Results 21 to 30 of about 30,366 (254)

Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens

Molecules, 2021
Rapidly growing antimicrobial resistance among clinically important bacterial and fungal pathogens accounts for high morbidity and mortality worldwide.
Dovilė Malūkaitė, Birutė Grybaitė, Rita Vaickelionienė, Giedrius Vaickelionis, Birutė Sapijanskaitė-Banevič, Povilas Kavaliauskas, Vytautas Mickevičius   +6 more
doaj   +1 more source

Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control [PDF]

, 2013
This review summarises recent investigations into the molecular mechanisms responsible for the decline in sensitivity to azole (imidazole and triazole) fungicides in European populations of the Septoria leaf blotch pathogen, Mycosphaerella graminicola ...
Fraaije, B. A., Cools, H. J.
core   +1 more source

Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata

Journal of Fungi, 2018
Candida glabrata has thoroughly adapted to successfully colonize human mucosal membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all the medically relevant Candida species, C.
Kelley R. Healey, David S. Perlin
doaj   +1 more source

Uncovering New Mutations Conferring Azole Resistance in the Aspergillus fumigatus cyp51A Gene

Frontiers in Microbiology, 2020
The opportunistic pathogen Aspergillus fumigatus has developed worldwide resistance to azoles largely through mutations in cytochromeP450 enzyme Cyp51.
Peiying Chen, Musang Liu, Musang Liu, Qiuqiong Zeng, Zheng Zhang, Weida Liu, Weida Liu, Hong Sang, Ling Lu   +8 more
doaj   +1 more source

CYP51 Mutations in the Fusarium solani Species Complex: First Clue to Understand the Low Susceptibility to Azoles of the Genus Fusarium

Journal of Fungi, 2022
Members of Fusarium solani species complex (FSSC) are cosmopolitan filamentous fungi responsible for invasive fungal infections in immunocompromised patients.
Pierre Vermeulen, Arnaud Gruez, Anne-Lyse Babin, Jean-Pol Frippiat, Marie Machouart, Anne Debourgogne   +5 more
doaj   +1 more source

How to: EUCAST recommendations on the screening procedure E.Def 10.1 for the detection of azole resistance in Aspergillus fumigatus isolates using four-well azole-containing agar plates. [PDF]

, 2019
BACKGROUND The emergence of azole-resistant Aspergillus fumigatus isolates is a matter of significant concern in Europe, with countries reporting resistance rates (which can be as high as 30%) in hospitalized patients.
Verweij, P E, Guinea, J, Arendrup, M C, Meletiadis, J., Mouton †, J.W., Barchiesi, F., Meletiadis, J, Barchiesi, F, Arendrup, M.C., Verweij, P.E., Guinea, J., Mouton, J W, Mouton, J.W.   +12 more
core   +1 more source

The Crystal and Molecular Structure of (2Z)-2-[3-(4-Methoxybenzoyl)-4,4-dimethyl-1,2-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone

Crystals, 2011
The crystal and molecular structure of the title compound, viz., (2Z)-2-[3-(4-methoxybenzoyl)-4,4-dimethyl-1,2,-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone (4), is reported.
Robert A. Gossage, Alan J. Lough, Douglas G. Vaughan, Anna Petrov, Roderick C. Jones   +4 more
doaj   +1 more source

Differentially Regulated Transcription Factors and ABC Transporters in a Mitochondrial Dynamics Mutant Can Alter Azole Susceptibility of Aspergillus fumigatus

Frontiers in Microbiology, 2020
Azole resistance of the fungal pathogen Aspergillus fumigatus is an emerging problem. To identify novel mechanisms that could mediate azole resistance in A.
Laura Sturm, Bernadette Geißel, Ronny Martin, Ronny Martin, Johannes Wagener, Johannes Wagener, Johannes Wagener   +6 more
doaj   +1 more source

The biochemical-mode of action of some newer azole fungicides [PDF]

, 1993
The effects of the newer azole fungicides BAS 480F, flusilazole, and tebuconazole on growth and sterol composition of the plant pathogenic fungi Botrytis cinerea, Pyrenophora teres, Pyricularia oryzae, Rhynchosporium secalis, Ustilago maydis and Erysiphe
R. Thomas Loeffler, Iris M.‐Y. Kwok, Kwok, I. M. Y., Loeffler, R. T.   +3 more
core   +1 more source

Biochemical Identification of a Nuclear Coactivator Protein Required for AtrR-Dependent Gene Regulation in Aspergillus fumigatus

mSphere, 2022
Azole drugs represent the primary means of treating infections associated with the filamentous fungal pathogen Aspergillus fumigatus. A central player in azole resistance is the Zn2Cys6 zinc cluster-containing transcription factor AtrR.
Sanjoy Paul, Shivani Ror, W. Hayes McDonald, W. Scott Moye-Rowley   +3 more
doaj   +1 more source