Results 21 to 30 of about 13,385 (164)

Resistance to echinocandin antifungal agents in the United Kingdom in clinical isolates of Candida glabrata: Fifteen years of interpretation and assessment [PDF]

, 2020
Candidaemia is widely reported as the fourth most common form of bloodstream infection worldwide. Reports of breakthrough cases of candidaemia are increasing, especially in the context of a move away from azole antifungals as prophylactic or first line ...
Lawrance, Lynne M., Thorn, Robin, Fraser, Mark, Borman, Andrew M.   +3 more
core   +1 more source

Early Tacrolimus C0/D Ratio and Subsequent Proven Invasive Fungal Disease After Liver Transplantation with Routine Early Echinocandin Prophylaxis [PDF]

Infection and Drug Resistance
Wenjing Hou,1,* Zhizhong Liang,2,* Xiao Luo,1 Heng Guo,1 Yuhong Zhang,3 Hongwei Li,3 Jinlin Guo4,51Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Bone ...
Hou W, Liang Z, Luo X, Guo H, Zhang Y, Li H, Guo J   +6 more
doaj   +2 more sources

Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication

Microbiology Spectrum, 2022
The proposed life cycle of fungi in the genus Pneumocystis has typically included both an asexual cycle via binary fission and a sexual cycle. Until recently, the strategy used for sexual replication was largely unknown, but genomic and functional assays
Melanie T. Cushion, Alan Ashbaugh, Steven G. Sayson, Christopher Mosley, Philippe M. Hauser   +4 more
doaj   +1 more source

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

, 2022
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C.
Jiajun Xu (510477), Shengjie Li (3340212), Yingchun Xu (320157), Yuguang Guo (8470503), Yi Li (1144), Zhongju Chen (3462413), Yanan Zhao (3132906), Zhengyu Luo (14184154), David S. Perlin (7849838), Lingli Liu (471131), Yun Liu (84346), Rongchen Dai (11873652), Fushun Li (11032059), Hong He (221185), Tianshu Sun (7022348), Yating Ning (11264310), Minya Lu (14184151), Li Zhang (8200), Meng Xiao (591353)   +18 more
core   +1 more source

An Alanine Aminotransferase Is Required for Biofilm-Specific Resistance of Aspergillus fumigatus to Echinocandin Treatment

mBio, 2022
Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants to mammals. Within the pulmonary infection microenvironment, Aspergillus fumigatus forms biofilms with steep oxygen gradients defined by
Joshua D. Kerkaert, François Le Mauff, Benjamin R. Wucher, Sarah R. Beattie, Elisa M. Vesely, Donald C. Sheppard, Carey D. Nadell, Robert A. Cramer   +7 more
doaj   +1 more source

Update 2016–2018 of the Nationwide Danish Fungaemia Surveillance Study: Epidemiologic Changes in a 15-Year Perspective

Journal of Fungi, 2021
As part of a national surveillance programme initiated in 2004, fungal blood isolates from 2016–2018 underwent species identification and EUCAST susceptibility testing. The epidemiology was described and compared to data from previous years. In 2016–2018,
Malene Risum, Karen Astvad, Helle Krogh Johansen, Henrik Carl Schønheyder, Flemming Rosenvinge, Jenny Dahl Knudsen, Rasmus Krøger Hare, Raluca Datcu, Bent Løwe Røder, Valeria Stanislavovna Antsupova, Lise Kristensen, Jan Berg Gertsen, Jens Kjølseth Møller, Esad Dzajic, Turid Snekloth Søndergaard, Maiken Cavling Arendrup   +15 more
doaj   +1 more source

Evaluation of Fluconazole versus Echinocandins for Treatment of Candidemia Caused by Susceptible Common Candida Species: A Propensity Score Matching Analysis

Journal of Fungi, 2023
This study aimed to evaluate the effectiveness of fluconazole and echinocandins in the treatment of candidemia caused by both fluconazole- and echinocandin-susceptible common Candida species. A retrospective study which enrolled adult candidemia patients
Jong Hun Kim, Jin Woong Suh, Min Ja Kim
doaj   +1 more source

Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in \u3cem\u3eCandida glabrata\u3c/em\u3e [PDF]

, 2022
Here, we report two paired sets of an index wild-type Candida glabrata bloodstream isolate and subsequent echinocandin-resistant FKS mutant. One paired set exhibited a higher proportion of clumping cells and was more virulent in the invertebrate host ...
Kontoyiannis, Dimitrios P., Wurster, Sebastian, Beyda, Nicholas D., Fong, Gary, Hu, Chenlin   +4 more
core   +1 more source

Navigating the New Reality: A Review of the Epidemiological, Clinical, and Microbiological Characteristics of Candida auris, with a Focus on Children

Journal of Fungi, 2023
During the past decade, Candida auris emerged across the world, causing nosocomial outbreaks in both pediatric and adult populations, particularly in intensive care settings.
Liat Ashkenazi-Hoffnung, Chen Rosenberg Danziger   +1 more
doaj   +1 more source

Echinocandin resistance in Candida parapsilosis sensu stricto: Role of alterations in CHS3, FKS1 and Rho gene expression

Journal of Global Antimicrobial Resistance, 2020
Objectives: The rate of resistance of Candida parapsilosis to echinocandins remains unexplored in Iran. The main aims of this study were to investigate the susceptibility patterns and possible mechanisms of echinocandin resistance in echinocandin ...
Amirhossein Davari, Iman Haghani, Fozieh Hassanmoghadam, Mojtaba Nabili, Tahereh Shokohi, Mohammad Taghi Hedayati, Shafigheh Shabanzadeh, Maryam Moazeni   +7 more
doaj   +1 more source