Results 41 to 50 of about 33,379 (274)

Azole resistance inCandida

European Journal of Clinical Microbiology & Infectious Diseases, 1997
Resistance of Candida to azoles is an increasing problem. Susceptibility testing of Candida against fluconazole and ketoconazole is now feasible and desirable. Good correlation of resistance in vitro with clinical failure of fluconazole therapy has now been shown in mucosal candidiasis.
Denning, D.W.; id_orcid 0000-0001-5626-2251, Baily, G.G., Hood, S.V.   +2 more
openaire   +4 more sources

Sterol content analysis suggests altered eburicol 14 alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides [PDF]

, 2009
The recent decline in the effectiveness of some azole fungicides in controlling the wheat pathogen Mycosphaerella graminicola has been associated with mutations in the CYP51 gene encoding the azole target, the eburicol 14 alpha-demethylase (CYP51), an ...
Bean, T. P., Michael W. Shaw, Shaw, M. W., Bart A. Fraaije, Tim P. Bean, Jane L. Ward, Fraaije, B. A., Hawkins, N. D., John A. Lucas, Lucas, J. A., Nathaniel D. Hawkins, Hans J. Cools, Cools, H. J., Ward, J. L.   +13 more
core   +1 more source

Molecular Detection of Azole-Resistant Aspergillus fumigatus in Clinical Samples

Frontiers in Microbiology, 2018
Aspergillus diseases are often caused by Aspergillus fumigatus. Azoles are the mainstay of therapy, but the management of aspergillosis is hampered by the emergence of azole resistance.
Jochem B. Buil, Jochem B. Buil, Jan Zoll, Jan Zoll, Paul E. Verweij, Paul E. Verweij, Willem J. G. Melchers, Willem J. G. Melchers   +7 more
doaj   +1 more source

[Final accepted version, unedited] Understanding the Environmental Drivers of Clinical Azole Resistance in Aspergillus Spp.

Drug Target Insights, 2022
Aspergilli are ubiquitous fungal pathogens associated with several life-threatening infections, especially in immunocompromised patients. Azoles are the first line of treatment for most Aspergillus related infections.
Pooja Sen, Mukund Vijay, Shweta Singh, Saif Hameed, Pooja Vijayaraghvan   +4 more
doaj   +1 more source

Synthesis and oxidation of some azole-containing thioethers

Beilstein Journal of Organic Chemistry, 2011
Pyrazole and benzotriazole-containing thioethers, namely 1,5-bis(3,5-dimethylpyrazol-1-yl)-3-thiapentane, 1,8-bis(3,5-dimethylpyrazol-1-yl)-3,6-dithiaoctane and 1,3-bis(1,2,3-benzotriazol-1-yl)-2-thiapropane were prepared and fully characterized ...
Andrei S. Potapov, Nina P. Chernova, Vladimir D. Ogorodnikov, Tatiana V. Petrenko, Andrei I. Khlebnikov   +4 more
doaj   +1 more source

4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases

Molecules, 2014
A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay ...
Kęstutis Rutkauskas, Asta Zubrienė, Ingrida Tumosienė, Kristina Kantminienė, Marytė Kažemėkaitė, Alexey Smirnov, Justina Kazokaitė, Vaida Morkūnaitė, Edita Čapkauskaitė, Elena Manakova, Saulius Gražulis, Zigmuntas J. Beresnevičius, Daumantas Matulis   +12 more
doaj   +1 more source

Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control

, 2013
This review summarises recent investigations into the molecular mechanisms responsible for the decline in sensitivity to azole (imidazole and triazole) fungicides in European populations of the Septoria leaf blotch pathogen, Mycosphaerella graminicola ...
Fraaije, B. A., Cools, H. J.
core   +1 more source

Azoles

, 2014
Capítulo cuarto del temario del segundo bloque de la asignatura Ampliación de Química Orgánica Avanzada. Azoles.
Raoul Herbrecht, Yasmine Nivoix
openaire   +3 more sources

Heat shock protein 90 (Hsp90) as a molecular target for the development of novel drugs against the dermatophyte Trichophyton rubrum

Frontiers in Microbiology, 2015
Treatment of fungal infections is difficult due to several reasons, such as side effects of drugs, emergence of resistant strains, and limited number of molecular targets for the drug compounds. In fungi, heat shock proteins (HSP) have been implicated in
Tiago R. Jacob, Nalu T. A. ePeres, Maíra P. Martins, Elza A. S. Lang, Pablo R. Sanches, Antonio eRossi, Nilce Maria eMartinez-Rossi   +6 more
doaj   +1 more source

Surveillance for azole resistance in clinical and environmental isolates of Aspergillus fumigatus in Australia and cyp51A homology modelling of azole-resistant isolates

, 2018
Background: The prevalence of azole resistance in Aspergillus fumigatus is uncertain in Australia. Azole exposure may select for resistance. We investigated the frequency of azole resistance in a large number of clinical and environmental isolates ...
Park, R., Park, Robert F, Lopez-Ruiz, Francisco J, Louise Cooley, Chen, Sharon C-A, Robert F Park, Talbot, J., Cooley, L., Harper, Lincoln, Barrs, Vanessa R, Lopez-Ruiz, Fran, William S Cuddy, Harper, L., David E Hibbs, Sorrell, T., Jessica J Talbot, Subedi, Shradha, Biswas, Chayanika, Francisco J Lopez-Ruiz, Vanessa R Barrs, Biswas, C., Lincoln Harper, Hibbs, David E, Cuddy, William S, Chayanika Biswas, Tania C Sorrell, Subedi, S., Dee Carter, Catriona L Halliday, Carter, Dee, Lai, F., Halliday, C., Lai, Felcia, Barrs, V., Sorrell, Tania C, Chen, S., Shradha Subedi, Hibbs, D., Cuddy, W., Felcia Lai, Cooley, Louise, Carter, D., Halliday, Catriona L, Sharon C -A Chen, Talbot, Jessica J   +44 more
core   +1 more source