Results 31 to 40 of about 13,317 (169)

In Vitro Killing Activities of Anidulafungin and Micafungin with and without Nikkomycin Z against Four Candida auris Clades

Pharmaceutics, 2023
Candida auris is a multidrug-resistant pathogen against which echinocandins are the drug of choice. However, information on how the chitin synthase inhibitor nikkomycin Z influences the killing activities of echinocandins against C.
Awid Adnan, Andrew M. Borman, Zoltán Tóth, Lajos Forgács, Renátó Kovács, Dávid Balázsi, Bence Balázs, Gergely Udvarhelyi, Gábor Kardos, László Majoros   +9 more
doaj   +1 more source

Some issues of the resistance of Candida glabrata to echinocandins [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2019
Invasive candidiasis is a common, severe and often difficult to treat complication in various categories of patients. Despite the fact that in most cases Candida albicans retains a leading position as an etiological cause, a pathogen such as Candida ...
Veselov A.V.
doaj   +1 more source

The Elevated Endogenous Reactive Oxygen Species Contribute to the Sensitivity of the Amphotericin B-Resistant Isolate of Aspergillus flavus to Triazoles and Echinocandins

Frontiers in Microbiology, 2021
Aspergillus flavus has been frequently reported as the second cause of invasive aspergillosis (IA), as well as the leading cause in certain tropical countries.
Tianyu Liang, Wei Chen, Xinyu Yang, Qiqi Wang, Zhe Wan, Ruoyu Li, Wei Liu   +6 more
doaj   +1 more source

Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans

Cell Reports, 2018
Summary: Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via mutations in the drug target gene, FKS1.
Tavia Caplan, Elizabeth J. Polvi, Jinglin L. Xie, Shoshana Buckhalter, Michelle D. Leach, Nicole Robbins, Leah E. Cowen   +6 more
doaj   +1 more source

The in vitro Activity of Echinocandins Against Clinical Trichophyton rubrum Isolates and Review of the Susceptibility of T. rubrum to Echinocandins Worldwide

, 2023
Huilin Su,1– 3,* Weiwei Jiang,4,* Paul E Verweij,3,5 Li Li,2 Junhao Zhu,2 Jiande Han,1 Min Zhu,2 Shuwen Deng6 1Department of Dermatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department ...
Zhu M, Deng S, Zhu J, Jiang W, Verweij PE, Han J, Su H, Li L   +7 more
core  

Highly Conserved gsc1 Gene of Pneumocystis jirovecii in Patients with or without Prior Exposure to Echinocandins

, 2022
Echinocandins are noncompetitive inhibitors of the GSC1 subunit of the enzymatic complex involved in synthesis of 1,3-beta-d-glucan, a cell wall component of most fungi, including Pneumocystis spp.
Bouchara, Jean-Philippe, Bonnet, Pierre, de Quélen, Athéna, Le Pape, Patrice, Le Gal, Solène, Grégoire, Matthieu, Papon, Nicolas, Cogulet, Virginie, Bonnet, Pierre L., Diabira, Fouleymata, Negri, Steven, Hoffmann, Claire V., Huon, Jean-François, Morio, Florent, Nevez, Gilles, Curral, Guillaume, Hoffmann, Claire   +16 more
core   +1 more source

Comparative evaluation of Sensititre YeastOne and CLSI M38-Ed3 reference method for determining echinocandin minimum effective concentrations against Aspergillus isolates

Microbiology Spectrum
The minimum inhibitory concentration (MIC) of echinocandins against Aspergillus spp. does not represent the actual inhibition threshold of echinocandins.
Assaf Potruch, Hila Elinav, Matan J. Cohen, Alexander Rouvinski, Itzhack Polacheck, Maya Korem   +5 more
doaj   +1 more source

An Overview of Recent Possibilities in Pharmacotherapy of Diseases of the Oral Mucosa, Salivary Glands, and Periodontal Tissue

Česká Stomatologie a Praktické Zubní Lékařství, 2013
Introduction: A review of newer drugs for topical or systemic administration useful in contemporary dentistry in the therapy of diseases of periodontal tissue, oral mucous membrane, and salivary glands available in Czech Republic was given in this ...
R. Slezák, I. Lindrová, V. Buchta, V. Paulusová, Z. Šustová, O. Kopecký, L. Ryšková   +6 more
doaj   +1 more source

Echinocandins in antifungal pharmacotherapy

, 2017
ObjectivesEchinocandins are the newest addition of the last decade to the antifungal armamentarium, which, owing to their unique mechanism of action, selectively target the fungal cells without affecting mammalian cells.
Akash Patil, Soumyajit Majumdar
core   +1 more source

Effectiveness and safety of echinocandins combination therapy with the standard of care compared to the standard of care monotherapy for the treatment of invasive aspergillosis infection: a meta-analysis

Frontiers in Pharmacology
BackgroundThis meta-analysis aims to evaluate the effectiveness and safety of combining echinocandins with standard of care (SOC) antifungal drugs for treating invasive aspergillosis infection (IAI).MethodWe searched PubMed, Embase, and Cochrane Library ...
Yazed Saleh Alsowaida, Bader Alshoumr, Shuroug A. Alowais, Khalid Bin Saleh, Alia Alshammari, Kareemah Alshurtan, Haytham A. Wali   +6 more
doaj   +1 more source