Results 21 to 30 of about 6,869 (208)

Retrospective cohort study comparing the risk of severe hepatotoxicity in hospitalized patients treated with echinocandins for invasive candidiasis in the presence of confounding by indication

BMC Infectious Diseases, 2018
Background To compare the risk of severe hepatotoxicity with anidulafungin versus caspofungin and micafungin in hospitalized adults. Methods This retrospective cohort study combined data from two large US- based hospital electronic medical record ...
Francis Vekeman, Lisa Weiss, Jalal Aram, Raluca Ionescu-Ittu, Shahrzad Moosavi, Yongling Xiao, Wendy Y. Cheng, Rachel H. Bhak, Margaret Tawadrous, M. Rita Capparella, Philippe Montravers, Mei Sheng Duh   +11 more
doaj   +1 more source

SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus

Advanced Science, 2022
Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co‐opting of host factors. Here, it is demonstrated that induction of host serine and arginine‐rich splicing factor 5 (SRSF5) by IAV facilitated ...
Qiuchen Li, Zhimin Jiang, Shuning Ren, Hui Guo, Zhimin Song, Saini Chen, Xintao Gao, Fanfeng Meng, Junda Zhu, Litao Liu, Qi Tong, Honglei Sun, Yipeng Sun, Juan Pu, Kin‐Chow Chang, Jinhua Liu   +15 more
doaj   +1 more source

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

Journal of Fungi, 2022
The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed ...
Maria Siopi, Antonios Papadopoulos, Anastasia Spiliopoulou, Fotini Paliogianni, Nissrine Abou-Chakra, Maiken Cavling Arendrup, Christina Damoulari, Georgios Tsioulos, Efthymia Giannitsioti, Frantzeska Frantzeskaki, Iraklis Tsangaris, Spyros Pournaras, Joseph Meletiadis   +12 more
doaj   +1 more source

Does Weight Impact Anidulafungin Pharmacokinetics? [PDF]

, 2016
Contains fulltext : 172336.pdf (Publisher’s version ) (Open Access)Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose)
Vincent J. Lempers, Roger J. Brüggemann, Rob E. Aarnoutse, Knibbe, C.A., Lempers, V.J., Knibbe, C.A.J., Bert van Ramshorst, Eric P. van Dongen, Burger, D.M., Rongen, A. van, Rongen, A., Dongen, E.P. Van, Bruggemann, R.J., Anne van Rongen, Ramshorst, B. van, David M. Burger, Aarnoutse, R.E., Lempers, V.J.C., Bruggemann, R.J.M., Catherijne A. Knibbe   +19 more
core   +3 more sources

Efficacy of liposomal amphotericin B and anidulafungin using an antifungal lock technique (ALT) for catheter-related Candida albicans and Candida glabrata infections in an experimental model.

PLoS ONE, 2019
ObjectiveThe aims of this study were as follows. First, we sought to compare the in vitro susceptibility of liposomal amphotericin B (LAmB) and anidulafungin on Candida albicans and Candida glabrata biofilms growing on silicone discs.
Jana Basas, Marta Palau, Xavier Gomis, Benito Almirante, Joan Gavaldà   +4 more
doaj   +1 more source

Pharmacology and metabolism of anidulafungin, caspofungin and micafungin in the treatment of invasive candidosis - review of the literature

European Journal of Medical Research, 2011
Echinocandins represent the newest class of antifungal agents. Currently, three echinocandins, anidulafungin, caspofungin and micafungin are licensed for clinical use in various indications.
Kofla G, Ruhnke M
doaj   +1 more source

Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction

Frontiers in Genetics, 2022
Drug repositioning continues to be the most effective, practicable possibility to treat COVID-19 patients. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters target cells by binding to the ACE2 receptor via its spike (S ...
Shahzaib Ahamad, Hashim Ali, Hashim Ali, Ilaria Secco, Mauro Giacca, Mauro Giacca, Mauro Giacca, Dinesh Gupta   +7 more
doaj   +1 more source

Comparing the results of invasive candidiasis prevention with anidulafungin vs. the lipid formulation of amphotericin B in high-risk patients in the early postoperative period after liver transplantation

Трансплантология (Москва), 2020
Introduction. The development of invasive candidiasis leads to high mortality after liver transplantation. Choosing an effective prophylaxis is an important task.The study purpose was to compare the results  of invasive candidiasis prevention with ...
S. V. Zhuravel, N. K. Kuznetsova, I. I. Utkina, M. S. Novruzbekov, P. V. Gavrilov, T. V. Chernenkaya, G. K. Ospanova   +6 more
doaj   +1 more source

Safety, efficacy and pharmacokinetics of anidulafungin in patients 1 month to <2 years of age with Invasive candidiasis, including candidemia [PDF]

, 2020
Nineteen patients 1 month to <2 years of age with (n = 16) or at high risk of (n = 3) invasive candidiasis received anidulafungin for 5-35 days (3 mg/kg day 1, 1.5 mg/kg daily thereafter) followed by optional fluconazole (NCT00761267).
Roilides E., Sandra Arnold, Joan Robinson, Fabio Motta, Cheng-Hsun Chiu, Yan J. L., Audra Deveikis, Jong Jin Seo, William Steinbach, Tawadrous M., Nelson Horigoshi, Brian Patrick Lee, Aram J. A., Chuhl Joo Lyu, Rainer Gedeit, Raber S., Jaime Deville, Antonio Arrieta, Queiroz-Telles F. The Anidulafungin A8851008 Pediatric Study Group members are as follows: Natalia Dmitrieva, Carlesse F., Conte U., Leister-Tebbe H., Vassiliki Syriopoulou, Swanson R., Giuseppe Gentile, Richard Grundy, Irina Shipitsina   +26 more
core   +1 more source

In Vitro Interaction and Killing-Kinetics of Amphotericin B Combined with Anidulafungin or Caspofungin against Candida auris

Pharmaceutics, 2021
Treatment of invasive infections caused by Candida auris is challenging due to the limited therapeutic options. The combination of antifungal drugs may be an interesting and feasible approach to be investigated.
Unai Caballero, Elena Eraso, Guillermo Quindós, Nerea Jauregizar   +3 more
doaj   +1 more source