Results 51 to 60 of about 13,385 (164)

Gold Nanoparticles Coated With the Antimicrobial Peptide Os‐C(W5): Anticandidal and Biological Activity

Journal of Peptide Science, Volume 32, Issue 9, September 2026.
Gold nanoparticles conjugated with a tick‐derived antimicrobial peptide, Os‐C(W5), demonstrate enhanced proteolytic stability and potent antifungal activity against Candida albicans biofilms and planktonic cells. These non‐cytotoxic nanoconjugates represent a promising biocompatible strategy for combating resistant fungal infections while maintaining ...
P. J. Palm, R. R. Chirombo, C. K. Chiramba, J. C. Serem, H. Taute, M. van der Walt, A. R. M. Gaspar, M. J. Bester   +7 more
wiley   +1 more source

Endobronchial Aspergillosis Presenting as an Isolated Airway Lesion in an Immunocompromised Patient

Respirology Case Reports, Volume 14, Issue 9, September 2026.
Endobronchial Aspergillus infection should be considered in immunocompromised patients presenting with airway obstruction, even in the absence of parenchymal lung involvement. This case highlights the potential for rapid clinical deterioration and the diagnostic challenges in distinguishing endobronchial aspergillosis from more aggressive forms of ...
Mohsen Sadeghi, Fatemeh Sadat Hosseini Khajouei, Haniyeh GhanbarAliAkhavan, Amir Morteza Soleimani   +3 more
wiley   +1 more source

Pyrosequencing To Detect Mutations In FKS1 That Confer Reduced Echinocandin Susceptibility In Candida Albicans [PDF]

, 2008
Pyrosequencing was compared to Sanger dideoxy sequencing to detect mutations in FKS1 responsible for reduced echinocandin susceptibility in Candida albicans.
Perlin, David S., Grabinski, Jodi L., Wiederhold, Nathan P., Garcia-Effron, Guillermo, Lee, Samuel A.   +4 more
core   +1 more source

Synergistic activity of caspofungin and posaconazole against Candida (Candidozyma) auris biofilms based on phenotypic, transcriptomic, and in vivo insights

Microbiology Spectrum
Candida (Candidozyma) auris is an emerging multidrug-resistant fungal pathogen capable of establishing persistent skin colonization, contaminating the environment, and causing nosocomial outbreaks associated with high mortality rates.
Fruzsina Kovács, Andrea Harmath, Dávid Balázsi, Lajos Forgács, Ágota Ragyák, Noémi Balla, Zoltán Tóth, Aliz Bozó, Andrew M. Borman, László Majoros, Renátó Kovács, Ágnes Jakab   +11 more
doaj   +1 more source

Mechanistic Investigations of a Novel Lactam Antifungal Agent Against Candida albicans

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT Candida albicans presents a major, yet underestimated challenge in clinical settings due to its increased resistance to treatment. This study intended to focus on the utility of a novel proprietary lactam molecule, a quorum sensing (QS) inhibitor, against C. albicans. We assessed isolate susceptibility to lactam treatment. In addition, RNA‐Seq
Hafsa Abduljalil, William Johnston, Mark Butcher, Neil Parry, Joanne O'Keeffe, Yvonne Davies, Gordon Ramage   +6 more
wiley   +1 more source

Echinocandin Resistance in Candida Species: Mechanisms of Reduced Susceptibility and Therapeutic Approaches

, 2012
OBJECTIVE: To summarize published data regarding mechanisms of reduced echinocandin susceptibility in Candida spp., the impact of echinocandin resistance on the fitness and virulence of Candida isolates, and current and future treatment approaches.
LEWIS, RUSSEL EDWARD, K. W. Garey, N. D. Beyda   +2 more
core   +1 more source

FDA-Approved Antibacterials and Echinocandins

Antibiotics
Since 1955, a total of 12 peptide-based drugs with antimicrobial or antifungal properties have received approval from the Food and Drug Administration (FDA).
Othman Al Musaimi
doaj   +1 more source

Central Nervous System Aspergillosis: Advances in Diagnosis, Therapeutics, and Multidisciplinary Management (2026 Update)

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Background Central nervous system (CNS) aspergillosis is a life‐threatening infection with mortality rates exceeding 50%, especially in immunocompromised patients. Significant challenges persist due to limited antifungal drug penetration into the CNS, emerging resistance, and diagnostic delays, despite advancements in therapy and diagnostics ...
Moustafa A. Mansour, Mohamed Wahid, Mohamed A. S. El Molla, Mohamed H. Helmy, Taha Mohammed Adel, Hamdi Nabawi Mostafa   +5 more
wiley   +1 more source

Rapid Emergence of Echinocandin Resistance during Candida kefyr Fungemia Treatment with Caspofungin

, 2013
International audienceABSTRACT Echinocandin drugs are widely used for the treatment of candidemia. Resistance is considered rare, and only a few cases of breakthrough candidiasis in patients receiving echinocandin have been reported worldwide.
Brossas, J., Leblond, V., Palous, M., Meyer, I., Nguyen, S., Datry, A., Uzunov, M., Mazier, D., Dannaoui, E., Fekkar, A.   +9 more
core   +1 more source

Relative Frequency of Paradoxical Growth and Trailing Effect with Caspofungin, Micafungin, Anidulafungin, and the Novel Echinocandin Rezafungin against Candida Species

Journal of Fungi, 2020
Rezafungin is a next-generation echinocandin that has favorable pharmacokinetic properties. We compared the occurrence of paradoxical growth (PG) and trailing effect (TE) characteristics to echinocadins with rezafungin, caspofungin, micafungin and ...
Zoltán Tóth, Lajos Forgács, Tamás Kardos, Renátó Kovács, Jeffrey B. Locke, Gábor Kardos, Fruzsina Nagy, Andrew M. Borman, Awid Adnan, László Majoros   +9 more
doaj   +1 more source