Results 61 to 70 of about 8,703 (161)

Resistance to echinocandins comes at a cost [PDF]

Virulence, 2012
The emergence of Candida strains carrying FKS1 hotspot mutations associated with resistance to echinocandins is cause for concern. However, to assess the potential of such strains to spread within the community and cause lethal infection, the impact of FKS1 mutations on Candida fitness must be determined. We present evidence that C.
Ronen, Ben-Ami, Dimitrios P, Kontoyiannis   +1 more
openaire   +2 more sources

Rapid emergence of FKS mutations in Candida glabrata isolates in a peritoneal candidiasis

Medical Mycology Case Reports, 2017
We report a rapid acquisition of echinocandin resistance after 12 days of micafungin treatment, without prior exposure, in a patient with peritoneal candidiasis due to C. glabrata. Isolates recovered before and after treatment were compared by multilocus
Milène Sasso, Claire Roger, Laurence Lachaud   +2 more
doaj   +1 more source

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, Volume 13, Issue 41, 22 July 2026.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Development of Echinocandin Resistance in Clavispora lusitaniae during Caspofungin Treatment [PDF]

Journal of Clinical Microbiology, 2011
ABSTRACT Clavispora lusitaniae is an opportunistic human pathogen responsible for 0.6 to 2% of candidemia. This species is intrinsically susceptible to echinocandins. Nevertheless, in this study, development of echinocandin resistance in C.
Desnos-Ollivier, Marie, Moquet, Olivier, Chouaki, Taieb, Guérin, Anne-Marie, Dromer, Françoise   +4 more
openaire   +3 more sources

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2250-2259, July 2026.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

Nikkomycin Z supersensitivity of an echinocandin-resistant mutant of Saccharomyces cerevisiae [PDF]

Antimicrobial Agents and Chemotherapy, 1995
Echinocandins and nikkomycins are antibiotics that inhibit the synthesis of the essential cell wall polysaccharide polymers 1,3-beta-glucan and chitin, respectively. Some 40 echinocandin-resistant Saccharomyces cerevisiae mutants were isolated and assigned to five complementation groups.
M, el-Sherbeini, J A, Clemas
openaire   +2 more sources

Combination Antifungal Therapy and Formulary Optimization for Progressive Invasive Pulmonary Aspergillosis in a Pediatric Patient With Acute Myeloid Leukemia: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Therapeutic response in refractory invasive pulmonary aspergillosis may depend not only on antifungal class escalation, but also on formulation choice. In this complex pediatric acute myeloid leukemia (AML) case, radiologic improvement followed combination therapy and switch to brand‐name liposomal amphotericin B, underscoring the importance ...
Faryal Khamis, Amal Al Busaidi, Kawther Al Bahrani, Asia Al‐Rashdi   +3 more
wiley   +1 more source

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum, Against Aspergillus fumigatus: Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna, Lovely Gupta, Rani Singh, Yash Varshney, Rishabh Dev, Pardeep Nain, Savita Lochab, Anurag Varshney   +7 more
wiley   +1 more source

Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis.

PLoS Genetics, 2016
Fungal pathogens have evolved diverse strategies to sense host-relevant cues and coordinate cellular responses, which enable virulence and drug resistance.
Elizabeth J Polvi, Anna F Averette, Soo Chan Lee, Taeyup Kim, Yong-Sun Bahn, Amanda O Veri, Nicole Robbins, Joseph Heitman, Leah E Cowen   +8 more
doaj   +1 more source