Results 31 to 40 of about 6,869 (208)

Are We Ready for Nosocomial Candida auris Infections? Rapid Identification and Antifungal Resistance Detection Using MALDI-TOF Mass Spectrometry May Be the Answer

Frontiers in Cellular and Infection Microbiology, 2021
The occurrence of multidrug-resistant Candida auris isolates and the increased mortality associated with invasive infections or outbreaks due to this Candida species have been reported in many healthcare settings.
Elena De Carolis, Federica Marchionni, Marilisa La Rosa, Jacques F. Meis, Jacques F. Meis, Anuradha Chowdhary, Brunella Posteraro, Maurizio Sanguinetti, Maurizio Sanguinetti   +8 more
doaj   +1 more source

Parallel and cross-resistances of clinical yeast isolates determined by susceptibility pattern analysis

GMS Infectious Diseases, 2016
For calculated initial antifungal therapy, knowledge on parallel and cross-resistances are vitally important particularly in the case of multiresistant isolates.
Schmalreck, Arno F., Willinger, Birgit, Idelevich, Evgeny A., Fegeler, Christian, Lass-Flörl, Cornelia, Fegeler, Wolfgang, Becker, Karsten   +6 more
doaj   +1 more source

Intravenous anidulafungin followed optionally by oral voriconazole for the treatment of candidemia in Asian patients: results from an open-label Phase III trial

, 2014
Background: Candidemia is a significant cause of morbidity and mortality in hospitalized patients, particularly in Asia. Anidulafungin has been reported to be an effective treatment for candidemia in Western populations, but little is known about its ...
Mootsikapun, Piroon;Hsueh, Po-Ren;Talwar, Deepak;Co, Vilma M.;Rajadhyaksha, Viraj;Ong, Moh-Lim, 薛博仁   +1 more
core   +1 more source

Comparison of In Vitro Killing Activity of Rezafungin, Anidulafungin, Caspofungin, and Micafungin against Four Candida auris Clades in RPMI-1640 in the Absence and Presence of Human Serum

Microorganisms, 2021
Candida auris is an emerging and frequently multidrug-resistant pathogen against which the echinocandins are the preferred therapeutic option. We compared killing activities of anidulafungin, caspofungin, micafungin, and rezafungin against 13 isolates ...
Renátó Kovács, Zoltán Tóth, Jeffrey B. Locke, Lajos Forgács, Gábor Kardos, Fruzsina Nagy, Andrew M. Borman, László Majoros   +7 more
doaj   +1 more source

Isolation, identification and characterization of potential impurities of anidulafungin

, 2017
Eight impurities ranging from 0.03 to 0.97% in anidulafungin bulk drug were detected by HPLC. Four impurities (Imp-I, Imp-II, Imp-III and Imp-VIII) among impurities were isolated from the self-prepared or marketed samples of anidulafungin bulk drug by ...
Bie, Y, Lu, XX (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Wang, QL, Lu, XX, Zhao, LN   +4 more
core   +1 more source

Limited-sampling strategies for anidulafungin in critically ill patients [PDF]

, 2015
Efficacy of anidulafungin is driven by the area under the concentration-time curve (AUC)/MIC ratio. Determination of the anidulafungin AUC along with MIC values can therefore be useful.
Kosterink, Jos G.W., Alffenaar, Jan-Willem C., Kosterink, Jos G.W.; id_orcid, Zijlstra, Jan G.; id_orcid, van der Werf, Tjip S., Zijlstra, Jan G., Uges, Donald R.A., Proost, Johannes H., van Wanrooy, Marjolijn J.P., Rodgers, Michael G. G.   +9 more
core   +2 more sources

Successfully treated bilateral renal fungal balls with continuous Anidulafulgin irrigation

Urology Case Reports, 2021
A 73-year-old man with a history of type 2 diabetes mellitus, nephrolithiasis, and recurrent urinary tract infections caused by Candida glabrata was admitted to our hospital. Urosepsis was diagnosed and C.
N.A.M. van Merode, J.J. Pat, M.J.H.M. Wolfhagen, G.A. Dijkstra   +3 more
doaj   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie International Edition, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Anidulafungin in combination with amphotericin B against Aspergillus fumigatus. [PDF]

, 2009
We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at
C. Loretelli, Loretelli, Cristian, G. Scalise, Barchiesi, F., E. Spreghini, Manso, Esther, Pisa, Eleonora, Spreghini, E, Santinelli, A, Scalise, Giorgio, F. Barchiesi, Milici, Maria Eleonara, Manso,E, Orlando, Fiorenza, MILICI, Maria Eleonora, Pisa, E, E. Manso, Loretelli, C, E. Pisa, Barchiesi, Francesco, F. Orlando, A. Santinelli, M. E. Milici, Spreghini, Elisabetta, Santinelli, Alfredo, Orlando, F, Scalise, G   +26 more
core   +1 more source

Echinocandin Drugs Induce Differential Effects in Cytokinesis Progression and Cell Integrity

Pharmaceuticals, 2021
Fission yeast contains three essential β(1,3)-D-glucan synthases (GSs), Bgs1, Bgs3, and Bgs4, with non-overlapping roles in cell integrity and morphogenesis.
Natalia Yagüe, Laura Gómez-Delgado, M. Ángeles Curto, Vanessa S. D. Carvalho, M. Belén Moreno, Pilar Pérez, Juan Carlos Ribas, Juan Carlos G. Cortés   +7 more
doaj   +1 more source