Results 61 to 70 of about 33,379 (274)

PDR Transporter ABC1 Is Involved in the Innate Azole Resistance of the Human Fungal Pathogen Fusarium keratoplasticum

Frontiers in Microbiology, 2021
Fusarium keratoplasticum is arguably the most common Fusarium solani species complex (FSSC) species associated with human infections. Invasive fusariosis is a life-threatening fungal infection that is difficult to treat with conventional azole ...
Jasper Elvin James, Jasper Elvin James, Erwin Lamping, Jacinta Santhanam, Richard David Cannon   +4 more
doaj   +1 more source

Pharmacology of new azole antifungal drugs

, 2020
About new azole drugs and their relevance in the futurehbkáltalános orvosangolegységes ...
Krümmel, Fabian
core  

An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.

, 2019
Artículo digital.We recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over wild-type isolates
Peters, Brian M., Rogers, David P., Tournu, Héléne, Palmer, Glen E., Luna Tapia, Arturo, Rybak, Jeffrey M.   +5 more
core   +1 more source

Aluminium Mediated Isocyanide Insertion and Sequential Ring Opening Cyclization (SROC) Strategy: Synthesis of Azole Fused Benzimidazoquinazoline Skeletons [PDF]

, 2021
A first report on transition-metal-free aluminium chloride mediated isocyanide insertion between two amine nucleophiles have been presented. Also, an unusual C-N bond cleavage allow for the further development of copper mediated ring open-ing cyclization
D. S., Sharada, Nagarjuna Babu, Venkata, Punith, S., anand , H. Shinde   +3 more
core   +5 more sources

[Azole-resistant invasive aspergillosis] [PDF]

, 2009
Invasive aspergillosis caused by medical triazole-resistant Aspergillus fumigatus is described in two patients. A 31-year-old male with chronic granulomatous disease developed pulmonary aspergillosis despite itraconazole prophylaxis. A.
Warris, A., Melchers, W.J.G., Bresters, D., Meer, J.W.M. van der, Linden, J.W.M. van der, Verweij, P.E.   +5 more
core   +1 more source

Photoinduced Copper‐Catalyzed Cross‐Coupling of Acylsilanes with Heteroarenes via Bimetallic Relay

Advanced Science
The transition metal‐catalyzed direct coupling reactions involving electron‐rich Fischer carbene species are largely underdeveloped and remain a big challenge.
Long Zheng, Ying‐Chao Li, Yichen Wu, Peng Wang   +3 more
doaj   +1 more source

Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.

, 2012
BACKGROUND: The recent evolution towards resistance to azole fungicides in European populations of the wheat pathogen Mycosphaerella graminicola has been caused by the progressive accumulation of mutations in MgCYP51 gene, encoding the azole target ...
Fraaije, B. A., John A Lucas, Carlos Bayon, Atkins, S., Bayon, C., Lucas, J. A., Hans J Cools, Cools, H. J., Sarah Atkins, Bart A Fraaije   +9 more
core   +1 more source

Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties

Molecules, 2022
Macrocyclic chemistry has been extensively developed over the past several decades. In fact, the architecture of new macrocyclic models has undergone exponential growth to offer molecules with specific properties.
Fouad Malek, Tarik Harit, Mounir Cherfi, Bonglee Kim   +3 more
doaj   +1 more source

Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals.

, 2019
Artículo digital.The purpose of this study was to characterize the effects of azole treatment upon the integrity of the Candida albicans vacuole and to determine whether, in turn, vacuolar trafficking influences azole susceptibility.
Kerns, Morgan E., Eberle, Karen E., Jursic, Branko S., Palmer, Glen E., Luna Tapia, Arturo   +4 more
core   +1 more source

Multicenter surveillance of antifungal susceptibility of clinical Aspergillus isolates to conventional and novel antifungal agents in Taiwan, 2021–2023

Microbiology Spectrum
Periodic surveillance of antifungal susceptibility among Aspergillus isolates is essential to guide effective treatment. This multicenter study analyzed 550 clinical Aspergillus isolates collected in Taiwan from 2021 to 2023, primarily from the ...
Ming-I Hsieh, Pui-Ching Choi, Wan-Lin Wu, Yu-Fu Lin, Chi-Jung Wu   +4 more
doaj   +1 more source