Emerging Microbes and Infections, 2023 Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C.
Yating Ning +18 more
doaj +5 more sources
Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in Candida glabrata [PDF]
Microbiology Spectrum, 2022 Here, we report two paired sets of an index wild-type Candida glabrata bloodstream isolate and subsequent echinocandin-resistant FKS mutant. One paired set exhibited a higher proportion of clumping cells and was more virulent in the invertebrate host ...
Chenlin Hu +4 more
doaj +2 more sources
Molecular characterization of Echinocandin resistance and the CHS3-mediated adaptive response in Candida glabrata bloodstream infections in Eastern China [PDF]
BMC MicrobiologyBackground Candidemia caused by Candida glabrata is a serious fungal infection, and rising echinocandin resistance presents a significant clinical challenge.
Peishan Cong +7 more
doaj +2 more sources
Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance? [PDF]
mBioEchinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported.
Hans Carolus +13 more
doaj +2 more sources
More than flipping the lid: Cdc50 contributes to echinocandin resistance by regulating calcium homeostasis in Cryptococcus neoformans [PDF]
Microbial Cell, 2020 Echinocandins are the newest fungicidal drug class approved for clinical use against common invasive mycoses. Yet, they are ineffective against cryptococcosis, predominantly caused by Cryptococcus neoformans.
Chengjun Cao, Chaoyang Xue
doaj +2 more sources
Emergence of invasive candidiasis with multiple Candida species exhibiting azole and echinocandin resistance [PDF]
Frontiers in MicrobiologyBackgroundInvasive candidiasis (IC) is an increasingly common, expensive, and potentially fatal infection. However, IC caused by multiple Candida species is rarely reported in China.
Si-Jia Huang +9 more
doaj +2 more sources
Journal of Global Antimicrobial Resistance, 2020 Objectives: The rate of resistance of Candida parapsilosis to echinocandins remains unexplored in Iran. The main aims of this study were to investigate the susceptibility patterns and possible mechanisms of echinocandin resistance in echinocandin ...
Amirhossein Davari +7 more
doaj +3 more sources
A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in
mBio, 2019 Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve ...
Chengjun Cao +4 more
doaj +2 more sources
Immunological fitness of echinocandin-resistant Nakaseomyces glabratus (former Candida glabrata): The impact on the management of candidemia [PDF]
VirulenceNakaseomyces glabratus (formerly Candida glabrata) (N. glabratus) is a commensal yeast that is increasingly associated with invasive candidiasis. The rapid acquisition of echinocandin resistance by N.
Louise Basmaciyan +11 more
doaj +2 more sources
Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris
Emerging Microbes and InfectionsIntroduction: Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before an isolate develops to resistance via FKS1 mutations ...
Sufei Tian +8 more
doaj +3 more sources