Implication of Candida parapsilosis FKS1 and FKS2 Mutations in Reduced Echinocandin Susceptibility [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT We evaluated FKS1 and FKS2 mutations in Candida parapsilosis bloodstream isolates and correlated them with the echinocandin MIC values determined by guidelines in CLSI document M27-A3 and the YeastOne panel.
Martí-Carrizosa M +4 more
openaire +4 more sources
Fks1 and Fks2 Are Functionally Redundant but Differentially Regulated in Candida glabrata: Implications for Echinocandin Resistance [PDF]
Antimicrobial Agents and Chemotherapy, 2012 ABSTRACT The echinocandins caspofungin, micafungin, and anidulafungin, inhibitors of cell wall β-1,3-glucan synthesis, were recently elevated to first-line agents for treating infections due to the azole-refractory yeast Candida glabrata .
Santosh K, Katiyar +5 more
openaire +5 more sources
Candida parapsilosis isolates carrying mutations outside FKS1 hotspot regions confer high echinocandin tolerance and facilitate the development of echinocandin resistance [PDF]
, 2023 Candida parapsilosis is a significant cause of candidemia worldwide. Echinocandin-resistant (ECR) and echinocandin-tolerant (ECT) C. parapsilosis isolates have been reported in various countries but are rare.
Daneshnia, Farnaz +10 more
core +3 more sources
Echinocandin Failure Case Due to a Previously Unreported FKS1 Mutation in Candida krusei [PDF]
Antimicrobial Agents and Chemotherapy, 2014 ABSTRACT Echinocandins are the preferred therapy for invasive infections due to Candida krusei . We present here a case of clinical failure involving C. krusei with a characteristic FKS1 hot spot mutation not previously reported in C. krusei
Jensen, Rasmus Hare +4 more
openaire +4 more sources
Analysis of molecular resistance to azole and echinocandin in Candida species in patients with vulvovaginal candidiasis [PDF]
Current Medical Mycology, 2022 Background and Purpose: Vulvovaginal candidiasis (VVC) is considered the most common mucosal infection caused by Candida species. Azoles were considered the firstline treatment for VVC or recurrent vulvovaginal candidiasis (RVVC) in both healthy and ...
Ensieh Lotfali +5 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Diutina catenulata (Candida catenulata) is an ascomycete yeast species widely used in environmental and industrial research and capable of causing infections in humans and animals. At present, there are only a few studies on D.
Xin-Fei Chen +37 more
doaj +1 more source
Novel non hot spot modification in Fks1 of Candida auris confers echinocandin resistance
Antimicrobial Agents and Chemotherapy, 2023 ABSTRACT We determined echinocandin susceptibility and FKS1 genotypes of thirteen clinical isolates of Candida auris recovered from four patients at a tertiary care center in Salvador, Brazil.
Milena Kordalewska +6 more
openaire +2 more sources
Engineering the TetO System to Test the Contribution of FKS1 to Yeast Cell Wall Strength [PDF]
, 2021 Society has a demand for manufactured proteins such as insulin, which can be produced by the yeast Saccharomyces cerevisiae, but such proteins are not easily accessible due to this yeast’s rigid cell wall. I hypothesize that if S.
Jenkins, Steffany
core +1 more source
Journal of Fungi, 2022 Candida parapsilosis is the second most common cause of candidemia in some geographical areas and in children in particular. Yet, the proportion among children varies, for example, from 10.4% in Denmark to 24.7% in Tehran, Iran.
Rasmus Krøger Hare +9 more
doaj +1 more source
Journal of Fungi, 2020 Background. Candida tropicalis is a virulent fungal pathogen for which echinocandins are the primary therapy. Emergence of resistance to echinocandins of C. tropicalis carries potentially ominous therapeutic implications. Methods.
Maroun M. Sfeir +8 more
doaj +1 more source