Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1 [PDF]
Journal of Fungi, 2020 Invasive infections caused by the opportunistic pathogen Candida glabrata are treated with echinocandin antifungals that target β-1,3-glucan synthase, an enzyme critical for fungal cell wall biosynthesis. Echinocandin resistance develops upon mutation of
Kelley R. Healey +7 more
doaj +5 more sources
Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy [PDF]
Journal of Fungi, 2022 The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed ...
Maria Siopi +12 more
doaj +7 more sources
Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata [PDF]
Emerging Microbes and Infections, 2019 Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study.
Xin Hou +14 more
doaj +7 more sources
A benchmark dataset for validating FKS1 mutations in Candida auris [PDF]
Microbiology SpectrumEchinocandins are the recommended antifungal therapy for Candida auris infections in many countries. While echinocandin resistance remains uncommon, recent reports demonstrate an increase in such cases, with the potential for echinocandin-resistant C ...
Elizabeth Misas +12 more
doaj +4 more sources
Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans [PDF]
Journal of Clinical Microbiology, 2015 ABSTRACT A rapid molecular-based assay for the detection of the Candida albicans FKS1 gene mutations responsible for resistance to echinocandin drugs was designed and evaluated. The assay consisted of a multiplexed PCR set of 5 tubes able to detect the most commonly described resistance mechanism ...
Dudiuk, Catiana Beatriz +6 more
core +21 more sources
Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolates [PDF]
npj Antimicrobials and ResistanceCandida glabrata (Nakaseomyces glabratus) is the most common cause of drug-resistant candidemia and is associated with a high mortality rate. Only a few mechanisms of drug resistance are known in C.
Christopher Zajac +4 more
doaj +4 more sources
Evaluation of a Novel FKS1 R1354H Mutation Associated with Caspofungin Resistance in Candida auris Using the CRISPR-Cas9 System [PDF]
Journal of Fungi, 2023 Outbreaks of invasive infections, with high mortality rates, caused by multidrug-resistant Candida auris have been reported worldwide. Although hotspot mutations in FKS1 are an established cause of echinocandin resistance, the actual contribution of ...
Maiko Kiyohara +16 more
doaj +8 more sources
Do Candida albicans Isolates with Borderline Resistant Micafungin MICs Always Harbor FKS1 Hot Spot Mutations? [PDF]
Journal of Fungi, 2021 Antifungal susceptibility testing is important in guiding patient therapy due to an increasing number of resistant Candida isolates. In the clinical strain collection of the Austrian resistance report (AURES), a high number of micafungin-resistant C ...
Kathrin Spettel +4 more
doaj +2 more sources
Effect of Conformational Variability on the Drug Resistance of Candida auris ERG11p and FKS1 [PDF]
ACS OmegaCandida auris infection has been recognized as an urgent threat to antifungal drug resistance, and the Eagle effect of C. auris FKS1 (1,3-β-d-glucan synthase) wild-type isolates has also been noted. The Eagle effect, namely, where higher concentrations of antifungals reduce fungicidal activity relative to lower concentrations, is a confounding factor ...
Hiroshi Izumi +2 more
doaj +4 more sources
Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations [PDF]
Antimicrobial Agents and Chemotherapy, 2023 Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin.
Tatsuro Hirayama +14 more
openaire +4 more sources