Results 81 to 90 of about 2,691 (173)

FKS2 and FKS3 Genes of Opportunistic Human Pathogen Candida albicans Influence Echinocandin Susceptibility [PDF]

, 2018
Candida albicans , a prevailing opportunistic fungal pathogen of humans, has a diploid genome containing three homologous FKS genes that are evolutionarily conserved. One of these, the essential gene FKS1
David S. Perlin, Elena Rustchenko, Sumanun Suwunnakorn, Hironao Wakabayashi, Milena Kordalewska   +4 more
core   +1 more source

Structural, Mechanical, and Genetic Insights into Heat‐Pressed Fomes Fomentarius Mycelium from Solid‐State and Liquid Cultivations

Advanced Sustainable Systems, Volume 9, Issue 10, October 2025.
Fungal mycelium‐based materials are an upcoming class of sustainable materials. Heat ‐pressing is a promising post‐processing technique to produce fungal mycelium‐based particle boards or leather substitutes. However, little is known about the mechanism involved.
Huaiyou Chen, Sophie Klemm, Ernesto Scoppola, Bertram Schmidt, Yunpeng Wu, Claudia Fleck, Aleksander Gurlo, Vera Meyer, Carsten Freidank‐Pohl, Ulla Simon   +9 more
wiley   +1 more source

New Fks Hot Spot for Acquired Echinocandin Resistance in Saccharomyces cerevisiae and Its Contribution to Intrinsic Resistance of Scedosporium Species [PDF]

, 2011
Echinocandins represent a new antifungal group with potent activity against Candida species. These lipopeptides inhibit the synthesis of β-1,3-glucan, the major cell wall polysaccharide. Acquired resistance or reduced echinocandin
Michael E. Johnson, Thomas D. Edlind, Santosh K. Katiyar   +2 more
core   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Yeast species-specific, differential inhibition of β-1,3-glucan synthesis by poacic acid and caspofungin

The Cell Surface, 2018
The rise of widespread antifungal resistance fuels the need to explore new classes of inhibitory molecules as potential novel inhibitors. Recently a plant natural product poacic acid (PA) was shown to inhibit β-1,3-glucan synthesis, and to have ...
Keunsook K. Lee, Karen Kubo, Jehan Abdelmoneim Abdelaziz, Iain Cunningham, Alessandra de Silva Dantas, Xiaolin Chen, Hiroki Okada, Yoshikazu Ohya, Neil A.R. Gow   +8 more
doaj   +1 more source

CWI‐MAPKs Regulate the Formation of Hyphopodia Required for Virulence in Ceratocystis fimbriata

Molecular Plant Pathology, Volume 26, Issue 7, July 2025.
The Slt2‐Swi6 pathway is crucial for the pathogenicity of Ceratocystis fimbriata. It regulates septin assembly at the base of the penetration peg, thereby influencing penetration peg formation—a key virulence determinant. ABSTRACT Ceratocystis fimbriata is a destructive fungal pathogen that infects various economic crops.
Kailun Lu, Hao Cong, Ru Xin, Yong Sun, Qinghe Cao, Lianwei Li, Jihong Jiang   +6 more
wiley   +1 more source

Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin [PDF]

, 2012
Echinocandins are first-line agents for treating severe invasive candidiasis. Glucan synthase gene (FKS1) mutations lead to echinocandin resistance but the role of enhanced chitin expression is not well recognized in clinical isolates.
Bal, A.M., Johnson, E.M., MacCallum, D.M., MacGregor, M.S., Shankland, G.S., Imtiaz, T., Munro, C.A., Lee, K.K.   +7 more
core   +1 more source

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

mBio, 2019
Aspergillus fumigatus is a leading cause of invasive fungal infections. Resistance to first-line triazole antifungals has led to therapy with echinocandin drugs. Recently, we identified several high-minimum-effective-concentration (MEC) A.
Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W. Denning, Olaf Kniemeyer, Axel A. Brakhage, David S. Perlin   +10 more
doaj   +1 more source

Production of yeast cell wall polysaccharides‐β‐glucan and chitin by using food waste substrates: Biosynthesis, production, extraction, and purification methods

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 3, May 2025.
Abstract Food waste causes significant environmental and economic challenges worldwide, prompting many nations to prioritize its reduction and recycling. As a nutrient‐rich material containing vitamins, proteins, and carbohydrates, it serves as a promising substrate for the cultivation of single‐cell microorganisms like yeast.
Deniz Günal‐Köroğlu, Gulsah Karabulut, Fariddudin Mohammadian, Aslı Can Karaca, Esra Capanoglu, Tuba Esatbeyoglu   +5 more
wiley   +1 more source

Susceptibilidade de Candida albicans à Caspofungina e mutações de FKS1 [PDF]

, 2011
Mestrado em Biologia Molecular e CelularA incidência e a prevalência de infecções fúngicas invasivas com comprometimento de vida são um grave problema de saúde humana e, não obstante dos tratamentos antifúngicos agressivos bem estabelecidos ou com novos ...
Pedrosa, Joana Margarida Duarte
core