Results 91 to 100 of about 2,198,221 (190)

Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis.

PLoS Genetics, 2016
Fungal pathogens have evolved diverse strategies to sense host-relevant cues and coordinate cellular responses, which enable virulence and drug resistance.
Elizabeth J Polvi, Anna F Averette, Soo Chan Lee, Taeyup Kim, Yong-Sun Bahn, Amanda O Veri, Nicole Robbins, Joseph Heitman, Leah E Cowen   +8 more
doaj   +1 more source

Practices of Antifungal Prophylaxis Among Italian Pediatric Oncology–Hematology Centers

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Background IFD is a significant cause of illness and death among pediatric patients undergoing chemotherapy or HSCT. Application of AFP in children varies widely and is frequently off‐label. This survey aims to describe real‐world AFP practices across centers within AIEOP and provide an estimate of IFD incidence.
Martina Colli, Antonio Grasso, Manuela Spadea, Francesca Compagno, Lorenzo Chiusaroli, Paola Muggeo, Alessia Pancaldi, Rosamaria Mura, Daniela Onofrillo, Raffaella De Santis, Beatrice Mongelli, Angelica Barone, Simona Rinieri, Paola Coccia, Erica Ricci, Maura Faraci, Maria Rosaria D'Amico, Federica Galaverna, Pietro Gasperini, Letizia Brescia, Antonella Colombini, Riccardo Masetti, Francesco Baccelli, Simone Cesaro   +23 more
wiley   +1 more source

Effects of the HDAC6/8 Inhibitor MC1568, Alone and in Combination With Fluconazole, in Non‐Albicans Candida Species Infections

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
This study explores new antifungal strategies to combat non‐albicans Candida species. We tested clinically approved HDAC inhibitors—Vorinostat, Romidepsin, Tucidinostat—and the HDAC6/8‐selective MC1568, alone and with Fluconazole. The Fluconazole/MC1568 combination significantly enhanced antifungal activity and reduced biofilm formation.
Andrea Giammarino, Chiara Lambona, Alessia Raucci, Giovanna Simonetti, Salvatore Macrì, Angela Iuzzolino, Daniela Trisciuoglio, Sergio Valente, Gustavo Giusiano, Letizia Angiolella, Antonello Mai   +10 more
wiley   +1 more source

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source

Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance [PDF]

, 2011
The identification of FKS1 mutations in Candida albicans associated with echinocandin resistance has raised concerns over the spread of drug-resistant strains. We studied the impact of fks1 mutations on C. albicans virulence and fitness.
David S. Perlin, S. Gamarra, LEWIS, RUSSEL EDWARD, Konstantinos Leventakos, Lewis, Rusell E., G. Garcia Effron, Soledad Gamarra, Gamarra, Maria Soledad, Ben Ami, Ronen, Garcia, Guillermo Manuel, Russell E. Lewis, R. Ben Ami, K. Leventakos, D. S. Perlin, Kontoyiannis, Dimitrios P., Perlin, David S., Ronen Ben-Ami, Dimitrios P. Kontoyiannis, Guillermo Garcia-Effron, Leventakos, Konstantinos, D. P. Kontoyiannis   +20 more
core   +1 more source

Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance.

PLoS Genetics, 2019
Aspergillus fumigatus causes invasive aspergillosis, the most common life-threatening fungal disease of immuno-compromised humans. The treatment of disseminated infections with antifungal drugs, including echinocandin cell wall biosynthesis inhibitors ...
Patrícia Alves de Castro, Ana Cristina Colabardini, Adriana Oliveira Manfiolli, Jéssica Chiaratto, Lilian Pereira Silva, Eliciane Cevolani Mattos, Giuseppe Palmisano, Fausto Almeida, Gabriela Felix Persinoti, Laure Nicolas Annick Ries, Laura Mellado, Marina Campos Rocha, Michael Bromley, Roberto Nascimento Silva, Gabriel Scalini de Souza, Flávio Vieira Loures, Iran Malavazi, Neil Andrew Brown, Gustavo H Goldman   +18 more
doaj   +1 more source

The characterization of a new stabilized lactonase from the endophytic fungi Aspergillus pseudonomiae with anti‐bacterial and anti‐fungal properties

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Microorganisms use diverse small‐molecule signals to coordinate behavior, supporting interspecies and interkingdom communication. These chemical dialogs shape fundamental biological processes and define interactions from cooperation to antagonism.
Dor Ben Tovim, Olena Trofimyuk, Elon Yariv, Gali Prag, Livnat Afriat‐Jurnou   +4 more
wiley   +1 more source

Core histones govern echinocandin susceptibility in Candida glabrata

Microbiology Spectrum
The dynamic chromatin structure regulates many biological processes including gene expression, DNA repair, and genome stability in eukaryotic cells.
Aditi Pareek, Rupinder Kaur
doaj   +1 more source

Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus Candida glabrata

mBio
Recent epidemiological studies documented an alarming increase in the prevalence of echinocandin-resistant (ECR) Candida glabrata blood isolates. ECR isolates are known to arise from a minor subpopulation of a clonal population, termed echinocandin ...
Amir Arastehfar, Farnaz Daneshnia, Daniel J. Floyd, Nathan Elias Jeffries, Mostafa Salehi, David S. Perlin, Macit Ilkit, Cornelia Lass-Flöerl, Michael K. Mansour   +8 more
doaj   +1 more source

Antifungal Echinocandin

, 2019
Infeksi fungal invasif (IFI) masih menjadi penyebab utama morbiditas dan mortalitas pasien immunocompromised. Pilihan antifungal yang tersedia untuk IFI terbatas pada polyene, triazole, dan echinocandin.
Lukito, J. I. (Johan)
core