Results 101 to 110 of about 3,923 (195)

Enhancing Flucytosine Anticandidal Activity Using PEGylated Squalene Nanocarrier

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
Our study focused on improving the effectiveness of the antifungal drug 5‐fluorocytosine (5FC) by loading it in micellar structures formed by PEGylated squalene copolymer. The obtained results for 5FC‐loaded micelles showed in vitro prolonged release under physiological conditions and improved in vitro antifungal activity without cytotoxicity for ...
Bogdan‐Florin Craciun, Irina Rosca, Dragos Peptanariu, Mariana Pinteala   +3 more
wiley   +1 more source

Reconstructing phylogenetic level-1 networks from nondense binet and trinet sets [PDF]

, 2014
Binets and trinets are phylogenetic networks with two and three leaves, respectively. Here we consider the problem of deciding if there exists a binary level-1 phylogenetic network displaying a given set T of binary binets or trinets over a taxon set X ...
AV Aho, B Holland, C Choy, C Semple, Celine Scornavacca, D Gusfield, D Huson, DH Huson, E Bapteste, F Pardi, G Cardona, H Poormohammadi, J Jansson, J Jansson, J Jansson, K Strimmer, Katharina T. Huber, KT Huber, KT Huber, KT Huber, Leo van Iersel, LJJ Iersel van, P Gambette, Taoyang Wu, Vincent Moulton, Y Yu   +25 more
core   +6 more sources

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

Functional specialization of the yeast Rho1 GTP exchange factors [PDF]

, 2012
Rho GTPases are regulated in complex spatiotemporal patterns that may be dependent, in part at least, on the multiplicity of their GTP exchange factors (GEFs).
Cundell, M., Gray, J., Johnston, G., Krause, S., McGhie, J., Poon, P., Price, C.   +6 more
core  

Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis [PDF]

, 2017
The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds.
Ana C. A. de Paula e Silva, Ana M. Fusco-Almeida, Caroline B. Costa-Orlandi, Caroline M. Marcos, Haroldo C. de Oliveira, Liliana Scorzoni, Maria J. S. Mendes-Giannini, Patrícia A. Assato, Wanessa C. M. A. de Melo   +8 more
core   +1 more source

The Candida auris Infection After the COVID‐19 Pandemic Seems to be an Urgent Public Health Emergency: A Call to Attention

Health Science Reports, Volume 7, Issue 11, November 2024.
Abstract Background and Aims Inconsequential diseases can sometimes become extremely dangerous through mutation. Antifungal resistance has increased by 24%, and resistance only due to Candida auris (C. auris) species have increased by 60%. Here, we aimed to assess the knowledge of antifungal treatment and preventative measures to mitigate the ...
Md. Ashrafur Rahman, Evangelos Victoros, Yeasna Shanjana, Marie Roke Thomas, Md. Rabiul Islam   +4 more
wiley   +1 more source

Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]

, 2017
This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N, Istel, F, Jenull, S, Lion, T, Nogueira, MF, Walker, L A   +5 more
core   +1 more source

Multicentre Study of Candida parapsilosis Blood Isolates in Türkiye Highlights an Increasing Rate of Fluconazole Resistance and Emergence of Echinocandin and Multidrug Resistance

Mycoses, Volume 67, Issue 11, November 2024.
ABSTRACT Objectives Worldwide emergence of clonal outbreaks caused by fluconazole‐resistant (FLCR) and the recent emergence of echinocandin‐ and multidrug‐resistant (ECR and MDR) Candida parapsilosis isolates pose serious threats to modern clinics.
Nevzat Ünal, Bram Spruijtenburg, Amir Arastehfar, Ramazan Gümral, Theun de Groot, Eelco F. J. Meijer, Hatice Türk‐Dağı, Asuman Birinci, Süleyha Hilmioğlu‐Polat, Jacques F. Meis, Cornelia Lass‐Flörl, Macit Ilkit   +11 more
wiley   +1 more source

Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae

FEBS Letters, 2000
Deletion of the 1,3‐β‐D‐glucan synthase gene FKS1 in Saccharomyces cerevisiae induces a compensatory mechanism that is reflected in a significant increase in chitin synthase III (CSIII) activity, leading to high rates of chitin synthesis. Deregulation of CSIII activity is mainly due to the intracellular delocalization of Chs3p and Chs4p, the two main ...
Garcı́a-Rodriguez, L.J, Trilla, J.A, Castro, C, Valdivieso, M.H, Durán, A, Roncero, C   +5 more
openaire   +2 more sources

Epidemiological investigation of non-albicans Candida species recovered from mycotic mastitis of cows in Yinchuan, Ningxia of China

BMC Veterinary Research, 2018
Background Candida spp. is the vital pathogen involved in mycotic mastitis of cows. However the epidemiology and infection of Candida species in mycotic mastitis of cow in Ningxia province of China has not been explored.
Jun Du, Xiaoyu Wang, Huixia Luo, Yujiong Wang, Xiaoming Liu, Xuezhang Zhou   +5 more
doaj   +1 more source