Results 11 to 20 of about 12,523 (206)
Journal of Fungi, 2022 The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed ...
Maria Siopi +12 more
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Marine DrugsNaturally occurring echinocandin B and FR901379 are potent antifungal lipopeptides featuring a cyclic hexapeptide nucleus and a fatty acid side chain.
Xuejian Jiang +5 more
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Cell Reports, 2018 Summary: Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via mutations in the drug target gene, FKS1.
Tavia Caplan +6 more
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Fungal echinocandin resistance [PDF]
F1000 Biology Reports, 2010 Echinocandins are the most recent introduction to the antifungal armamentarium and target the synthesis of β-(1,3)-glucan, the major structural polysaccharide of the fungal cell wall. Mechanisms have been identified that reduce the efficacy of the echinocandins: mutations of the Fks subunit of the target enzyme complex or a compensatory increase in the
Walker, Louise A. +2 more
core +5 more sources
Biotechnology Reports, 2018 Echinocandin B is a potent antifungal against the majority of fungal pathogens and its biosynthesis occurred by ecd and hty gene clusters in Emericella rugulosa NRRL 11440. We elucidated the functional necessity of in-clustered transcription factor; ecdB
Arvind Kumar +4 more
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Unresolving Pneumonia in Type 2 Diabetes: Case Report of Polymicrobial Lung Disease [PDF]
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT Polymicrobial pneumonia caused by the simultaneous infection with multiple pathogens is increasingly recognized in individuals with comorbidities such as type 2 diabetes mellitus (T2DM). The immunocompromised state associated with T2DM predisposes patients to both typical and opportunistic infections, including multidrug‐resistant bacteria and
Micheal Collins Segawa
wiley +2 more sources
Journal of Fungi, 2023 Invasive fungal infections (IFIs) are frequent and outcome-relevant complications in the early postoperative period after orthotopic liver transplantation (OLT).
Robert Breitkopf +4 more
doaj +2 more sources
Immunological fitness of echinocandin-resistant Nakaseomyces glabratus (former Candida glabrata): The impact on the management of candidemia [PDF]
VirulenceNakaseomyces glabratus (formerly Candida glabrata) (N. glabratus) is a commensal yeast that is increasingly associated with invasive candidiasis. The rapid acquisition of echinocandin resistance by N.
Louise Basmaciyan +11 more
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Clinical Case Report on the Use of Rezafungin in Pneumocystis jirovecii Pneumonia in a Critically Ill Patient [PDF]
MicroorganismsPneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic infection predominantly affecting immunocompromised patients. Trimethoprim–sulfamethoxazole (TMP–SMX) remains the standard therapy but is often limited by severe toxicity ...
Rosario Fernández-Fernández +4 more
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Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity [PDF]
Microbiology SpectrumAntifungal tolerance can promote the emergence of resistance yet often incurs fitness costs for fungal pathogens. How tolerant populations compensate for these deficits and how they may be therapeutically targeted remain poorly understood.
Farnaz Daneshnia +28 more
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