Results 21 to 30 of about 22,252 (260)
Recent Insights into the Paradoxical Effect of Echinocandins
Journal of Fungi, 2017 Echinocandin antifungals represent one of the most important drug classes for the treatment of invasive fungal infections. The mode of action of the echinocandins relies on inhibition of the β-1,3-glucan synthase, an enzyme essentially required for the ...
Johannes Wagener, Veronika Loiko
doaj +2 more sources
Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance? [PDF]
mBioEchinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported.
Hans Carolus +13 more
doaj +2 more sources
Clinical Outcomes of Intra-Abdominal Candidiasis by Initial Antifungal Therapy. [PDF]
MycosesABSTRACT Background Intra‐abdominal candidiasis (IAC) is a severe and heterogeneous infection associated with significant morbidity and mortality. Objectives To evaluate outcomes of IAC according to initial antifungal therapy and to identify predictors of persistent infection and 30‐day mortality.
Albanell-Fernández M +6 more
europepmc +2 more sources
Efficacy and safety of triazoles versus echinocandins in the treatment of invasive aspergillosis: A meta-analysis [PDF]
Vojnosanitetski Pregled, 2020 Backgroun/Aim. Although majority of guidelines recommend triazoles (voriconazole, posaconazole, itraconazole and isavuconazole) as first-line therapeutic option for treatment of invasive aspergillosis, echinocandins (caspofungin, micafungin and ...
Uzelac Sanja M. +4 more
doaj +1 more source
Echinocandins – structure, mechanism of action and use in antifungal therapy
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 With increasing number of immunocompromised patients as well as drug resistance in fungi, the risk of fatal fungal infections in humans increases as well.
Mateusz Szymański +4 more
semanticscholar +1 more source
Frontiers in Oncology, 2021 Invasive Candida glabrata infections are not common complications after radical cystoprostatectomy. Furthermore, resistance to echinocandins arising during the course of a patient’s treatment is rarely recognised.
Maria Szymankiewicz +6 more
doaj +1 more source
The current place of echinocandins in the treatment and prophylaxis of invasive fungal infections [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2020 Invasive fungal infections continue to show steady growth among various patient populations, accompanied by high rates of both morbidity and attributive mortality.
Veselov A.V.
doaj +1 more source
Microbiology spectrum, 2023 The multidrug-resistant Candida auris is a global health emergency, being responsible for outbreaks of invasive candidiasis worldwide. Limited effective therapeutic options make it difficult to treat this emerging pathogen.
Ainara Hernando-Ortiz +5 more
semanticscholar +1 more source
Fungal echinocandin resistance [PDF]
F1000 Biology Reports, 2010 Echinocandins are the most recent introduction to the antifungal armamentarium and target the synthesis of β-(1,3)-glucan, the major structural polysaccharide of the fungal cell wall. Mechanisms have been identified that reduce the efficacy of the echinocandins: mutations of the Fks subunit of the target enzyme complex or a compensatory increase in the
Walker, Louise A. +2 more
openaire +4 more sources
The Epidemiology and Infection Control of Candida Auris in Shanghai. [PDF]
MycosesABSTRACT Background Candida auris is a globally emerging multidrug‐resistant fungus. Its dissemination is driven by patient movement and asymptomatic carriers. However, molecular epidemiological studies linking imported cases to local strains in large metropolitan areas remain limited.
Wei M +8 more
europepmc +2 more sources