Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy [PDF]
Journal of Fungi, 2022 The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed ...
Maria Siopi +12 more
doaj +5 more sources
Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1 [PDF]
Journal of Fungi, 2020 Invasive infections caused by the opportunistic pathogen Candida glabrata are treated with echinocandin antifungals that target β-1,3-glucan synthase, an enzyme critical for fungal cell wall biosynthesis. Echinocandin resistance develops upon mutation of
Kelley R. Healey +7 more
doaj +3 more sources
Do Candida albicans Isolates with Borderline Resistant Micafungin MICs Always Harbor FKS1 Hot Spot Mutations? [PDF]
Journal of Fungi, 2021 Antifungal susceptibility testing is important in guiding patient therapy due to an increasing number of resistant Candida isolates. In the clinical strain collection of the Austrian resistance report (AURES), a high number of micafungin-resistant C ...
Kathrin Spettel +4 more
doaj +3 more sources
Journal of Fungi, 2023 Outbreaks of invasive infections, with high mortality rates, caused by multidrug-resistant Candida auris have been reported worldwide. Although hotspot mutations in FKS1 are an established cause of echinocandin resistance, the actual contribution of ...
Maiko Kiyohara +16 more
doaj +3 more sources
Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata [PDF]
Emerging Microbes and Infections, 2019 Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study.
Xin Hou +14 more
doaj +3 more sources
Journal of Global Antimicrobial Resistance, 2020 Objectives: The rate of resistance of Candida parapsilosis to echinocandins remains unexplored in Iran. The main aims of this study were to investigate the susceptibility patterns and possible mechanisms of echinocandin resistance in echinocandin ...
Amirhossein Davari +7 more
doaj +3 more sources
Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris
Emerging Microbes and InfectionsIntroduction: Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before an isolate develops to resistance via FKS1 mutations ...
Sufei Tian +8 more
doaj +3 more sources
Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance? [PDF]
mBioEchinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported.
Hans Carolus +13 more
doaj +2 more sources
Effective treatment of systemic candidiasis by synergistic targeting of cell wall synthesis [PDF]
Nature CommunicationsFungal infections pose a serious threat to global human health fueled by the increase in immunosuppressive therapies, medical implants, and transplantation.
Ju Yeon Chung +7 more
doaj +2 more sources
Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans [PDF]
Journal of Clinical Microbiology, 2015 ABSTRACT A rapid molecular-based assay for the detection of the Candida albicans FKS1 gene mutations responsible for resistance to echinocandin drugs was designed and evaluated. The assay consisted of a multiplexed PCR set of 5 tubes able to detect the most commonly described resistance mechanism ...
Dudiuk, Catiana Beatriz +6 more
+11 more sources