Echinocandin Resistance in Candida [PDF]
Clinical Infectious Diseases, 2015 Invasive fungal infections are an important infection concern for patients with underlying immunosuppression. Antifungal therapy is a critical component of patient care, but therapeutic choices are limited due to few drug classes. Antifungal resistance, especially among Candida species, aggravates the problem.
David Perlin, Perlin David S
exaly +5 more sources
Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata [PDF]
Journal of Fungi, 2018 Candida glabrata has thoroughly adapted to successfully colonize human mucosal membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all the medically relevant Candida species, C.
Kelley R. Healey, David S. Perlin
doaj +3 more sources
Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. [PDF]
PLoS Pathogens, 2012 The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are front-line therapeutics for ...
Sheena D Singh-Babak +9 more
doaj +5 more sources
Medical Mycology Case Reports, 2016 Mixed fungal infection and acquired echinocandin resistance of Candida spp. remain infrequent. In this study we have reported the case of a patient hospitalized for tuberculosis who experienced multiple infections due to three common Candida species (C ...
Marine Grosset +4 more
doaj +3 more sources
Emerging Microbes and Infections, 2019 Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study.
Xin Hou +14 more
doaj +3 more sources
Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-
mBio, 2019 Aspergillus fumigatus is a leading cause of invasive fungal infections. Resistance to first-line triazole antifungals has led to therapy with echinocandin drugs. Recently, we identified several high-minimum-effective-concentration (MEC) A.
Shruthi Satish +10 more
doaj +2 more sources
Prevalence of Antifungal Resistance, Genetic Basis of Acquired Azole and Echinocandin Resistance, and Genotyping of Candida krusei Recovered from an International Collection [PDF]
Antimicrobial Agents and Chemotherapy, 2022 Hazim Khalifa +2 more
exaly +2 more sources
Genetic Basis of Azole and Echinocandin Resistance in Clinical Candida glabrata in Japan [PDF]
Antimicrobial Agents and Chemotherapy, 2020 Hazim Khalifa +2 more
exaly +2 more sources
Recent Outbreaks, Resistance Trends, and Control Measures in Candida auris and Candida glabrata Infections [PDF]
Journal of FungiThe global rise in multidrug-resistant (MDR) fungal pathogens has positioned Candida auris and Candida glabrata as major threats to public health. In recent years, these pathogens have increasingly been reported beyond traditional hospital settings ...
Sepinoud Raeisi +2 more
doaj +2 more sources
Fungal echinocandin resistance [PDF]
F1000 Biology Reports, 2010 Echinocandins are the most recent introduction to the antifungal armamentarium and target the synthesis of β-(1,3)-glucan, the major structural polysaccharide of the fungal cell wall. Mechanisms have been identified that reduce the efficacy of the echinocandins: mutations of the Fks subunit of the target enzyme complex or a compensatory increase in the
Walker, Louise A. +2 more
openaire +4 more sources