Results 41 to 50 of about 2,198,221 (190)
Journal of Fungi, 2020 Background. Candida tropicalis is a virulent fungal pathogen for which echinocandins are the primary therapy. Emergence of resistance to echinocandins of C. tropicalis carries potentially ominous therapeutic implications. Methods.
Maroun M. Sfeir +8 more
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Abdominal Candidiasis Is a Hidden Reservoir of Echinocandin Resistance [PDF]
Antimicrobial Agents and Chemotherapy, 2014 ABSTRACT FKS mutant Candida isolates were recovered from 24% (6/25) of abdominal candidiasis patients exposed to echinocandin. Candida glabrata (29%) and Candida albicans (14%) mutants were identified.
Ryan K, Shields +3 more
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BMC Microbiology, 2023 Background Candida glabrata is an important cause of invasive candidiasis. Echinocandins are the first-line treatment of invasive candidiasis caused by C. glabrata.
Yi Li +15 more
doaj +1 more source
Carbohydrate derived fulvic acid : an in vitro investigation of a novel membrane active antiseptic agent against Candida albicans biofilms [PDF]
, 2012 Carbohydrate derived fulvic acid (CHD-FA) is a heat stable low molecular weight, water soluble, cationic, colloidal material with proposed therapeutic properties.
Murray, Colin +7 more
core +4 more sources
Cell Reports, 2018 Summary: Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via mutations in the drug target gene, FKS1.
Tavia Caplan +6 more
doaj +1 more source
Journal of Fungi, 2021 The frequency of invasive fungal infections shows a rising trend as well as a high morbidity and mortality. Among the causative agents, a shift toward the non-albicans Candida species including Candida glabrata species complex is being observed in ...
Ali Korhan Sig +5 more
doaj +1 more source
Biofilm Production and Antibiofilm Activity of Echinocandins and Liposomal Amphotericin B in Echinocandin-Resistant Yeast Species [PDF]
Antimicrobial Agents and Chemotherapy, 2016 ABSTRACT The echinocandins and liposomal amphotericin B are active against biofilm produced by echinocandin-susceptible Candida strains. However, few data have been reported on the production of biofilm by echinocandin-resistant isolates and their antifungal susceptibility.
Laura Judith Marcos-Zambrano +5 more
openaire +3 more sources
Cryptococcus neoformans Resistance to Echinocandins: (1,3)β-Glucan Synthase Activity Is Sensitive to Echinocandins [PDF]
Antimicrobial Agents and Chemotherapy, 2005 ABSTRACT (1,3)β- d -Glucan synthase (EC 2.4.1.34. UDP-glucose: 1,3-β- d -glucan 3-β-glucosyltransferase) uses UDP-glucose as substrate and catalyzes the polymerization of glucose ([1,3]-β-linkages) to form the major carbohydrate component of the fungal cell wall.
Marybeth A, Maligie +1 more
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Pharmacokinetics of echinocandins in suspected candida peritonitis: A potential risk for resistance [PDF]
International Journal of Infectious Diseases, 2020 A possible increase in Candida resistance, especially in Candida glabrata, has been speculated according to poor diffusion of echinocandins to peritoneal fluid.Peritoneal and serum concentrations of caspofungin, micafungin and anidulafungin were analysed in surgical patients with suspected candida peritonitis.
Gioia, Francesca +7 more
openaire +5 more sources
Mechanisms of echinocandin antifungal drug resistance [PDF]
Annals of the New York Academy of Sciences, 2015 Fungal infections due to Candida and Aspergillus species cause extensive morbidity and mortality, especially among immunosuppressed patients, and antifungal therapy is critical to patient management. Yet only a few drug classes are available to treat invasive fungal diseases, and this problem is compounded by the emergence of antifungal resistance ...
openaire +2 more sources