Results 41 to 50 of about 3,923 (195)

Multiple genome analysis of Candida glabrata clinical isolates renders new insights into genetic diversity and drug resistance determinants

Microbial Cell, 2022
The emergence of drug resistance significantly hampers the treatment of human infections, including those caused by fungal pathogens such as Candida species.
Pedro Pais, Mónica Galocha, Azusa Takahashi-Nakaguchi, Hiroji Chibana, Miguel C. Teixeira   +4 more
doaj   +1 more source

The Fungal Cell Wall : Structure, Biosynthesis, and Function [PDF]

, 2017
N.G. is funded by the Wellcome Trust via a senior investigator award and a strategic award and by the MRC Centre for Medical Mycology. C.M. acknowledges the support of the Wellcome Trust and the MRC. N.G. and C.M.
Aimanianda, Aimanianda, Al-Fattani, Albrecht, Albuquerque, Alvarez, Arroyo, Babady, Baker, Beauvais, Beauvais, Beauvais, Becker, Bonhomme, Bowen, Brown, Bruno, Bulmer, Butler, Cabib, Cabib, Cabib, Cabib, Casadevall, Casadevall, Cassone, Cassone, Castillo, Chaffin, Cheetham, Cho, Coronado, Couto, Crowe, Cushion, Cutler, Cutler, Da Silva, Dadachova, Dadachova, Dague, Dan, De Las Peñas, Del Poeta, DeMarini, Dennehy, Doering, Domer, Douglas, Douglas, Duro, Eisenhaber, Eisenman, Ene, Erwig, Fairlamb, Fernandes, Firon, Fleet, Fontaine, Frieman, Fu, Gagnon-Arsenault, García, García, Gilbert, Glasgow, Gravelat, Gresnigt, Groot, Groot, Groot, Groot, Hall, Hancock, Henry, Herrero, Hiller, Hilpert, Hohl, Hoyer, Hurtado-Guerrero, Ibrahim, Iorio, Irazoqui, Ito, Johnson, Kanetsuna, Karababa, Kaur, Kim, Klis, Klis, Klutts, Kozubowski, Kozubowski, Lamaris, Langfelder, Larsen, Latge, Latgé, Lee, Lee, Lee, Lenardon, Lenardon, Lesage, Levin, Li, Li, Li, Lipschutz, Lombard, Ma, Ma, MacCallum, Machesky, Macho, Martinez, Marty, Martín-Cuadrado, McFadden, Mentlak, Money, Money, Morelle, Morozov, Mouyna, Mouyna, Moyrand, Munro, Munro, Munro, Müller, Netea, Nett, Nobile, Norice, Nosanchuk, Nosanchuk, Odds, Oliveira-Garcia, Oliveira-Garcia, Ostrosky-Zeichner, Paolo, Paris, Park, Perlin, Piotrowski, Pitarch, Popolo, Pérez, Rachini, Rajendran, Rappleye, Rappleye, Rauceo, Reese, Reese, Reese, Reid, Reinoso-Martín, Rispail, Román, Roncero, Rowbottom, Sandini, Schorr, Schuster, Seidl, Selvaggini, Sendid, Shahinian, Sheppard, Sohn, Sorgo, Spellberg, Staab, Steinbach, Steinbach, Steinberg, Steinberg, Stynen, Sudbery, Sundstrom, Sánchez-Vallet, Thompson, Torosantucci, Treitschke, Tsai, Urban, Valdivia, Vargas-Muñiz, Veerdonk, Virag, Wagener, Walker, Walker, Walker, Walton, Weber, Wessels, Wessels, Wheeler, Wheeler, Wiederhold, Wozniak, Wösten, Xin, xSchuster, Yin, Yoneda, Zaragoza, Zarnowski, Zipfel, Zupancic   +215 more
core   +1 more source

Effect of Conformational Variability on the Drug Resistance of Candida auris ERG11p and FKS1

