Results 71 to 80 of about 8,703 (161)

Functional Implications of Marine Biosurfactants and Their Therapeutic Potential Against Alzheimer's Disease

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Marine‐derived biosurfactants produced by microorganisms (including bacteria, fungi, and yeast) have amphiphilic properties that facilitate membrane interactions and transport across the blood–brain barrier (BBB). These biosurfactants exhibit neuroprotective activity by targeting mechanisms implicated in Alzheimer's disease, including reducing ...
Zainab Irfan, Shakti Ketan Prusty, Sumon Giri, Arijit Nandi, Mostafa Gouda   +4 more
wiley   +1 more source

Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity

Microbiology Spectrum
Antifungal tolerance can promote the emergence of resistance yet often incurs fitness costs for fungal pathogens. How tolerant populations compensate for these deficits and how they may be therapeutically targeted remain poorly understood.
Farnaz Daneshnia, Liuyang Cai, Deepika Gunasekaran, Isha Gautam, Austin M. Perry, Pegah Mosharaf Ghahfarokhy, Arefeh Ebadati, Julieta Munoz, Dorian Padilla, Süleyha Hilmioglu-Polat, Shenglin Mei, Daniel J. Floyd, Miquel Àngel Schikora-Tamarit, Diego Fuentes, Maria Artigues-Lleixà, Louise A. Walker, Samuel M. Gonçalves, Mostafa Salehi, Agostinho Carvalho, Jigar V. Desai, David S. Perlin, Carol A. Munro, Alex Hopke, Tuo Wang, Toni Gabaldón, Wenjie Fang, Clarissa J. Nobile, Michael K. Mansour, Amir Arastehfar   +28 more
doaj   +1 more source

Decoding the Structural Complexity of Fungal α‐ and β‐Glucan Matrix via Statistical Analysis of Solid‐State NMR Chemical Shifts

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Solid‐state NMR combined with principal component analysis enables quantitative classification of fungal α‐ and β‐glucan architectures in intact cell walls, revealing conserved triple‐helical β‐1,3‐glucan conformations across species and predominantly bundled‐sheet α‐1,3‐glucan assemblies with condition‐dependent polymorphism. Statistical clustering of
Ankur Ankur, Cameron S. Vojvodin, Debkumar Debnath, Tuo Wang   +3 more
wiley   +1 more source

Some issues of the resistance of Candida glabrata to echinocandins [PDF]

Clinical Microbiology and Antimicrobial Chemotherapy, 2019
Invasive candidiasis is a common, severe and often difficult to treat complication in various categories of patients. Despite the fact that in most cases Candida albicans retains a leading position as an etiological cause, a pathogen such as Candida glabrata is becoming an increasingly relevant species, especially in oncohematology patients who have ...
openaire   +2 more sources

Reduced Activity of Triazole Antifungal Agents Against Aspergillus tubingensis From a Global Collection of Genomically‐Characterized Aspergillus Section Nigri Clinical Isolates (2020–2023)

Mycoses, Volume 69, Issue 7, July 2026.
ABSTRACT Background The black moulds comprising Aspergillus section Nigri are clinically important organisms causing aspergillosis and otomycosis; triazole (azole) antifungal agents represent the primary prophylaxis and treatment option for these infections.
John H. Kimbrough, Marisa L. Winkler, Maura H. Karr, Jessica M. Ewald, Mariana Castanheira   +4 more
wiley   +1 more source

Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance.

PLoS Genetics, 2019
Aspergillus fumigatus causes invasive aspergillosis, the most common life-threatening fungal disease of immuno-compromised humans. The treatment of disseminated infections with antifungal drugs, including echinocandin cell wall biosynthesis inhibitors ...
Patrícia Alves de Castro, Ana Cristina Colabardini, Adriana Oliveira Manfiolli, Jéssica Chiaratto, Lilian Pereira Silva, Eliciane Cevolani Mattos, Giuseppe Palmisano, Fausto Almeida, Gabriela Felix Persinoti, Laure Nicolas Annick Ries, Laura Mellado, Marina Campos Rocha, Michael Bromley, Roberto Nascimento Silva, Gabriel Scalini de Souza, Flávio Vieira Loures, Iran Malavazi, Neil Andrew Brown, Gustavo H Goldman   +18 more
doaj   +1 more source

The Underestimated Role of Environmental Factors in the Prevention of Invasive Fungal Disease: Experience From a European Childhood Cancer Centre

Mycoses, Volume 69, Issue 7, July 2026.
ABSTRACT Background Immunocompromised children with hematologic malignancies or undergoing allogeneic haematopoietic stem cell transplantation (HSCT) are at high risk for invasive fungal diseases (IFDs). Reported incidence varies considerably due to heterogeneous diagnostic criteria, antifungal strategies and environmental conditions.
Stefano Malvestiti, Felicia Andresen, Markus Hufnagel, Carsten Speckmann, Brigitte Strahm, Tobias Feuchtinger, Alexander Puzik   +6 more
wiley   +1 more source

Rezafungin Versus Caspofungin in Candidaemia and Invasive Candidiasis: A Post Hoc Pooled Analysis of Phase 2 and Phase 3 Trials

Mycoses, Volume 69, Issue 7, July 2026.
ABSTRACT Background The efficacy and safety of rezafungin in invasive candidiasis (IC) and candidaemia was demonstrated in the Phase 2 STRIVE and Phase 3 ReSTORE trials, and an additional cohort of patients in ReSTORE from China (ReSTORE China). Objectives This post hoc analysis is the first time that combined data from all double‐blind, randomised ...
Alex Soriano, George R. Thompson III, Oliver A. Cornely, Matteo Bassetti, Bart Jan Kullberg, Patrick M. Honoré, Hervé Dupont, Jose A. Vazquez, Haihui Huang, Yingyuan Zhang, Sara Dickerson, Laura Cox, Peter G. Pappas   +12 more
wiley   +1 more source

Clinical Utility of the Paed‐EQUAL Candida Score in Paediatric Candidemia: A Real‐World Cohort Study

Mycoses, Volume 69, Issue 7, July 2026.
ABSTRACT Background The Paed‐EQUAL Candida Score was developed to assess adherence to guideline‐recommended management in paediatric candidemia; however, its clinical utility in predicting outcomes remains unclear, particularly in paediatric populations where validation data are scarce. Methods We conducted a retrospective observational study including
Kubra Aykac, Ilgın Sirin, Turgut Ozdemir, Osman Oguz Demir, Aylin Irmak Kuruc, Hanife Avcı, Ali Bulent Cengiz, Yasemin Ozsurekci   +7 more
wiley   +1 more source

Core histones govern echinocandin susceptibility in Candida glabrata

Microbiology Spectrum
The dynamic chromatin structure regulates many biological processes including gene expression, DNA repair, and genome stability in eukaryotic cells.
Aditi Pareek, Rupinder Kaur
doaj   +1 more source