Results 91 to 100 of about 2,691 (173)

Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris [PDF]

, 2018
Candida auris has simultaneously emerged on five continents as a fungal pathogen causing nosocomial outbreaks. The challenges in the treatment of C.
David S. Perlin, Steven Park, Lee, Annie, Anuradha Chowdhary, Chowdhary, Anuradha, Zhao, Yanan, Indira Berrio, Kordalewska, Milena, Park, Steven, Perlin, David S., Annie Lee, Milena Kordalewska, Berrio, Indira, Yanan Zhao   +13 more
core   +1 more source

Synergistic in vitro activity of sodium houttuyfonate with fluconazole against clinical Candida albicans strains under planktonic growing conditions

Pharmaceutical Biology, 2017
Context: Fluconazole resistance is an intractable problem of treating Candida albicans, calling for more antifungal agents to enhance the activity of fluconazole. Objective: This work investigates the anti-C.
Jing Shao, YanYan Cui, MengXiang Zhang, TianMing Wang, DaQiang Wu, ChangZhong Wang   +5 more
doaj   +1 more source

Candida kefyr in Kuwait: Prevalence, antifungal drug susceptibility and genotypic heterogeneity.

PLoS ONE, 2020
ObjectiveCandida kefyr causes invasive candidiasis in immunocompromised patients, particularly among those with oncohematological diseases. This study determined the prevalence of C.
Suhail Ahmad, Ziauddin Khan, Noura Al-Sweih, Wadha Alfouzan, Leena Joseph, Mohammad Asadzadeh   +5 more
doaj   +1 more source

Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential

Advanced Science, Volume 12, Issue 10, March 13, 2025.
The fungal BET protein Bdf1 is a potential antifungal target in pathogenic Candida species requiring the inhibition of both its bromodomains. Humanized Candida strains and NanoBiT complementation assays developed to evaluate on‐target antifungal efficacy expedite the discovery of Bdf1 bromodomain inhibitors with antifungal potential, supporting BET ...
Kaiyao Wei, Marie Arlotto, Justin M. Overhulse, Tuan‐Anh Dinh, Yingsheng Zhou, Nathan J. Dupper, Jiayi Yang, Boris A. Kashemirov, Hasan Dawi, Cécile Garnaud, Gaëlle Bourgine, Flore Mietton, Morgane Champleboux, Amédé Larabi, Yordan Hayat, Rose‐Laure Indorato, Marjolaine Noirclerc‐Savoye, Dimitrios Skoufias, Muriel Cornet, Gwenaël Rabut, Charles E. McKenna, Carlo Petosa, Jérôme Govin   +22 more
wiley   +1 more source

Suppressed Protein Translation Caused by MSP‐8 Deficiency Determines Fungal Multidrug Resistance with Fitness Cost

Advanced Science, Volume 12, Issue 6, February 10, 2025.
This study identifies msp‐8 as a novel multidrug‐resistance gene encoding a helicase in fungi, and reveals a previously unrecognized resistance mechanism. Dysfunction of MSP‐8 disrupts translation homeostasis, leading to reductions in intracellular ketoconazolelevels, membrane‐bound amphotericin B contents, and reactive oxygen species.
Mi Zhou, Pengju Yu, Chengcheng Hu, Wenxia Fang, Cheng Jin, Shaojie Li, Xianyun Sun   +6 more
wiley   +1 more source

Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling [PDF]

