Results 21 to 30 of about 2,691 (173)

Presence of L701 M mutation in the FKS1 gene of echinocandin-susceptible Candida krusei isolates [PDF]

Diagnostic Microbiology and Infectious Disease, 2018
Resistance of Candida krusei isolates to echinocandins, the recommended drugs to treat candidemia, has been associated with mutations in hot spot (HS) regions of the FKS1 gene or L701 M mutation in a region between HS1 and HS3 of FKS1. However, the role of L701 M mutation alone in causing reduced echinocandins susceptibility is still unclear.
F. Lallitto, A. Prigitano, F. Mangione, A. Piralla, F. Tamarozzi, P. Marone, C. Cavanna   +6 more
openaire   +4 more sources

Fatal Breakthrough Candidemia in an Immunocompromised Patient in Kuwait Due to Candida auris Exhibiting Reduced Susceptibility to Echinocandins and Carrying a Novel Mutation in Hotspot-1 of FKS1 [PDF]

Journal of Fungi, 2022
Candida auris is an emerging yeast pathogen that has recently caused major outbreaks in healthcare facilities worldwide. Clinical C. auris isolates are usually resistant to fluconazole and readily develop resistance to echinocandins and amphotericin B ...
Inaam Al-Obaid, Mohammad Asadzadeh, Suhail Ahmad, Khaled Alobaid, Wadha Alfouzan, Ritu Bafna, Maha Emara, Leena Joseph   +7 more
doaj   +2 more sources

Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae [PDF]

FEBS Letters, 2000
Deletion of the 1,3‐β‐D‐glucan synthase gene FKS1 in Saccharomyces cerevisiae induces a compensatory mechanism that is reflected in a significant increase in chitin synthase III (CSIII) activity, leading to high rates of chitin synthesis. Deregulation of CSIII activity is mainly due to the intracellular delocalization of Chs3p and Chs4p, the two main ...
Garcı́a-Rodriguez, L.J, Trilla, J.A, Castro, C, Valdivieso, M.H, Durán, A, Roncero, C   +5 more
openaire   +3 more sources

Disseminated Candidiasis Caused by Candida albicans with Amino Acid Substitutions in Fks1 at Position Ser645 Cannot Be Successfully Treated with Micafungin [PDF]

Antimicrobial Agents and Chemotherapy, 2011
ABSTRACT The clinical utility of the echinocandins is potentially compromised by the emergence of drug resistance. We investigated whether Candida albicans with amino acid substitutions at position Ser645 in Fks1 can be treated with either a conventional or an elevated dosage of micafungin. We studied
Slater, J. L., Howard, S. J., Sharp, A., Goodwin, J., Gregson, L. M., Alastruey-Izquierdo, A., Arendrup, M. C., Warn, P. A., Perlin, D. S., Hope, W. W.   +9 more
openaire   +5 more sources

In Vitro Killing Activities of Anidulafungin and Micafungin with and without Nikkomycin Z against Four Candida auris Clades [PDF]

Pharmaceutics, 2023
Candida auris is a multidrug-resistant pathogen against which echinocandins are the drug of choice. However, information on how the chitin synthase inhibitor nikkomycin Z influences the killing activities of echinocandins against C.
Awid Adnan, Andrew M. Borman, Zoltán Tóth, Lajos Forgács, Renátó Kovács, Dávid Balázsi, Bence Balázs, Gergely Udvarhelyi, Gábor Kardos, László Majoros   +9 more
doaj   +2 more sources

Isolation of a multidrug-resistant Candida auris Clade V from an asymptomatic acute myeloid leukemia patient in the intensive care unit [PDF]

Medical Mycology Case Reports
Candida auris is a multidrug-resistant fungal pathogen, that rapidly spreads within healthcare settings. Here, an acute myeloid leukemia patient undergoing chemotherapy was admitted to the intensive care unit. From the skin, C.
Azam Moslemi, Maryam Salimi, Reza Valadan, Zoha Asgari, Javad Javidnia, Tahereh Shokohi, Bram Spruijtenburg, Eelco F.J. Meijer, Mahdi Abastabar   +8 more
doaj   +2 more sources

Drug Resistance-Associated Mutations in ERG11 of Multidrug-Resistant Candida auris in a Tertiary Care Hospital of Eastern Saudi Arabia [PDF]

Journal of Fungi, 2020
Candida auris is an emerging multi-drug resistant pathogen with high mortality rate; nosocomial infections have been reported worldwide, causing a major challenge for clinicians and microbiological laboratories. The study aims to describe new cases of C.
Reem AlJindan, Doaa M. AlEraky, Nehal Mahmoud, Baha Abdalhamid, Mashael Almustafa, Sayed AbdulAzeez, J. Francis Borgio   +6 more
doaj   +2 more sources

Candida albicans Genes Modulating Echinocandin Susceptibility of Caspofungin-Adapted Mutants Are Constitutively Expressed in Clinical Isolates with Intermediate or Full Resistance to Echinocandins [PDF]

Journal of Fungi
The opportunistic fungus Candida albicans is the leading cause of invasive candidiasis in immune-compromised individuals. Drugs from the echinocandin (ECN) class, including caspofungin, are used as a first line of therapy against invasive candidiasis ...
Anshuman Yadav, Sudisht K. Sah, David S. Perlin, Elena Rustchenko   +3 more
doaj   +2 more sources

Echinocandin resistance in Candida parapsilosis sensu stricto: Role of alterations in CHS3, FKS1 and Rho gene expression

Journal of Global Antimicrobial Resistance, 2020
Objectives: The rate of resistance of Candida parapsilosis to echinocandins remains unexplored in Iran. The main aims of this study were to investigate the susceptibility patterns and possible mechanisms of echinocandin resistance in echinocandin ...
Amirhossein Davari, Iman Haghani, Fozieh Hassanmoghadam, Mojtaba Nabili, Tahereh Shokohi, Mohammad Taghi Hedayati, Shafigheh Shabanzadeh, Maryam Moazeni   +7 more
doaj   +3 more sources

The Epidemiology and Infection Control of Candida Auris in Shanghai. [PDF]

Mycoses
ABSTRACT Background Candida auris is a globally emerging multidrug‐resistant fungus. Its dissemination is driven by patient movement and asymptomatic carriers. However, molecular epidemiological studies linking imported cases to local strains in large metropolitan areas remain limited.
Wei M, Guo J, Li L, Zhu J, Xue Y, Chen G, Yang F, Wu W, Zhu M.   +8 more
europepmc   +2 more sources