Results 101 to 110 of about 28,829 (241)

Stimulation of Eryptosis by Caspofungin

Cellular Physiology and Biochemistry, 2016
Background/Aims: The echinocandin antifungal agent caspofungin has been shown to trigger apoptosis of fungal cells. Beyond that, caspofungin is toxic for host mitochondria.
Thomas Peter, Rosi Bissinger, Florian Lang   +2 more
doaj   +1 more source

A Rare Case of Cutaneous Mucormycosis by Syncephalastrum Species in a Patient With Diabetes Mellitus: A Case Report and Review of the Literature

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Infections caused by Syncephalastrum species in humans are relatively rare. However, clinicians must maintain a high suspicion for it in immunocompromised patients with cutaneous mucormycosis. Prompt histopathological and microbiological investigations, combined with timely antifungal therapy and surgical intervention, are crucial to prevent ...
Iqra Maryam, Khawaja Abdul Rehman, Aymen Shafqat, Obaid Ur Rehman, Omama Ayatullah, M Rafiqul Islam, Allahdad Khan   +6 more
wiley   +1 more source

Fighting Emerging Caspofungin-Resistant Candida Species: Mitigating Fks1-Mediated Resistance and Enhancing Caspofungin Efficacy by Chitosan

Antibiotics
Invasive candidiasis poses a worldwide threat because of the rising prevalence of antifungal resistance, resulting in higher rates of morbidity and mortality. Additionally, Candida species, which are opportunistic infections, have significant medical and
Aya Tarek, Yasmine H. Tartor, Mohamed N. Hassan, Ioan Pet, Mirela Ahmadi, Adel Abdelkhalek   +5 more
doaj   +1 more source

A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in Cryptococcus neoformans

mBio, 2019
Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve ...
Chengjun Cao, Yina Wang, Seema Husain, Patricia Soteropoulos, Chaoyang Xue   +4 more
doaj   +1 more source

The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance

mBio, 2020
The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of immunocompromised humans. The mitogen-activated protein kinase (MAPK)
Eliciane Cevolani Mattos, Lilian Pereira Silva, Clara Valero, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Liliane F. C. Ribeiro, Mark R. Marten, Rafael Silva-Rocha, Cauã Westmann, Carlos Henrique Tomich de Paula da Silva, Carlton Anthony Taft, Narjes Al-Furaiji, Michael Bromley, Uffe H. Mortensen, J. Philipp Benz, Neil Andrew Brown, Gustavo H. Goldman   +16 more
doaj   +1 more source

Gastric Microbiome Alterations in Sepsis‐Related Gastrointestinal Bleeding: Two Case Reports and Literature Review

JGH Open, Volume 10, Issue 3, March 2026.
ABSTRACT Sepsis, characterized by life‐threatening organ dysfunction resulting from an uncontrolled response to infection, can impact various systems of the body, including the digestive system. Prior research has identified sepsis as a significant risk factor for gastrointestinal bleeding.
Fangjie Fu, Chen Zhang, Zhengying Xu, Peng Ji, Zhongwei Zhang   +4 more
wiley   +1 more source

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis [PDF]

, 2018
The quantification of lung fungal burden is critical for the determination of the relative levels of immune protection and fungal virulence in mouse models of pulmonary fungal infection.
Amarsaikhan, Nansalmaa, Sands, Ethan M., Stolz, Dylan J., Templeton, Steven P., Tsoggerel, Angar   +4 more
core   +1 more source

In Vitro Activities of Five Antifungal Drugs Against Conidia and Sclerotic Cells of Chromoblastomycosis Agent Fonsecaea spp

Microbiology and Immunology, Volume 70, Issue 3, Page 139-147, March 2026.
ABSTRACT Chromoblastomycosis (CBM) is a chronic skin and subcutaneous infection mainly caused by Fonsecaea pedrosoi, a dematiaceous fungus with various morphotypes. Characteristic sclerotic cells—globe‐shaped, multiseptated and pigmented—are found in lesions of infected individuals, though their differentiation in the host remains poorly understood. To
Aline Barral Takahashi, Daniella Paternostro de Araújo Grisólia, Moises Batista da Silva, Naila Ferreira da Cruz, Sâmela Miranda da Silva, Patrícia Fagundes da Costa, Claudio Guedes Salgado   +6 more
wiley   +1 more source

Clinical Outcomes of Intra‐Abdominal Candidiasis by Initial Antifungal Therapy

Mycoses, Volume 69, Issue 3, March 2026.
ABSTRACT Background Intra‐abdominal candidiasis (IAC) is a severe and heterogeneous infection associated with significant morbidity and mortality. Objectives To evaluate outcomes of IAC according to initial antifungal therapy and to identify predictors of persistent infection and 30‐day mortality.
M. Albanell‐Fernández, A. Vergara, F. Marco, S. Herrera, M. Tuset, A. Soriano, M. Bodro   +6 more
wiley   +1 more source

Rapid and direct quantification of viable Candida species in whole blood by use of immunomagnetic separation and solid-phase cytometry [PDF]

, 2010
Candida species are a common source of nosocomial bloodstream infections in critically ill patients. The sensitivity of the traditional diagnostic procedure based on blood culture is variable, and it usually takes 2 to 4 days before growth of Candida ...
Vanhee, Lies, Meersseman, Wouter, Lagrou, Katrien, Maertens, Johan, Nelis, Hans, Coenye, Tom   +5 more
core   +1 more source