Results 91 to 100 of about 13,385 (164)

FKS Mutations and Elevated Echinocandin MIC Values among Candida glabrata Isolates from U.S. Population-Based Surveillance

, 2010
Candida glabrata is the second leading cause of candidemia in the United States. Its high-level resistance to triazole antifungal drugs has led to the increased use of the echinocandin class of antifungal agents for primary therapy of these ...
Lee H. Harrison, Shawn R. Lockhart, Alicia J. Zimbeck, Monica M. Farley, Tom Chiller, Naureen Iqbal, Angela M. Ahlquist   +6 more
core   +1 more source

In vivo efficacy of high dose caspofungin against echinocandin resistant Candida albicans isolates

, 2019
The aim of our study was to examine whether high dose echinocandin therapy may be beneficial compared to amphoterincin B in the treament of echinocandin resistant Candida bloodstream infection in a neutropenic murine modelgjgyógyszerészangolMSc ...
Ngo, Hoang Bao Tran
core  

Multicenter surveillance of antifungal susceptibility of clinical Aspergillus isolates to conventional and novel antifungal agents in Taiwan, 2021–2023

Microbiology Spectrum
Periodic surveillance of antifungal susceptibility among Aspergillus isolates is essential to guide effective treatment. This multicenter study analyzed 550 clinical Aspergillus isolates collected in Taiwan from 2021 to 2023, primarily from the ...
Ming-I Hsieh, Pui-Ching Choi, Wan-Lin Wu, Yu-Fu Lin, Chi-Jung Wu   +4 more
doaj   +1 more source

Echinocandin use in an Australian tertiary hospital: implications for antifungal stewardship

, 2023
Echinocandin use in an Australian tertiary hospital: implications for antifungal ...
S Poole (13334736), K Mackie (15184504), Z Rashidzada (15184507), C Ierano (15184501), JH Mcmahon (15184513), CO Morrissey (15184516), Mia Percival (13092360), C Corallo (15184510), A Duncan (8412225)   +8 more
core  

A Ser678Pro Substitution in Fks1p Confers Resistance to Echinocandin Drugs in Aspergillus fumigatus

, 2007
An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echino-candin resistance.
David S. Perlin, F. Rocha, Steven Park, Guillermo Garcia-effron, Eleusa Maria   +4 more
core  

Predictors of Candida auris Infection in Previously Colonized Patients: A Retrospective Cohort Study from a Large Tertiary Reference Center

Journal of Fungi
Candida auris is a multidrug-resistant fungal pathogen associated with high mortality in healthcare settings. Although colonization is recognized as the harbinger of invasive infection, predicting which patients will develop bloodstream infection (BSI ...
Nadide Ergün, Sevim Selen Karabulut, Melda Türken, Bengü Tatar, Süheyla Serin Senger   +4 more
doaj   +1 more source

Results of treatment for candidemia in patients with blood system tumors

Терапевтический архив, 2013
AIM: To study the etiology, clinical manifestations, risk factors, and results of treatment for candidemia (CE) in patients with blood system tumors/MATERIAL AND METHODS: The investigation included the patients with CE and hemoblastoses treated at the ...
G A Kliasova, E V Blokhina, A N Gracheva, S K Kravchenko, E N Parovichnikova, G M Galstian   +5 more
doaj  

Differential Activity of the Oral Glucan Synthase Inhibitor SCY-078 against Wild-Type and Echinocandin-Resistant Strains of Candida Species

, 2017
SCY-078 (formerly MK-3118) is a novel orally active inhibitor of fungal β-(1,3)-glucan synthase (GS). SCY-078 is a derivative of enfumafungin and is structurally distinct from the echinocandin class of antifungal agents.
Mariana Castanheira, Michael A. Pfaller, Katyna Borroto-Esoda, Shawn A. Messer, Paul R. Rhomberg   +4 more
core   +1 more source

Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus Candida glabrata

mBio
Recent epidemiological studies documented an alarming increase in the prevalence of echinocandin-resistant (ECR) Candida glabrata blood isolates. ECR isolates are known to arise from a minor subpopulation of a clonal population, termed echinocandin ...
Amir Arastehfar, Farnaz Daneshnia, Daniel J. Floyd, Nathan Elias Jeffries, Mostafa Salehi, David S. Perlin, Macit Ilkit, Cornelia Lass-Flöerl, Michael K. Mansour   +8 more
doaj   +1 more source

Echinocandin-Resistant Candidemia, the Next Upcoming Threat in the Era of Echinocandin Prophylaxis Among Pediatric Hematological Malignancies in Limited Resources Countries

Background Hematological cancer patients are at risk for developing candidemia, and echinocandins are commonly employed for prevention in those patients. The rising resistance of Candida spp. to echinocandins poses an emerging threat.
Khaled ELsheshtawy, Alaa Alhaddad, Reham Khedr, Mervat Gaber, Lobna Shalby, Naglaa Adel, Youssef Madney, Hanfy Hafez   +7 more
core   +1 more source