Results 81 to 90 of about 3,777 (166)

Oral Microbiota: Findings, Classification, Clinical Significance, and Therapeutic Interventions for Human Systemic Diseases

iMetaMed, Volume 2, Issue 1, March 2026.
Oral microbiota: findings, classification, clinical significance, and therapeutic interventions for human systemic diseases ABSTRACT The oral microbiota is an ecological community of commensal, symbiotic, and pathogenic microorganisms that colonizes the oral cavity.
Miao Zhang, Meihang Du, Wenjiang Zhang, Renhuan Huang, Wanting Li, Tongqi Li, Junping Bai, Ning Zhang, Jungang Chen, Jing Zhou, Bing Wang, Liwei An, Hideaki Kagami, Yiming Zhang   +13 more
wiley   +1 more source

First Report of Fluconazole‐Resistant Candida parapsilosis Harbouring the G458S ERG11p Substitution in a Brazilian Hospital

Mycoses, Volume 69, Issue 3, March 2026.
ABSTRACT Background Fluconazole‐resistant Candida parapsilosis is a matter of concern. Objectives To investigate fluconazole resistance among Candida parapsilosis complex isolates from patients admitted to three Brazilian hospitals, and to characterise resistance mechanisms and clonal relatedness. Patients/Methods A total of 76 C.
Sarah Santos Gonçalves, Simone Bravim Maifrede, Eduardo Yäkel, Pedro Massaroni Peçanha, Francisco Ozório Bessa‐Neto, Rodrigo Cayô, Anderson Messias Rodrigues, Patricia Muñoz, Pilar Escribano, Jesús Guinea   +9 more
wiley   +1 more source

First report of amphotericin B resistant Candida haemulonii isolated from the ICU of a referral hospital in Indonesia

Iranian Journal of Microbiology
Background and Objectives: Amphotericin B is a broad-spectrum antifungal agent commonly used to treat Candida haemulonii infection. C. haemulonii was isolated from patients reported to be intrinsically resistant to amphotericin B, encoded by the ERG2 ...
Rifdah Hanifah, Mardiastuti Wahid, Andi Yasmon   +2 more
doaj   +1 more source

Molecular epidemiology and azole resistance mechanism study of Candida guilliermondii from a Chinese surveillance system

Scientific Reports, 2017
We studied the molecular epidemiology and mechanism of azole resistance of 164 C. guilliermondii isolates from a nationwide multi-center surveillance program.
Jing-Wei Cheng, Kang Liao, Timothy Kudinha, Shu-Ying Yu, Meng Xiao, He Wang, Fanrong Kong, Ying-Chun Xu   +7 more
doaj   +1 more source

[Investigation of ERG11 and MRR1 Resistance Genes in Candida parapsilosis Isolates].

Mikrobiyoloji bulteni
Candida parapsilosis is an important fungal pathogen that is particularly isolated from blood cultures. In recent years, although there are regional differences between centres, resistance to fluconazole which is the most commonly preferred drug for candidemia, has increased in many regions.
Kurt, Ozge, Kuskucu, Mert Ahmet, Yazgan, Zeynep, Arslan, Nese, Aygun, Gokhan, Kucukbasmaci, Omer   +5 more
openaire   +2 more sources

MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates

BMC Infectious Diseases, 2018
Background Marked increases in fluconazole resistance in Candida tropicalis have been recently reported. In this study, the molecular mechanisms behind fluconazole resistance were investigated. Methods Twenty-two C.
Longyang Jin, Zhuorui Cao, Qi Wang, Yichen Wang, Xiaojuan Wang, Hongbin Chen, Hui Wang   +6 more
doaj   +1 more source

Non-synonymous ERG11 mutations in M. restricta and M. arunalokei: impact on azole susceptibility

Microbiology Spectrum
Malassezia are commensal lipid-dependent yeasts and opportunistic pathogens that cause superficial mycoses and systemic infection. Azole antifungals target cell wall ergosterol synthesis and are the first line of antifungal treatment.
Cheryl Leong, Wisely Chua, Cheng-Shoong Chong, Shi Mun Lee, Sebastian Maurer-Stroh, Won Hee Jung, Thomas L. Dawson   +6 more
doaj   +1 more source

Harnessing Machine Learning to Uncover Hidden Patterns in Azole-Resistant CYP51/ERG11 Proteins

Microorganisms
Fungal resistance is a public health concern due to the limited availability of antifungal resources and the complexities associated with treating persistent fungal infections. Azoles are thus far the primary line of defense against fungi. Specifically, azoles inhibit the conversion of lanosterol to ergosterol, producing defective sterols and impairing
Otávio Guilherme Gonçalves de Almeida, Marcia Regina von Zeska Kress   +1 more
openaire   +3 more sources

Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans

Current Medical Mycology, 2017
Background and Purpose: The frequency of opportunistic fungal infections in immunocompromised patients, especially by Candida species, has sharply increased in the last few decades.
Fahimeh Alizadeh, Alireza Khodavandi, Sara Zalakian   +2 more
doaj  

Effect of biogenic selenium nanoparticles on ERG11 and CDR1 gene expression in both fluconazole-resistant and -susceptible Candida albicans isolates

Current Medical Mycology, 2017
Background and Purpose: Candida albicans is the most common Candida species (spp.) isolated from fungal infections. Azole resistance in Candida species has been considerably increased in the last decades.
Nasrin Parsamehr, Sasan Rezaie, Sadegh Khodavaisy, Samira Salari, Sanaz Hadizadeh, Mohammad Kord, Seyed Amin Ayatollahi Mousavi   +6 more
doaj