Results 71 to 80 of about 16,315 (211)

Covalent Organic Framework Electrolytes for Solid‐State Lithium Batteries: Designing Ion Highways for Next‐Generation Energy Storage

Small, EarlyView.
Covalent organic frameworks provide a structurally programmable platform for solid‐state lithium batteries. This review outlines a design framework linking structural descriptors to ion‐transport metrics. It examines mechanisms of confinement, channel architecture, and hybrid designs, addressing the reasons for the occasional failure of high intrinsic ...
Rajesh Dhanushkotti, Ningaraju G. N., Karthik C. S., Karthik V, Anil Kumar M R, Jitendrasingh Rajpurohit, Jeremy I. G. Dawkins, Karim Zaghib   +7 more
wiley   +1 more source

Ocular and cutaneous infection due to Curvularia pseudobrachyspora in an immunosuppressed dog: Case report and in vitro antimycotic susceptibilities

Australian Veterinary Journal, EarlyView.
A 3‐year‐old male Border Collie diagnosed with immune‐mediated dermatopathy, managed with tapering prednisolone and cyclosporine, developed rapidly progressive ocular signs and additional cutaneous lesions. Histopathology, mycological culture, polymerase chain reaction and sequencing confirmed intraocular and cutaneous infection due to Curvularia ...
T Brasil‐Ervedosa, R Clark, J Granados‐Soler, C Palmieri, V Gonzalez‐Astudillo   +4 more
wiley   +1 more source

An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence.

PLoS ONE, 2020
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms.
Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels   +4 more
doaj   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

High Azole Resistance in Aspergillus fumigatus Isolates from Strawberry Fields, China, 2018

Emerging Infectious Diseases, 2020
In 2018, we conducted a cross-sectional study to investigate azole resistance in environmental Aspergillus fumigatus isolates obtained from different agricultural fields in China. Using 63 soil cores, we cultured for azole-resistant A.
Yong Chen, Fengshou Dong, Jingya Zhao, Hong Fan, Chunping Qin, Runan Li, Paul E. Verweij, Yongquan Zheng, Li Han   +8 more
doaj   +1 more source

Emergence of Trichophyton indotineae in Switzerland (2014–2025): Clinical analysis and antifungal susceptibility

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Trichophyton indotineae is an emerging dermatophyte associated with chronic, recalcitrant dermatophytosis and terbinafine resistance due to squalene epoxidase (SQLE) mutations. We analyzed clinical characteristics, antifungal susceptibility profiles, SQLE mutations, and treatment outcomes of cases diagnosed in ...
Annabel H. Lechner, Dennis D. Arnold, Philipp P. Bosshard   +2 more
wiley   +1 more source

Mechanisms of resistance to azole antifungals.

Acta Biochimica Polonica, 1995
Until the late eighties, clinical resistance to azole antifungals was a rare phenomenon. Only a few cases of resistance to ketoconazole were found in patients with chronic mucocutaneous candidiasis (CMC). The spread of AIDS and the widespread prophylactic and therapeutic use of the hydrophilic azole compound fluconazole resulted both in the selection ...
P, Marichal, H, Vanden Bossche
openaire   +3 more sources

Variability in competitive fitness among environmental and clinical azole-resistant Aspergillus fumigatus isolates

mBio
Azoles are the primary antifungal drugs used to treat infections caused by Aspergillus fumigatus. However, the emergence of azole resistance in A. fumigatus has become a global health concern despite the low proportion of resistant isolates in natural ...
Shu Chen, Guoxing Zhu, Huiping Lin, Jian Guo, Shuwen Deng, Wenjuan Wu, Gustavo H. Goldman, Ling Lu, Yuanwei Zhang   +8 more
doaj   +1 more source

Consensus‐based Guideline on tinea capitis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The consensus‐based guideline developed under the auspices of the German Dermatological Society (DDG) is intended to provide physicians with a structured framework for clinical decision‐making in the management of patients with tinea capitis and to contribute to improved diagnostic accuracy, treatment adherence, and prevention. Tinea capitis is
Peter Mayser, Dietrich Abeck, Philipp P. Bosshard, Jochen Brasch, Georg Daeschlein, Isaak Effendy, Yvonne Gräser, Peter Höger, Julia Huynh, Maria Kinberger, Annette Kolb‐Mäurer, Katharina Antonia Langen, Bartosz Malisiewicz, Alexander Nast, Hagen Ott, Christin Pelzer, Dieter Reinel, Martin Schaller, Silke Uhrlaß, Pietro Nenoff   +19 more
wiley   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source