Results 31 to 40 of about 12,460 (212)

Echinocandins for candidemia: a rational choice

, 2013
Among antifungal drugs, echinocandins (micafungin, caspofungin and anidulafungin) represent a rational choice for the first-line therapy of candidemia/invasive candidiasis in critically ill patients.
Menichetti, Francesco, Tagliaferri, Enrico   +1 more
core   +1 more source

Comparative evaluation of Sensititre YeastOne and CLSI M38-Ed3 reference method for determining echinocandin minimum effective concentrations against Aspergillus isolates

Microbiology Spectrum
The minimum inhibitory concentration (MIC) of echinocandins against Aspergillus spp. does not represent the actual inhibition threshold of echinocandins.
Assaf Potruch, Hila Elinav, Matan J. Cohen, Alexander Rouvinski, Itzhack Polacheck, Maya Korem   +5 more
doaj   +1 more source

An Overview of Recent Possibilities in Pharmacotherapy of Diseases of the Oral Mucosa, Salivary Glands, and Periodontal Tissue

Česká Stomatologie a Praktické Zubní Lékařství, 2013
Introduction: A review of newer drugs for topical or systemic administration useful in contemporary dentistry in the therapy of diseases of periodontal tissue, oral mucous membrane, and salivary glands available in Czech Republic was given in this ...
R. Slezák, I. Lindrová, V. Buchta, V. Paulusová, Z. Šustová, O. Kopecký, L. Ryšková   +6 more
doaj   +1 more source

Cdc14 phosphatase contributes to cell wall integrity and pathogenesis in Candida albicans

Frontiers in Microbiology, 2023
The Cdc14 phosphatase family is highly conserved in fungi. In Saccharomyces cerevisiae, Cdc14 is essential for down-regulation of cyclin-dependent kinase activity at mitotic exit.
Kedric L. Milholland, Ahmed AbdelKhalek, Kortany M. Baker, Smriti Hoda, Andrew G. DeMarco, Noelle H. Naughton, Angela N. Koeberlein, Gabrielle R. Lorenz, Kartikan Anandasothy, Antonio Esperilla-Muñoz, Sanjeev K. Narayanan, Jaime Correa-Bordes, Scott D. Briggs, Scott D. Briggs, Mark C. Hall, Mark C. Hall   +15 more
doaj   +1 more source

Role of Antifungal Combinations in Difficult to Treat Candida Infections

Journal of Fungi, 2021
Candida infections are varied and, depending on the immune status of the patient, a life-threatening form may develop. C. albicans is the most prevalent species isolated, however, a significant shift towards other Candida species has been noted ...
Roxana G. Vitale
doaj   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Echinocandins have an alternative mode of action on biomimetic membranes that is not directly related to the functioning of (1,3) beta-glucan synthase

Cell Death Discovery
Echinocandins are the preferred agents for treating invasive candidiasis; however, rising resistance in Candida species poses a significant challenge for patient care.
Anna I. Malykhina, Svetlana S. Efimova, Natalia E. Grammatikova, Anna N. Tevyashova, Andrey E. Shchekotikhin, Olga S. Ostroumova   +5 more
doaj   +1 more source

Effectiveness and safety of echinocandins combination therapy with the standard of care compared to the standard of care monotherapy for the treatment of invasive aspergillosis infection: a meta-analysis

Frontiers in Pharmacology
BackgroundThis meta-analysis aims to evaluate the effectiveness and safety of combining echinocandins with standard of care (SOC) antifungal drugs for treating invasive aspergillosis infection (IAI).MethodWe searched PubMed, Embase, and Cochrane Library ...
Yazed Saleh Alsowaida, Bader Alshoumr, Shuroug A. Alowais, Khalid Bin Saleh, Alia Alshammari, Kareemah Alshurtan, Haytham A. Wali   +6 more
doaj   +1 more source

Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species

Cells, 2023
Candidiasis is a highly pervasive infection posing major health risks, especially for immunocompromised populations. Pathogenic Candida species have evolved intrinsic and acquired resistance to a variety of antifungal medications.
Karolina M. Czajka, Krishnan Venkataraman, Danielle Brabant-Kirwan, Stacey A. Santi, Chris Verschoor, Vasu D. Appanna, Ravi Singh, Deborah P. Saunders, Sujeenthar Tharmalingam   +8 more
doaj   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source