Results 81 to 90 of about 13,385 (164)

Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients

, 2014
The frequency of breakthrough invasive fungal diseases (IFDs) during echinocandin therapy is unclear. We retrospectively analyzed 534 hematologic patients treated with echinocandin (caspofungin, N = 55; micafungin, N = 306; anidulafungin, N = 173).
Khong, Pek Lan, Gill, Harinder, Lie, Albert, Kwong, Yok Lam, Chan, Thomas S Y, Loong, Florence, Sim, Joycelyn, Tse, Eric, Tse, AlancT, Leung, Anska Y H, Chim, James C S, Hwang, Yuyan   +11 more
core   +1 more source

Fungal echinocandin resistance [PDF]

, 2010
The echinocandins are the newest class of antifungal agents in the clinical armory. These secondary metabolites are non-competitive inhibitors of the synthesis of β-(1,3)-glucan, a major structural component of the fungal cell wall. Recent work has shown
Gow, Neil A.R., Walker, Louise A., Munro, Carol A.   +2 more
core   +1 more source

Comparative evaluation of Sensititre YeastOne and CLSI M38-Ed3 reference method for determining echinocandin minimum effective concentrations against Aspergillus isolates

Microbiology Spectrum
The minimum inhibitory concentration (MIC) of echinocandins against Aspergillus spp. does not represent the actual inhibition threshold of echinocandins.
Assaf Potruch, Hila Elinav, Matan J. Cohen, Alexander Rouvinski, Itzhack Polacheck, Maya Korem   +5 more
doaj   +1 more source

Novel FKS Mutations Associated with Echinocandin Resistance in Candida Species

, 2010
We studied three clinical isolates of Candida spp. (one C. tropicalis isolate and two C. glabrata isolates) from patients with invasive candidiasis.
David S. Perlin, Mahmoud Ghannoum, Hector Bonilla   +2 more
core  

Echinocandin inhibition of 1,3-β-D-glucan synthase from Candida albicans [PDF]

, 1984
The cyclic peptide antibiotic echinocandin was found to inhibit 1,3-β-D-glucan synthase activity present in a mixed membrane fraction from Candida albicans. Addition of antibiotic reduced the Vmax of the enzyme, but the Km was unaffected.
Kerridge, D., E.T. Sawistowska-Schröder, D. Kerridge, Sawistowska-Schröder, E.T., Perry, H., H. Perry   +5 more
core   +1 more source

MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation in Aspergillus fumigatus

mSphere
Aspergillus fumigatus is a major invasive mold pathogen and the most frequent etiologic agent of invasive aspergillosis. The currently available treatments for invasive aspergillosis are limited in both number and efficacy.
Harrison I. Thorn, Xabier Guruceaga, Adela Martin-Vicente, Ashley V. Nywening, Jinhong Xie, Wenbo Ge, Jarrod R. Fortwendel   +6 more
doaj   +1 more source

Clinical Case Report on the Use of Rezafungin in Pneumocystis jirovecii Pneumonia in a Critically Ill Patient

Microorganisms
Pneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic infection predominantly affecting immunocompromised patients. Trimethoprim–sulfamethoxazole (TMP–SMX) remains the standard therapy but is often limited by severe toxicity ...
Rosario Fernández-Fernández, Roberto García-Martínez, Waldo Sánchez-Yebra Fernández, Natalia Chueca-Porcuna, Manuel Colmenero-Ruiz   +4 more
doaj   +1 more source

Biofilm Production and Antibiofilm Activity of Echinocandins and Liposomal Amphotericin B in Echinocandin-Resistant Yeast Species.

, 2016
The echinocandins and liposomal amphotericin B are active against biofilm produced by echinocandin-susceptible Candida strains. However, few data have been reported on the production of biofilm by echinocandin-resistant isolates and their antifungal ...
Marcos-Zambrano, Laura Judith, Gómez-Perosanz, Marta, Escribano, Pilar, Bouza, Emilio, Guinea, Jesús, Zaragoza, Oscar   +5 more
core   +1 more source

Differential Aspergillus lentulus Echinocandin Susceptibilities Are Fksp Independent

, 2010
The recently described species Aspergillus lentulus exhibits differential and reduced susceptibilities to echinocandins and other antifungal drugs in vitro. A. lentulus isolates overall are less susceptible
Janet F. Staab, Kieren A. Marr, Jennifer Nielsen Kahn   +2 more
core   +1 more source

Functional Genomic and Chemical Biology Analysis of Echinocandin Resistance in Candida albicans [PDF]

, 2018
Candida albicans is a leading cause of invasive fungal infections, with mortality rates of ~40%. Effective treatment is hindered by the paucity of antifungal drugs and the emergence of resistance.
Caplan, Tavia
core   +2 more sources