Results 81 to 90 of about 12,523 (206)

Repositioning 2‐Mercaptobenzothiazole and Sulfonamides as Antifungals Against Multidrug‐Resistant Candida albicans: In Vitro and In Silico Insights

ChemistrySelect, Volume 11, Issue 19, 20 May 2026.
This study highlights the antifungal potential of 2‐mercaptobenzothiazole (MBT) and sulfonamides against multidrug‐resistant Candida albicans. In vitro assays and molecular docking with lanosterol 14α‐demethylase (L14αDM) reveal favorable activity and binding, supporting their repositioning as promising antifungal candidates. ABSTRACT Fungal infections
Bruno A. de Oliveira, Ari Sérgio de Oliveira Lemos, Gabrielle Silva de Campos Lazzarini, Natasha Silva Mayrink, Elaine Soares Coimbra, Adilson D. da Silva, Rodrigo Luiz Fabri   +6 more
wiley   +1 more source

Host Transcriptomics and Culture‐Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit

European Journal of Haematology, Volume 116, Issue 5, Page 625-634, May 2026.
ABSTRACT Background Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non‐infectious fever. T2 magnetic resonance (T2MR) is a culture‐independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is a host response assay ...
Anna Maria Peri, Andrea S. Henden, Ricky Nelles, Mark D. Chatfield, Patrick N. A. Harris, Glen Kennedy, David L. Paterson   +6 more
wiley   +1 more source

Candida Drug Resistance in Patients With Diabetic Foot Ulcers: A Systematic Review and Meta‐Analysis

International Wound Journal, Volume 23, Issue 5, May 2026.
ABSTRACT Diabetic foot ulcers (DFUs) are one of the most serious and common complications that, if not treated properly, can lead to potential damage and even amputation. The aim of this systematic review and meta‐analysis was to assess the drug‐resistant Candida species in DFU.
Mohammad Hossein Ekvan, Hojjat Sayyadi, Sarina Alidadpour, Masoume Karimi, Muhammad Ibrahim Getso, Ahmad Reza Ebrahimi, Mohammad Mirpanahi, Omid Raiesi   +7 more
wiley   +1 more source

Echinocandin termelő törzs molekuláris genetikai törzsfejlesztése

, 2018
A dolgozatban bemutatásra kerül egy ipari és orvosi jelentőségű fonalas gomba, és annak iparilag releváns megközelítése. Továbbá ismertetésre kerül számos ipari technológia, mely segítségével a fonalas gomba hatóanyag termelése optimalizálható ...
Bodnár, Veronika
core  

Cryptic Production of trans -3-Hydroxyproline in Echinocandin B Biosynthesis

, 2018
Echinocandins are antifungal nonribosomal hexapeptides produced by fungi. Two of the amino acids are hydroxy- l -prolines: trans -4-hydroxy- l -proline and, in most echinocandin ...
Stefanie Houwaart, Houwaart, Stefanie, Hüttel, Wolfgang, Johanna Mattay, Mattay, Johanna, Wolfgang Hüttel   +5 more
core   +1 more source

Development and Validation of Taqman Chemistry Probe-Based Rapid Assay for the Detection of Echinocandin-Resistance in Candida Auris

, 2023
Candida auris is a multidrug-resistant yeast pathogen causing outbreaks in health care facilities worldwide, and the emergence of echinocandin-resistant C. auris is a concern.
Banavali, Nilesh K, Chaturvedi, Vishnu, Hager, Kelli M, Chaturvedi, Sudha, Manjari, Swati R, Zhu, YanChun   +5 more
core   +1 more source

Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients

, 2014
The frequency of breakthrough invasive fungal diseases (IFDs) during echinocandin therapy is unclear. We retrospectively analyzed 534 hematologic patients treated with echinocandin (caspofungin, N = 55; micafungin, N = 306; anidulafungin, N = 173).
Khong, Pek Lan, Gill, Harinder, Lie, Albert, Kwong, Yok Lam, Chan, Thomas S Y, Loong, Florence, Sim, Joycelyn, Tse, Eric, Tse, AlancT, Leung, Anska Y H, Chim, James C S, Hwang, Yuyan   +11 more
core   +1 more source

Novel FKS Mutations Associated with Echinocandin Resistance in Candida Species

, 2010
We studied three clinical isolates of Candida spp. (one C. tropicalis isolate and two C. glabrata isolates) from patients with invasive candidiasis.
David S. Perlin, Mahmoud Ghannoum, Hector Bonilla   +2 more
core  

Multicenter surveillance of antifungal susceptibility of clinical Aspergillus isolates to conventional and novel antifungal agents in Taiwan, 2021–2023

Microbiology Spectrum
Periodic surveillance of antifungal susceptibility among Aspergillus isolates is essential to guide effective treatment. This multicenter study analyzed 550 clinical Aspergillus isolates collected in Taiwan from 2021 to 2023, primarily from the ...
Ming-I Hsieh, Pui-Ching Choi, Wan-Lin Wu, Yu-Fu Lin, Chi-Jung Wu   +4 more
doaj   +1 more source

Pyrosequencing To Detect Mutations In FKS1 That Confer Reduced Echinocandin Susceptibility In Candida Albicans

, 2008
Pyrosequencing was compared to Sanger dideoxy sequencing to detect mutations in FKS1 responsible for reduced echinocandin susceptibility in Candida albicans.
Perlin, David S., Grabinski, Jodi L., Wiederhold, Nathan P., Garcia-Effron, Guillermo, Lee, Samuel A.   +4 more
core   +1 more source