Results 51 to 60 of about 16,526 (218)

Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans

Cell Reports, 2018
Summary: Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via mutations in the drug target gene, FKS1.
Tavia Caplan, Elizabeth J. Polvi, Jinglin L. Xie, Shoshana Buckhalter, Michelle D. Leach, Nicole Robbins, Leah E. Cowen   +6 more
doaj   +1 more source

Review of the Novel Echinocandin Antifungal Rezafungin: Animal Studies and Clinical Data

Journal of Fungi, 2020
Rezafungin is a novel echinocandin drug being developed as a first-line option for treatment and prevention of invasive fungal infections. As a result of a structural modification in its parent molecule anidulafungin, rezafungin has acquired unique ...
Yanan Zhao, David S. Perlin
doaj   +1 more source

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

Emerging Microbes and Infections, 2023
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C.
Yating Ning, Meng Xiao, David S. Perlin, Yanan Zhao, Minya Lu, Yi Li, Zhengyu Luo, Rongchen Dai, Shengjie Li, Jiajun Xu, Lingli Liu, Hong He, Yun Liu, Fushun Li, Yuguang Guo, Zhongju Chen, Yingchun Xu, Tianshu Sun, Li Zhang   +18 more
doaj   +1 more source

Predictors of choice of initial antifungal treatment in intraabdominal candidiasis [PDF]

, 2016
Intraabdominal candidiasis (IAC) is the second most frequent form of invasive candidiasis, and is associated with high mortality rates. This study aims to identify current practices in initial antifungal treatment (IAT) in a real-world scenario and to ...
Almirante, B., Ansaldi, F., Antonelli, M., Baldin, G., Bassetti, Matteo, Borgatta, B., Bouza, E., Brugnaro, P., Busetti, M., Colombo, A. L., de Egea, V., De Pascale, G., Del Bono, V., Diaz Martin, A., Dimopoulos, G., Esteves, P., Esteves, P., Garnacho Montero, J., Grandesso, S., Lagunes, L., Luzzati, R., Mart\uedn Gomez, M. T., Martin, M. T., Menichetti, F., Menichetti, F., Merelli, M., Mesini, A., Mu\uf1oz, P., Nou\ue9r, S. A., Nucci, M., Palacios Garcia, I., Pelaez, T., Posteraro, B., Pumarola, T., Raise, E., Rello, J., Rey P\ue9rez, A., Righi, E., Rosin, C., Sanguinetti, M., Sartor, A., Scarparo, C., Scarparo, C., Scotton, G., Sganga, G., Tagliaferri, E., Tascini, C., Trucchi, C., Tumbarello, M., Vena, A., Viscoli, C.   +50 more
core   +1 more source

An Alanine Aminotransferase Is Required for Biofilm-Specific Resistance of Aspergillus fumigatus to Echinocandin Treatment

mBio, 2022
Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants to mammals. Within the pulmonary infection microenvironment, Aspergillus fumigatus forms biofilms with steep oxygen gradients defined by
Joshua D. Kerkaert, François Le Mauff, Benjamin R. Wucher, Sarah R. Beattie, Elisa M. Vesely, Donald C. Sheppard, Carey D. Nadell, Robert A. Cramer   +7 more
doaj   +1 more source

New Horizons in Antifungal Therapy

Journal of Fungi, 2016
Recent investigations have yielded both profound insights into the mechanisms required by pathogenic fungi for virulence within the human host, as well as novel potential targets for antifungal therapeutics.
Kaila M. Pianalto, J. Andrew Alspaugh
doaj   +1 more source

Invasive Fungal Breakthrough Infections under Targeted Echinocandin Prophylaxis in High-Risk Liver Transplant Recipients

Journal of Fungi, 2023
Invasive fungal infections (IFIs) are frequent and outcome-relevant complications in the early postoperative period after orthotopic liver transplantation (OLT).
Robert Breitkopf, Benedikt Treml, Thomas Senoner, Zoran Bukumirić, Sasa Rajsic   +4 more
doaj   +1 more source

Resistance in Candida albicans: exploring the cell wall barrier by proteomics [PDF]

, 2015
The incidence of candidiasis has dramatically increased and bloodstream infections due to different species of Candida are becoming a prime cause of morbidity and mortality in different types of immunocompromised patients.
Angiolella, Letizia, Maras, Bruno, Mignogna, Giuseppina   +2 more
core   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Sentinel Case of Candida auris in the Western United States Following Prolonged Occult Colonization in a Returned Traveler from India. [PDF]

, 2019
Candida auris is an emerging multidrug-resistant yeast with high mortality. We report the sentinel C. auris case on the United States West Coast in a patient who relocated from India.
Crawford, Emily D, Derisi, Joseph L, Doernberg, Sarah B, Dynerman, David, Langelier, Charles, Li, Lucy M, Lyden, Amy, Miller, Steve, Nichols, Amy, Ramirez-Avila, Lynn, Serpa, Paula Hayakawa, Tato, Cristina M, Woodworth, Michael H   +12 more
core   +1 more source