Results 31 to 40 of about 12,521 (204)

Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland [PDF]

Infection, 2020
AbstractEchinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes.
A. T. Coste, A. Kritikos, J. Li, N. Khanna, D. Goldenberger, C. Garzoni, C. Zehnder, K. Boggian, D. Neofytos, A. Riat, D. Bachmann, D. Sanglard, F. Lamoth, F. Lamoth, N. Khanna, K. Boggian, D. Sanglard   +16 more
openaire   +4 more sources

Echinocandin-resistant Candida tropicalis Bloodstream Infections [PDF]

Open Forum Infectious Diseases, 2017
BACKGROUND: The aim of this study is to describe the clinical manifestations, molecular mechanisms, and treatment outcomes of patients with echinocandin-resistant Candida tropicalis (C. tropicalis) bloodstream infections (BSI). METHODS: A PubMed search was conducted using the search terms related to C. tropicalis BSI and echinocandin resistance.
Sfeir, Maroun, Jiménez-Ortigosa, Cristina, Schuetz, Audrey, Jenkins, Stephen, Jones, Sian, Soave, Rosemary, Van Besien, Koen, Satlin, Michael, Small, Catherine, Perlin, David, Walsh, Thomas   +10 more
openaire   +1 more source

Set of Classical PCRs for Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance [PDF]

, 2014
Clinical echinocandin resistance among Candida glabrata strains is increasing, especially in the United States. Antifungal susceptibility testing is considered mandatory to guide therapeutic decisions.
Afeltra, Javier, Dudiuk, Catiana Beatriz, Gamarra, Maria Soledad, Garcia, Guillermo Manuel, Jimenez Ortigoza, Cristina, Leonardelli, Florencia, Perlin, David S., Vitale, Roxana Gabriela   +7 more
core   +2 more sources

Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies

Journal of Fungi, 2020
Background. Candida tropicalis is a virulent fungal pathogen for which echinocandins are the primary therapy. Emergence of resistance to echinocandins of C. tropicalis carries potentially ominous therapeutic implications. Methods.
Maroun M. Sfeir, Cristina Jiménez-Ortigosa, Maria N. Gamaletsou, Audrey N. Schuetz, Rosemary Soave, Koen Van Besien, Catherine B. Small, David S. Perlin, Thomas J. Walsh   +8 more
doaj   +1 more source

Critical Assessment of Cell Wall Integrity Factors Contributing to in vivo Echinocandin Tolerance and Resistance in Candida glabrata

Frontiers in Microbiology, 2021
Fungal infections are on the rise, and emergence of drug-resistant Candida strains refractory to treatment is particularly alarming. Resistance to azole class antifungals, which have been extensively used worldwide for several decades, is so high in ...
Rocio Garcia-Rubio, Rosa Y. Hernandez, Alissa Clear, Kelley R. Healey, Erika Shor, Erika Shor, David S. Perlin, David S. Perlin, David S. Perlin   +8 more
doaj   +1 more source

Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies [PDF]

, 2015
Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D.
Gow, Neil A R, Lee, Keunsook, Munro, Carol A, Walker, Louise A   +3 more
core   +1 more source

Resistance of Candida to azoles and echinocandins worldwide [PDF]

Clinical Microbiology and Infection, 2019
Recently there has been an increase in Candida infections worldwide. A handful of species in the genus Candida are opportunistic pathogens and have been known to cause infections in immunocompromised or otherwise impaired hosts. These infections can be superficial, affecting the skin or mucous membrane, or invasive, which can be life-threatening ...
K E, Pristov, M A, Ghannoum
openaire   +2 more sources

Biofilm Production and Antibiofilm Activity of Echinocandins and Liposomal Amphotericin B in Echinocandin-Resistant Yeast Species [PDF]

Antimicrobial Agents and Chemotherapy, 2016
ABSTRACT The echinocandins and liposomal amphotericin B are active against biofilm produced by echinocandin-susceptible Candida strains. However, few data have been reported on the production of biofilm by echinocandin-resistant isolates and their antifungal susceptibility.
Laura Judith Marcos-Zambrano, Marta Gómez-Perosanz, Pilar Escribano, Oscar Zaragoza, Emilio Bouza, Jesús Guinea   +5 more
openaire   +6 more sources

The Emergence of Echinocandin-Resistant Candida glabrata Exhibiting High MICs and Related FKS Mutations in Turkey

Journal of Fungi, 2021
The frequency of invasive fungal infections shows a rising trend as well as a high morbidity and mortality. Among the causative agents, a shift toward the non-albicans Candida species including Candida glabrata species complex is being observed in ...
Ali Korhan Sig, Meliha Cagla Sonmezer, Dolunay Gülmez, Serhat Duyan, Ömrüm Uzun, Sevtap Arikan-Akdagli   +5 more
doaj   +1 more source

Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]

, 2017
This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N, Istel, F, Jenull, S, Lion, T, Nogueira, MF, Walker, L A   +5 more
core   +1 more source