ACS Omega
Candida auris infection has been recognized as an urgent threat to antifungal drug resistance, and the Eagle effect of C. auris FKS1 (1,3-β-d-glucan synthase) wild-type isolates has also been noted. The Eagle effect, namely, where higher concentrations of antifungals reduce fungicidal activity relative to lower concentrations, is a confounding factor ...
Hiroshi Izumi, Laurence A. Nafie, Rina K. Dukor   +2 more
doaj   +3 more sources

Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin [PDF]

, 2014
We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them
Bizerra, Fernando Cesar, Breda, Giovanni Luis, Colombo, Arnaldo L., Jimenez-Ortigosa, Cristina, Perlin, David S., Queiroz-Telles, Flavio, Souza, Ana Carolina R.   +6 more
core   +2 more sources

Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies

Journal of Fungi, 2020
Background. Candida tropicalis is a virulent fungal pathogen for which echinocandins are the primary therapy. Emergence of resistance to echinocandins of C. tropicalis carries potentially ominous therapeutic implications. Methods.
Maroun M. Sfeir, Cristina Jiménez-Ortigosa, Maria N. Gamaletsou, Audrey N. Schuetz, Rosemary Soave, Koen Van Besien, Catherine B. Small, David S. Perlin, Thomas J. Walsh   +8 more
doaj   +1 more source

Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition [PDF]

, 2018
Acknowledgments We acknowledge Jeanette Wagener and Louise Walker for performing the HPAEC-PAD analysis and Neil Gow for providing access to the Dionex HPAEC-PAD instrumentation.
Alspaugh, J. Andrew, Campuzano, Althea, Esher, Shannon K., Kohlbrenner, Maria A., Munro, Carol, Nichols, Connie B., Ost, Kyla S., Pianalto, Kaila M., Telzrow, Calla L., Wormley, Jr, Floyd L.   +9 more
core   +2 more sources

Potential Use of MALDI-ToF Mass Spectrometry for Rapid Detection of Antifungal Resistance in the Human Pathogen Candida glabrata. [PDF]

, 2017
The echinocandins are relatively new antifungal drugs that represent, together with the older azoles, the recommended and/or preferred agents to treat candidaemia and other forms of invasive candidiasis in human patients.
De Carolis, E., Mello, E., Perlin, D.S., Posteraro, B., Sanglard, D., Sanguinetti, M., Vella, A.   +6 more
core   +2 more sources

Inhibitory Mechanisms of trans-2-Hexenal on the Growth of Geotrichum citri-aurantii

Journal of Fungi, 2023
Geotrichum citri-aurantii (G. citri-aurantii) is one of the most important postharvest pathogens leading to a postharvest loss of citrus by causing sour rot. In this study, the antifungal activity of trans-2-hexenal, a natural component of essential oil,
Qiuli Ouyang, Shiwei Shi, Yangmei Liu, Yanqin Yang, Yonghua Zhang, Xingxing Yuan, Nengguo Tao, Lu Li   +7 more
doaj   +1 more source

Influence of glucose concentration on the structure and quantity of biofilms formed by Candida parapsilosis [PDF]

, 2015
Candida parapsilosis is nowadays an emerging opportunistic pathogen and its increasing incidence is part related to the capacity to produce biofilm. In addition, one of the most important C.
Almirante, Azeredo, Bruno Ribeiro, Joana Azeredo, Leonel Pereira, Mariana Henriques, Nguyen, Nguyen, Pannanusorn, Pfaffl, Richard Calderone, Santana, Silva, Sónia Silva, Williams, Zambranoa   +15 more
core   +1 more source

Two Sequential Clinical Isolates of Candida glabrata with Multidrug-Resistance to Posaconazole and Echinocandins

Antibiotics, 2021
Candida glabrata is one of the most prevalent causative pathogens of invasive candidiasis, and multidrug-resistant strains are emerging. We identified two clinical isolates of C. glabrata, BMU10720 and BMU10722 sequentially isolated from one patient with
Qiqi Wang, Yun Li, Xuan Cai, Ruoyu Li, Bo Zheng, Ence Yang, Tianyu Liang, Xinyu Yang, Zhe Wan, Wei Liu   +9 more
doaj   +1 more source