Results 81 to 90 of about 2,823 (143)

Glucan synthase of Phytophthora sojae [PDF]

, 2002
Glucans, with the (1-3)-b-glucosidic linkage as major feature, are present in most of the higher plants, in many lower plants, as well as in microorganisms (Stone and Clarke, 1992). The synthesis of (1-3)-b-glucan in vivo is catalysed by the enzyme (1-3)-
Antelo, Luis
core   +1 more source

Antifungal susceptibility, molecular epidemiology, and clinical risk factors of Candida glabrata in intensive care unit in a Chinese Tertiary Hospital

Frontiers in Cellular and Infection Microbiology
BackgroundThe increasing incidence and high mortality rate of Candida glabrata infection in ICU patients is an important issue. Therefore, it is imperative to investigate the antifungal susceptibility profiles and epidemiological characteristics in local
Si-Jia Huang, Si-Jia Huang, Geng Lv, Geng Lv, Yi-Hui Song, Jun-Tao Zhao, Jin-Yan Liu, Lu-Ling Wang, Lu-Ling Wang, Ming-Jie Xiang, Ming-Jie Xiang   +10 more
doaj   +1 more source

Intracellular trafficking and localization of the β-(1,3)-glucan synthase, Fks1, are impaired in the mar1Δ mutant.

, 2018
(A) Uptake of the lipophilic dye, FM4-64, is irregular in mar1Δ cells. Cells were incubated overnight in YPD (30°C) or TC (37°) and stained with FM4-64 for 30 minutes with shaking, followed by pelleting and refreshing in the indicated media for an ...
Carol Munro (108688), Connie B. Nichols (252902), Floyd L. Wormley Jr. (220899), Kyla S. Ost (720285), Althea Campuzano (3687070), Maria A. Kohlbrenner (5334965), Kaila M. Pianalto (5334962), Calla L. Telzrow (5334959), J. Andrew Alspaugh (252904), Shannon K. Esher (720288)   +9 more
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Underlying resistance mechanisms of C. glabrata - Differentiation of polymorphisms and resistance causal mutations in CgPDR1, ERG11, ERG3, FKS1, FKS2, FUR1 and MSH2, of C. glabrata

, 2020
Einleitung Der opportunistische Sprosspilz C. glabrata gilt in Europa als der zweithäufigste pathogene Pilz. In den vergangenen 30 Jahren konnte ein signifikanter Anstieg an Pilzinfektionen festgestellt werden.
Winkler, Konstantin
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A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance

, 2018
Item does not contain fulltextBackground: Candida auris has emerged globally as an MDR nosocomial pathogen in ICU patients. Objectives: We studied the antifungal susceptibility of C.
Shalini Upadhyay, Bansidhar Tarai, Priyanka Yadav, Kumar, A., Cheshta Sharma, Sarma, Smita, Chowdhary, Anuradha, Sharma, Cheshta, Kordalewska, Milena, Smita Sarma, Khillan, Vikas, Singh, A., Meis, Jacques F, Singh, Ashutosh, Prakash, A., Upadhyay, Shalini, Sachdeva, N., Meis, J.F.G.M., Gargi Upadhyaya, Vikas Khillan, Singh, Pradeep K, Anil Kumar, Sharma, C., Perlin, D.S., Jacques F Meis, Perlin, David S, Tarai, B., Anupam Prakash, Tarai, Bansidhar, Chowdhary, A., David S Perlin, Singh, P.K., Kordalewska, M., Yadav, P., Upadhyaya, Gargi, Anuradha Chowdhary, Prakash, Anupam, Sarma, S., Sachdeva, Neelam, Khillan, V., Ashutosh Singh, Pradeep K Singh, Yadav, Priyanka, Milena Kordalewska, Neelam Sachdeva, Upadhyaya, G., Kumar, Anil, Upadhyay, S.   +47 more
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Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance?

mBio
Echinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported.
Hans Carolus, Judith Díaz-García, Vladislav Biriukov, Stef Jacobs, Dimitrios Sofras, Alicia Pageau, Celia Lobo Romero, Lore Vinken, Pilar Escribano, Jesús Guinea, Katrien Lagrou, Christian R. Landry, Toni Gabaldón, Patrick Van Dijck   +13 more
doaj   +1 more source

J Antimicrob Chemother

, 2019
A strain of the opportunistic pathogenic yeast Candida lusitaniae was genetically engineered for full-length replacement of the FKS1 gene encoding the target of echinocandin antifungals in order to assess the impact of FKS mutations on echinocandin ...
BITEAU, Nicolas, ACCOCEBERRY, Isabelle, FITTON-OUHABI, Valerie, COUZIGOU, Celia, NOEL, Thierry   +4 more
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Role of Fks1p and Matrix Glucan in Candida albicans Biofilm Resistance to an Echinocandin, Pyrimidine, and Polyene

, 2010
Candida infections frequently involve drug-resistant biofilm growth on device surfaces. Glucan synthase gene FKS1 has been linked to triazole resistance in Candida biofilms. We tested the impact
Karen Marchillo, David R. Andes, Jeniel E. Nett, Kyler Crawford   +3 more
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A pan-azole and pan-echinocandin resistant Wickerhamomyces anomalus isolate causing bloodstream infection: ERG11Y140F, K151R with copy number variation and FKS1 F665S mutation

International Journal of Medical Microbiology
Fungal infections pose a growing global threat, particularly due to the emergence of multidrug-resistant pathogens. This study reports the first globally documented case of a Wickerhamomyces anomalus isolate (XN272) displaying dual high-level resistance ...
Zhengyu Luo, Yating Ning, Rongchen Dai, Ailifeire Ainiwaer, Yanhong Li, Ruike Zhang, Meng Xiao, Xiaoxi Wang, Yang Yang, Yuyan Huang, Dingding Li, Lingli Liu, Roujie Huang, Tingying Xu, Yingchun Xu, Zhiyong Liu, Li Zhang, Tianshu Sun   +17 more
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Role of Pbr1, a putative oxidoreductase, in the ER quality control and folding of yeast Fks1 glucan synthase. [PDF]

Proc Natl Acad Sci U S A
Obara K, Okada H, Tan G, Ohnuki S, Suzuki G, Ohtake H, Kubo K, Ghanegolmohammadi F, Ishizaka S, Yashiroda Y, Okita A, Mishiro-Sato E, Suzuki K, Tamura Y, Ashine R, Ikeda Y, Kamura T, van Leeuwen J, Andrews B, Bi E, Noda NN, Boone C, Ohya Y.   +22 more
europepmc   +1 more source