Results 51 to 60 of about 2,691 (173)

Multiple genome analysis of Candida glabrata clinical isolates renders new insights into genetic diversity and drug resistance determinants

Microbial Cell, 2022
The emergence of drug resistance significantly hampers the treatment of human infections, including those caused by fungal pathogens such as Candida species.
Pedro Pais, Mónica Galocha, Azusa Takahashi-Nakaguchi, Hiroji Chibana, Miguel C. Teixeira   +4 more
doaj   +1 more source

Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 1997
Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a gene from the diploid organism Candida albicans that encodes a target of these inhibitors.
C M, Douglas, J A, D'Ippolito, G J, Shei, M, Meinz, J, Onishi, J A, Marrinan, W, Li, G K, Abruzzo, A, Flattery, K, Bartizal, A, Mitchell, M B, Kurtz   +11 more
openaire   +2 more sources

Inhibitory Mechanisms of trans-2-Hexenal on the Growth of Geotrichum citri-aurantii

Journal of Fungi, 2023
Geotrichum citri-aurantii (G. citri-aurantii) is one of the most important postharvest pathogens leading to a postharvest loss of citrus by causing sour rot. In this study, the antifungal activity of trans-2-hexenal, a natural component of essential oil,
Qiuli Ouyang, Shiwei Shi, Yangmei Liu, Yanqin Yang, Yonghua Zhang, Xingxing Yuan, Nengguo Tao, Lu Li   +7 more
doaj   +1 more source

546. Transmission of Candida auris FKS1 Mutations in Orange County, CA [PDF]

Open Forum Infect Dis
Abstract Background Candida auris (C. auris) is a potentially multidrug-resistant yeast that can cause severe infections in high-risk patient care populations and is endemic in Orange County (OC). U.S.
Brown, Jennifer, Le, Mi, Tirol, Denise, Kryger, Elizabeth, Villareal, Gabrielle, Fontela, Cherry Q, Torres, Angelica, Chiem, Tania, Buchanan, Victoria, Kapsak, Curtis J, Crumpler, Megan, Zahn, Matthew   +11 more
europepmc   +3 more sources

Two Sequential Clinical Isolates of Candida glabrata with Multidrug-Resistance to Posaconazole and Echinocandins

Antibiotics, 2021
Candida glabrata is one of the most prevalent causative pathogens of invasive candidiasis, and multidrug-resistant strains are emerging. We identified two clinical isolates of C. glabrata, BMU10720 and BMU10722 sequentially isolated from one patient with
Qiqi Wang, Yun Li, Xuan Cai, Ruoyu Li, Bo Zheng, Ence Yang, Tianyu Liang, Xinyu Yang, Zhe Wan, Wei Liu   +9 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Low Prevalence of fks1 Hot Spot 1 Mutations in a Worldwide Collection of Candida Strains [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT We evaluated the prevalence of fks1 hot spot (HS) 1 mutations among 133 Candida strains from six species displaying various caspofungin MIC values (from ≤0.008 to >8 μg/ml). Only 4 (2.9%) strains displayed FKS1 HS1 amino acid substitutions: 1 C. albicans
Mariana, Castanheira, Leah N, Woosley, Daniel J, Diekema, Shawn A, Messer, Ronald N, Jones, Michael A, Pfaller   +5 more
openaire   +2 more sources

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source

A Glucan Synthase FKS1 Homolog in Cryptococcus neoformans Is Single Copy and Encodes an Essential Function [PDF]

Journal of Bacteriology, 1999
ABSTRACT Cryptococcal meningitis is a fungal infection, caused by Cryptococcus neoformans , which is prevalent in immunocompromised patient populations. Treatment failures of this disease are emerging in the clinic, usually associated with long-term treatment with existing antifungal agents.
J R, Thompson, C M, Douglas, W, Li, C K, Jue, B, Pramanik, X, Yuan, T H, Rude, D L, Toffaletti, J R, Perfect, M, Kurtz   +9 more
openaire   +2 more sources