Results 91 to 100 of about 3,923 (195)

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

mBio, 2019
Aspergillus fumigatus is a leading cause of invasive fungal infections. Resistance to first-line triazole antifungals has led to therapy with echinocandin drugs. Recently, we identified several high-minimum-effective-concentration (MEC) A.
Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W. Denning, Olaf Kniemeyer, Axel A. Brakhage, David S. Perlin   +10 more
doaj   +1 more source

Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential

Advanced Science, Volume 12, Issue 10, March 13, 2025.
The fungal BET protein Bdf1 is a potential antifungal target in pathogenic Candida species requiring the inhibition of both its bromodomains. Humanized Candida strains and NanoBiT complementation assays developed to evaluate on‐target antifungal efficacy expedite the discovery of Bdf1 bromodomain inhibitors with antifungal potential, supporting BET ...
Kaiyao Wei, Marie Arlotto, Justin M. Overhulse, Tuan‐Anh Dinh, Yingsheng Zhou, Nathan J. Dupper, Jiayi Yang, Boris A. Kashemirov, Hasan Dawi, Cécile Garnaud, Gaëlle Bourgine, Flore Mietton, Morgane Champleboux, Amédé Larabi, Yordan Hayat, Rose‐Laure Indorato, Marjolaine Noirclerc‐Savoye, Dimitrios Skoufias, Muriel Cornet, Gwenaël Rabut, Charles E. McKenna, Carlo Petosa, Jérôme Govin   +22 more
wiley   +1 more source

Candida glabrata : a review of its features and resistance [PDF]

, 2014
Candida species belong to the normal microbiota of the oral cavity and gastrointestinal and vaginal tracts, and are responsible for several clinical manifestations, from mucocutaneous overgrowth to bloodstream infections.
A Chakrabarti, A Chakrabarti, A Kalkanci, A Kramer, A Peñas De Las, A Roetzer, A Roetzer, A Roetzer, A Roetzer, A Thierry, AA Almeida de, AL Colombo, AM Calcagno, AM Nicola, AW Segal, B Dujon, B Guo, B Klempp-Selb, BB Magee, BD Alexander, BP Cormack, C Lass-Flörl, C Marcos-Arias, C. F. Rodrigues, CJ Seneviratne, CS Kaufmann, CS Lim, CT Hittinger, CY Lin, D Dyk van, D Wilson, DA Stead, DC Sheppard, DJ Klionsky, DJ Klionsky, DM Kuhn, DR Reagan, EA Kraneveld, EJ Helmerhorst, EJ Helmerhorst, EK Bethea, EM Kojic, F Bambeke Van, F Barchiesi, F Hasan, FC Odds, FG Oppenheim, FG Oppenheim, G Butler, G Butler, G Luo, G Luo, G Ramage, G Ramage, GM Cox, GR Thompson 3rd, H Muller, H Tsai, H Urk Van, H Wisplinghoff, HM Bandara, HT Taff, I Castaño, I Iraqui, J Chandra, J Chandra, J Kim, J Lee, JA Hagerty, JA Jayatilake, JA Noble, JA Vazquez, JA Vazquez, JCO Sardi, JE Bennett, JH Shin, JL Vincent, JP Vermitsky, JR Blankenship, K Gulshan, K Lewis, K Lewis, K Seider, K Ueno, KE Caudle, KH Chen, KH Wolfe, KJ Verstrepen, KW Henry, L Vale-Silva, LP Samaranayake, LP Samaranayake, M Bassetti, M Edgerton, M Negri, M Niimi, M Niimi, M Riera, M Sikora, M Tscherner, M. Henriques, MA Al-Fattani, MA Pfaller, MA Pfaller, MA Pfaller, MC Arendrup, MC Lorenz, MD LaFleur, MD Lafleur, MN Rai, N Berila, NK Tamura, O Bader, P Gutiérrez-Escribano, P Perumal, P Shahi, P Sundstrom, P Uppuluri, P Vandeputte, P Vandeputte, PL Fidel Jr, PW Groot De, R Domergue, R Kaur, R Kaur, R Kaur, R Rajendran, RA Akins, RA Calderone, RD Cannon, RK Shields, S Brunke, S Brunke, S Farahyar, S Ferrari, S Ferrari, S Hawser, S Paul, S Silva, S Silva, S Silva, S Silva, S Silva, S. Silva, SC Halliwell, SP Hawser, SY Ruan, T Miyazaki, T Saijo, TFC Mah, V Krcmery, V Krcmery, V Mohan das, Y Nakagawa, Z Jandric, Z Xie   +155 more
core   +1 more source

