Results 11 to 20 of about 13,385 (164)

Slt2 kinase of the cell wall integrity pathway is required for Fks2-specific echinocandin resistance in Candida glabrata [PDF]

Microbiology Spectrum
Candida glabrata is an opportunistic yeast that causes invasive infections in immunocompromised individuals. Echinocandin antifungals are first-line agents in the treatment of invasive candidiasis and act by inhibiting fungal cell wall synthesis by ...
Zubayeda Uddin, Saira Tahsin, Klara Valickova, Tengfei Long, Laura Fruhauf De Macedo, Gabrielle Popencuk, Yanan Zhao, Kelley R. Healey   +7 more
doaj   +3 more sources

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

Journal of Fungi, 2022
The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed ...
Maria Siopi, Antonios Papadopoulos, Anastasia Spiliopoulou, Fotini Paliogianni, Nissrine Abou-Chakra, Maiken Cavling Arendrup, Christina Damoulari, Georgios Tsioulos, Efthymia Giannitsioti, Frantzeska Frantzeskaki, Iraklis Tsangaris, Spyros Pournaras, Joseph Meletiadis   +12 more
doaj   +2 more sources

A Hadal Streptomyces-Derived Echinocandin Acylase Discovered through the Prioritization of Protein Families

Marine Drugs
Naturally occurring echinocandin B and FR901379 are potent antifungal lipopeptides featuring a cyclic hexapeptide nucleus and a fatty acid side chain.
Xuejian Jiang, Hongjun Shu, Shuting Feng, Pinmei Wang, Zhizhen Zhang, Nan Wang   +5 more
doaj   +2 more sources

Functional redundancy in Echinocandin B in-cluster transcription factor ecdB of Emericella rugulosa NRRL 11440

Biotechnology Reports, 2018
Echinocandin B is a potent antifungal against the majority of fungal pathogens and its biosynthesis occurred by ecd and hty gene clusters in Emericella rugulosa NRRL 11440. We elucidated the functional necessity of in-clustered transcription factor; ecdB
Arvind Kumar, Varun Jaiswal, Vinay Kumar, Amitava Dey, Antresh Kumar   +4 more
doaj   +2 more sources

Invasive Fungal Breakthrough Infections under Targeted Echinocandin Prophylaxis in High-Risk Liver Transplant Recipients

Journal of Fungi, 2023
Invasive fungal infections (IFIs) are frequent and outcome-relevant complications in the early postoperative period after orthotopic liver transplantation (OLT).
Robert Breitkopf, Benedikt Treml, Thomas Senoner, Zoran Bukumirić, Sasa Rajsic   +4 more
doaj   +2 more sources

Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans

Cell Reports, 2018
Summary: Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via mutations in the drug target gene, FKS1.
Tavia Caplan, Elizabeth J. Polvi, Jinglin L. Xie, Shoshana Buckhalter, Michelle D. Leach, Nicole Robbins, Leah E. Cowen   +6 more
doaj   +2 more sources

Immunological fitness of echinocandin-resistant Nakaseomyces glabratus (former Candida glabrata): The impact on the management of candidemia [PDF]

Virulence
Nakaseomyces glabratus (formerly Candida glabrata) (N. glabratus) is a commensal yeast that is increasingly associated with invasive candidiasis. The rapid acquisition of echinocandin resistance by N.
Louise Basmaciyan, Nidia Alvarez-Rueda, Delphine Aldebert, Hafsa Sahnouni, Cecile Garnaud, Delphine Patarot, Amandine Ducreux, Fabienne Bon, Pascale Winckler, Patrice Le Pape, Murielle Cornet, Frédéric Dalle   +11 more
doaj   +2 more sources

Persistence, Source Control, and Secondary Bacterial Bloodstream Infection in Catheter-Related Candidemia: A Retrospective Cohort Study [PDF]

Journal of Fungi
Background: In catheter-related candidemia, a true catheter-source infection is often difficult to distinguish from a catheter that merely marks critical illness.
Emel Gürcüoğlu, Gülbahar Çalışkan, Müzeyyen Tuğçe Benli, Demet Timur   +3 more
doaj   +2 more sources

ZfpA-regulated chitin synthesis in Aspergillus fumigatus hyphae determines fungicidal tip lysis by FksA-targeting antifungals [PDF]

Antimicrobial Agents and Chemotherapy
Aspergillus fumigatus poses a serious threat to the health of a growing immunocompromised population. Invasive aspergillosis infections have one of the highest mortality rates of any disease, and treatment options are extremely limited.
Dante G. Calise, Madeline L. Michaelis, Sung Chul Park, Andrew S. Wagner, Nancy P. Keller   +4 more
doaj   +2 more sources

Reshaping Echinocandin Antifungal Drugs to Circumvent Glucan Synthase Point Mutation-Mediated Resistance [PDF]

, 2023
Echinocandins are important antifungal drugs that inhibit the activity of the membrane-bound glucan synthase complex, which is responsible for the synthesis of the fungal cell wall β-(1,3)-glucan.
Moriah, Jospe-Kaufman, Shmuel , Carmeli, Micha, Fridman, Efrat, Ben-Zeev   +3 more
core   +2 more sources