Results 21 to 30 of about 13,317 (169)

Clinically Important Emerging and Uncommon Fungal Pathogens in Asia: Epidemiology, Antifungal Resistance and Challenges in Diagnosis and Management. [PDF]

Mycoses
ABSTRACT Fungal infections in Asia are influenced by warm, humid climates, high population density and expanding healthcare systems, which together facilitate the emergence, transmission and detection of both common and rare pathogens. While Candida and Aspergillus species remain the leading causes of invasive fungal disease, increasing attention has ...
Chancharussin N, Jitmuang A, Chakrabarti A, Chayakulkeeree M.   +3 more
europepmc   +2 more sources

Case Report: Echinocandin-Resistance Candida glabrata FKS Mutants From Patient Following Radical Cystoprostatectomy Due to Muscle-Invasive Bladder Cancer

Frontiers in Oncology, 2021
Invasive Candida glabrata infections are not common complications after radical cystoprostatectomy. Furthermore, resistance to echinocandins arising during the course of a patient’s treatment is rarely recognised.
Maria Szymankiewicz, Krzysztof Kamecki, Sylwia Jarzynka, Anna Koryszewska-Bagińska, Gabriela Olędzka, Tomasz Nowikiewicz, Tomasz Nowikiewicz   +6 more
doaj   +1 more source

In Vitro Characterization of Twenty-One Antifungal Combinations against Echinocandin-Resistant and -Susceptible Candida glabrata

Journal of Fungi, 2021
This study was designed to analyze the interaction of 21 antifungal combinations consisting of seven major antifungal agents against 11 echinocandin- susceptible and six-resistant C. glabrata isolates. The combinations were divided into five major groups
Hazim O. Khalifa, Hidetaka Majima, Akira Watanabe, Katsuhiko Kamei   +3 more
doaj   +1 more source

Pharmacoeconomic analysis of antifungal therapy for primary treatment of invasive candidiasis caused by Candida albicans and non-albicans Candida species

BMC Infectious Diseases, 2017
Background Cost-effectiveness studies of echinocandins for the treatment of invasive candidiasis, including candidemia, are rare in Asia. No study has determined whether echinocandins are cost-effective for both Candida albicans and non-albicans Candida ...
Huang-Tz Ou, Tsung-Ying Lee, Yee-Chun Chen, Claudie Charbonneau   +3 more
doaj   +1 more source

FKS1 Is Required for Cryptococcus neoformans Fitness In Vivo: Application of Copper-Regulated Gene Expression to Mouse Models of Cryptococcosis

mSphere, 2022
There is an urgent need for new antifungals to treat cryptococcal meningoencephalitis, a leading cause of mortality in people living with HIV/AIDS. An important aspect of antifungal drug development is the validation of targets to determine whether they ...
Sarah R. Beattie, Andrew J. Jezewski, Laura C. Ristow, Melanie Wellington, Damian J. Krysan   +4 more
doaj   +1 more source

In Vitro Interaction and Killing-Kinetics of Amphotericin B Combined with Anidulafungin or Caspofungin against Candida auris

Pharmaceutics, 2021
Treatment of invasive infections caused by Candida auris is challenging due to the limited therapeutic options. The combination of antifungal drugs may be an interesting and feasible approach to be investigated.
Unai Caballero, Elena Eraso, Guillermo Quindós, Nerea Jauregizar   +3 more
doaj   +1 more source

Two Sequential Clinical Isolates of Candida glabrata with Multidrug-Resistance to Posaconazole and Echinocandins

Antibiotics, 2021
Candida glabrata is one of the most prevalent causative pathogens of invasive candidiasis, and multidrug-resistant strains are emerging. We identified two clinical isolates of C. glabrata, BMU10720 and BMU10722 sequentially isolated from one patient with
Qiqi Wang, Yun Li, Xuan Cai, Ruoyu Li, Bo Zheng, Ence Yang, Tianyu Liang, Xinyu Yang, Zhe Wan, Wei Liu   +9 more
doaj   +1 more source

Echinocandins for candidemia: a rational choice [PDF]

, 2013
Among antifungal drugs, echinocandins (micafungin, caspofungin and anidulafungin) represent a rational choice for the first-line therapy of candidemia/invasive candidiasis in critically ill patients.
Menichetti, Francesco, Tagliaferri, Enrico   +1 more
core   +1 more source

Stimulation of chitin synthesis rescues Candida albicans from echinocandins.

PLoS Pathogens, 2008
Echinocandins are a new generation of novel antifungal agent that inhibit cell wall beta(1,3)-glucan synthesis and are normally cidal for the human pathogen Candida albicans. Treatment of C.
Louise A Walker, Carol A Munro, Irene de Bruijn, Megan D Lenardon, Alastair McKinnon, Neil A R Gow   +5 more
doaj   +1 more source

ECHINOCANDINS VERSUS DATED ANTIFUNGALS IN COMBINATION AGAINST OPPORTUNISTIC MYCOTIC INFECTIONS [PDF]

, 2017
Scientific and clinical reports globally demonstrated that the opportunistic mycotic infections are at major risk to the human fitness. In past few decades, development of resistance in microbes to existing antifungals, has emphasized on the search of ...
Balhara, Meenakshi, Chaudhary, Renu, Narwal, Mrridula Dangi, Ak, Chhillar   +3 more
core   +2 more sources