Results 31 to 40 of about 6,415 (210)

SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus

Advanced Science, 2022
Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co‐opting of host factors. Here, it is demonstrated that induction of host serine and arginine‐rich splicing factor 5 (SRSF5) by IAV facilitated ...
Qiuchen Li, Zhimin Jiang, Shuning Ren, Hui Guo, Zhimin Song, Saini Chen, Xintao Gao, Fanfeng Meng, Junda Zhu, Litao Liu, Qi Tong, Honglei Sun, Yipeng Sun, Juan Pu, Kin‐Chow Chang, Jinhua Liu   +15 more
doaj   +1 more source

Human Tissue Distribution of Anidulafungin and Micafungin

, 2021
Concentrations of anidulafungin and micafungin were determined in eight different tissues obtained during autopsy of four deceased who had been treated with anidulafungin and of seven who had obtained micafungin.
Joannidis, Michael, Gasperetti, Tiziana, Bellmann, Romuald, Marx, Jana, Welte, René, Moser, Patrizia   +5 more
core   +1 more source

Retrospective cohort study comparing the risk of severe hepatotoxicity in hospitalized patients treated with echinocandins for invasive candidiasis in the presence of confounding by indication

BMC Infectious Diseases, 2018
Background To compare the risk of severe hepatotoxicity with anidulafungin versus caspofungin and micafungin in hospitalized adults. Methods This retrospective cohort study combined data from two large US- based hospital electronic medical record ...
Francis Vekeman, Lisa Weiss, Jalal Aram, Raluca Ionescu-Ittu, Shahrzad Moosavi, Yongling Xiao, Wendy Y. Cheng, Rachel H. Bhak, Margaret Tawadrous, M. Rita Capparella, Philippe Montravers, Mei Sheng Duh   +11 more
doaj   +1 more source

In Vitro Interaction and Killing-Kinetics of Amphotericin B Combined with Anidulafungin or Caspofungin against Candida auris

Pharmaceutics, 2021
Treatment of invasive infections caused by Candida auris is challenging due to the limited therapeutic options. The combination of antifungal drugs may be an interesting and feasible approach to be investigated.
Unai Caballero, Elena Eraso, Guillermo Quindós, Nerea Jauregizar   +3 more
doaj   +1 more source

Does Weight Impact Anidulafungin Pharmacokinetics? [PDF]

, 2016
Contains fulltext : 172336.pdf (Publisher’s version ) (Open Access)Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose)
Vincent J. Lempers, Roger J. Brüggemann, Rob E. Aarnoutse, Knibbe, C.A., Lempers, V.J., Knibbe, C.A.J., Bert van Ramshorst, Eric P. van Dongen, Burger, D.M., Rongen, A. van, Rongen, A., Dongen, E.P. Van, Bruggemann, R.J., Anne van Rongen, Ramshorst, B. van, David M. Burger, Aarnoutse, R.E., Lempers, V.J.C., Bruggemann, R.J.M., Catherijne A. Knibbe   +19 more
core   +1 more source

Efficacy of liposomal amphotericin B and anidulafungin using an antifungal lock technique (ALT) for catheter-related Candida albicans and Candida glabrata infections in an experimental model.

PLoS ONE, 2019
ObjectiveThe aims of this study were as follows. First, we sought to compare the in vitro susceptibility of liposomal amphotericin B (LAmB) and anidulafungin on Candida albicans and Candida glabrata biofilms growing on silicone discs.
Jana Basas, Marta Palau, Xavier Gomis, Benito Almirante, Joan Gavaldà   +4 more
doaj   +1 more source

Parallel and cross-resistances of clinical yeast isolates determined by susceptibility pattern analysis

GMS Infectious Diseases, 2016
For calculated initial antifungal therapy, knowledge on parallel and cross-resistances are vitally important particularly in the case of multiresistant isolates.
Schmalreck, Arno F., Willinger, Birgit, Idelevich, Evgeny A., Fegeler, Christian, Lass-Flörl, Cornelia, Fegeler, Wolfgang, Becker, Karsten   +6 more
doaj   +1 more source

Are We Ready for Nosocomial Candida auris Infections? Rapid Identification and Antifungal Resistance Detection Using MALDI-TOF Mass Spectrometry May Be the Answer

Frontiers in Cellular and Infection Microbiology, 2021
The occurrence of multidrug-resistant Candida auris isolates and the increased mortality associated with invasive infections or outbreaks due to this Candida species have been reported in many healthcare settings.
Elena De Carolis, Federica Marchionni, Marilisa La Rosa, Jacques F. Meis, Jacques F. Meis, Anuradha Chowdhary, Brunella Posteraro, Maurizio Sanguinetti, Maurizio Sanguinetti   +8 more
doaj   +1 more source

Comparing the results of invasive candidiasis prevention with anidulafungin vs. the lipid formulation of amphotericin B in high-risk patients in the early postoperative period after liver transplantation

Трансплантология (Москва), 2020
Introduction. The development of invasive candidiasis leads to high mortality after liver transplantation. Choosing an effective prophylaxis is an important task.The study purpose was to compare the results  of invasive candidiasis prevention with ...
S. V. Zhuravel, N. K. Kuznetsova, I. I. Utkina, M. S. Novruzbekov, P. V. Gavrilov, T. V. Chernenkaya, G. K. Ospanova   +6 more
doaj   +1 more source

Safety, efficacy and pharmacokinetics of anidulafungin in patients 1 month to <2 years of age with Invasive candidiasis, including candidemia [PDF]

, 2020
Nineteen patients 1 month to <2 years of age with (n = 16) or at high risk of (n = 3) invasive candidiasis received anidulafungin for 5-35 days (3 mg/kg day 1, 1.5 mg/kg daily thereafter) followed by optional fluconazole (NCT00761267).
Roilides E., Sandra Arnold, Joan Robinson, Fabio Motta, Cheng-Hsun Chiu, Yan J. L., Audra Deveikis, Jong Jin Seo, William Steinbach, Tawadrous M., Nelson Horigoshi, Brian Patrick Lee, Aram J. A., Chuhl Joo Lyu, Rainer Gedeit, Raber S., Jaime Deville, Antonio Arrieta, Queiroz-Telles F. The Anidulafungin A8851008 Pediatric Study Group members are as follows: Natalia Dmitrieva, Carlesse F., Conte U., Leister-Tebbe H., Vassiliki Syriopoulou, Swanson R., Giuseppe Gentile, Richard Grundy, Irina Shipitsina   +26 more
core   +1 more source