Results 31 to 40 of about 2,198,221 (190)

Echinocandin resistance in Candida parapsilosis sensu stricto: Role of alterations in CHS3, FKS1 and Rho gene expression

Journal of Global Antimicrobial Resistance, 2020
Objectives: The rate of resistance of Candida parapsilosis to echinocandins remains unexplored in Iran. The main aims of this study were to investigate the susceptibility patterns and possible mechanisms of echinocandin resistance in echinocandin ...
Amirhossein Davari, Iman Haghani, Fozieh Hassanmoghadam, Mojtaba Nabili, Tahereh Shokohi, Mohammad Taghi Hedayati, Shafigheh Shabanzadeh, Maryam Moazeni   +7 more
doaj   +1 more source

Resistance to Echinocandins Complicates a Case of Candida albicans Bloodstream Infection: A Case Report

Journal of Fungi, 2021
Invasive candidiasis is known to be one of the most common healthcare-associated complications and is caused by several Candida species. First-line drugs, particularly echinocandins, are effective, but there are increasing reports of resistance to these ...
Laura Trovato, Dafne Bongiorno, Maddalena Calvo, Giuseppe Migliorisi, Albino Boraccino, Nicolò Musso, Salvatore Oliveri, Stefania Stefani, Guido Scalia   +8 more
doaj   +1 more source

Emerging Echinocandin Resistance – A Review

Journal of Pharmaceutical Research International, 2021
Worldwide there is a steady increase in the number of fungal infections each year. Simultaneously, there is a high rise of antifungal resistance among the Candida isolates. This has now become a major concern in hospitalized patients resulting in poor treatment outcome.
V. Sangamithra, Mahalakshmi Krishnan, P. Sneka   +2 more
openaire   +2 more sources

Update 2016–2018 of the Nationwide Danish Fungaemia Surveillance Study: Epidemiologic Changes in a 15-Year Perspective

Journal of Fungi, 2021
As part of a national surveillance programme initiated in 2004, fungal blood isolates from 2016–2018 underwent species identification and EUCAST susceptibility testing. The epidemiology was described and compared to data from previous years. In 2016–2018,
Malene Risum, Karen Astvad, Helle Krogh Johansen, Henrik Carl Schønheyder, Flemming Rosenvinge, Jenny Dahl Knudsen, Rasmus Krøger Hare, Raluca Datcu, Bent Løwe Røder, Valeria Stanislavovna Antsupova, Lise Kristensen, Jan Berg Gertsen, Jens Kjølseth Møller, Esad Dzajic, Turid Snekloth Søndergaard, Maiken Cavling Arendrup   +15 more
doaj   +1 more source

New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories [PDF]

Candidaemia is widely reported as the fourth most common form of bloodstream infection worldwide. Reports of cases of candidaemia whilst patients are in receipt of antifungal therapy are increasing, and this is especially relevant as prescribing ...
Fraser, Mark Andrew
core   +5 more sources

Resistance of Candida to azoles and echinocandins worldwide [PDF]

Clinical Microbiology and Infection, 2019
Recently there has been an increase in Candida infections worldwide. A handful of species in the genus Candida are opportunistic pathogens and have been known to cause infections in immunocompromised or otherwise impaired hosts. These infections can be superficial, affecting the skin or mucous membrane, or invasive, which can be life-threatening ...
K E, Pristov, M A, Ghannoum
openaire   +2 more sources

Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]

, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Ramage Gordon, Lopez-Ribot, J.L., Rajendran Ranjith, Ramage, G., Leah E. Cowen, Uppuluri Priya, Robbins, N., Priya Uppuluri, Rajendran, R., Andes, D., Jose L Lopez-Ribot, David Andes, Leah E Cowen, Nicole Robbins, Uppuluri, P., Robbins Nicole, Nett Jeniel, Lopez-Ribot Jose L., Jose L. Lopez-Ribot, Cowen, L.E., Nett, J., Ranjith Rajendran, Gordon Ramage, Jeniel Nett, Andes David, Cowen Leah E.   +25 more
core   +2 more sources

Critical Assessment of Cell Wall Integrity Factors Contributing to in vivo Echinocandin Tolerance and Resistance in Candida glabrata

Frontiers in Microbiology, 2021
Fungal infections are on the rise, and emergence of drug-resistant Candida strains refractory to treatment is particularly alarming. Resistance to azole class antifungals, which have been extensively used worldwide for several decades, is so high in ...
Rocio Garcia-Rubio, Rosa Y. Hernandez, Alissa Clear, Kelley R. Healey, Erika Shor, Erika Shor, David S. Perlin, David S. Perlin, David S. Perlin   +8 more
doaj   +1 more source

Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland [PDF]

Infection, 2020
AbstractEchinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes.
A. T. Coste, A. Kritikos, J. Li, N. Khanna, D. Goldenberger, C. Garzoni, C. Zehnder, K. Boggian, D. Neofytos, A. Riat, D. Bachmann, D. Sanglard, F. Lamoth, F. Lamoth, N. Khanna, K. Boggian, D. Sanglard   +16 more
openaire   +4 more sources

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy [PDF]

Journal of Fungi, 2022
The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described.
Maria Siopi, Antonios Papadopoulos, Anastasia Spiliopoulou, Fotini Paliogianni, Nissrine Abou-Chakra, Maiken Cavling Arendrup, Christina Damoulari, Georgios Tsioulos, Efthymia Giannitsioti, Frantzeska Frantzeskaki, Iraklis Tsangaris, Spyros Pournaras, Joseph Meletiadis   +12 more
openaire   +5 more sources