, 2019
Extracellular vesicles (EVs) are membranous vesicles that are released by cells. In this study, the role of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery in the biogenesis of yeast EVs was examined.
Bulone, V, Mark Bleackley (9490823), Kalra, Hina, Gangoda, Lahiru, Vincent Bulone (243055), Zhao, Kening, Lock, P., Anderson, M.A., David Chisanga (9452276), Poon, I.K., Liem, Michael, Jiang, L, Mathivanan, S, Ang, C.-S., Bleackley, Mark, Bulone, V., Keerthikumar, S, Al Saffar, H, Anderson, Marilyn, Suresh Mathivanan (9487679), Ching-Seng Ang (1304451), Shivakumar Keerthikumar (9484178), Jiang, L., Chisanga, D., Zhao, K, Keerthikumar, S., Kening Zhao (9474839), Christopher Adda (9474695), Yap, K., Bleackley, M, Fonseka, P, Kalra, H, Fonseka, Pamali, Peter Lock (9487988), Bulone, Vincent, Mathivanan, Suresh, Gangoda, L., Mathivanan, S., Kalra, H., Adda, C.G., Hina Kalra (293466), Liem, M., Poon, Ivan K., Jiang, Lanzhou, Michael Liem (9475190), Chisanga, David, Lock, P, Al Saffar, Haidar, Keerthikumar, Shivakumar, Gangoda, L, Fonseka, P., Lahiru Gangoda (9498728), Lock, Peter, Zhao, K., Pamali Fonseka (9478169), Marilyn Anderson (9487799), Haidar Al Saffar (20515820), Adda, Christopher G., Ivan Poon (9481238), Ang, Ching-Seng, Yap, K, Chisanga, D, Poon, IK, Anderson, M, Yap, Kuok, Al Saffar, H., Liem, M, Adda, CG, Bleackley, M., Ang, CS, Kuok Yap (1430608), Lanzhou Jiang (9488762)   +71 more
core   +1 more source

Virulence and resistance factors of Nakaseomyces glabratus (formerly known as Candida glabrata) in Europe: A systematic review

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 2, Page 377-388, February 2025.
Nakaseomyces glabratus (formerly known as Candida glabrata) is an endogenous opportunistic pathogen that causes various clinical manifestations, ranging from mucocutaneous overgrowth to bloodstream infections. This review aims to summarize the biology, epidemiology and pathology of N.
Carmen Rodríguez‐Cerdeira, Rodolfo Pinto‐Almazán, Ditte M. L. Saunte, R. Hay, Jacek C. Szepietowski, Gabriela Moreno‐Coutiño, Mihael Skerlev, Asja Prohic, Erick Martínez‐Herrera   +8 more
wiley   +1 more source

Caspofungin-mediated growth inhibition and paradoxical growth in Aspergillus fumigatus involve fungicidal hyphal tip lysis coupled with regenerative intrahyphal growth and dynamic changes in β-1,3-glucan synthase localization [PDF]

, 2017
Caspofungin targets cell wall β-1,3-glucan synthesis and is the international consensus guideline-recommended salvage therapy for invasive aspergillosis. Although caspofungin is inhibitory at low concentrations, it exhibits a paradoxical effect (reversal
Moreno-Velásquez, Sergio D., Sergio D. Moreno-Velásquez, Constanze Seidel, Praveen R. Juvvadi, Seidel, Constanze, Juvvadi, Praveen R., William J. Steinbach, Read, Nick D., Nick D. Read, Steinbach, William J.   +9 more
core   +1 more source

Cell wall stress depolarizes cell growth via hyperactivation of RHO1 [PDF]

, 1999
Cells sense and physiologically respond to environmental stress via signaling pathways. Saccharomyces cerevisiae cells respond to cell wall stress by transiently depolarizing the actin cytoskeleton.
Hall, M. N., Delley, P. A., Pierre-Alain Delley, Michael N. Hall   +3 more
core   +1 more source

The novel antifungal agent NPD2560 perturbs the Rho1-centered signaling network to induce a cell wall integrity response

Microbiology Spectrum
Fungal pathogens pose an increasing threat to human health. The limited diversity of antifungal drug classes and the rapid emergence of resistance highlight the urgent need for the identification and development of agents with novel mechanisms of action.
Wei Liu, Hiroki Sekiguchi, Sheena C. Li, Luis Alberto Vega Isuhuaylas, Daisuke Yamanaka, Kaori Itto-Nakama, Yoichi Noda, Charles Boone, Yoko Yashiroda, Yoshikazu Ohya   +9 more
doaj   +1 more source