Results 31 to 40 of about 2,691 (173)

Challenging SNP impact on caspofungin resistance by full-lengthFKS1allele replacement inCandida lusitaniae [PDF]

Journal of Antimicrobial Chemotherapy, 2018
A strain of the opportunistic pathogenic yeast Candida lusitaniae was genetically engineered for full-length replacement of the FKS1 gene encoding the target of echinocandin antifungals in order to assess the impact of FKS mutations on echinocandin resistance and reduced echinocandin susceptibility (RES).FKS1 allelic exchange was achieved by ...
Isabelle Accoceberry, Célia Couzigou, Valérie Fitton-Ouhabi, Nicolas Biteau, Thierry Noël   +4 more
openaire   +3 more sources

Acquired echinocandin resistance in a Candida krusei blood isolate confirmed by mutations in the fks1 gene. [PDF]

The new microbiologica, 2014
We describe a case of bloodstream infection caused by a Candida krusei strain that developed echinocandin resistance during caspofungin therapy. Three mutations were found in the HS1 region of the fks1 gene, two of them have never been reported either in C. krusei nor in C. albicans.
A.C.M. Prigitano, M.C. Esposto, M. Cogliati, L. Pitzurra, C. Santamaria, A.M. Tortorano   +5 more
openaire   +3 more sources

Adaptation of the tetracycline-repressible system for modulating the expression of essential genes in Cryptococcus neoformans [PDF]

mSphere
The opportunistic human fungal pathogen Cryptococcus neoformans has an enormous impact on human health as the causative agent of cryptococcal meningitis, and there is a dire need to expand our current antifungal arsenal.
Ci Fu, Nicole Robbins, Leah E. Cowen
doaj   +2 more sources

Emergence of multidrug-resistant Candidozyma auris in southern China: a multicenter study on genetic diversity and antifungal resistance [PDF]

Frontiers in Microbiology
PurposeCandidozyma auris (C. auris) is an emerging fungal pathogen that is resistant to multiple drugs and poses a serious threat to global health. This study aimed to investigate the genetic diversity and antifungal resistance profiles of C.
Penghao Guo, Jingchun Fang, Ruizhi Wang, Weihong Lin, Yueting Jiang, Jun Long, Lingjuan Chen, Xudong Huang, Kang Liao, Yaqin Peng   +9 more
doaj   +2 more sources

Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance? [PDF]

mBio
Echinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported.
Hans Carolus, Judith Díaz-García, Vladislav Biriukov, Stef Jacobs, Dimitrios Sofras, Alicia Pageau, Celia Lobo Romero, Lore Vinken, Pilar Escribano, Jesús Guinea, Katrien Lagrou, Christian R. Landry, Toni Gabaldón, Patrick Van Dijck   +13 more
doaj   +2 more sources

Upc2A transcriptionally regulates FKS1 expression. [PDF]

, 2021
A. An isogenic series of strains with the listed UPC2A genotypes was tested for resistance to the indicated stress agents that affect the cell wall. Strains were grown to mid-log phase and then serially diluted across each plate. Caspofungin was included
Bao Gia Vu (11507192), Mark A. Stamnes (11507195), P. David Rogers (11507198), Yu Li (183836), W. Scott Moye-Rowley (3615197)   +4 more
core   +1 more source

Candidemia in cancer patients: phenotypical and molecular-genetic characteristics of antifungal drug resistance, pathogenic factor genes of Candida spp.

Сибирский онкологический журнал, 2022
Relevance. The global trend of rapid increase in resistance to antifungal drugs due to multiple factors, dictates the need for continuous monitoring of taxonomic structure and susceptibility of nosocomial pathogens, causing invasive fungal infections ...
N. S. Bagirova, E. A. Goremykina, P. V. Slukin, O. E. Khokhlova, N. K. Fursova, I. N. Petukhova, Z. V. Grigorievskaya   +6 more
doaj   +1 more source

Topological and Mutational Analysis of Saccharomyces cerevisiae Fks1 [PDF]

Eukaryotic Cell, 2012
ABSTRACT Fks1, with orthologs in nearly all fungi as well as plants and many protists, plays a central role in fungal cell wall formation as the putative catalytic component of β-1,3-glucan synthase. It is also the target for an important new antifungal group, the echinocandins, as evidenced by the localization of resistance ...
Michael E, Johnson, Thomas D, Edlind
openaire   +2 more sources

FKS1 Is Required for Cryptococcus neoformans Fitness In Vivo: Application of Copper-Regulated Gene Expression to Mouse Models of Cryptococcosis

mSphere, 2022
There is an urgent need for new antifungals to treat cryptococcal meningoencephalitis, a leading cause of mortality in people living with HIV/AIDS. An important aspect of antifungal drug development is the validation of targets to determine whether they ...
Sarah R. Beattie, Andrew J. Jezewski, Laura C. Ristow, Melanie Wellington, Damian J. Krysan   +4 more
doaj   +1 more source

FKS1 mutation associated with decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure [PDF]

Scientific Reports, 2020
AbstractInvasive aspergillosis (IA) is a potentially lethal infection that affects mostly immunocompromised patients caused by Aspergillus fumigatus. Echinocandins are a second-line therapy against IA, used as a salvage therapy as well as for empirical or prophylactic therapy.
e Silva, Ana Pinto, Miranda, Isabel Marcos, Branco, Joana, Oliveira, Patricia, Faria-Ramos, Isabel, Silva, Raquel M., Rodrigues, Acácio Gonçalves, Costa-de-Oliveira, Sofia   +7 more
openaire   +2 more sources