Results 11 to 20 of about 9,092 (211)

Prevalence Rates, Species Distribution and Antifungal Susceptibility of Rare Candida and Related Saccharomycotina Yeasts Causing Bloodstream Infections in 28 Medical Centres. [PDF]

Mycoses
ABSTRACT Background There is a lack of contemporary studies addressing the prevalence rates and antifungal susceptibility of bloodstream infections (BSI) caused by rare yeasts (RY) from the Saccharomycotina subphylum. Objectives This 16‐year multicentre study (2007–2023) aimed to assess the prevalence and antifungal susceptibility of rare yeasts ...
Buonafine CP, Dos Santos AE, Favarello LM, Cognialli RCR, Aquino VR, Mendes AVA, Guimarães T, Sukiennik TCT, Carlesse F, Castro PTOE, Vicente VA, Francisco EC, Colombo AL.   +12 more
europepmc   +2 more sources

Cost-Effectiveness of Once Weekly Rezafungin for the Treatment of Invasive Candidiasis in the United Kingdom. [PDF]

Mycoses
ABSTRACT Background Invasive candidiasis (IC), life‐threatening fungal infections with high economic burden, are often treated first‐line with daily intravenous echinocandins. A new once weekly echinocandin, rezafungin, demonstrated statistically non‐inferior efficacy and numerically shorter intensive care unit (ICU) stay compared to caspofungin in ...
Muszbek N, Angdembe A, Garcia-Vidal C, Bielicka I, Abrams KR, Tolley K, Ruhnke M, Lebmeier M, Hawkins N, Manamley N, Dickerson S.   +10 more
europepmc   +2 more sources

Invasive candidiasis in children

Журнал инфектологии, 2021
The prevalence of invasive candidiasis (IC) in pediatric hospitals is from 4,3 to 15,2 per 10,000 hospitalized, in ICU – from 3,5 to 7 cases per 1,000, with HSCT – 2,9%. The average length of stay of a patient in the hospital before the development of IC
N. N. Klimko, O. P. Kozlova
doaj   +1 more source

Micafungin versus anidulafungin in critically ill patients with invasive candidiasis: A retrospective study [PDF]

, 2016
_Background:_ In critically ill patients the incidence of invasive fungal infections caused by Candida spp. has increased remarkably. Echinocandins are recommended as initial treatment for invasive fungal infections. The safety and efficacy of micafungin
Geest, P.J. (Patrick) van der, Groeneveld, A.B.J. (Johan), Hunfeld, N.G.M. (Nicole), Ladage, S.E. (Sophie E.)   +3 more
core   +5 more sources

Evaluation of the in vitro Activity and in vivo Efficacy of Anidulafungin-Loaded Human Serum Albumin Nanoparticles Against Candida albicans

Frontiers in Microbiology, 2021
Recent decades have seen a significant increase in invasive fungal infections, resulting in unacceptably high mortality rates. Anidulafungin (AN) is the newest echinocandin and appears to have several advantages over existing antifungals.
Yu Zhang, Yan-Chao Liu, Yan-Chao Liu, Si-Min Chen, Hui Zong, Wei-Tong Hou, Xi-Ran Qiu, Shi-Yu Guo, Yu-Fang Sun, Yuan-Ying Jiang, Mao-Mao An, Hui Shen   +11 more
doaj   +1 more source

Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies [PDF]

, 2015
Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D.
Gow, Neil A R, Lee, Keunsook, Munro, Carol A, Walker, Louise A   +3 more
core   +1 more source

In vitro synergy of echinocandins with triazoles against fluconazole-resistant Candida parapsilosis complex isolates

Journal of Global Antimicrobial Resistance, 2020
Introduction: Candida parapsilosis (C. parapsilosis) is a common non-albicans Candida species ranked as the second common cause of bloodstream infections. Azole resistance and elevated echinocandin MICs have been reported for these fungi.
Ali Ahmadi, Shahram Mahmoudi, Sassan Rezaie, Sayed Jamal Hashemi, Eric Dannaoui, Hamid Badali, Mansoureh Ghaffari, Farzad Aala, Alireza Izadi, Aida Maleki, Jacques F. Meis, Sadegh Khodavaisy   +11 more
doaj   +1 more source

SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus

Advanced Science, 2022
Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co‐opting of host factors. Here, it is demonstrated that induction of host serine and arginine‐rich splicing factor 5 (SRSF5) by IAV facilitated ...
Qiuchen Li, Zhimin Jiang, Shuning Ren, Hui Guo, Zhimin Song, Saini Chen, Xintao Gao, Fanfeng Meng, Junda Zhu, Litao Liu, Qi Tong, Honglei Sun, Yipeng Sun, Juan Pu, Kin‐Chow Chang, Jinhua Liu   +15 more
doaj   +1 more source

First Report of Fluconazole-Resistant Candida parapsilosis Harbouring the G458S ERG11p Substitution in a Brazilian Hospital. [PDF]

Mycoses
ABSTRACT Background Fluconazole‐resistant Candida parapsilosis is a matter of concern. Objectives To investigate fluconazole resistance among Candida parapsilosis complex isolates from patients admitted to three Brazilian hospitals, and to characterise resistance mechanisms and clonal relatedness. Patients/Methods A total of 76 C.
Gonçalves SS, Maifrede SB, Yäkel E, Peçanha PM, Bessa-Neto FO, Cayô R, Rodrigues AM, Muñoz P, Escribano P, Guinea J.   +9 more
europepmc   +2 more sources

Set of Classical PCRs for Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance [PDF]

, 2014
Clinical echinocandin resistance among Candida glabrata strains is increasing, especially in the United States. Antifungal susceptibility testing is considered mandatory to guide therapeutic decisions.
Afeltra, Javier, Dudiuk, Catiana Beatriz, Gamarra, Maria Soledad, Garcia, Guillermo Manuel, Jimenez Ortigoza, Cristina, Leonardelli, Florencia, Perlin, David S., Vitale, Roxana Gabriela   +7 more
core   +2 more sources