Results 121 to 130 of about 2,198,221 (190)

In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022. [PDF]

Euro Surveill, 2023
Codda G, Willison E, Magnasco L, Morici P, Giacobbe DR, Mencacci A, Marini D, Mikulska M, Bassetti M, Marchese A, Di Pilato V.   +10 more
europepmc   +1 more source

Echinocandins: Resistance Mechanisms [PDF]

, 2015
Santosh Katiyar, Thomas Edlind
openaire   +1 more source

Transcriptomics and Phenotyping Define Genetic Signatures Associated with Echinocandin Resistance in Candida auris. [PDF]

mBio, 2022
Jenull S, Shivarathri R, Tsymala I, Penninger P, Trinh PC, Nogueira F, Chauhan M, Singh A, Petryshyn A, Stoiber A, Chowdhary A, Chauhan N, Kuchler K.   +12 more
europepmc   +1 more source

Anidulafungin, a new echinocandin : in vitro activity

, 2009
Anidulafungin is an antifungal drug belonging to the echinocandin class with a potent in vitro fungicidal activity against a wide range of Candida species, including C. glabrata and C. krusei.
G. Morace, R. Iatta, E. Borghi, M. T. Montagna   +3 more
core   +1 more source

Mechanisms of multidrug resistance caused by an Ipi1 mutation in the fungal pathogen Candida glabrata

Nature Communications
Multidrug resistance in the pathogenic fungus Candida glabrata is a growing global threat. Here, we study mechanisms of multidrug resistance in this pathogen. Exposure of C.
Taiga Miyazaki, Shintaro Shimamura, Yohsuke Nagayoshi, Hironobu Nakayama, Akihiro Morita, Yutaka Tanaka, Yasuhiko Matsumoto, Tatsuo Inamine, Hiroshi Nishikawa, Nana Nakada, Makoto Sumiyoshi, Tatsuro Hirayama, Shigeru Kohno, Hiroshi Mukae   +13 more
doaj   +1 more source

A pan-azole and pan-echinocandin resistant Wickerhamomyces anomalus isolate causing bloodstream infection: ERG11Y140F, K151R with copy number variation and FKS1 F665S mutation

International Journal of Medical Microbiology
Fungal infections pose a growing global threat, particularly due to the emergence of multidrug-resistant pathogens. This study reports the first globally documented case of a Wickerhamomyces anomalus isolate (XN272) displaying dual high-level resistance ...
Zhengyu Luo, Yating Ning, Rongchen Dai, Ailifeire Ainiwaer, Yanhong Li, Ruike Zhang, Meng Xiao, Xiaoxi Wang, Yang Yang, Yuyan Huang, Dingding Li, Lingli Liu, Roujie Huang, Tingying Xu, Yingchun Xu, Zhiyong Liu, Li Zhang, Tianshu Sun   +17 more
doaj   +1 more source

The role of aneuploidy in the emergence of echinocandin resistance in human fungal pathogen Candida albicans. [PDF]

PLoS Pathog, 2021
Sah SK, Hayes JJ, Rustchenko E.
europepmc   +1 more source

Emergence of multidrug-resistant Candidozyma auris in southern China: a multicenter study on genetic diversity and antifungal resistance

Frontiers in Microbiology
PurposeCandidozyma auris (C. auris) is an emerging fungal pathogen that is resistant to multiple drugs and poses a serious threat to global health. This study aimed to investigate the genetic diversity and antifungal resistance profiles of C.
Penghao Guo, Jingchun Fang, Ruizhi Wang, Weihong Lin, Yueting Jiang, Jun Long, Lingjuan Chen, Xudong Huang, Kang Liao, Yaqin Peng   +9 more
doaj   +1 more source

Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of candida parapsilosis

, 2017
Among emerging non-albicans Candida species, Candida parapsilosis is of particular concern as a cause of nosocomial bloodstream infections in neonatal and intensive care unit patients.
Dickens, C. Michael, Parker, Josie E., Caudle, Kelly E., Rybak, Jeffrey M.   +3 more
core   +1 more source

Recent Outbreaks, Resistance Trends, and Control Measures in Candida auris and Candida glabrata Infections

Journal of Fungi
The global rise in multidrug-resistant (MDR) fungal pathogens has positioned Candida auris and Candida glabrata as major threats to public health. In recent years, these pathogens have increasingly been reported beyond traditional hospital settings ...
Sepinoud Raeisi, Priya Madhavan, Diajeng Sekar Adisuri   +2 more
doaj   +1 more source