Results 51 to 60 of about 11,227 (157)

Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata

Journal of Fungi, 2018
Candida glabrata has thoroughly adapted to successfully colonize human mucosal membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all the medically relevant Candida species, C.
Kelley R. Healey, David S. Perlin
doaj   +1 more source

[Echinocandins].

Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 2012
The echinocandins, caspofugin, micafungin, and anidulafungin, are lipopeptides that inhibit fungal growth by binding to β - (1.3) d glucan synthase. This enzyme is responsible for the formation of the peptidoglycan cell wall, and it is essential in fungi such as Candida spp, but less important in the case of Aspergillus and Fusarium species.
Jorge A, Cortés L, July A, Russi N
openaire   +1 more source

Comparative evaluation of Sensititre YeastOne and CLSI M38-Ed3 reference method for determining echinocandin minimum effective concentrations against Aspergillus isolates

Microbiology Spectrum
The minimum inhibitory concentration (MIC) of echinocandins against Aspergillus spp. does not represent the actual inhibition threshold of echinocandins.
Assaf Potruch, Hila Elinav, Matan J. Cohen, Alexander Rouvinski, Itzhack Polacheck, Maya Korem   +5 more
doaj   +1 more source

MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation in Aspergillus fumigatus

mSphere
Aspergillus fumigatus is a major invasive mold pathogen and the most frequent etiologic agent of invasive aspergillosis. The currently available treatments for invasive aspergillosis are limited in both number and efficacy.
Harrison I. Thorn, Xabier Guruceaga, Adela Martin-Vicente, Ashley V. Nywening, Jinhong Xie, Wenbo Ge, Jarrod R. Fortwendel   +6 more
doaj   +1 more source

Multicenter surveillance of antifungal susceptibility of clinical Aspergillus isolates to conventional and novel antifungal agents in Taiwan, 2021–2023

Microbiology Spectrum
Periodic surveillance of antifungal susceptibility among Aspergillus isolates is essential to guide effective treatment. This multicenter study analyzed 550 clinical Aspergillus isolates collected in Taiwan from 2021 to 2023, primarily from the ...
Ming-I Hsieh, Pui-Ching Choi, Wan-Lin Wu, Yu-Fu Lin, Chi-Jung Wu   +4 more
doaj   +1 more source

Results of treatment for candidemia in patients with blood system tumors

Терапевтический архив, 2013
AIM: To study the etiology, clinical manifestations, risk factors, and results of treatment for candidemia (CE) in patients with blood system tumors/MATERIAL AND METHODS: The investigation included the patients with CE and hemoblastoses treated at the ...
G A Kliasova, E V Blokhina, A N Gracheva, S K Kravchenko, E N Parovichnikova, G M Galstian   +5 more
doaj  

Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus Candida glabrata

mBio
Recent epidemiological studies documented an alarming increase in the prevalence of echinocandin-resistant (ECR) Candida glabrata blood isolates. ECR isolates are known to arise from a minor subpopulation of a clonal population, termed echinocandin ...
Amir Arastehfar, Farnaz Daneshnia, Daniel J. Floyd, Nathan Elias Jeffries, Mostafa Salehi, David S. Perlin, Macit Ilkit, Cornelia Lass-Flöerl, Michael K. Mansour   +8 more
doaj   +1 more source

Tn-seq screens in Candida glabrata treated with echinocandins and ibrexafungerp reveal pathways of antifungal resistance and cross-resistance

mSphere
Candida glabrata (also known as Nakaseomyces glabratus) is the second most common cause of candidiasis, next to Candida albicans, and is rising in prevalence due to intrinsic and acquired mechanisms of antifungal resistance.
Timothy J. Nickels, Kyle W. Cunningham
doaj   +1 more source

Echinocandins and coagulation dysfunction events

Thrombosis Journal
Despite the recently reported real-world evidence of the signals between echinocandins and coagulation dysfunction events, there are some concerns that may impact the robustness and implications of these findings. For the study design, combining hypercoagulation and hypocoagulation into a single category, "coagulation dysfunction events," may introduce
Pham, Hong Tham, Truong-Nguyen, Kim-Huong, Tran, Minh-Hoang   +2 more
openaire   +2 more sources

Rezafungin and catheter-related candidemia: a new player in a high-stakes game. [PDF]

Infez Med
Venturini S, Reffo I, Zanus-Fortes A, Del Fabro G, Callegari A, Giovagnorio F, Negri C, Casarotto M, Basaglia G, Zanusso C, Basso B.   +10 more
europepmc   +1 more source