Results 51 to 60 of about 12,523 (206)

A benchmark dataset for validating FKS1 mutations in Candida auris

Microbiology Spectrum
Echinocandins are the recommended antifungal therapy for Candida auris infections in many countries. While echinocandin resistance remains uncommon, recent reports demonstrate an increase in such cases, with the potential for echinocandin-resistant C ...
Elizabeth Misas, Lindsay A. Parnell, Malavika Rajeev, Luisa F. López, Amanda Ribeiro dos Santos, Zachary B. Mudge, Lalitha Gade, Kaitlin Forsberg, Meghan Lyman, D. Joseph Sexton, Anastasia P. Litvintseva, Shawn R. Lockhart, Nancy A. Chow   +12 more
doaj   +1 more source

Treatment of Invasive Candidiasis: A Narrative Review

Journal of Fungi, 2018
Invasive candidiasis occurs frequently in hospitalized patients, and is associated with high mortality rates due to delays in recognition and initiation of appropriate antifungals.
Ronen Ben-Ami
doaj   +1 more source

An Update on Invasive Fungal Infections in Solid Organ Transplant Recipients

Transplant Infectious Disease, EarlyView.
ABSTRACT Invasive fungal infections (IFI) remain a significant infection‐related complication in solid organ transplant recipients (SOTRs), the incidence of which has not changed overtime. With a focus on studies and data published after 2019, this narrative review provides an update on the epidemiology and prevention of IFIs in SOTRs and highlights ...
Tina Marinelli, Shahid Husain
wiley   +1 more source

Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata

Journal of Fungi, 2018
Candida glabrata has thoroughly adapted to successfully colonize human mucosal membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all the medically relevant Candida species, C.
Kelley R. Healey, David S. Perlin
doaj   +1 more source

Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium

Antibiotics, 2020
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar, Toni Gabaldón, Rocio Garcia-Rubio, Jeffrey D. Jenks, Martin Hoenigl, Helmut J. F. Salzer, Macit Ilkit, Cornelia Lass-Flörl, David S. Perlin   +8 more
doaj   +1 more source

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum, Against Aspergillus fumigatus: Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna, Lovely Gupta, Rani Singh, Yash Varshney, Rishabh Dev, Pardeep Nain, Savita Lochab, Anurag Varshney   +7 more
wiley   +1 more source

Development of Echinocandin Resistance in Clavispora lusitaniae during Caspofungin Treatment

, 2011
International audienceClavispora lusitaniae is an opportunistic human pathogen responsible for 0.6 to 2% of candidemia. This species is intrinsically susceptible to echinocandins.
Desnos-Ollivier, Marie, Moquet, Olivier, Taieb Chouaki, Dromer, Françoise, Chouaki, Taieb, Anne-Marie Guérin, Marie Desnos-Ollivier, Olivier Moquet, Françoise Dromer, Guérin, Anne-Marie   +9 more
core   +1 more source

Molecular characterization of Echinocandin resistance and the CHS3-mediated adaptive response in Candida glabrata bloodstream infections in Eastern China

BMC Microbiology
Background Candidemia caused by Candida glabrata is a serious fungal infection, and rising echinocandin resistance presents a significant clinical challenge.
Peishan Cong, Biao Wang, Hong He, Xiaoying Li, Lijing Peng, Ji Liu, Hui Guo, Guirong Sun   +7 more
doaj   +1 more source

Decoding the Structural Complexity of Fungal α‐ and β‐Glucan Matrix via Statistical Analysis of Solid‐State NMR Chemical Shifts

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Solid‐state NMR combined with principal component analysis enables quantitative classification of fungal α‐ and β‐glucan architectures in intact cell walls, revealing conserved triple‐helical β‐1,3‐glucan conformations across species and predominantly bundled‐sheet α‐1,3‐glucan assemblies with condition‐dependent polymorphism. Statistical clustering of
Ankur Ankur, Cameron S. Vojvodin, Debkumar Debnath, Tuo Wang   +3 more
wiley   +1 more source

Caspofungin Induced Cell Wall Changes of Candida Species Influences Macrophage Interactions

Frontiers in Cellular and Infection Microbiology, 2020
Candida species are known to differ in their ability to cause infection and have been shown to display varied susceptibilities to antifungal drugs. Treatment with the echinocandin, caspofungin, leads to compensatory alterations in the fungal cell wall ...
Louise A. Walker, Carol A. Munro
doaj   +1 more source