Results 61 to 70 of about 30,366 (254)

Molecular Detection of Azole-Resistant Aspergillus fumigatus in Clinical Samples

Frontiers in Microbiology, 2018
Aspergillus diseases are often caused by Aspergillus fumigatus. Azoles are the mainstay of therapy, but the management of aspergillosis is hampered by the emergence of azole resistance.
Jochem B. Buil, Jochem B. Buil, Jan Zoll, Jan Zoll, Paul E. Verweij, Paul E. Verweij, Willem J. G. Melchers, Willem J. G. Melchers   +7 more
doaj   +1 more source

Hospital Environment as a Source of Azole-Resistant Aspergillus fumigatus Strains with TR34/L98H and G448S Cyp51A Mutations

Journal of Fungi, 2021
Azole-resistant Aspergillus fumigatus is an emerging worldwide problem with increasing reports of therapy failure cases produced by resistant isolates. A case of azole-resistant A.
Irene Gonzalez-Jimenez, Jose Lucio, Maria Dolores Menéndez-Fraga, Emilia Mellado, Teresa Peláez   +4 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Aluminium Mediated Isocyanide Insertion and Sequential Ring Opening Cyclization (SROC) Strategy: Synthesis of Azole Fused Benzimidazoquinazoline Skeletons [PDF]

, 2021
A first report on transition-metal-free aluminium chloride mediated isocyanide insertion between two amine nucleophiles have been presented. Also, an unusual C-N bond cleavage allow for the further development of copper mediated ring open-ing cyclization
D. S., Sharada, Nagarjuna Babu, Venkata, Punith, S., anand , H. Shinde   +3 more
core   +1 more source

4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases

Molecules, 2014
A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay ...
Kęstutis Rutkauskas, Asta Zubrienė, Ingrida Tumosienė, Kristina Kantminienė, Marytė Kažemėkaitė, Alexey Smirnov, Justina Kazokaitė, Vaida Morkūnaitė, Edita Čapkauskaitė, Elena Manakova, Saulius Gražulis, Zigmuntas J. Beresnevičius, Daumantas Matulis   +12 more
doaj   +1 more source

Aneuploidy is associated with azole resistance in Aspergillus fumigatus [PDF]

, 2023
Azole resistance in Aspergillus fumigatus is on the rise. Non-target mediated mechanisms are a common cause of azole resistance in chronic pulmonary aspergillosis (CPA). Here we investigate resistance mechanisms using whole genome sequencing.
Richardson, Malcolm, Gago, Sara; id_orcid, Bowyer, Paul, Khateb, Aiah, Bromley, Michael; id_orcid   +4 more
core   +1 more source

Heat shock protein 90 (Hsp90) as a molecular target for the development of novel drugs against the dermatophyte Trichophyton rubrum

Frontiers in Microbiology, 2015
Treatment of fungal infections is difficult due to several reasons, such as side effects of drugs, emergence of resistant strains, and limited number of molecular targets for the drug compounds. In fungi, heat shock proteins (HSP) have been implicated in
Tiago R. Jacob, Nalu T. A. ePeres, Maíra P. Martins, Elza A. S. Lang, Pablo R. Sanches, Antonio eRossi, Nilce Maria eMartinez-Rossi   +6 more
doaj   +1 more source

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?

Molecules, 2021
Invasive aspergillosis, mainly caused by Aspergillus fumigatus, can lead to severe clinical outcomes in immunocompromised individuals. Antifungal treatment, based on the use of azoles, is crucial to increase survival rates.
Irene Gonzalez-Jimenez, Jose Lucio, Alejandra Roldan, Laura Alcazar-Fuoli, Emilia Mellado   +4 more
doaj   +1 more source

Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium

Antibiotics, 2020
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar, Toni Gabaldón, Rocio Garcia-Rubio, Jeffrey D. Jenks, Martin Hoenigl, Helmut J. F. Salzer, Macit Ilkit, Cornelia Lass-Flörl, David S. Perlin   +8 more
doaj   +1 more source

High-Level Pan-Azole-Resistant Aspergillosis [PDF]

, 2015
Contains fulltext : 152983.pdf (Publisher’s version ) (Open Access)High-level pan-azole-resistant Aspergillus fumigatus was recovered from four patients with chronic lung disease.
Snelders, Eveline, Lee, H.A.L. van der, Snelders, E., Melchers, W.J.G., Van Der Lee, Henrich A.L., Verweij, Paul E., Ingen, J. van, Rijs, Antonius J.M.M., Melchers, Willem J.G., Rijs, A.J.M.M., Verweij, P.E., Van Ingen, Jakko   +11 more
core   +1 more source