Results 41 to 50 of about 6,415 (210)

Pharmacology and metabolism of anidulafungin, caspofungin and micafungin in the treatment of invasive candidosis - review of the literature

European Journal of Medical Research, 2011
Echinocandins represent the newest class of antifungal agents. Currently, three echinocandins, anidulafungin, caspofungin and micafungin are licensed for clinical use in various indications.
Kofla G, Ruhnke M
doaj   +1 more source

Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction

Frontiers in Genetics, 2022
Drug repositioning continues to be the most effective, practicable possibility to treat COVID-19 patients. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters target cells by binding to the ACE2 receptor via its spike (S ...
Shahzaib Ahamad, Hashim Ali, Hashim Ali, Ilaria Secco, Mauro Giacca, Mauro Giacca, Mauro Giacca, Dinesh Gupta   +7 more
doaj   +1 more source

Comparison of In Vitro Killing Activity of Rezafungin, Anidulafungin, Caspofungin, and Micafungin against Four Candida auris Clades in RPMI-1640 in the Absence and Presence of Human Serum

Microorganisms, 2021
Candida auris is an emerging and frequently multidrug-resistant pathogen against which the echinocandins are the preferred therapeutic option. We compared killing activities of anidulafungin, caspofungin, micafungin, and rezafungin against 13 isolates ...
Renátó Kovács, Zoltán Tóth, Jeffrey B. Locke, Lajos Forgács, Gábor Kardos, Fruzsina Nagy, Andrew M. Borman, László Majoros   +7 more
doaj   +1 more source

First Report of Fluconazole-Resistant Candida parapsilosis Harbouring the G458S ERG11p Substitution in a Brazilian Hospital. [PDF]

Mycoses
ABSTRACT Background Fluconazole‐resistant Candida parapsilosis is a matter of concern. Objectives To investigate fluconazole resistance among Candida parapsilosis complex isolates from patients admitted to three Brazilian hospitals, and to characterise resistance mechanisms and clonal relatedness. Patients/Methods A total of 76 C.
Gonçalves SS, Maifrede SB, Yäkel E, Peçanha PM, Bessa-Neto FO, Cayô R, Rodrigues AM, Muñoz P, Escribano P, Guinea J.   +9 more
europepmc   +2 more sources

Successfully treated bilateral renal fungal balls with continuous Anidulafulgin irrigation

Urology Case Reports, 2021
A 73-year-old man with a history of type 2 diabetes mellitus, nephrolithiasis, and recurrent urinary tract infections caused by Candida glabrata was admitted to our hospital. Urosepsis was diagnosed and C.
N.A.M. van Merode, J.J. Pat, M.J.H.M. Wolfhagen, G.A. Dijkstra   +3 more
doaj   +1 more source

Intravenous anidulafungin followed optionally by oral voriconazole for the treatment of candidemia in Asian patients: results from an open-label Phase III trial

, 2014
Background: Candidemia is a significant cause of morbidity and mortality in hospitalized patients, particularly in Asia. Anidulafungin has been reported to be an effective treatment for candidemia in Western populations, but little is known about its ...
Mootsikapun, Piroon;Hsueh, Po-Ren;Talwar, Deepak;Co, Vilma M.;Rajadhyaksha, Viraj;Ong, Moh-Lim, 薛博仁   +1 more
core   +1 more source

Echinocandin Drugs Induce Differential Effects in Cytokinesis Progression and Cell Integrity

Pharmaceuticals, 2021
Fission yeast contains three essential β(1,3)-D-glucan synthases (GSs), Bgs1, Bgs3, and Bgs4, with non-overlapping roles in cell integrity and morphogenesis.
Natalia Yagüe, Laura Gómez-Delgado, M. Ángeles Curto, Vanessa S. D. Carvalho, M. Belén Moreno, Pilar Pérez, Juan Carlos Ribas, Juan Carlos G. Cortés   +7 more
doaj   +1 more source

Isolation, identification and characterization of potential impurities of anidulafungin

, 2017
Eight impurities ranging from 0.03 to 0.97% in anidulafungin bulk drug were detected by HPLC. Four impurities (Imp-I, Imp-II, Imp-III and Imp-VIII) among impurities were isolated from the self-prepared or marketed samples of anidulafungin bulk drug by ...
Bie, Y, Lu, XX (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Wang, QL, Lu, XX, Zhao, LN   +4 more
core   +1 more source

Limited-sampling strategies for anidulafungin in critically ill patients [PDF]

, 2015
Efficacy of anidulafungin is driven by the area under the concentration-time curve (AUC)/MIC ratio. Determination of the anidulafungin AUC along with MIC values can therefore be useful.
Kosterink, Jos G.W., Alffenaar, Jan-Willem C., Kosterink, Jos G.W.; id_orcid, Zijlstra, Jan G.; id_orcid, van der Werf, Tjip S., Zijlstra, Jan G., Uges, Donald R.A., Proost, Johannes H., van Wanrooy, Marjolijn J.P., Rodgers, Michael G. G.   +9 more
core   +1 more source

Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication

Microbiology Spectrum, 2022
The proposed life cycle of fungi in the genus Pneumocystis has typically included both an asexual cycle via binary fission and a sexual cycle. Until recently, the strategy used for sexual replication was largely unknown, but genomic and functional assays
Melanie T. Cushion, Alan Ashbaugh, Steven G. Sayson, Christopher Mosley, Philippe M. Hauser   +4 more
doaj   +1 more source