Synergistic in vitro activity of sodium houttuyfonate with fluconazole against clinical Candida albicans strains under planktonic growing conditions

Pharmaceutical Biology, 2017
Context: Fluconazole resistance is an intractable problem of treating Candida albicans, calling for more antifungal agents to enhance the activity of fluconazole. Objective: This work investigates the anti-C.
Jing Shao, YanYan Cui, MengXiang Zhang, TianMing Wang, DaQiang Wu, ChangZhong Wang   +5 more
doaj   +1 more source

Suppressed Protein Translation Caused by MSP‐8 Deficiency Determines Fungal Multidrug Resistance with Fitness Cost

Advanced Science, Volume 12, Issue 6, February 10, 2025.
This study identifies msp‐8 as a novel multidrug‐resistance gene encoding a helicase in fungi, and reveals a previously unrecognized resistance mechanism. Dysfunction of MSP‐8 disrupts translation homeostasis, leading to reductions in intracellular ketoconazolelevels, membrane‐bound amphotericin B contents, and reactive oxygen species.
Mi Zhou, Pengju Yu, Chengcheng Hu, Wenxia Fang, Cheng Jin, Shaojie Li, Xianyun Sun   +6 more
wiley   +1 more source

Estado actual de las resistencias de Candida a los fármacos antifúngidos y estudio de los mecanismos implicados [PDF]

, 2018
[ES] El género Candida se encuentra taxonómicamente ubicado dentro del reino Fungi,subreino Dikarya y orden Sacharomycetales (Bonifaz, 2012). Se trata de una levadura redonda u ovalada de 4-6 μm de tamaño denominada blastoconidio, que forma gemaciones ...
Bilbao Bilbao, Nagore
core  

Калоза: локалізація, функції та синтез в рослинних клітинах [PDF]

, 2015
Калоза відіграє ключову роль у формуванні фрагмопласту при цитокенезі, пор у флоемі, в проходженні мікроспорогенезу, функціонуванні замикаючих клітин продихів, у захисті рослинних клітин при біотичних та абіотичних стресах, тому особлива увага приділена ...
Недуха, О.М.
core   +1 more source

Virulence and resistance factors of Nakaseomyces glabratus (formerly known as Candida glabrata) in Europe: A systematic review

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 2, Page 377-388, February 2025.
Nakaseomyces glabratus (formerly known as Candida glabrata) is an endogenous opportunistic pathogen that causes various clinical manifestations, ranging from mucocutaneous overgrowth to bloodstream infections. This review aims to summarize the biology, epidemiology and pathology of N.
Carmen Rodríguez‐Cerdeira, Rodolfo Pinto‐Almazán, Ditte M. L. Saunte, R. Hay, Jacek C. Szepietowski, Gabriela Moreno‐Coutiño, Mihael Skerlev, Asja Prohic, Erick Martínez‐Herrera   +8 more
wiley   +1 more source

Determinantal random point fields

, 2000
The paper contains an exposition of recent as well as old enough results on determinantal random point fields. We start with some general theorems including the proofs of the necessary and sufficient condition for the existence of the determinantal ...
Soshnikov, Alexander
core   +3 more sources

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. [PDF]

, 2016
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins.
Alexander, B.D., Farmakiotis, D., Healey, K.R., Jimenez-Ortigosa, C., Kontoyiannis, D.P., Lockhart, S.R., Perez, W.B., Perlin, D.S., Sanglard, D., Shor, E., Sobel, J.D., Taj-Aldeen, S.J., Zhao, Y.   +12 more
core   +1 more source