Results 91 to 100 of about 8,703 (161)

Candidemia: Evolution of Drug Resistance and Novel Therapeutic Approaches

Infection and Drug Resistance, 2021
Anna Maria Tortorano,1 Anna Prigitano,1 Gianluca Morroni,2 Lucia Brescini,2,3 Francesco Barchiesi2,4 1Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milano, Italy; 2Department of Biomedical Sciences and Public Health ...
Tortorano AM, Prigitano A, Morroni G, Brescini L, Barchiesi F   +4 more
doaj  

Development of Echinocandin Resistance in Candida haemulonii: An Emergent, Widespread, and Opportunistic Fungal Pathogen. [PDF]

J Fungi (Basel), 2023
Silva LN, Ramos LS, Oliveira SSC, Magalhães LB, Cypriano J, Abreu F, Macedo AJ, Branquinha MH, Santos ALS.   +8 more
europepmc   +1 more source

Novel Non-Hot Spot Modification in Fks1 of Candida auris Confers Echinocandin Resistance. [PDF]

Antimicrob Agents Chemother, 2023
Kordalewska M, Cancino-Prado G, Nobrega de Almeida Júnior J, Brasil Brandão I, Tigulini de Souza Peral R, Colombo AL, Perlin DS.   +6 more
europepmc   +1 more source

Micafungin microevolution in Candida auris reveals resistance development without in vivo fitness compromise

Virulence
Candida auris is an emerging multidrug-resistant pathogen with high transmissibility in healthcare settings. Although echinocandin resistance in Candida is typically associated with fitness loss, we found that micafungin-resistant C.
Flora Bohner, Zora Szilovics, Éva Veres, Csaba Papp, Joshua D. Nosanchuk, Attila Gácser   +5 more
doaj   +1 more source

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations. [PDF]

Antimicrob Agents Chemother, 2023
Hirayama T, Miyazaki T, Sumiyoshi M, Ito Y, Ashizawa N, Takeda K, Iwanaga N, Takazono T, Yamamoto K, Izumikawa K, Yanagihara K, Makimura K, Tsukamoto K, Kohno S, Mukae H.   +14 more
europepmc   +1 more source

Tn-seq screens in Candida glabrata treated with echinocandins and ibrexafungerp reveal pathways of antifungal resistance and cross-resistance

mSphere
Candida glabrata (also known as Nakaseomyces glabratus) is the second most common cause of candidiasis, next to Candida albicans, and is rising in prevalence due to intrinsic and acquired mechanisms of antifungal resistance.
Timothy J. Nickels, Kyle W. Cunningham
doaj   +1 more source

Fluconazole and echinocandin resistance of Candida species in invasive candidiasis at a university hospital during pre-COVID-19 and the COVID-19 outbreak. [PDF]

Epidemiol Infect, 2023
Szekely J, Rakchang W, Rattanaphan P, Kositpantawong N.   +3 more
europepmc   +1 more source

A pan-azole and pan-echinocandin resistant Wickerhamomyces anomalus isolate causing bloodstream infection: ERG11Y140F, K151R with copy number variation and FKS1 F665S mutation

International Journal of Medical Microbiology
Fungal infections pose a growing global threat, particularly due to the emergence of multidrug-resistant pathogens. This study reports the first globally documented case of a Wickerhamomyces anomalus isolate (XN272) displaying dual high-level resistance ...
Zhengyu Luo, Yating Ning, Rongchen Dai, Ailifeire Ainiwaer, Yanhong Li, Ruike Zhang, Meng Xiao, Xiaoxi Wang, Yang Yang, Yuyan Huang, Dingding Li, Lingli Liu, Roujie Huang, Tingying Xu, Yingchun Xu, Zhiyong Liu, Li Zhang, Tianshu Sun   +17 more
doaj   +1 more source

Development and Validation of TaqMan Chemistry Probe-Based Rapid Assay for the Detection of Echinocandin-Resistance in Candida auris. [PDF]

J Clin Microbiol, 2023
Zhu Y, Hager KM, Manjari SR, Banavali NK, Chaturvedi V, Chaturvedi S.   +5 more
europepmc   +1 more source

Mechanisms of multidrug resistance caused by an Ipi1 mutation in the fungal pathogen Candida glabrata

Nature Communications
Multidrug resistance in the pathogenic fungus Candida glabrata is a growing global threat. Here, we study mechanisms of multidrug resistance in this pathogen. Exposure of C.
Taiga Miyazaki, Shintaro Shimamura, Yohsuke Nagayoshi, Hironobu Nakayama, Akihiro Morita, Yutaka Tanaka, Yasuhiko Matsumoto, Tatsuo Inamine, Hiroshi Nishikawa, Nana Nakada, Makoto Sumiyoshi, Tatsuro Hirayama, Shigeru Kohno, Hiroshi Mukae   +13 more
doaj   +1 more source