Results 71 to 80 of about 2,691 (173)
Aspergillus fumigatus devoid of cell wall ?-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors. [PDF]
, 2015 Echinocandins inhibit ?-1,3-glucan synthesis and are one of the few antimycotic drug classes effective against Aspergillus spp. In this study, we characterized the ?-1,3-glucan synthase Fks1 of Aspergillus fumigatus, the putative target of echinocandins.
Dichtl, Karl;Samantaray, Sweta;Aimanianda, Vishukumar;Zhu, Zhaojun;Prévost, Marie-Christine;Latgé, Jean-Paul;Ebel, Frank;Wagener, Johannes
core +3 more sources
Emerging Microbes and Infections, 2023 Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C.
Yating Ning +18 more
doaj +1 more source
Biocide Response of Candida auris
Mycoses, Volume 69, Issue 3, March 2026.ABSTRACT Candida auris is an emerging multidrug‐resistant yeast demonstrating remarkable persistence in healthcare environments, contributing to nosocomial transmission and outbreak persistence. Increasing disinfectant failure reports have raised concerns regarding infection control policies, as environmental reservoirs play central roles in its spread.
Sidre Erganis +3 more
wiley +1 more source
, 2023 Caspofungin is an echinocandin antifungal agent that inhibits synthesis of glucan required for the fungal cell wall. Resistance is mediated by mutation of Fks1 glucan synthase, among which S645P is the most common resistance-associated polymorphism ...
BITEAU, Nicolas +4 more
core +1 more source
The first invasive Candida auris infection in Taiwan
Emerging Microbes and Infections, 2022 Candida auris, a multidrug resistant pathogenic yeast, has spread worldwide and caused several outbreaks in healthcare settings. Here, we report the first case of C.
Yu-Te Tsai +7 more
doaj +1 more source
Mycoses, Volume 69, Issue 2, February 2026.ABSTRACT Background Candida (Candidozyma) auris is an emerging yeast that poses a significant global health threat due to its multidrug resistance and ability to cause healthcare‐associated outbreaks. Genomic surveillance is essential for monitoring spread, transmission and antifungal resistance.
Luiz Marcelo Ribeiro Tomé +19 more
wiley +1 more source
Role of Fks1p and Matrix Glucan in Candida albicans Biofilm Resistance to an Echinocandin, Pyrimidine, and Polyene [PDF]
, 2010 Candida infections frequently involve drug-resistant biofilm growth on device surfaces. Glucan synthase gene FKS1 has been linked to triazole resistance in Candida biofilms. We tested the impact
Karen Marchillo +3 more
core +1 more source
Two echinocandin-resistant Candida glabrata FKS mutants from South Africa
Medical Mycology Case Reports, 2016 Echinocandins are recommended as first-line agents to treat invasive infections caused by Candida glabrata since this organism is inherently less susceptible to azoles. However, resistance to echinocandins has been described in C.
Serisha D. Naicker +6 more
doaj +1 more source
International Journal of Microbiology, Volume 2026, Issue 1, 2026.Candida species are well‐known for their capacity to cause a broad range of infections in humans. Invasive and device‐related infections caused by Candida albicans and non‐albicans contribute to a relatively high mortality rate, thereby becoming a major public health concern around the world.
Evita Mayasari +2 more
wiley +1 more source
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.The incidence of infections caused by rare pathogens has increased in recent years. This necessitates the development of effective diagnostic and therapeutic approaches. In this study, we report the first documented case of Aspergillus steynii‐induced pulmonary infection in humans.
Ruixuan Wang +12 more
wiley +1 more source