Results 111 to 120 of about 2,198,221 (190)

Parallel evolution under constraint shapes echinocandin resistance in Candida auris

Drug resistance emerges repeatedly in outbreaks of Candida fungal pathogens, but little is known about its origins or persistence. Here, we investigated the evolutionary processes shaping echinocandin resistance in Candida auris, a globally emerging and ...
David Rogers, Erika N Dort, Nicholas C Cauldron, Christina A A Cuomo, Garrett Weeks   +4 more
core   +1 more source

Supranational surveillance of antimicrobial resistance: The legacy of the last decade and proposals for the future

, 2010
Antimicrobial resistance among clinically important bacteria is widely acknowledged as a major global public health threat. A decade ago, several supranational surveillance initiatives were introduced. Few of them are still ongoing, and only one features
CORNAGLIA, Giuseppe, Giske CG, European Study Group on Antimicrobial Resistance Surveillance   +2 more
core   +1 more source

Novel Non-Hot Spot Modification in Fks1 of Candida auris Confers Echinocandin Resistance. [PDF]

Antimicrob Agents Chemother, 2023
Kordalewska M, Cancino-Prado G, Nobrega de Almeida Júnior J, Brasil Brandão I, Tigulini de Souza Peral R, Colombo AL, Perlin DS.   +6 more
europepmc   +1 more source

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations. [PDF]

Antimicrob Agents Chemother, 2023
Hirayama T, Miyazaki T, Sumiyoshi M, Ito Y, Ashizawa N, Takeda K, Iwanaga N, Takazono T, Yamamoto K, Izumikawa K, Yanagihara K, Makimura K, Tsukamoto K, Kohno S, Mukae H.   +14 more
europepmc   +1 more source

Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis.

, 2019
Artículo digital.Among emerging non-albicans Candida species, Candida parapsilosis is of particular concern as a cause of nosocomial bloodstream infections in neonatal and intensive care unit patients.
Dickens, C. Michael, Parker, Josie E., Caudle, Kelly E., Rybak, Jeffrey M., Luna Tapia, Arturo   +4 more
core   +1 more source

Fluconazole and echinocandin resistance of Candida species in invasive candidiasis at a university hospital during pre-COVID-19 and the COVID-19 outbreak. [PDF]

Epidemiol Infect, 2023
Szekely J, Rakchang W, Rattanaphan P, Kositpantawong N.   +3 more
europepmc   +1 more source

Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050 [PDF]

Background: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed ...
GBD, 2021 Antimicrobial Resistance Collaborators, GBD 2021 Antimicrobial Resistance Collaborators   +1 more
core   +1 more source

Tn-seq screens in Candida glabrata treated with echinocandins and ibrexafungerp reveal pathways of antifungal resistance and cross-resistance

mSphere
Candida glabrata (also known as Nakaseomyces glabratus) is the second most common cause of candidiasis, next to Candida albicans, and is rising in prevalence due to intrinsic and acquired mechanisms of antifungal resistance.
Timothy J. Nickels, Kyle W. Cunningham
doaj   +1 more source

Micafungin microevolution in Candida auris reveals resistance development without in vivo fitness compromise

Virulence
Candida auris is an emerging multidrug-resistant pathogen with high transmissibility in healthcare settings. Although echinocandin resistance in Candida is typically associated with fitness loss, we found that micafungin-resistant C.
Flora Bohner, Zora Szilovics, Éva Veres, Csaba Papp, Joshua D. Nosanchuk, Attila Gácser   +5 more
doaj   +1 more source

Systematic analysis of echinocandin-associated adverse reactions using the FAERS database: identification of unique DRESS and resistance signals

Frontiers in Medicine
AimThis pharmacovigilance study analyzed echinocandin-related adverse events (AEs) using the FDA Adverse Event Reporting System (FAERS) database to identify agent-specific safety signals and inform clinical decision-making.MethodsAE reports were ...
Xue Zhang, Ji Nie, Yuanchun Xie, Ya Ran, Hanhan Zhou, Bin Li   +5 more
doaj   +1 more source