Results 21 to 30 of about 12,523 (206)

Resistance to echinocandin antifungal agents in the United Kingdom in clinical isolates of Candida glabrata: Fifteen years of interpretation and assessment [PDF]

, 2020
Candidaemia is widely reported as the fourth most common form of bloodstream infection worldwide. Reports of breakthrough cases of candidaemia are increasing, especially in the context of a move away from azole antifungals as prophylactic or first line ...
Lawrance, Lynne M., Thorn, Robin, Fraser, Mark, Borman, Andrew M.   +3 more
core   +1 more source

Efficacy of Trimethoprim–Sulfamethoxazole in Combination with an Echinocandin as a First-Line Treatment Option for Pneumocystis Pneumonia: A Systematic Review and Meta-Analysis

Antibiotics, 2022
Although combination therapy using trimethoprim–sulfamethoxazole (TMP–SMX) plus echinocandins has been reported to reduce the mortality of patients with pneumocystis pneumonia (PCP), it remains unclear whether it is more effective than TMP–SMX ...
Hideo Kato, Mao Hagihara, Nobuhiro Asai, Takumi Umemura, Yuichi Shibata, Jun Hirai, Yuka Yamagishi, Takuya Iwamoto, Hiroshige Mikamo   +8 more
doaj   +1 more source

Comparison of In Vitro Killing Activity of Rezafungin, Anidulafungin, Caspofungin, and Micafungin against Four Candida auris Clades in RPMI-1640 in the Absence and Presence of Human Serum

Microorganisms, 2021
Candida auris is an emerging and frequently multidrug-resistant pathogen against which the echinocandins are the preferred therapeutic option. We compared killing activities of anidulafungin, caspofungin, micafungin, and rezafungin against 13 isolates ...
Renátó Kovács, Zoltán Tóth, Jeffrey B. Locke, Lajos Forgács, Gábor Kardos, Fruzsina Nagy, Andrew M. Borman, László Majoros   +7 more
doaj   +1 more source

Reshaping Echinocandin Antifungal Drugs to Circumvent Glucan Synthase Point Mutation-Mediated Resistance

, 2023
Echinocandins are important antifungal drugs that inhibit the activity of the membrane-bound glucan synthase complex, which is responsible for the synthesis of the fungal cell wall β-(1,3)-glucan.
Moriah, Jospe-Kaufman, Shmuel , Carmeli, Micha, Fridman, Efrat, Ben-Zeev   +3 more
core   +1 more source

Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication

Microbiology Spectrum, 2022
The proposed life cycle of fungi in the genus Pneumocystis has typically included both an asexual cycle via binary fission and a sexual cycle. Until recently, the strategy used for sexual replication was largely unknown, but genomic and functional assays
Melanie T. Cushion, Alan Ashbaugh, Steven G. Sayson, Christopher Mosley, Philippe M. Hauser   +4 more
doaj   +1 more source

Echinocandin resistance in Candida parapsilosis sensu stricto: Role of alterations in CHS3, FKS1 and Rho gene expression

Journal of Global Antimicrobial Resistance, 2020
Objectives: The rate of resistance of Candida parapsilosis to echinocandins remains unexplored in Iran. The main aims of this study were to investigate the susceptibility patterns and possible mechanisms of echinocandin resistance in echinocandin ...
Amirhossein Davari, Iman Haghani, Fozieh Hassanmoghadam, Mojtaba Nabili, Tahereh Shokohi, Mohammad Taghi Hedayati, Shafigheh Shabanzadeh, Maryam Moazeni   +7 more
doaj   +1 more source

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

, 2022
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C.
Jiajun Xu (510477), Shengjie Li (3340212), Yingchun Xu (320157), Yuguang Guo (8470503), Yi Li (1144), Zhongju Chen (3462413), Yanan Zhao (3132906), Zhengyu Luo (14184154), David S. Perlin (7849838), Lingli Liu (471131), Yun Liu (84346), Rongchen Dai (11873652), Fushun Li (11032059), Hong He (221185), Tianshu Sun (7022348), Yating Ning (11264310), Minya Lu (14184151), Li Zhang (8200), Meng Xiao (591353)   +18 more
core   +1 more source

Micafungin: A New Echinocandin [PDF]

Clinical Infectious Diseases, 2006
Micafungin, a potent inhibitor of 1,3-beta-D-glucan synthase, has become the second available agent in the echinocandins class that is approved for use in clinical practice. This agent shares with caspofungin an identical spectrum of in vitro activity against Candida albicans, non-albicans species of Candida, and Aspergillus species, as well as several
P H, Chandrasekar, J D, Sobel
openaire   +2 more sources

Evaluation of an Antifungal Stewardship Initiative Targeting Micafungin at an Academic Medical Center

Antibiotics, 2023
Delays in the treatment of proven invasive fungal disease have been shown to be harmful. However, empiric treatment for all patients at risk of infection has not demonstrated benefit.
J. Myles Keck, David A. Cretella, Kayla R. Stover, Jamie L. Wagner, Katie E. Barber, Tulip A. Jhaveri, Prakhar Vijayvargiya, Zerelda Esquer Garrigos, Mary Joyce B. Wingler   +8 more
doaj   +1 more source

Update 2016–2018 of the Nationwide Danish Fungaemia Surveillance Study: Epidemiologic Changes in a 15-Year Perspective

Journal of Fungi, 2021
As part of a national surveillance programme initiated in 2004, fungal blood isolates from 2016–2018 underwent species identification and EUCAST susceptibility testing. The epidemiology was described and compared to data from previous years. In 2016–2018,
Malene Risum, Karen Astvad, Helle Krogh Johansen, Henrik Carl Schønheyder, Flemming Rosenvinge, Jenny Dahl Knudsen, Rasmus Krøger Hare, Raluca Datcu, Bent Løwe Røder, Valeria Stanislavovna Antsupova, Lise Kristensen, Jan Berg Gertsen, Jens Kjølseth Møller, Esad Dzajic, Turid Snekloth Søndergaard, Maiken Cavling Arendrup   +15 more
doaj   +1 more source