Results 11 to 20 of about 2,823 (143)

Decoding resistance in Diutina catenulata by validating clinically relevant Erg11/Fks1 mutations [PDF]

Frontiers in Cellular and Infection Microbiology
ObjectiveTo verify the causal relationship between specific mutations in the ERG11 and FKS1 genes and antifungal drug resistance in clinical isolates of Diutina catenulata.MethodsRecombinant plasmids expressing mutant alleles of ERG11 (F126L, K143R) or ...
Wei Zhang, Wei Zhang, Wei Zhang, Na Wang, Xin-Fei Chen, Bao-Hua He, Meng Xiao, Ying-Chun Xu, Qi Li   +8 more
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Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata

Emerging Microbes and Infections, 2019
Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study.
Xin Hou, Kelley R. Healey, Erika Shor, Milena Kordalewska, Cristina Jiménez Ortigosa, Padmaja Paderu, Meng Xiao, He Wang, Ying Zhao, Li-Yan Lin, Yan-Hai Zhang, Yong-Zhe Li, Ying-Chun Xu, David S. Perlin, Yanan Zhao   +14 more
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Slt2 kinase of the cell wall integrity pathway is required for Fks2-specific echinocandin resistance in Candida glabrata [PDF]

Microbiology Spectrum
Candida glabrata is an opportunistic yeast that causes invasive infections in immunocompromised individuals. Echinocandin antifungals are first-line agents in the treatment of invasive candidiasis and act by inhibiting fungal cell wall synthesis by ...
Zubayeda Uddin, Saira Tahsin, Klara Valickova, Tengfei Long, Laura Fruhauf De Macedo, Gabrielle Popencuk, Yanan Zhao, Kelley R. Healey   +7 more
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Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1 [PDF]

Nature Communications
FKS1 is a β−1,3-glucan synthase critical for fungal cell wall formation and a target for antifungal drugs such as echinocandin and ibrexafungerp. However, the mechanisms regulating FKS1 activity remain largely unknown.
Jialu Li, Jian Li, Angqi Zhu, Xinli Dai, Juxiu Liu, Huayi Liu, Zhili Xia, Yuefan Dong, Wenyu Qian, Lunzhi Dai, Li Guo, Chuangye Yan, Dong Deng, Yunzi Luo, Xiang Wang   +14 more
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Evaluation of Sensititre YeastOne for antifungal susceptibility testing of Candida (Candidozyma) auris: misclassification of FKS1 mutants and overestimation of caspofungin resistance in a global collection of isolates [PDF]

Journal of Clinical Microbiology
Sensititre YeastOne (SYO) is a widely used commercial colorimetric assay, yet its performance for C. auris remains uncertain. We tested 113 global isolates, including 24 FKS1 mutants, using SYO and the Clinical and Laboratory Standards Institute (CLSI ...
Maria Siopi, Sevasti Leventaki, Ioannis Pachoulis, Aikaterini Rentoumi, Nikiforos Argyris, Bram Spruijtenburg, Eelco F. J. Meijer, Jacques F. Meis, Spyros Pournaras, Athanasios Tsakris, Georgia Vrioni, Joseph Meletiadis   +11 more
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Antifungal susceptibility, FKS1 gene expression, and virulence determinants of Candida albicans in pediatric and neonatal candidiasis [PDF]

BMC Infectious Diseases
Background Candida albicans is a major cause of invasive fungal infections in pediatric patients, including subgroups of neonates and young infants, particularly in intensive care settings where premature and low birth weight infants are at high risk ...
Mandana Rezaei-Mojaz, Hanie Hajghafari, Masoomeh Shams-Ghahfarokhi, Simasadat Seyedjavadi, Zahra Salehi, Ali Eslamifar, Fatemehsadat Jamzivar, Mehdi Razzaghi-Abyaneh   +7 more
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Multidimensional assessment of in-host fitness costs of echinocandin resistance in the opportunistic fungal pathogen Candida glabrata reveals the niche-specific requirement for FKS1 and FKS2 during infection and gut colonization [PDF]

Antimicrobial Agents and Chemotherapy
Host stresses are often considered a major barrier against the emergence of echinocandin resistance (ECR) in prominent infecting organisms like Candida albicans due to fitness defects. Yet, ECR strains of C.
Amir Arastehfar, Farnaz Daneshnia, Hrant Hovhannisyan, Nathaly Cabrera, Sebastian Jusuf, Mostafa Salehi, Michael K. Mansour, Toni Gabaldón, Erika Shor, David S. Perlin   +9 more
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The novel antifungal agent NPD2560 perturbs the Rho1-centered signaling network to induce a cell wall integrity response [PDF]

Microbiology Spectrum
Fungal pathogens pose an increasing threat to human health. The limited diversity of antifungal drug classes and the rapid emergence of resistance highlight the urgent need for the identification and development of agents with novel mechanisms of action.
Wei Liu, Hiroki Sekiguchi, Sheena C. Li, Luis Alberto Vega Isuhuaylas, Daisuke Yamanaka, Kaori Itto-Nakama, Yoichi Noda, Charles Boone, Yoko Yashiroda, Yoshikazu Ohya   +9 more
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Inhibition mechanism of the fungal β−1,3-glucan synthases by triterpenoid antifungal drugs [PDF]

Nature Communications
β−1,3-glucan synthase is the molecular target for triterpenoid and echinocandin antifungal drugs in clinical. It catalyzes the formation of β−1,3-glucan, which is the primary component of the fungal cell wall.
Zi-Long You, Lei Sun, Le-Xuan Wang, Yue-Ran Ni, Rui-Qing Lyu, Dan-Dan Chen, Cai-Hong Yun, Tiefeng Song, Yinggai Song, Lin Bai   +9 more
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Wastewater intelligence predicts the emergence of clinically-relevant and drug-resistant Candidozyma auris at healthcare facilities [PDF]

Nature Communications
The rapid evolution of antifungal resistance in Candidozyma auris (formerly Candida auris) presents significant challenges for conventional public health surveillance methods, particularly in detecting emergent and highly transmissible drug-resistant ...
Ching-Lan Chang, Michael A. Moshi, Quang-Huy Nguyen, Junghun Oh, Ha Nguyen, Pratik Paranjape, Mohammed Abushanab, Austin J. Tang, Jose Yani Itorralba, Lauryn Massic, Eakalak Khan, Cassius Lockett, Horng-Yuan Kan, Mark Pandori, Daniel Gerrity, Van Vo, Tin Nguyen, David Hess, Edwin C. Oh   +18 more
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