Results 21 to 30 of about 12,460 (212)

Micafungin: A New Echinocandin [PDF]

Clinical Infectious Diseases, 2006
Micafungin, a potent inhibitor of 1,3-beta-D-glucan synthase, has become the second available agent in the echinocandins class that is approved for use in clinical practice. This agent shares with caspofungin an identical spectrum of in vitro activity against Candida albicans, non-albicans species of Candida, and Aspergillus species, as well as several
P H, Chandrasekar, J D, Sobel
openaire   +2 more sources

Stimulation of chitin synthesis rescues Candida albicans from echinocandins.

PLoS Pathogens, 2008
Echinocandins are a new generation of novel antifungal agent that inhibit cell wall beta(1,3)-glucan synthesis and are normally cidal for the human pathogen Candida albicans. Treatment of C.
Louise A Walker, Carol A Munro, Irene de Bruijn, Megan D Lenardon, Alastair McKinnon, Neil A R Gow   +5 more
doaj   +1 more source

In Vitro Killing Activities of Anidulafungin and Micafungin with and without Nikkomycin Z against Four Candida auris Clades

Pharmaceutics, 2023
Candida auris is a multidrug-resistant pathogen against which echinocandins are the drug of choice. However, information on how the chitin synthase inhibitor nikkomycin Z influences the killing activities of echinocandins against C.
Awid Adnan, Andrew M. Borman, Zoltán Tóth, Lajos Forgács, Renátó Kovács, Dávid Balázsi, Bence Balázs, Gergely Udvarhelyi, Gábor Kardos, László Majoros   +9 more
doaj   +1 more source

The Elevated Endogenous Reactive Oxygen Species Contribute to the Sensitivity of the Amphotericin B-Resistant Isolate of Aspergillus flavus to Triazoles and Echinocandins

Frontiers in Microbiology, 2021
Aspergillus flavus has been frequently reported as the second cause of invasive aspergillosis (IA), as well as the leading cause in certain tropical countries.
Tianyu Liang, Wei Chen, Xinyu Yang, Qiqi Wang, Zhe Wan, Ruoyu Li, Wei Liu   +6 more
doaj   +1 more source

Some issues of the resistance of Candida glabrata to echinocandins [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2019
Invasive candidiasis is a common, severe and often difficult to treat complication in various categories of patients. Despite the fact that in most cases Candida albicans retains a leading position as an etiological cause, a pathogen such as Candida ...
Veselov A.V.
doaj   +1 more source

Comparative effectiveness of echinocandins and liposomal amphotericin B for fluconazole-resistant <i>Candida parapsilosis</i> bloodstream infections. [PDF]

Antimicrob Agents Chemother
Current therapeutic options for fluconazole-resistant Candida parapsilosis (FLZR-CP) bloodstream infections (BSI) are limited to echinocandins and liposomal amphotericin B (L-AmB).
Vena A, Bartalucci C, Muccio M, Tiseo G, Muñoz P, Cesaretti M, Di Pilato V, Marchese A, Barbieri R, Forniti A, Giacobbe DR, Limongelli A, Lupetti A, Mikulska M, Salmanton-García J, Soriano Martín A, Taramasso L, Valerio M, Escribano P, Guinea J, Bouza E, Falcone M, Bassetti M, ESCMID Fungal Infection Study Group (EFISG).   +23 more
europepmc   +2 more sources

Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans

Cell Reports, 2018
Summary: Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via mutations in the drug target gene, FKS1.
Tavia Caplan, Elizabeth J. Polvi, Jinglin L. Xie, Shoshana Buckhalter, Michelle D. Leach, Nicole Robbins, Leah E. Cowen   +6 more
doaj   +1 more source

Highly Conserved gsc1 Gene of Pneumocystis jirovecii in Patients with or without Prior Exposure to Echinocandins

, 2022
Echinocandins are noncompetitive inhibitors of the GSC1 subunit of the enzymatic complex involved in synthesis of 1,3-beta-d-glucan, a cell wall component of most fungi, including Pneumocystis spp.
Bouchara, Jean-Philippe, Bonnet, Pierre, de Quélen, Athéna, Le Pape, Patrice, Le Gal, Solène, Grégoire, Matthieu, Papon, Nicolas, Cogulet, Virginie, Bonnet, Pierre L., Diabira, Fouleymata, Negri, Steven, Hoffmann, Claire V., Huon, Jean-François, Morio, Florent, Nevez, Gilles, Curral, Guillaume, Hoffmann, Claire   +16 more
core   +1 more source

The in vitro Activity of Echinocandins Against Clinical Trichophyton rubrum Isolates and Review of the Susceptibility of T. rubrum to Echinocandins Worldwide

, 2023
Huilin Su,1– 3,* Weiwei Jiang,4,* Paul E Verweij,3,5 Li Li,2 Junhao Zhu,2 Jiande Han,1 Min Zhu,2 Shuwen Deng6 1Department of Dermatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department ...
Zhu M, Deng S, Zhu J, Jiang W, Verweij PE, Han J, Su H, Li L   +7 more
core  

Echinocandin resistance [PDF]

Current Opinion in Infectious Diseases, 2014
Echinocandin resistance in Candida is a great concern, as the echinocandin drugs are recommended as first-line therapy for patients with invasive candidiasis. Here, we review recent advances in our understanding of the epidemiology, underlying mechanisms, methods for detection and clinical implications.Echinocandin resistance has emerged over the ...
Maiken C, Arendrup, David S, Perlin
openaire   +2 more sources