Results 21 to 30 of about 3,923 (195)

Candidemia in cancer patients: phenotypical and molecular-genetic characteristics of antifungal drug resistance, pathogenic factor genes of Candida spp.

Сибирский онкологический журнал, 2022
Relevance. The global trend of rapid increase in resistance to antifungal drugs due to multiple factors, dictates the need for continuous monitoring of taxonomic structure and susceptibility of nosocomial pathogens, causing invasive fungal infections ...
N. S. Bagirova, E. A. Goremykina, P. V. Slukin, O. E. Khokhlova, N. K. Fursova, I. N. Petukhova, Z. V. Grigorievskaya   +6 more
doaj   +1 more source

Topological and Mutational Analysis of Saccharomyces cerevisiae Fks1 [PDF]

Eukaryotic Cell, 2012
ABSTRACT Fks1, with orthologs in nearly all fungi as well as plants and many protists, plays a central role in fungal cell wall formation as the putative catalytic component of β-1,3-glucan synthase. It is also the target for an important new antifungal group, the echinocandins, as evidenced by the localization of resistance ...
Michael E, Johnson, Thomas D, Edlind
openaire   +2 more sources

FKS1 mutation associated with decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure [PDF]

Scientific Reports, 2020
AbstractInvasive aspergillosis (IA) is a potentially lethal infection that affects mostly immunocompromised patients caused by Aspergillus fumigatus. Echinocandins are a second-line therapy against IA, used as a salvage therapy as well as for empirical or prophylactic therapy.
e Silva, Ana Pinto, Miranda, Isabel Marcos, Branco, Joana, Oliveira, Patricia, Faria-Ramos, Isabel, Silva, Raquel M., Rodrigues, Acácio Gonçalves, Costa-de-Oliveira, Sofia   +7 more
openaire   +2 more sources

FKS1 Is Required for Cryptococcus neoformans Fitness In Vivo: Application of Copper-Regulated Gene Expression to Mouse Models of Cryptococcosis

mSphere, 2022
There is an urgent need for new antifungals to treat cryptococcal meningoencephalitis, a leading cause of mortality in people living with HIV/AIDS. An important aspect of antifungal drug development is the validation of targets to determine whether they ...
Sarah R. Beattie, Andrew J. Jezewski, Laura C. Ristow, Melanie Wellington, Damian J. Krysan   +4 more
doaj   +1 more source

Implication of Candida parapsilosis FKS1 and FKS2 Mutations in Reduced Echinocandin Susceptibility [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT We evaluated FKS1 and FKS2 mutations in Candida parapsilosis bloodstream isolates and correlated them with the echinocandin MIC values determined by guidelines in CLSI document M27-A3 and the YeastOne panel.
Martí-Carrizosa M, Sánchez-Reus F, March F, Cantón E, Coll P   +4 more
openaire   +5 more sources

Novel non hot spot modification in Fks1 ofCandida aurisconfers echinocandin resistance

Antimicrobial Agents and Chemotherapy, 2023
ABSTRACTWe determined echinocandin susceptibility andFKS1genotypes of thirteen clinical isolates ofCandida aurisrecovered from four patients at a tertiary care center in Salvador, Brazil. Three isolates were categorized as echinocandin-resistant and harbored a novelFKS1mutation leading to an amino acid change W691L located downstream from hot-spot 1 ...
Milena Kordalewska, Geselle Cancino-Prado, João Nobrega de Almeida Júnior, Igor Brasil Brandão, Renata Tigulini de Souza Peral, Arnaldo L. Colombo, David S. Perlin   +6 more
openaire   +2 more sources

Fatal Breakthrough Candidemia in an Immunocompromised Patient in Kuwait Due to Candida auris Exhibiting Reduced Susceptibility to Echinocandins and Carrying a Novel Mutation in Hotspot-1 of FKS1

Journal of Fungi, 2022
Candida auris is an emerging yeast pathogen that has recently caused major outbreaks in healthcare facilities worldwide. Clinical C. auris isolates are usually resistant to fluconazole and readily develop resistance to echinocandins and amphotericin B ...
Inaam Al-Obaid, Mohammad Asadzadeh, Suhail Ahmad, Khaled Alobaid, Wadha Alfouzan, Ritu Bafna, Maha Emara, Leena Joseph   +7 more
doaj   +1 more source

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +2 more sources

In Vitro Killing Activities of Anidulafungin and Micafungin with and without Nikkomycin Z against Four Candida auris Clades

Pharmaceutics, 2023
Candida auris is a multidrug-resistant pathogen against which echinocandins are the drug of choice. However, information on how the chitin synthase inhibitor nikkomycin Z influences the killing activities of echinocandins against C.
Awid Adnan, Andrew M. Borman, Zoltán Tóth, Lajos Forgács, Renátó Kovács, Dávid Balázsi, Bence Balázs, Gergely Udvarhelyi, Gábor Kardos, László Majoros   +9 more
doaj   +1 more source

Analysis of molecular resistance to azole and echinocandin in Candida species in patients with vulvovaginal candidiasis [PDF]

Current Medical Mycology, 2022
Background and Purpose: Vulvovaginal candidiasis (VVC) is considered the most common mucosal infection caused by Candida species. Azoles were considered the firstline treatment for VVC or recurrent vulvovaginal candidiasis (RVVC) in both healthy and ...
Ensieh Lotfali, Mahzad Erami, Mahsa Fattahi, Houshang Nemati, Zeinab Ghasemi, Elham Mahdavi   +5 more
doaj   +1 more source