Results 1 to 10 of about 2,220 (119)

Cryo-EM structure of the β-1,3-glucan synthase FKS1-Rho1 complex [PDF]

Nature Communications
β-1,3 Glucan synthase (GS) is essential for fungal cell wall biosynthesis. The GS holoenzyme comprises the glycosyltransferase FKS1 and its regulatory factor Rho1, a small GTPase.
Jialu Li, Huayi Liu, Dong Deng
exaly   +3 more sources

Decoding resistance in Diutina catenulata by validating clinically relevant Erg11/Fks1 mutations [PDF]

Frontiers in Cellular and Infection Microbiology
ObjectiveTo verify the causal relationship between specific mutations in the ERG11 and FKS1 genes and antifungal drug resistance in clinical isolates of Diutina catenulata.MethodsRecombinant plasmids expressing mutant alleles of ERG11 (F126L, K143R) or ...
Wei Zhang, Wei Zhang, Wei Zhang, Na Wang, Xin-Fei Chen, Bao-Hua He, Meng Xiao, Ying-Chun Xu, Qi Li   +8 more
doaj   +2 more sources

Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1 [PDF]

Nature Communications
FKS1 is a β−1,3-glucan synthase critical for fungal cell wall formation and a target for antifungal drugs such as echinocandin and ibrexafungerp. However, the mechanisms regulating FKS1 activity remain largely unknown.
Jialu Li, Jian Li, Angqi Zhu, Xinli Dai, Juxiu Liu, Huayi Liu, Zhili Xia, Yuefan Dong, Wenyu Qian, Lunzhi Dai, Li Guo, Chuangye Yan, Dong Deng, Yunzi Luo, Xiang Wang   +14 more
doaj   +2 more sources

Inhibition mechanism of the fungal β−1,3-glucan synthases by triterpenoid antifungal drugs [PDF]

Nature Communications
β−1,3-glucan synthase is the molecular target for triterpenoid and echinocandin antifungal drugs in clinical. It catalyzes the formation of β−1,3-glucan, which is the primary component of the fungal cell wall.
Zi-Long You, Lei Sun, Le-Xuan Wang, Yue-Ran Ni, Rui-Qing Lyu, Dan-Dan Chen, Cai-Hong Yun, Tiefeng Song, Yinggai Song, Lin Bai   +9 more
doaj   +2 more sources

In vitro activity of eight antifungal drugs against clinical and hospital isolates of Candida parapsilosis complex; a multicenter study, 2023–2024 [PDF]

BMC Infectious Diseases
Background Candida parapsilosis complex is an emerging opportunistic pathogen associated with bloodstream infections and healthcare‑associated outbreaks, particularly in intensive care units.
Azam Moslemi, Maryam Salimi, Mahdi Abastabar, Reza Valadan, Maryam Moazeni, Mohammad Taghi Hedayati, Seyed Reza Aghili, Leila Faeli, Zoha Asgari, Iman Haghani, Hossein Zarrinfar, Sabah Mayahi, Tahereh Shokohi, Hamid Badali   +13 more
doaj   +2 more sources

The Epidemiology and Infection Control of Candida Auris in Shanghai. [PDF]

Mycoses
ABSTRACT Background Candida auris is a globally emerging multidrug‐resistant fungus. Its dissemination is driven by patient movement and asymptomatic carriers. However, molecular epidemiological studies linking imported cases to local strains in large metropolitan areas remain limited.
Wei M, Guo J, Li L, Zhu J, Xue Y, Chen G, Yang F, Wu W, Zhu M.   +8 more
europepmc   +2 more sources

A benchmark dataset for validating FKS1 mutations in Candida auris [PDF]

Microbiology Spectrum
Echinocandins are the recommended antifungal therapy for Candida auris infections in many countries. While echinocandin resistance remains uncommon, recent reports demonstrate an increase in such cases, with the potential for echinocandin-resistant C ...
Elizabeth Misas, Lindsay A. Parnell, Malavika Rajeev, Luisa F. López, Amanda Ribeiro dos Santos, Zachary B. Mudge, Lalitha Gade, Kaitlin Forsberg, Meghan Lyman, D. Joseph Sexton, Anastasia P. Litvintseva, Shawn R. Lockhart, Nancy A. Chow   +12 more
doaj   +2 more sources

Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolates [PDF]

npj Antimicrobials and Resistance
Candida glabrata (Nakaseomyces glabratus) is the most common cause of drug-resistant candidemia and is associated with a high mortality rate. Only a few mechanisms of drug resistance are known in C.
Christopher Zajac, Nancy E. Scott, Susan Kline, Serin E. Erayil, Anna Selmecki   +4 more
doaj   +2 more sources

Adaptation of the tetracycline-repressible system for modulating the expression of essential genes in Cryptococcus neoformans [PDF]

mSphere
The opportunistic human fungal pathogen Cryptococcus neoformans has an enormous impact on human health as the causative agent of cryptococcal meningitis, and there is a dire need to expand our current antifungal arsenal.
Ci Fu, Nicole Robbins, Leah E. Cowen
doaj   +2 more sources

Emergence of multidrug-resistant Candidozyma auris in southern China: a multicenter study on genetic diversity and antifungal resistance [PDF]

Frontiers in Microbiology
PurposeCandidozyma auris (C. auris) is an emerging fungal pathogen that is resistant to multiple drugs and poses a serious threat to global health. This study aimed to investigate the genetic diversity and antifungal resistance profiles of C.
Penghao Guo, Jingchun Fang, Ruizhi Wang, Weihong Lin, Yueting Jiang, Jun Long, Lingjuan Chen, Xudong Huang, Kang Liao, Yaqin Peng   +9 more
doaj   +2 more sources