Results 101 to 110 of about 12,523 (206)

FKS Mutations and Elevated Echinocandin MIC Values among Candida glabrata Isolates from U.S. Population-Based Surveillance

, 2010
Candida glabrata is the second leading cause of candidemia in the United States. Its high-level resistance to triazole antifungal drugs has led to the increased use of the echinocandin class of antifungal agents for primary therapy of these ...
Lee H. Harrison, Shawn R. Lockhart, Alicia J. Zimbeck, Monica M. Farley, Tom Chiller, Naureen Iqbal, Angela M. Ahlquist   +6 more
core   +1 more source

New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories

Candidaemia is widely reported as the fourth most common form of bloodstream infection worldwide. Reports of cases of candidaemia whilst patients are in receipt of antifungal therapy are increasing, and this is especially relevant as prescribing ...
Fraser, Mark Andrew
core  

Differential Activity of the Oral Glucan Synthase Inhibitor SCY-078 against Wild-Type and Echinocandin-Resistant Strains of Candida Species

, 2017
SCY-078 (formerly MK-3118) is a novel orally active inhibitor of fungal β-(1,3)-glucan synthase (GS). SCY-078 is a derivative of enfumafungin and is structurally distinct from the echinocandin class of antifungal agents.
Mariana Castanheira, Michael A. Pfaller, Katyna Borroto-Esoda, Shawn A. Messer, Paul R. Rhomberg   +4 more
core   +1 more source

Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus Candida glabrata

mBio
Recent epidemiological studies documented an alarming increase in the prevalence of echinocandin-resistant (ECR) Candida glabrata blood isolates. ECR isolates are known to arise from a minor subpopulation of a clonal population, termed echinocandin ...
Amir Arastehfar, Farnaz Daneshnia, Daniel J. Floyd, Nathan Elias Jeffries, Mostafa Salehi, David S. Perlin, Macit Ilkit, Cornelia Lass-Flöerl, Michael K. Mansour   +8 more
doaj   +1 more source

Why do echinocandins fail? Identifying key predictors to improve clinical outcomes of candida bloodstream infections: a retrospective multicenter cohort study

International Journal of Infectious Diseases
Background: Echinocandins represent first-line therapy for Candida Bloodstream Infections (C-BSIs). Incidence of treatment failure (TF) remains high with unclear risk factors. Aim: to evaluate predictors of echinocandin TF for C-BSIs.
Davide Fiore Bavaro, Lucia Diella, Alessandro De Angelis, Massimo Vanoni, Alessandra Belati, Laura De Santis, Linda Bussini, Laura Montemurro, Roberto Papale, Luigi Ronga, Maria Calabrò, Erminia Casari, Monica Stufano, Lidia Dalfino, Federica Tordato, Paola Morelli, Nadia Fusilli, Gianluca Castellani, Elena Costantini, Francesco Di Gennaro, Valeria Cento, Dario Cattaneo, Salvatore Grasso, Annalisa Saracino, Sergio Carbonara, Giovanni Berna, Maurizio Cecconi, Michele Bartoletti   +27 more
doaj   +1 more source

A Ser678Pro Substitution in Fks1p Confers Resistance to Echinocandin Drugs in Aspergillus fumigatus

, 2007
An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echino-candin resistance.
David S. Perlin, F. Rocha, Steven Park, Guillermo Garcia-effron, Eleusa Maria   +4 more
core  

Echinocandin to fluconazole step-down therapy in critically ill patients with invasive, susceptible Candida albicans infections

, 2016
Invasive Candida spp. infections are increasingly diagnosed in critically ill patients. For initial treatment, an echinocandin is recommended with a possible step-down to fluconazole when the patients' condition is improving and the isolate appears ...
Geest, Patrick, Vonk, Alieke, Rijnders, Bart; id_orcid, Groeneveld, Johan   +3 more
core   +1 more source

Tn-seq screens in Candida glabrata treated with echinocandins and ibrexafungerp reveal pathways of antifungal resistance and cross-resistance

mSphere
Candida glabrata (also known as Nakaseomyces glabratus) is the second most common cause of candidiasis, next to Candida albicans, and is rising in prevalence due to intrinsic and acquired mechanisms of antifungal resistance.
Timothy J. Nickels, Kyle W. Cunningham
doaj   +1 more source

EcdGHK Are Three Tailoring Iron Oxygenases for Amino Acid Building Blocks of the Echinocandin Scaffold

, 2016
The echinocandins are a small group of fungal N-acylated cyclic hexapeptides that are fungicidal for candida strains and fungistatic for aspergilli by targeting cell wall 1,3-β-glucan synthases.
Yi Tang (55726), Ralph A. Cacho (1453285), Christopher T. Walsh (1265718), Neil K. Garg (1307112), Wei Jiang (14986), Grace Chiou (1934371)   +5 more
core   +1 more source

Comparative in vivo dose-dependent activity of caspofungin and anidulafungin against echinocandin-susceptible and -resistant Aspergillus fumigatus

, 2011
Background: Echinocandin resistance in Aspergillus species is rare. We examined if mutations in FKS1 would result in a complete loss of echinocandin activity in vivo in an experimental model of aspergillosis.
LEWIS, RUSSEL EDWARD, G. Liao, J. Hou, D. P. Kontoyiannis, R. A. Prince, R. E. Lewis   +5 more
core   +1 more source