Results 41 to 50 of about 2,823 (143)

Two Sequential Clinical Isolates of Candida glabrata with Multidrug-Resistance to Posaconazole and Echinocandins

Antibiotics, 2021
Candida glabrata is one of the most prevalent causative pathogens of invasive candidiasis, and multidrug-resistant strains are emerging. We identified two clinical isolates of C. glabrata, BMU10720 and BMU10722 sequentially isolated from one patient with
Qiqi Wang, Yun Li, Xuan Cai, Ruoyu Li, Bo Zheng, Ence Yang, Tianyu Liang, Xinyu Yang, Zhe Wan, Wei Liu   +9 more
doaj   +1 more source

Genetic insights into bacterial wilt resistance using genomic prediction and association mapping in blueberry

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Bacterial wilt, caused by Ralstonia spp., poses a major threat to blueberry (Vaccinium corymbosum) production due to its persistence and rapid spread through soil and infected stock, highlighting the need for genetic insights to guide breeding strategies. This study investigated the genetic basis of bacterial wilt resistance in blueberry using
Lushan Ghimire, Norma Flor, Paul Adunola, Philip F. Harmon, Felix Enciso‐Rodriguez, Juliana Benevenuto, Luis Felipe V. Ferrão, Patricio R. Munoz   +7 more
wiley   +1 more source

Mechanistic Investigations of a Novel Lactam Antifungal Agent Against Candida albicans

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT Candida albicans presents a major, yet underestimated challenge in clinical settings due to its increased resistance to treatment. This study intended to focus on the utility of a novel proprietary lactam molecule, a quorum sensing (QS) inhibitor, against C. albicans. We assessed isolate susceptibility to lactam treatment. In addition, RNA‐Seq
Hafsa Abduljalil, William Johnston, Mark Butcher, Neil Parry, Joanne O'Keeffe, Yvonne Davies, Gordon Ramage   +6 more
wiley   +1 more source

Presence of L701 M mutation in the FKS1 gene of echinocandin-susceptible Candida krusei isolates

, 2018
Resistance of Candida krusei isolates to echinocandins, the recommended drugs to treat candidemia, has been associated with mutations in hot spot (HS) regions of the FKS1 gene or L701 M mutation in a region between HS1 and HS3 of FKS1.
F. Mangione, F. Tamarozzi, P. Marone, A. Piralla, A. Prigitano, C. Cavanna, F. Lallitto   +6 more
core   +1 more source

Clinically Important Emerging and Uncommon Fungal Pathogens in Asia: Epidemiology, Antifungal Resistance and Challenges in Diagnosis and Management

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Fungal infections in Asia are influenced by warm, humid climates, high population density and expanding healthcare systems, which together facilitate the emergence, transmission and detection of both common and rare pathogens. While Candida and Aspergillus species remain the leading causes of invasive fungal disease, increasing attention has ...
Narut Chancharussin, Anupop Jitmuang, Arunaloke Chakrabarti, Methee Chayakulkeeree   +3 more
wiley   +1 more source

Analysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing.

PLoS ONE, 2019
Introduction/objectivesAn increase in antifungal resistant Candida strains has been reported in recent years. The aim of this study was to detect mutations in resistance genes of azole-resistant, echinocandin-resistant or multi-resistant strains using ...
Kathrin Spettel, Wolfgang Barousch, Athanasios Makristathis, Iris Zeller, Marion Nehr, Brigitte Selitsch, Michaela Lackner, Peter-Michael Rath, Joerg Steinmann, Birgit Willinger   +9 more
doaj   +1 more source

Disseminated candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafungin

, 2011
The clinical utility of the echinocandins is potentially compromised by the emergence of drug resistance. We investigated whether Candida albicans with amino acid substitutions at position Ser645 in Fks1 can be treated with either a conventional or an ...
M. C. Arendrup, A. Alastruey-Izquierdo, Warn, P. A., Slater, J. L., Sharp, A., Perlin, D. S., Arendrup, M. C., Goodwin, J., J. L. Slater, Alastruey-Izquierdo, A., Hope, W. W., S. J. Howard, D. S. Perlin, P. A. Warn, Howard, S. J., Gregson, L. M., W. W. Hope, L. M. Gregson, A. Sharp, J. Goodwin   +19 more
core   +1 more source

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source

Pyrosequencing To Detect Mutations In FKS1 That Confer Reduced Echinocandin Susceptibility In Candida Albicans [PDF]

, 2008
Pyrosequencing was compared to Sanger dideoxy sequencing to detect mutations in FKS1 responsible for reduced echinocandin susceptibility in Candida albicans.
Perlin, David S., Grabinski, Jodi L., Wiederhold, Nathan P., Garcia-Effron, Guillermo, Lee, Samuel A.   +4 more
core   +1 more source

Emerging Antifungal Resistance in Tropical Mycoses: A Genomic and Clinical Perspective From Endemic Zones

Journal of the Royal Society of New Zealand, Volume 56, Issue 4, August 2026.
Antifungal resistance in tropical mycoses is an increasingly important component of the global antimicrobial resistance crisis, particularly in endemic regions where diagnostic capacity, therapeutic options, and surveillance systems are limited. This review synthesizes clinical, environmental, and genomic evidence on resistance in major endemic and ...
Meral Miraloglu
wiley   +1 more source