Results 51 to 60 of about 3,923 (195)

New cell wall-affecting antifungal antibiotics [PDF]

open access: yes, 2013
Capítulo 9.Fungi have emerged worldwide as increasingly frequent causes of healthcare-associated infections. Invasive fungal infections can be life-threatening.
Cortés, Juan Carlos G.   +2 more
core   +2 more sources

Double-Pole Approximation in Time-Dependent Density Functional Theory [PDF]

open access: yes, 2005
A simple approximate solution to the linear response equations of time-dependent density functional theory (TDDFT) is given. This extends the single-pole approximation (SPA) to two strongly-coupled poles. The analysis provides both an illustration of how
Appel   +18 more
core   +1 more source

Portrait of matrix gene expression in Candida glabrata biofilms with stress induced by different drugs [PDF]

open access: yes, 2018
(1) Background: Candida glabrata is one of the most significant Candida species associated with severe cases of candidiasis. Biofilm formation is an important feature, closely associated with antifungal resistance, involving alterations of gene ...
Henriques, Mariana, Rodrigues, Célia F.
core   +2 more sources

Low Prevalence of fks1 Hot Spot 1 Mutations in a Worldwide Collection of Candida Strains [PDF]

open access: yesAntimicrobial Agents and Chemotherapy, 2010
ABSTRACT We evaluated the prevalence of fks1 hot spot (HS) 1 mutations among 133 Candida strains from six species displaying various caspofungin MIC values (from ≤0.008 to >8 μg/ml). Only 4 (2.9%) strains displayed FKS1 HS1 amino acid substitutions: 1 C. albicans
Mariana, Castanheira   +5 more
openaire   +2 more sources

New strategic insights into managing fungal biofilms [PDF]

open access: yes, 2015
Fungal infections have dramatically increased in the last decades in parallel with an increase of populations with impaired immunity, resulting from medical conditions such as cancer, transplantation or other chronic diseases.
Borghi, Elisa   +6 more
core   +4 more sources

Candida albicans Genes Modulating Echinocandin Susceptibility of Caspofungin-Adapted Mutants Are Constitutively Expressed in Clinical Isolates with Intermediate or Full Resistance to Echinocandins

open access: yesJournal of Fungi
The opportunistic fungus Candida albicans is the leading cause of invasive candidiasis in immune-compromised individuals. Drugs from the echinocandin (ECN) class, including caspofungin, are used as a first line of therapy against invasive candidiasis ...
Anshuman Yadav   +3 more
doaj   +1 more source

Integrated Genomic and Phenotypic Analyses Reveal Convergent Resistance Patterns in Clinical Candida tropicalis Isolates

open access: yesMycoses, Volume 69, Issue 5, May 2026.
ABSTRACT Background The incidence of Candida tropicalis isolation is increasing in hospital settings. High azole resistance and mortality rates make it a pathogen that requires further analysis. Methods Fourteen azole resistant Candida glabrata clinical isolates were collected from a Lebanese hospital and analysed through whole genome sequencing for ...
Christy Chedraoui   +9 more
wiley   +1 more source

Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris [PDF]

open access: yes, 2019
The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community.
Kean, Ryan, Ramage, Gordon
core   +2 more sources

Analysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing.

open access: yesPLoS ONE, 2019
Introduction/objectivesAn increase in antifungal resistant Candida strains has been reported in recent years. The aim of this study was to detect mutations in resistance genes of azole-resistant, echinocandin-resistant or multi-resistant strains using ...
Kathrin Spettel   +9 more
doaj   +1 more source

Molecular Epidemiology of Candida Auris Outbreak in a Major Secondary-Care Hospital in Kuwait

open access: yesJournal of Fungi, 2020
The emerging, often multidrug-resistant Candida auris is increasingly being associated with outbreaks in healthcare facilities. Here we describe the molecular epidemiology of a C.
Wadha Alfouzan   +11 more
doaj   +1 more source

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