Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. [PDF]
, 2019 Artículo digital.The purpose of this study was to characterize the effects of azole treatment upon the integrity of the Candida albicans vacuole and to determine whether, in turn, vacuolar trafficking influences azole susceptibility.
Kerns, Morgan E. +4 more
core +1 more source
Azole γ‐Peptides Helix Switching via Heterocycle Substitutions
Angewandte Chemie, EarlyView.Heterocycle substitution in azole‐based γ‐amino acids enables control over the helical shape of heterocyclic γ‐peptides. S↔N permutation in thiazole residues switches a canonical 9‐helix into a flexible helix exhibiting discontinuous hydrogen bonding.
Samantha Chaise +10 more
wiley +2 more sources
Journal of Fungi, 2023 The rapid emergence of invasive fungal infections correlates with the increasing population of immunocompromised individuals, with many cases leading to death.
Sarla Naicker +4 more
doaj +1 more source
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype. [PDF]
, 2012 BACKGROUND: The recent evolution towards resistance to azole fungicides in European populations of the wheat pathogen Mycosphaerella graminicola has been caused by the progressive accumulation of mutations in MgCYP51 gene, encoding the azole target ...
Fraaije, B. A. +9 more
core +1 more source
In vitro interaction of isavuconazole and anidulafungin against azole-susceptible and azole-resistant Aspergillus fumigatus isolates [PDF]
, 2020 BACKGROUND: The voriconazole and echinocandin combination has been found to be synergistic in vitro and in vivo against most Aspergillus fumigatus isolates, both with a WT azole phenotype and an azole-resistant phenotype.
Denardi, L.B. +4 more
core +1 more source
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. [PDF]
, 2019 Artículo digital.We recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over wild-type isolates
Peters, Brian M. +5 more
core +1 more source
Novel approach for azole fungicides extraction from aqueous environments using terpenes and eutectic solvents [PDF]
, 2023 The presence of azole fungicides in aquatic environments is a significant issue due to their toxicity and persistence related to a low removal of these compounds by conventional processes in wastewater treatment plants.
Juan García +7 more
core +1 more source
Examining Signatures of Natural Selection in Antifungal Resistance Genes Across Aspergillus Fungi
Frontiers in Fungal Biology, 2021 Certain Aspergillus fungi cause aspergillosis, a set of diseases that typically affect immunocompromised individuals. Most cases of aspergillosis are caused by Aspergillus fumigatus, which infects millions of people annually.
Renato Augusto Corrêa dos Santos +7 more
doaj +1 more source
European Journal of Clinical Microbiology & Infectious Diseases, 1997 Resistance of Candida to azoles is an increasing problem. Susceptibility testing of Candida against fluconazole and ketoconazole is now feasible and desirable. Good correlation of resistance in vitro with clinical failure of fluconazole therapy has now been shown in mucosal candidiasis.
Denning, D.W.; id_orcid 0000-0001-5626-2251 +2 more
openaire +4 more sources
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source