Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. [PDF]
PLoS Pathogens, 2012 The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are front-line therapeutics for ...
Sheena D Singh-Babak +9 more
doaj +7 more sources
Fungal echinocandin resistance [PDF]
Fungal Genetics and Biology, 2010 The echinocandins are the newest class of antifungal agents in the clinical armory. These secondary metabolites are non-competitive inhibitors of the synthesis of β-(1,3)-glucan, a major structural component of the fungal cell wall. Recent work has shown
Gow, Neil A.R. +2 more
core +6 more sources
Echinocandin Resistance in Candida. [PDF]
Clinical Infectious Diseases, 2015 Invasive fungal infections are an important infection concern for patients with underlying immunosuppression. Antifungal therapy is a critical component of patient care, but therapeutic choices are limited due to few drug classes. Antifungal resistance, especially among Candida species, aggravates the problem.
David S Perlin
exaly +5 more sources
Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris. [PDF]
Antimicrob Agents Chemother, 2018 Candida auris has simultaneously emerged on five continents as a fungal pathogen causing nosocomial outbreaks. The challenges in the treatment of C.
Kordalewska M +6 more
europepmc +5 more sources
Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata [PDF]
Journal of Fungi, 2018 Candida glabrata has thoroughly adapted to successfully colonize human mucosal membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all the medically relevant Candida species, C.
Kelley R. Healey, David S. Perlin
doaj +3 more sources
Development of Echinocandin Resistance in Clavispora lusitaniae during Caspofungin Treatment [PDF]
Journal of Clinical Microbiology, 2011 International audienceClavispora lusitaniae is an opportunistic human pathogen responsible for 0.6 to 2% of candidemia. This species is intrinsically susceptible to echinocandins.
Desnos-Ollivier, Marie +9 more
core +4 more sources
Prevalence of Antifungal Resistance, Genetic Basis of Acquired Azole and Echinocandin Resistance, and Genotyping of Candida krusei Recovered from an International Collection. [PDF]
Antimicrobial Agents and Chemotherapy, 2022 Hazim O Khalifa +2 more
exaly +2 more sources
Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-
mBio, 2019 Aspergillus fumigatus is a leading cause of invasive fungal infections. Resistance to first-line triazole antifungals has led to therapy with echinocandin drugs. Recently, we identified several high-minimum-effective-concentration (MEC) A.
Shruthi Satish +10 more
doaj +2 more sources
Genetic Basis of Azole and Echinocandin Resistance in Clinical Candida glabrata in Japan. [PDF]
Antimicrobial Agents and Chemotherapy, 2020 Hazim O Khalifa +2 more
exaly +2 more sources
Medical Mycology Case Reports, 2016 Mixed fungal infection and acquired echinocandin resistance of Candida spp. remain infrequent. In this study we have reported the case of a patient hospitalized for tuberculosis who experienced multiple infections due to three common Candida species (C ...
Marine Grosset +4 more
doaj +2 more sources