Results 61 to 70 of about 12,523 (206)

Comparison of echinocandin antifungals

Therapeutics and Clinical Risk Management, 2007
The incidence of invasive fungal infections, especially those due to Aspergillus spp. and Candida spp., continues to increase. Despite advances in medical practice, the associated mortality from these infections continues to be substantial. The echinocandin antifungals provide clinicians with another treatment option for serious fungal infections ...
Gregory, Eschenauer, Daryl D, Depestel, Peggy L, Carver   +2 more
openaire   +3 more sources

Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In Vivo

mBio, 2022
Antifungal drug resistance and tolerance pose a serious threat to global public health. In the human fungal pathogen, Candida auris, resistance to triazole, polyene, and echinocandin antifungals is rising, resulting in multidrug resistant isolates. Here,
Laura S. Burrack, Robert T. Todd, Natthapon Soisangwan, Nathan P. Wiederhold, Anna Selmecki   +4 more
doaj   +1 more source

Oral Cryptococcosis due to Naganishia diffluens in a Patient With Thalassemia: A Case Report and a Literature Review

Journal of Clinical Laboratory Analysis, Volume 40, Issue 11, June 2026.
Naganishia diffluens, a rare non‐neoformans cryptococcal species, was identified by PCR sequencing as the causative agent of oral cryptococcosis in a 31‐year‐old Iranian man with β‐thalassemia. This case represents the first documented instance of oral infection by N.
Zahra Yahyazadeh, Zeynab Haseli, Javad Javidnia, Mahdi Abastabar, Eisa Nazar, Hosein Jalali, Mohamad Taghi Hedayati, Hossein Karami, Mohsen Nosratabadi, Lotfollah Davoodi, Seyyed Reza Aghili, Maryam Moazeni, Iman Haghani, Hamid Badali   +13 more
wiley   +1 more source

Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect in Aspergillus fumigatus

Microbiology Spectrum, 2022
Aspergillus fumigatus is a deadly opportunistic fungal pathogen responsible for ~100,000 annual deaths. Azoles are the first line antifungal agent used against A.
Shu Zhao, Adela Martin-Vicente, Ana Cristina Colabardini, Lilian Pereira Silva, David C. Rinker, Jarrod R. Fortwendel, Gustavo Henrique Goldman, John G. Gibbons   +7 more
doaj   +1 more source

T‐Cell Acute Lymphoblastic Leukemia in a Young Patient With Andersen–Tawil Syndrome Successfully and Safely Treated With Intensive Chemotherapy Including Potential Precipitating Drugs: A Case Report After 3.5 Years of Follow‐up

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Andersen–Tawil syndrome (ATS) is a rare, hereditary channelopathy characterized by periodic paralysis, cardiac arrhythmias, and sometimes developmental anomalies. No association with hematologic malignancies has previously been reported. We describe the case of a 27‐year‐old man with genetically confirmed Type 1 ATS who developed T‐cell acute ...
Ramy Rahmé, Paule Moussounda Bamba, Thi Thuy Duong Do, Anthony Behin, Estelle Gandjbakhch, Claude Gardin, Thorsten Braun   +6 more
wiley   +1 more source

Fungal‐Bacterial Interactions in Polymicrobial Infections: Hidden Threats

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
ABSTRACT Polymicrobial infections involving fungi and bacteria represent a major and increasingly recognized clinical challenge, in which interkingdom interactions significantly amplify disease severity, antimicrobial resistance, and treatment failure. Rather than passive co‐existence, fungal–bacterial communities form highly coordinated systems driven
Mohammad Javad Roustaye Gourabi, Masoud Kargar, Atefeh Kamali, Javad Yasbolaghi Sharahi   +3 more
wiley   +1 more source

Echinocandin Resistance in Candida Species: Mechanisms of Reduced Susceptibility and Therapeutic Approaches

, 2012
OBJECTIVE: To summarize published data regarding mechanisms of reduced echinocandin susceptibility in Candida spp., the impact of echinocandin resistance on the fitness and virulence of Candida isolates, and current and future treatment approaches.
LEWIS, RUSSEL EDWARD, K. W. Garey, N. D. Beyda   +2 more
core   +1 more source

Phylogenetic Profiling of the Diabetic Foot Ulcer Microbiome of an Afro‐Caribbean Population

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Illumina amplicon sequencing revealed diverse bacterial and fungal communities in chronic diabetic foot ulcers (DFUs) and adjacent normal skin from Afro‐Caribbean patients. Corynebacterium striatum dominated both sites. DFUs had higher relative abundance of Pseudomonas aeruginosa and the antifungal‐resistant Candida duobushaemulonii, with significantly
Nkemcho Ojeh, Bidyut R. Mohapatra, Margaret O'Shea, Dale Springer, Judy Ward, Mohmmed Sallu, Natacha Paquette, Keith Gooding, Anna Springer, O. Peter Adams   +9 more
wiley   +1 more source

Rapid Emergence of Echinocandin Resistance during Candida kefyr Fungemia Treatment with Caspofungin

, 2013
International audienceABSTRACT Echinocandin drugs are widely used for the treatment of candidemia. Resistance is considered rare, and only a few cases of breakthrough candidiasis in patients receiving echinocandin have been reported worldwide.
Brossas, J., Leblond, V., Palous, M., Meyer, I., Nguyen, S., Datry, A., Uzunov, M., Mazier, D., Dannaoui, E., Fekkar, A.   +9 more
core   +1 more source

Pulmonary Aspergillosis Treated With Oral Amphotericin B (MAT2203) in a Patient With HIV‐Related Cryptococcal Meningitis

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Graphical abstract for a case of a 26‐year‐old female with advanced HIV disease, cryptococcal meningitis, and co‐infection with pulmonary aspergillosis. Both co‐infections were successfully treated with the novel oral lipid nanocrystal formulation of amphotericin B (MAT2203).
Enock Kagimu, Elizabeth Senkoro, Jane Gakuru, Morris K. Rutakingirwa, David R. Boulware, David B. Meya, Richard Kwizera   +6 more
wiley   +1 more source