Results 131 to 140 of about 2,198,221 (190)

Case Report: Echinocandin-Resistance Candida glabrata FKS Mutants From Patient Following Radical Cystoprostatectomy Due to Muscle-Invasive Bladder Cancer. [PDF]

Front Oncol, 2021
Szymankiewicz M, Kamecki K, Jarzynka S, Koryszewska-Bagińska A, Olędzka G, Nowikiewicz T.   +5 more
europepmc   +1 more source

A pseudo-outbreak of echinocandin-resistant Candida glabrata: The unreliability of caspofungin testing in predicting echinocandin susceptibility

Journal of the Association of Medical Microbiology and Infectious Disease Canada, 2021
Yahya Shabi, Audra Russell-Tattrie, Amrita Bharat, David Haldane, Glenn Patriquin   +4 more
openaire   +2 more sources

Uncovering actionable trade-offs of antifungal resistance in a yeast pathogen

Molecular Systems Biology
The increasing prevalence of antifungal resistance represents a major clinical challenge. To explore potential new therapeutic avenues, we investigated fitness trade-offs associated with azole and echinocandin resistance in Nakaseomyces glabratus (syn ...
Juan Carlos Nunez-Rodriguez, Miquel Àngel Schikora-Tamarit, Toni Gabaldón   +2 more
doaj   +1 more source

Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae. [PDF]

Genetics
Durand R, Torbey AG, Giguere M, Pageau A, Dubé AK, Lagüe P, Landry CR.   +6 more
europepmc   +1 more source

Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2. [PDF]

Cell Chem Biol, 2020
Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, Cowen LE.   +15 more
europepmc   +1 more source

Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance. [PDF]

Nat Commun
Zhu Q, Van de Velde S, Wijnants S, Carolus H, Jacobs S, Sofras D, Vandecruys P, Van Goethem O, Feil R, Vergauwen R, Van Genechten W, Van den Ende W, Rybak JM, Himmelreich U, Lunn JE, Van Dijck P.   +15 more
europepmc   +1 more source

Elevated Vacuolar Uptake of Fluorescently Labeled Antifungal Drug Caspofungin Predicts Echinocandin Resistance in Pathogenic Yeast. [PDF]

ACS Cent Sci, 2020
Jaber QZ, Bibi M, Ksiezopolska E, Gabaldon T, Berman J, Fridman M.   +5 more
europepmc   +1 more source

Inhibiting Fungal Echinocandin Resistance by Small-Molecule Disruption of Geranylgeranyltransferase Type I Activity. [PDF]

Antimicrob Agents Chemother, 2020
Sun Q, Xiong K, Yuan Y, Yu J, Yang L, Shen C, Su C, Lu Y.   +7 more
europepmc   +1 more source

Caspofungin paradoxical growth in <i>Candida albicans</i> requires stress pathway activation and promotes unstable echinocandin resistance mediated by aneuploidy. [PDF]

Front Cell Infect Microbiol
Wei Y, Wang J, Tang N, Lin Z, Li W, Xu Y, Guo L.   +6 more
europepmc   +1 more source

Acquired echinocandin resistance in a Candida krusei blood isolate confirmed by mutations in the fks1 gene

, 2014
We describe a case of bloodstream infection caused by a Candida krusei strain that developed echinocandin resistance during caspofungin therapy. Three mutations were found in the HS1 region of the fks1 gene, two of them have never been reported either in
A.M. Tortorano, M.C. Esposto, L. Pitzurra, A.C.M. Prigitano, C. Santamaria, M. Cogliati   +5 more
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