Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in Candida glabrata [PDF]
Microbiology Spectrum, 2022 Here, we report two paired sets of an index wild-type Candida glabrata bloodstream isolate and subsequent echinocandin-resistant FKS mutant. One paired set exhibited a higher proportion of clumping cells and was more virulent in the invertebrate host ...
Chenlin Hu +4 more
doaj +5 more sources
Echinocandin Resistance in Candida. [PDF]
Clin Infect Dis, 2015 Invasive fungal infections are an important infection concern for patients with underlying immunosuppression. Antifungal therapy is a critical component of patient care, but therapeutic choices are limited due to few drug classes. Antifungal resistance, especially among Candida species, aggravates the problem.
Perlin DS.
europepmc +6 more sources
Molecular characterization of Echinocandin resistance and the CHS3-mediated adaptive response in Candida glabrata bloodstream infections in Eastern China [PDF]
BMC MicrobiologyBackground Candidemia caused by Candida glabrata is a serious fungal infection, and rising echinocandin resistance presents a significant clinical challenge.
Peishan Cong +7 more
doaj +2 more sources
Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance? [PDF]
mBioEchinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported.
Hans Carolus +13 more
doaj +2 more sources
Resistance to echinocandin-class antifungal drugs [PDF]
Drug Resistance Updates, 2007 Invasive fungal infections cause morbidity and mortality in severely ill patients, and limited drug classes restrict treatment choices. The echinocandin drugs are the first new class of antifungal compounds that target the fungal cell wall by blocking beta-1,3-d-glucan synthase.
David S Perlin
openaire +4 more sources
More than flipping the lid: Cdc50 contributes to echinocandin resistance by regulating calcium homeostasis in Cryptococcus neoformans [PDF]
Microbial Cell, 2020 Echinocandins are the newest fungicidal drug class approved for clinical use against common invasive mycoses. Yet, they are ineffective against cryptococcosis, predominantly caused by Cryptococcus neoformans.
Chengjun Cao, Chaoyang Xue
doaj +2 more sources
Emergence of invasive candidiasis with multiple Candida species exhibiting azole and echinocandin resistance [PDF]
Frontiers in MicrobiologyBackgroundInvasive candidiasis (IC) is an increasingly common, expensive, and potentially fatal infection. However, IC caused by multiple Candida species is rarely reported in China.
Si-Jia Huang +9 more
doaj +2 more sources
Mechanisms of echinocandin antifungal drug resistance [PDF]
Annals of the New York Academy of Sciences, 2015 Fungal infections due to Candida and Aspergillus species cause extensive morbidity and mortality, especially among immunosuppressed patients, and antifungal therapy is critical to patient management. Yet only a few drug classes are available to treat invasive fungal diseases, and this problem is compounded by the emergence of antifungal resistance ...
David S Perlin
openaire +4 more sources
Emerging Microbes and Infections, 2023 Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C.
Yating Ning +18 more
doaj +3 more sources
A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in
mBio, 2019 Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve ...
Chengjun Cao +4 more
doaj +2 more sources