Results 71 to 80 of about 2,823 (143)

Synergistic in vitro activity of sodium houttuyfonate with fluconazole against clinical Candida albicans strains under planktonic growing conditions

Pharmaceutical Biology, 2017
Context: Fluconazole resistance is an intractable problem of treating Candida albicans, calling for more antifungal agents to enhance the activity of fluconazole. Objective: This work investigates the anti-C.
Jing Shao, YanYan Cui, MengXiang Zhang, TianMing Wang, DaQiang Wu, ChangZhong Wang   +5 more
doaj   +1 more source

Candida kefyr in Kuwait: Prevalence, antifungal drug susceptibility and genotypic heterogeneity.

PLoS ONE, 2020
ObjectiveCandida kefyr causes invasive candidiasis in immunocompromised patients, particularly among those with oncohematological diseases. This study determined the prevalence of C.
Suhail Ahmad, Ziauddin Khan, Noura Al-Sweih, Wadha Alfouzan, Leena Joseph, Mohammad Asadzadeh   +5 more
doaj   +1 more source

CWI‐MAPKs Regulate the Formation of Hyphopodia Required for Virulence in Ceratocystis fimbriata

Molecular Plant Pathology, Volume 26, Issue 7, July 2025.
The Slt2‐Swi6 pathway is crucial for the pathogenicity of Ceratocystis fimbriata. It regulates septin assembly at the base of the penetration peg, thereby influencing penetration peg formation—a key virulence determinant. ABSTRACT Ceratocystis fimbriata is a destructive fungal pathogen that infects various economic crops.
Kailun Lu, Hao Cong, Ru Xin, Yong Sun, Qinghe Cao, Lianwei Li, Jihong Jiang   +6 more
wiley   +1 more source

Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolates

npj Antimicrobials and Resistance
Candida glabrata (Nakaseomyces glabratus) is the most common cause of drug-resistant candidemia and is associated with a high mortality rate. Only a few mechanisms of drug resistance are known in C.
Christopher Zajac, Nancy E. Scott, Susan Kline, Serin E. Erayil, Anna Selmecki   +4 more
doaj   +1 more source

Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata

, 2019
Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study.
He Wang (250350), Cristina Jiménez Ortigosa (7849826), Ying Zhao (16546), Padmaja Paderu (7849829), Kelley R. Healey (7849820), Ying-Chun Xu (647163), Xin Hou (336157), Yong-Zhe Li (7849835), Yanan Zhao (3132906), Li-Yan Lin (353225), Milena Kordalewska (7849823), David S. Perlin (7849838), Yan-Hai Zhang (7849832), Erika Shor (256480), Meng Xiao (591353)   +14 more
core   +1 more source

Adaptation of the tetracycline-repressible system for modulating the expression of essential genes in Cryptococcus neoformans

mSphere
The opportunistic human fungal pathogen Cryptococcus neoformans has an enormous impact on human health as the causative agent of cryptococcal meningitis, and there is a dire need to expand our current antifungal arsenal.
Ci Fu, Nicole Robbins, Leah E. Cowen
doaj   +1 more source

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations [PDF]

Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C.
Sumiyoshi, Makoto, Ashizawa, Nobuyuki, Iwanaga, Naoki, Tsukamoto, Kazuhiro, Miyazaki, Taiga, Takeda, Kazuaki, Takazono, Takahiro, Yanagihara, Katsunori, Mukae, Hiroshi, Kohno, Shigeru, Yamamoto, Kazuko, Izumikawa, Koichi, Hirayama, Tatsuro, Ito, Yuya, Makimura, Koichi   +14 more
core  

Emergence of Echinocandin Resistance due to a Point Mutation in the fks1 Gene in a Patient with Chronic Pulmonary Aspergillosis

, 2017
We have identified the first case of fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a patient with an aspergilloma and chronic pulmonary aspergillosis who first failed azole ...
David S. Perlin, Perlin, David S., Cristina Jiménez-Ortigosa, Denning, David; id_orcid, Jiménez-Ortigosa, Cristina, Caroline Moore, David W. Denning, Moore, Caroline   +7 more
core   +1 more source

Epidemiological investigation of non-albicans Candida species recovered from mycotic mastitis of cows in Yinchuan, Ningxia of China

BMC Veterinary Research, 2018
Background Candida spp. is the vital pathogen involved in mycotic mastitis of cows. However the epidemiology and infection of Candida species in mycotic mastitis of cow in Ningxia province of China has not been explored.
Jun Du, Xiaoyu Wang, Huixia Luo, Yujiong Wang, Xiaoming Liu, Xuezhang Zhou   +5 more
doaj   +1 more source

Susceptibilidade de Candida albicans à Caspofungina e mutações de FKS1 [PDF]

, 2011
Mestrado em Biologia Molecular e CelularA incidência e a prevalência de infecções fúngicas invasivas com comprometimento de vida são um grave problema de saúde humana e, não obstante dos tratamentos antifúngicos agressivos bem estabelecidos ou com novos ...
Pedrosa, Joana Margarida Duarte
core