Results 1 to 10 of about 2,691 (173)

Cryo-EM structure of the β-1,3-glucan synthase FKS1-Rho1 complex [PDF]

Nature Communications
β-1,3 Glucan synthase (GS) is essential for fungal cell wall biosynthesis. The GS holoenzyme comprises the glycosyltransferase FKS1 and its regulatory factor Rho1, a small GTPase.
Huayi Liu, Wang Xiang, Jialu Li
exaly   +5 more sources

Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1 [PDF]

Nature Communications
FKS1 is a β−1,3-glucan synthase critical for fungal cell wall formation and a target for antifungal drugs such as echinocandin and ibrexafungerp. However, the mechanisms regulating FKS1 activity remain largely unknown.
Jialu Li, Jian Li, Angqi Zhu, Xinli Dai, Juxiu Liu, Huayi Liu, Zhili Xia, Yuefan Dong, Wenyu Qian, Lunzhi Dai, Li Guo, Chuangye Yan, Dong Deng, Yunzi Luo, Xiang Wang   +14 more
doaj   +5 more sources

Decoding resistance in Diutina catenulata by validating clinically relevant Erg11/Fks1 mutations [PDF]

Frontiers in Cellular and Infection Microbiology
ObjectiveTo verify the causal relationship between specific mutations in the ERG11 and FKS1 genes and antifungal drug resistance in clinical isolates of Diutina catenulata.MethodsRecombinant plasmids expressing mutant alleles of ERG11 (F126L, K143R) or ...
Wei Zhang, Wei Zhang, Wei Zhang, Na Wang, Xin-Fei Chen, Bao-Hua He, Meng Xiao, Ying-Chun Xu, Qi Li   +8 more
doaj   +4 more sources

Evolutionary accumulation of FKS 1 mutations from clinical echinocandin-resistant Candida auris [PDF]

Emerging Microbes and Infections
Introduction: Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before an isolate develops to resistance via FKS1 mutations ...
Hong Shang, Sufei Tian
exaly   +4 more sources

Antifungal susceptibility, FKS1 gene expression, and virulence determinants of Candida albicans in pediatric and neonatal candidiasis [PDF]

BMC Infectious Diseases
Background Candida albicans is a major cause of invasive fungal infections in pediatric patients, including subgroups of neonates and young infants, particularly in intensive care settings where premature and low birth weight infants are at high risk ...
Mandana Rezaei-Mojaz, Hanie Hajghafari, Masoomeh Shams-Ghahfarokhi, Simasadat Seyedjavadi, Zahra Salehi, Ali Eslamifar, Fatemehsadat Jamzivar, Mehdi Razzaghi-Abyaneh   +7 more
doaj   +3 more sources

Evaluation of Sensititre YeastOne for antifungal susceptibility testing of Candida (Candidozyma) auris: misclassification of FKS1 mutants and overestimation of caspofungin resistance in a global collection of isolates [PDF]

Journal of Clinical Microbiology
Sensititre YeastOne (SYO) is a widely used commercial colorimetric assay, yet its performance for C. auris remains uncertain. We tested 113 global isolates, including 24 FKS1 mutants, using SYO and the Clinical and Laboratory Standards Institute (CLSI ...
Maria Siopi, Sevasti Leventaki, Ioannis Pachoulis, Aikaterini Rentoumi, Nikiforos Argyris, Bram Spruijtenburg, Eelco F. J. Meijer, Jacques F. Meis, Spyros Pournaras, Athanasios Tsakris, Georgia Vrioni, Joseph Meletiadis   +11 more
doaj   +2 more sources

Inhibition mechanism of the fungal β−1,3-glucan synthases by triterpenoid antifungal drugs [PDF]

Nature Communications
β−1,3-glucan synthase is the molecular target for triterpenoid and echinocandin antifungal drugs in clinical. It catalyzes the formation of β−1,3-glucan, which is the primary component of the fungal cell wall.
Zi-Long You, Lei Sun, Le-Xuan Wang, Yue-Ran Ni, Rui-Qing Lyu, Dan-Dan Chen, Cai-Hong Yun, Tiefeng Song, Yinggai Song, Lin Bai   +9 more
doaj   +2 more sources

Wastewater intelligence predicts the emergence of clinically-relevant and drug-resistant Candidozyma auris at healthcare facilities [PDF]

Nature Communications
The rapid evolution of antifungal resistance in Candidozyma auris (formerly Candida auris) presents significant challenges for conventional public health surveillance methods, particularly in detecting emergent and highly transmissible drug-resistant ...
Ching-Lan Chang, Michael A. Moshi, Quang-Huy Nguyen, Junghun Oh, Ha Nguyen, Pratik Paranjape, Mohammed Abushanab, Austin J. Tang, Jose Yani Itorralba, Lauryn Massic, Eakalak Khan, Cassius Lockett, Horng-Yuan Kan, Mark Pandori, Daniel Gerrity, Van Vo, Tin Nguyen, David Hess, Edwin C. Oh   +18 more
doaj   +2 more sources

In vitro activity of eight antifungal drugs against clinical and hospital isolates of Candida parapsilosis complex; a multicenter study, 2023–2024 [PDF]

BMC Infectious Diseases
Background Candida parapsilosis complex is an emerging opportunistic pathogen associated with bloodstream infections and healthcare‑associated outbreaks, particularly in intensive care units.
Azam Moslemi, Maryam Salimi, Mahdi Abastabar, Reza Valadan, Maryam Moazeni, Mohammad Taghi Hedayati, Seyed Reza Aghili, Leila Faeli, Zoha Asgari, Iman Haghani, Hossein Zarrinfar, Sabah Mayahi, Tahereh Shokohi, Hamid Badali   +13 more
doaj   +2 more sources

Integrated Genomic and Phenotypic Analyses Reveal Convergent Resistance Patterns in Clinical Candida tropicalis Isolates. [PDF]

Mycoses
ABSTRACT Background The incidence of Candida tropicalis isolation is increasing in hospital settings. High azole resistance and mortality rates make it a pathogen that requires further analysis. Methods Fourteen azole resistant Candida glabrata clinical isolates were collected from a Lebanese hospital and analysed through whole genome sequencing for ...
Chedraoui C, Fattouh N, El Hachem S, Sourenian T, El Bitar L, El Moheb L, Sleiman AS, Bitar I, Husni R, Khalaf RA.   +9 more
europepmc   +2 more sources