Results 111 to 120 of about 8,703 (161)

Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2. [PDF]

Cell Chem Biol, 2020
Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, Cowen LE.   +15 more
europepmc   +1 more source

Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance. [PDF]

Nat Commun
Zhu Q, Van de Velde S, Wijnants S, Carolus H, Jacobs S, Sofras D, Vandecruys P, Van Goethem O, Feil R, Vergauwen R, Van Genechten W, Van den Ende W, Rybak JM, Himmelreich U, Lunn JE, Van Dijck P.   +15 more
europepmc   +1 more source

Elevated Vacuolar Uptake of Fluorescently Labeled Antifungal Drug Caspofungin Predicts Echinocandin Resistance in Pathogenic Yeast. [PDF]

ACS Cent Sci, 2020
Jaber QZ, Bibi M, Ksiezopolska E, Gabaldon T, Berman J, Fridman M.   +5 more
europepmc   +1 more source

Inhibiting Fungal Echinocandin Resistance by Small-Molecule Disruption of Geranylgeranyltransferase Type I Activity. [PDF]

Antimicrob Agents Chemother, 2020
Sun Q, Xiong K, Yuan Y, Yu J, Yang L, Shen C, Su C, Lu Y.   +7 more
europepmc   +1 more source

Caspofungin paradoxical growth in <i>Candida albicans</i> requires stress pathway activation and promotes unstable echinocandin resistance mediated by aneuploidy. [PDF]

Front Cell Infect Microbiol
Wei Y, Wang J, Tang N, Lin Z, Li W, Xu Y, Guo L.   +6 more
europepmc   +1 more source

Multidimensional assessment of in-host fitness costs of echinocandin resistance in the opportunistic fungal pathogen <i>Candida glabrata</i> reveals the niche-specific requirement for <i>FKS1</i> and <i>FKS2</i> during infection and gut colonization. [PDF]

Antimicrob Agents Chemother
Arastehfar A, Daneshnia F, Hovhannisyan H, Cabrera N, Jusuf S, Salehi M, Mansour MK, Gabaldón T, Shor E, Perlin DS.   +9 more
europepmc   +1 more source

Antifungal potential of marine bacterial compounds in inhibiting Candida albicans Yck2 to overcome echinocandin resistance: a molecular dynamics study. [PDF]

Front Pharmacol
Alshahrani MM.
europepmc   +1 more source

Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial Candida glabrata isolates. [PDF]

J Clin Microbiol
Misas E, Seagle E, Jenkins EN, Rajeev M, Hurst S, Nunnally NS, Bentz ML, Lyman MM, Berkow E, Harrison LH, Schaffner W, Markus TM, Pierce R, Farley MM, Chow NA, Lockhart SR, Litvintseva AP.   +16 more
europepmc   +1 more source

Erratum for Misas et al., "Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial Candida glabrata isolates". [PDF]

J Clin Microbiol
Misas E, Seagle E, Jenkins EN, Rajeev M, Hurst S, Nunnally NS, Bentz ML, Lyman MM, Berkow E, Harrison LH, Schaffner W, Markus TM, Pierce R, Farley MM, Chow NA, Lockhart SR, Litvintseva AP.   +16 more
europepmc   +1 more source

Clinical and Laboratory Development of Echinocandin Resistance in Candida glabrata: Molecular Characterization. [PDF]

Front Microbiol, 2019
Rivero-Menendez O, Navarro-Rodriguez P, Bernal-Martinez L, Martin-Cano G, Lopez-Perez L, Sanchez-Romero I, Perez-Ayala A, Capilla J, Zaragoza O, Alastruey-Izquierdo A.   +9 more
europepmc   +1 more source