Results 101 to 110 of about 2,198,221 (190)

Echinocandin Resistance, Susceptibility Testing and Prophylaxis: Implications for Patient Management [PDF]

Drugs, 2014
This article addresses the emergence of echinocandin resistance among Candida species, mechanisms of resistance, factors that promote resistance and confounding issues surrounding standard susceptibility testing. Fungal infections remain a significant cause of global morbidity and mortality, especially among patients with underlying immunosupression ...
openaire   +2 more sources

Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis.

PLoS Pathogens
Invasive fungal infections are associated with high mortality, which is exacerbated by the limited antifungal drug armamentarium and increasing antifungal drug resistance.
Yasmine Hassoun, Ariel A Aptekmann, Mikhail V Keniya, Rosa Y Gomez, Nicole Alayo, Giovanna Novi, Christopher Quinteros, Firat Kaya, Matthew Zimmerman, Diego H Caceres, Nancy A Chow, David S Perlin, Erika Shor   +12 more
doaj   +1 more source

Antifungal susceptibility, molecular epidemiology, and clinical risk factors of Candida glabrata in intensive care unit in a Chinese Tertiary Hospital

Frontiers in Cellular and Infection Microbiology
BackgroundThe increasing incidence and high mortality rate of Candida glabrata infection in ICU patients is an important issue. Therefore, it is imperative to investigate the antifungal susceptibility profiles and epidemiological characteristics in local
Si-Jia Huang, Si-Jia Huang, Geng Lv, Geng Lv, Yi-Hui Song, Jun-Tao Zhao, Jin-Yan Liu, Lu-Ling Wang, Lu-Ling Wang, Ming-Jie Xiang, Ming-Jie Xiang   +10 more
doaj   +1 more source

Echinocandin Resistance in Two Candida haemulonii Isolates from Pediatric Patients [PDF]

, 2012
We report 3 cases of patients with Candida haemulonii isolates that were obtained from hemocultures. in 2 of the 3 cases, isolates exhibited resistance to echinocandins and fluconazole.
Azevedo Melo, Analy Salles de [UNIFESP], Motta, Fabio de Araujo, Muro, Marisol Dominguez, Dalla-Costa, Libera Maria, Burger, Marion   +4 more
core   +1 more source

Novel FKS Mutations Associated with Echinocandin Resistance in Candida Species

, 2010
We studied three clinical isolates of Candida spp. (one C. tropicalis isolate and two C. glabrata isolates) from patients with invasive candidiasis.
David S. Perlin, Mahmoud Ghannoum, Hector Bonilla   +2 more
core  

A Ser678Pro Substitution in Fks1p Confers Resistance to Echinocandin Drugs in Aspergillus fumigatus

, 2007
An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echino-candin resistance.
David S. Perlin, F. Rocha, Steven Park, Guillermo Garcia-effron, Eleusa Maria   +4 more
core  

At What Cost Echinocandin Resistance? [PDF]

Journal of Infectious Diseases, 2011
Cornelius J, Clancy, M Hong, Nguyen
openaire   +2 more sources

Tolerance and heteroresistance to echinocandins in Candida auris: conceptual issues, clinical implications, and outstanding questions

mSphere
Candida auris is a significant public health threat due to its environmental persistence and multidrug resistance, with echinocandins being the preferred treatment.
Erika Shor, David S. Perlin, Dimitrios P. Kontoyiannis   +2 more
doaj   +1 more source

Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistant Candida tropicalis and Candida glabrata isolates with delineation of their resistance mechanisms

Infection and Drug Resistance, 2018
Meng Xiao,1,2,* Xin Fan,1–3,* Xin Hou,1,2,4,* Sharon CA Chen,5 He Wang,1,2 Fanrong Kong,5 Zi-Yong Sun,6,* Yun-Zhuo Chu,7 Ying-Chun Xu1,2 1Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences,
Xiao M, Fan X, Hou X, Chen SCA, Wang H, Kong F, Sun ZY, Chu YZ, Xu YC   +8 more
doaj  

Clonal

International Journal of Infectious Diseases
Objectives: Candida auris has emerged as a global public health threat because of its antifungal resistance and propensity for nosocomial transmission. This study characterized a C. auris outbreak at a tertiary care center in Türkiye and investigated its
Bram Spruijtenburg, Nevzat Unal, Carolina Melchior do Prado, Jacques F. Meis, Oğuzhan Bingöl, Tolga Toyran, Nida Akar, Nurettin Ay, Tuğba Arslan-Gülen, Tuba Turunç, Koray Daş, Ümit Çelik, Merve Kılıç-Çil, Macit Ilkit, Eelco F.J. Meijer   +14 more
doaj   +1 more source