Results 41 to 50 of about 12,521 (204)

Clinical perspectives on echinocandin resistance among Candida species [PDF]

Current Opinion in Infectious Diseases, 2015
We review and offer our clinical perspectives on the emergence of echinocandin-resistant Candida.Candida FKS gene mutations attenuate echinocandin activity, but overall mutation rates among clinical isolates remain low (Candida glabrata, ∼4%; other species,
Ryan K, Shields, M Hong, Nguyen, Cornelius J, Clancy   +2 more
openaire   +2 more sources

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation [PDF]

, 2017
We thank Cowen lab members for helpful discussions. We also thank David Rogers (University of Tennessee) for sharing microarray analysis of the CAS5 homozygous mutant, and Li Ang (University of Macau) for assistance in optimizing the ChIP-Seq experiments.
Andrews, Brenda J, Boone, Charles, Cowen, Leah E, Diaz, Jacinto De La Cruz, Grys, Ben T, Ho Wong, Koon, Ketela, Troy, Krieger, Jonathan R, Krysan, Damian J, Leach, Michelle D, Miao, Zhengqiang, Moran, Michael F, Qin, Longguang, Robbins, Nicole, Selmecki, Anna, Tan, Kaeling, Ting, Kenneth, Tong, Jiefei, Xie, Jinglin L   +18 more
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Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]

, 2020
Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E., Cowen, Leah E., Henkel, Thomas, Iyer, Kali R., Porco, Jr., John A., Robbins, Nicole, Whitesell, Luke   +6 more
core   +1 more source

Cryptococcus neoformans Resistance to Echinocandins: (1,3)β-Glucan Synthase Activity Is Sensitive to Echinocandins [PDF]

Antimicrobial Agents and Chemotherapy, 2005
ABSTRACT (1,3)β- d -Glucan synthase (EC 2.4.1.34. UDP-glucose: 1,3-β- d -glucan 3-β-glucosyltransferase) uses UDP-glucose as substrate and catalyzes the polymerization of glucose ([1,3]-β-linkages) to form the major carbohydrate component of the fungal cell wall.
Marybeth A, Maligie, Claude P, Selitrennikoff   +1 more
openaire   +2 more sources

Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans

Cell Reports, 2018
Summary: Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via mutations in the drug target gene, FKS1.
Tavia Caplan, Elizabeth J. Polvi, Jinglin L. Xie, Shoshana Buckhalter, Michelle D. Leach, Nicole Robbins, Leah E. Cowen   +6 more
doaj   +1 more source

Whole genome analysis of echinocandin non-susceptible Candida Glabrata clinical isolates: a multi-center study in China

BMC Microbiology, 2023
Background Candida glabrata is an important cause of invasive candidiasis. Echinocandins are the first-line treatment of invasive candidiasis caused by C. glabrata.
Yi Li, Xin Hou, Ruoyu Li, Kang Liao, Ling Ma, Xiaoming Wang, Ping Ji, Haishen Kong, Yun Xia, Hui Ding, Wei Kang, Ge Zhang, Jin Li, Meng Xiao, Yingxing Li, Yingchun Xu   +15 more
doaj   +1 more source

The Fungal Cell Wall : Structure, Biosynthesis, and Function [PDF]

, 2017
N.G. is funded by the Wellcome Trust via a senior investigator award and a strategic award and by the MRC Centre for Medical Mycology. C.M. acknowledges the support of the Wellcome Trust and the MRC. N.G. and C.M.
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Recent trends in molecular diagnostics of yeast infections : from PCR to NGS [PDF]

, 2019
The incidence of opportunistic yeast infections in humans has been increasing over recent years. These infections are difficult to treat and diagnose, in part due to the large number and broad diversity of species that can underlie the infection.
Arastehfar, A, Boekhout, T, Buda De Cesare, G, Butler, G, Dolk, E, Gabaldón, Tony, Hafez, A, Hagen, F, Hovhannisyan, H, Hube, B, Iracane, E, Kostrzewa, M, Lackner, M, Lass-Flörl, C, Llorens, C, Mixão, V, Munro, C, Oliveira-Pacheco, J, OPATHY Consortium, the, Pekmezovic, M, Pérez-Hansen, A, Rodriguez Sánchez, Antonio, Sauer, FM, Sparbier, K, Stavrou, AA, Vaneechoutte, Mario, Vatanshenassan, M   +26 more
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Antimicrobial activity, synergism and inhibition of germ tube formation by Crocus sativus-derived compounds against Candida spp [PDF]

, 2016
The limited arsenal of synthetic antifungal agents and the emergence of resistant Candida strains have prompted the researchers towards the investigation of naturally occurring compounds or their semisynthetic derivatives in order to propose new ...
ANGIOLELLA, Letizia, CARRADORI, Simone, CHIMENTI, Paola, Fazzari, Marina, GRANESE, ARIANNA   +4 more
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Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin [PDF]

, 2014
We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them
Bizerra, Fernando Cesar, Breda, Giovanni Luis, Colombo, Arnaldo L., Jimenez-Ortigosa, Cristina, Perlin, David S., Queiroz-Telles, Flavio, Souza, Ana Carolina R.   +6 more
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