Results 21 to 30 of about 8,703 (161)

Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells

mBio, 2021
Fungal infections cause significant mortality and morbidity worldwide, and the limited existing antifungal reservoir is further weakened by the emergence of strains resistant to echinocandins, a first line of antifungal therapy.
Rocio Garcia-Rubio, Cristina Jimenez-Ortigosa, Lucius DeGregorio, Christopher Quinteros, Erika Shor, David S. Perlin   +5 more
doaj   +1 more source

Echinocandin resistance: an emerging clinical problem? [PDF]

Curr Opin Infect Dis, 2014
Echinocandin resistance in Candida is a great concern, as the echinocandin drugs are recommended as first-line therapy for patients with invasive candidiasis. Here, we review recent advances in our understanding of the epidemiology, underlying mechanisms, methods for detection and clinical implications.Echinocandin resistance has emerged over the ...
Arendrup MC, Perlin DS.
europepmc   +4 more sources

An Alanine Aminotransferase Is Required for Biofilm-Specific Resistance of Aspergillus fumigatus to Echinocandin Treatment

mBio, 2022
Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants to mammals. Within the pulmonary infection microenvironment, Aspergillus fumigatus forms biofilms with steep oxygen gradients defined by
Joshua D. Kerkaert, François Le Mauff, Benjamin R. Wucher, Sarah R. Beattie, Elisa M. Vesely, Donald C. Sheppard, Carey D. Nadell, Robert A. Cramer   +7 more
doaj   +1 more source

Epidemiology of Echinocandin Resistance in Candida [PDF]

Current Fungal Infection Reports, 2014
Echinocandins are the newest antifungal agents approved for use in treating Candida infections in the US. They act by interfering with 1,3-β-D-glucan synthase and therefore disrupt cell wall production and lead to Candida cell death. There is no intrinsic resistance to echinocandins among Candida species, and isolates from historic collections archived
Nina T, Grossman, Tom M, Chiller, Shawn R, Lockhart   +2 more
openaire   +2 more sources

Emerging Echinocandin Resistance – A Review

Journal of Pharmaceutical Research International, 2021
Worldwide there is a steady increase in the number of fungal infections each year. Simultaneously, there is a high rise of antifungal resistance among the Candida isolates. This has now become a major concern in hospitalized patients resulting in poor treatment outcome.
V. Sangamithra, Mahalakshmi Krishnan, P. Sneka   +2 more
openaire   +2 more sources

Resistance to Echinocandins Complicates a Case of Candida albicans Bloodstream Infection: A Case Report

Journal of Fungi, 2021
Invasive candidiasis is known to be one of the most common healthcare-associated complications and is caused by several Candida species. First-line drugs, particularly echinocandins, are effective, but there are increasing reports of resistance to these ...
Laura Trovato, Dafne Bongiorno, Maddalena Calvo, Giuseppe Migliorisi, Albino Boraccino, Nicolò Musso, Salvatore Oliveri, Stefania Stefani, Guido Scalia   +8 more
doaj   +1 more source

Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris. [PDF]

Antimicrob Agents Chemother, 2018
ABSTRACT Candida auris has simultaneously emerged on five continents as a fungal pathogen causing nosocomial outbreaks. The challenges in the treatment of C. auris infections are the variable antifungal susceptibility profiles among clinical isolates and the development of resistance to single ...
Kordalewska M, Lee A, Park S, Berrio I, Chowdhary A, Zhao Y, Perlin DS.   +6 more
europepmc   +4 more sources

Update 2016–2018 of the Nationwide Danish Fungaemia Surveillance Study: Epidemiologic Changes in a 15-Year Perspective

Journal of Fungi, 2021
As part of a national surveillance programme initiated in 2004, fungal blood isolates from 2016–2018 underwent species identification and EUCAST susceptibility testing. The epidemiology was described and compared to data from previous years. In 2016–2018,
Malene Risum, Karen Astvad, Helle Krogh Johansen, Henrik Carl Schønheyder, Flemming Rosenvinge, Jenny Dahl Knudsen, Rasmus Krøger Hare, Raluca Datcu, Bent Løwe Røder, Valeria Stanislavovna Antsupova, Lise Kristensen, Jan Berg Gertsen, Jens Kjølseth Møller, Esad Dzajic, Turid Snekloth Søndergaard, Maiken Cavling Arendrup   +15 more
doaj   +1 more source

Resistance of Candida to azoles and echinocandins worldwide [PDF]

Clinical Microbiology and Infection, 2019
Recently there has been an increase in Candida infections worldwide. A handful of species in the genus Candida are opportunistic pathogens and have been known to cause infections in immunocompromised or otherwise impaired hosts. These infections can be superficial, affecting the skin or mucous membrane, or invasive, which can be life-threatening ...
K E, Pristov, M A, Ghannoum
openaire   +2 more sources

Biofilm Production and Antibiofilm Activity of Echinocandins and Liposomal Amphotericin B in Echinocandin-Resistant Yeast Species [PDF]

Antimicrobial Agents and Chemotherapy, 2016
ABSTRACT The echinocandins and liposomal amphotericin B are active against biofilm produced by echinocandin-susceptible Candida strains. However, few data have been reported on the production of biofilm by echinocandin-resistant isolates and their antifungal susceptibility.
Laura Judith Marcos-Zambrano, Marta Gómez-Perosanz, Pilar Escribano, Oscar Zaragoza, Emilio Bouza, Jesús Guinea   +5 more
openaire   +6 more sources