Results 81 to 90 of about 8,703 (161)

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 24: Suitability of taxonomic units notified to EFSA until March 2026

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The Qualified Presumption of Safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of knowledge and safety of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Marianne Chemaly, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Ingvar Sundh, Fulvio Barizzone, Marta Bisaschi, Sandra Correia, Lieve Herman   +26 more
wiley   +1 more source

Candida spp. with acquired echinocandin resistance, France, 2004-2010.

Emerging infectious diseases, 2012
We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related.
Dannaoui, Eric, Desnos-Ollivier, Marie, Garcia-Hermoso, Dea, Grenouillet, Fredéric, Cassaing, Sophie, Baixench, Marie-Thérèse, Bretagne, Stéphane, Dromer, Françoise, Lortholary, Olivier, Renseigné, Non   +9 more
openaire   +4 more sources

Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus Candida glabrata

mBio
Recent epidemiological studies documented an alarming increase in the prevalence of echinocandin-resistant (ECR) Candida glabrata blood isolates. ECR isolates are known to arise from a minor subpopulation of a clonal population, termed echinocandin ...
Amir Arastehfar, Farnaz Daneshnia, Daniel J. Floyd, Nathan Elias Jeffries, Mostafa Salehi, David S. Perlin, Macit Ilkit, Cornelia Lass-Flöerl, Michael K. Mansour   +8 more
doaj   +1 more source

Echinocandin Resistance, Susceptibility Testing and Prophylaxis: Implications for Patient Management [PDF]

Drugs, 2014
This article addresses the emergence of echinocandin resistance among Candida species, mechanisms of resistance, factors that promote resistance and confounding issues surrounding standard susceptibility testing. Fungal infections remain a significant cause of global morbidity and mortality, especially among patients with underlying immunosupression ...
openaire   +2 more sources

Antifungal susceptibility, molecular epidemiology, and clinical risk factors of Candida glabrata in intensive care unit in a Chinese Tertiary Hospital

Frontiers in Cellular and Infection Microbiology
BackgroundThe increasing incidence and high mortality rate of Candida glabrata infection in ICU patients is an important issue. Therefore, it is imperative to investigate the antifungal susceptibility profiles and epidemiological characteristics in local
Si-Jia Huang, Si-Jia Huang, Geng Lv, Geng Lv, Yi-Hui Song, Jun-Tao Zhao, Jin-Yan Liu, Lu-Ling Wang, Lu-Ling Wang, Ming-Jie Xiang, Ming-Jie Xiang   +10 more
doaj   +1 more source

Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistant Candida tropicalis and Candida glabrata isolates with delineation of their resistance mechanisms

Infection and Drug Resistance, 2018
Meng Xiao,1,2,* Xin Fan,1–3,* Xin Hou,1,2,4,* Sharon CA Chen,5 He Wang,1,2 Fanrong Kong,5 Zi-Yong Sun,6,* Yun-Zhuo Chu,7 Ying-Chun Xu1,2 1Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences,
Xiao M, Fan X, Hou X, Chen SCA, Wang H, Kong F, Sun ZY, Chu YZ, Xu YC   +8 more
doaj  

Tolerance and heteroresistance to echinocandins in Candida auris: conceptual issues, clinical implications, and outstanding questions

mSphere
Candida auris is a significant public health threat due to its environmental persistence and multidrug resistance, with echinocandins being the preferred treatment.
Erika Shor, David S. Perlin, Dimitrios P. Kontoyiannis   +2 more
doaj   +1 more source

At What Cost Echinocandin Resistance? [PDF]

Journal of Infectious Diseases, 2011
Cornelius J, Clancy, M Hong, Nguyen
openaire   +2 more sources

Fungal Cell Wall: Emerging Antifungals and Drug Resistance

Frontiers in Microbiology, 2019
The cell wall is an essential component in fungal homeostasis. The lack of a covering wall in human cells makes this component an attractive target for antifungal development. The host environment and antifungal stress can lead to cell wall modifications
Soraia L. Lima, Arnaldo L. Colombo, João N. de Almeida Junior   +2 more
doaj   +1 more source

Echinocandin-Induced Microevolution of Candida parapsilosis Influences Virulence and Abiotic Stress Tolerance

mSphere, 2018
Candida species are a major cause of life-threatening bloodstream infections worldwide. Although Candida albicans is responsible for the vast majority of infections, the clinical relevance of other Candida species has also emerged over the last twenty ...
Csaba Papp, Katica Kocsis, Renáta Tóth, László Bodai, Jesse R. Willis, Ewa Ksiezopolska, Nancy E. Lozoya-Pérez, Csaba Vágvölgyi, Hector Mora Montes, Toni Gabaldón, Joshua D. Nosanchuk, Attila Gácser   +11 more
doaj   +1 more source