Results 71 to 80 of about 2,198,221 (190)

Gold Nanoparticles Coated With the Antimicrobial Peptide Os‐C(W5): Anticandidal and Biological Activity

Journal of Peptide Science, Volume 32, Issue 9, September 2026.
Gold nanoparticles conjugated with a tick‐derived antimicrobial peptide, Os‐C(W5), demonstrate enhanced proteolytic stability and potent antifungal activity against Candida albicans biofilms and planktonic cells. These non‐cytotoxic nanoconjugates represent a promising biocompatible strategy for combating resistant fungal infections while maintaining ...
P. J. Palm, R. R. Chirombo, C. K. Chiramba, J. C. Serem, H. Taute, M. van der Walt, A. R. M. Gaspar, M. J. Bester   +7 more
wiley   +1 more source

Functional Genomic and Chemical Biology Analysis of Echinocandin Resistance in Candida albicans [PDF]

, 2018
Candida albicans is a leading cause of invasive fungal infections, with mortality rates of ~40%. Effective treatment is hindered by the paucity of antifungal drugs and the emergence of resistance.
Caplan, Tavia
core   +2 more sources

Drug-Resistant Candida glabrata Infection in Cancer Patients

Emerging Infectious Diseases, 2014
Cancer patients are at risk for candidemia, and increasing Candida spp. resistance poses an emerging threat. We determined rates of antifungal drug resistance, identified factors associated with resistance, and investigated the correlation between ...
Dimitrios Farmakiotis, Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis   +2 more
doaj   +1 more source

Endobronchial Aspergillosis Presenting as an Isolated Airway Lesion in an Immunocompromised Patient

Respirology Case Reports, Volume 14, Issue 9, September 2026.
Endobronchial Aspergillus infection should be considered in immunocompromised patients presenting with airway obstruction, even in the absence of parenchymal lung involvement. This case highlights the potential for rapid clinical deterioration and the diagnostic challenges in distinguishing endobronchial aspergillosis from more aggressive forms of ...
Mohsen Sadeghi, Fatemeh Sadat Hosseini Khajouei, Haniyeh GhanbarAliAkhavan, Amir Morteza Soleimani   +3 more
wiley   +1 more source

Echinocandin Resistance in Candida Species: Mechanisms of Reduced Susceptibility and Therapeutic Approaches

, 2012
OBJECTIVE: To summarize published data regarding mechanisms of reduced echinocandin susceptibility in Candida spp., the impact of echinocandin resistance on the fitness and virulence of Candida isolates, and current and future treatment approaches.
LEWIS, RUSSEL EDWARD, K. W. Garey, N. D. Beyda   +2 more
core   +1 more source

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

, 2022
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C.
Jiajun Xu (510477), Shengjie Li (3340212), Yingchun Xu (320157), Yuguang Guo (8470503), Yi Li (1144), Zhongju Chen (3462413), Yanan Zhao (3132906), Zhengyu Luo (14184154), David S. Perlin (7849838), Lingli Liu (471131), Yun Liu (84346), Rongchen Dai (11873652), Fushun Li (11032059), Hong He (221185), Tianshu Sun (7022348), Yating Ning (11264310), Minya Lu (14184151), Li Zhang (8200), Meng Xiao (591353)   +18 more
core   +1 more source

First report on echinocandin resistant Polish Candida isolates

Acta Biochimica Polonica, 2019
Purpose: Candida spp. are ranked as one of the four major causative agents of fungal infections. The number of infections caused by Candida species resistant to fluconazole, which is applied as the first line drug in candidiasis treatment, increases every year. In such cases the application of echinocandin is necessary.
Martyna Mroczyńska, Anna Brillowska-Dabrowska   +1 more
openaire   +3 more sources

Mechanistic Investigations of a Novel Lactam Antifungal Agent Against Candida albicans

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT Candida albicans presents a major, yet underestimated challenge in clinical settings due to its increased resistance to treatment. This study intended to focus on the utility of a novel proprietary lactam molecule, a quorum sensing (QS) inhibitor, against C. albicans. We assessed isolate susceptibility to lactam treatment. In addition, RNA‐Seq
Hafsa Abduljalil, William Johnston, Mark Butcher, Neil Parry, Joanne O'Keeffe, Yvonne Davies, Gordon Ramage   +6 more
wiley   +1 more source

Resistance to echinocandins comes at a cost [PDF]

Virulence, 2012
The emergence of Candida strains carrying FKS1 hotspot mutations associated with resistance to echinocandins is cause for concern. However, to assess the potential of such strains to spread within the community and cause lethal infection, the impact of FKS1 mutations on Candida fitness must be determined. We present evidence that C.
Ronen, Ben-Ami, Dimitrios P, Kontoyiannis   +1 more
openaire   +2 more sources

Rapid emergence of FKS mutations in Candida glabrata isolates in a peritoneal candidiasis

Medical Mycology Case Reports, 2017
We report a rapid acquisition of echinocandin resistance after 12 days of micafungin treatment, without prior exposure, in a patient with peritoneal candidiasis due to C. glabrata. Isolates recovered before and after treatment were compared by multilocus
Milène Sasso, Claire Roger, Laurence Lachaud   +2 more
doaj   +1 more source