Results 1 to 10 of about 6,464 (211)

EUCAST technical note on anidulafungin [PDF]

Clinical Microbiology and Infection, 2011
The European Committee on Antimicrobial Susceptibility Testing-Subcommittee on Antifungal Susceptibility Testing has determined breakpoints for anidulafungin for Candida spp. This Technical Note is based on the EUCAST anidulafungin rationale document (available at: http://www.eucast.org). Species-specific breakpoints for C.
William Hope, M Cuenca-Estrella, M C Arendrup   +2 more
exaly   +6 more sources

Multicenter evaluation of low inoculum and a colorimetric assay for antifungal susceptibility testing of Aspergillus fumigatus to echinocandins with the EUCAST E.Def 9.4 [PDF]

Journal of Clinical Microbiology
Echinocandin minimal effective concentration (MEC) determination for Aspergillus is challenging with the EUCAST method. We investigated the applicability of a lower inoculum (103 CFU/mL) and a colorimetric assay for micafungin and anidulafungin against ...
Joseph Meletiadis, Maria Siopi, Karin Meinike Jørgensen, Pilar Escribano, Jesus Guinea, Maiken Cavling Arendrup   +5 more
doaj   +2 more sources

Discovery of Small-Molecule PD-L1 Inhibitors via Virtual Screening and Their Immune-Mediated Anti-Tumor Effects [PDF]

Pharmaceuticals
Background/Objectives: Monoclonal antibodies targeting the PD-1/PD-L1 immune checkpoint have achieved clinical success but face drawbacks such as poor oral bioavailability, limited tumor penetration, and immune-related adverse events.
Chunlai Feng, Yingying Ge, Siqi Wang, Mengru Li, Qiying Chen, Hangyu Dong, Mengjie Rui   +6 more
doaj   +2 more sources

Fast detection of synergy and antagonism in antifungal combinations used against Candida albicans clinical isolates [PDF]

Scientific Reports
The rise in antifungal resistance has limited treatment options for serious fungal infections, emphasizing the need for effective combination therapies. However, low-cost and rapid systems to evaluate synergy and antagonism in antifungal combinations are
Hanna Lundvik, Ramona Santini, Tugce Unalan Altintop, Volkan Özenci, Dan I. Andersson, Nikos Fatsis-Kavalopoulos   +5 more
doaj   +2 more sources

A New Antifungal-Loaded Sol-Gel Can Prevent Candida albicans Prosthetic Joint Infection

Antibiotics, 2021
Fungal PJI is one of the most feared complications after arthroplasty. Although a rare finding, its high associated morbidity and mortality makes it an important object of study. The most frequent species causing fungal PJI is C. albicans. New technology
Hugo Garlito-Díaz, Jaime Esteban, Aranzazu Mediero, Rafael Alfredo Carias-Cálix, Beatriz Toirac, Francisca Mulero, Víctor Faus-Rodrigo, Antonia Jiménez-Morales, Emilio Calvo, John Jairo Aguilera-Correa   +9 more
doaj   +1 more source

In Vitro Susceptibilities of Worldwide Isolates of Intrapulmonary Aspergillus Species and Important Candida Species in Sterile Body Sites against Important Antifungals: Data from the Antimicrobial Testing Leadership and Surveillance Program, 2017–2020

Microbiology Spectrum, 2022
To understand the changes of resistance in clinically commonly encountered fungi, we used the Antimicrobial Testing Leadership and Surveillance (ATLAS) database to explore in vitro antifungal susceptibilities against clinically important isolates of ...
Shio-Shin Jean, Hung-Jen Yang, Po-Chuen Hsieh, Yu-Tsung Huang, Wen-Chien Ko, Po-Ren Hsueh   +5 more
doaj   +1 more source

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

Journal of Fungi, 2022
The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed ...
Maria Siopi, Antonios Papadopoulos, Anastasia Spiliopoulou, Fotini Paliogianni, Nissrine Abou-Chakra, Maiken Cavling Arendrup, Christina Damoulari, Georgios Tsioulos, Efthymia Giannitsioti, Frantzeska Frantzeskaki, Iraklis Tsangaris, Spyros Pournaras, Joseph Meletiadis   +12 more
doaj   +1 more source

Candidemia in cancer patients: phenotypical and molecular-genetic characteristics of antifungal drug resistance, pathogenic factor genes of Candida spp.

Сибирский онкологический журнал, 2022
Relevance. The global trend of rapid increase in resistance to antifungal drugs due to multiple factors, dictates the need for continuous monitoring of taxonomic structure and susceptibility of nosocomial pathogens, causing invasive fungal infections ...
N. S. Bagirova, E. A. Goremykina, P. V. Slukin, O. E. Khokhlova, N. K. Fursova, I. N. Petukhova, Z. V. Grigorievskaya   +6 more
doaj   +1 more source

Post-antifungal effect of the combination of anidulafungin with amphotericin B and fluconazole against fluconazolesusceptible and -resistant Candida albicans [PDF]

Current Medical Mycology, 2022
Background and Purpose: Invasive candidiasis is a life-threatening condition that kills a large number of immunocompromised patients each year worldwide.
narges aslani, Narges Vaseghi, Majid Piramoon, shaghayegh khojasteh, Kiana Abbasi, sahar mohseni, Javad Javidnia, Behrooz Naghili   +7 more
doaj   +1 more source

Invasive candidiasis in children

Журнал инфектологии, 2021
The prevalence of invasive candidiasis (IC) in pediatric hospitals is from 4,3 to 15,2 per 10,000 hospitalized, in ICU – from 3,5 to 7 cases per 1,000, with HSCT – 2,9%. The average length of stay of a patient in the hospital before the development of IC
N. N. Klimko, O. P. Kozlova
doaj   +1 more source