Results 81 to 90 of about 4,848 (182)

Synthesis of new imidazole-based ionic liquids with antifungal activity against Candida albicans

Iranian Journal of Microbiology, 2023
Background and Objectives: Candida albicans cause a problematic condition in immunocompromised patients that could not be treated quickly due to the resistant behavior of microorganisms. This study aimed to investigate the effect of a novel ionic liquid
Amir Habibi, Mansour Bayat, Behinb Omidi, Ali Ezabadi, Pejman Mortazavi   +4 more
doaj   +1 more source

Mechanistic Investigations of a Novel Lactam Antifungal Agent Against Candida albicans

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT Candida albicans presents a major, yet underestimated challenge in clinical settings due to its increased resistance to treatment. This study intended to focus on the utility of a novel proprietary lactam molecule, a quorum sensing (QS) inhibitor, against C. albicans. We assessed isolate susceptibility to lactam treatment. In addition, RNA‐Seq
Hafsa Abduljalil, William Johnston, Mark Butcher, Neil Parry, Joanne O'Keeffe, Yvonne Davies, Gordon Ramage   +6 more
wiley   +1 more source

Role of ERG11 and MDR1 genes in cycloheximide and multidrug resistance in Candida species

Brazilian Journal of Microbiology
Candida species are amongst the commensals of the mucosal surfaces of the human body which include the oral cavity, vagina, and intestinal mucosa. Fungal infections are on the rise worldwide. The overall burden of infections due to fungi is difficult to estimate because the majority of them remain undiagnosed.
Zill-e- Huma, Sidrah Saleem, Muhammad Imran, Syed Mohsin Raza, Kokab Jabeen, Faiqa Arshad   +5 more
openaire   +2 more sources

Erg11mutations associated with azole resistance in clinical isolates ofCandida albicans [PDF]

FEMS Yeast Research, 2013
The widespread use of azoles has led to increasing azole resistance among Candida albicans strains. One mechanism of azole resistance involves point mutations in the ERG11 gene, which encodes the target enzyme (cytochrome P450 lanosterol 14α-demethylase). In the present study, we amplified and sequenced the ERG11 gene of 23 C.
Ming-Jie, Xiang, Jin-Yan, Liu, Pei-Hua, Ni, Shengzheng, Wang, Ce, Shi, Bing, Wei, Yu-Xing, Ni, Hai-Liang, Ge   +7 more
openaire   +2 more sources

ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection [PDF]

International Journal of Oral Science, 2018
AbstractThe hyphal development of Candida albicans (C. albicans) has been considered as an essential virulent factor for host cell damage. However, the missing link between hyphae and virulence of C. albicans is also been discovered. Here, we identified that the null mutants of ERG3 and ERG11, two key genes in ergosterol biosynthesis pathway, can form ...
Zhou, Yujie, Liao, Min, Zhu, Chengguang, Hu, Yao, Tong, Ting, Peng, Xian, Li, Mingyun, Feng, Mingye, Cheng, Lei, Ren, Biao, Zhou, Xuedong   +10 more
openaire   +2 more sources

Comparison of ERG11 gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata [PDF]

Biological Journal of Microorganism, 2018
Introduction:Diseases caused by opportunistic pathogen Candida albicans are usually treated with antifungal drugs, but treatment failure is not uncommon especially in profoundly immunocompromised hosts.
Alireza Khodavandi, Fahimeh Alizadeh, Zeynab Abrahe   +2 more
doaj   +1 more source

Genotypes, Fluconazole Tolerance and Virulence Phenotypes of Candida albicans Bloodstream Isolates: A Multilocus Sequence Typing‐Based Analysis

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Background Fluconazole tolerance is an emerging phenotype in Candida albicans bloodstream infections, but its relationship to multilocus sequence typing (MLST) lineages and virulence traits is unclear. Objectives To investigate the relationships among MLST genotypes, fluconazole tolerance, and virulence phenotypes in C.
Shang‐Yi Lin, Yin‐Tse Huang, Ho‐Yin Huang, Wei‐Chun Hung, Yi‐Ting Tseng, Po‐Liang Lu   +5 more
wiley   +1 more source

ERG11 CNV

Copy number variants of ERG11 in C ...
Kuo-Yun Tseng (12879362)
core   +1 more source

Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutations [PDF]

Journal of Antimicrobial Chemotherapy, 2008
To investigate fluconazole susceptibility of Candida albicans from non-AIDS patients and to analyse the relationship between mutations in the ERG11 gene of these isolates and fluconazole resistance.Four hundred and twenty-six clinical isolates of Candida species were collected. Fluconazole susceptibility was tested in vitro using microdilution and disc
Yonghao, Xu, Lamei, Chen, Chunyang, Li
openaire   +2 more sources

Clinically Important Emerging and Uncommon Fungal Pathogens in Asia: Epidemiology, Antifungal Resistance and Challenges in Diagnosis and Management

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Fungal infections in Asia are influenced by warm, humid climates, high population density and expanding healthcare systems, which together facilitate the emergence, transmission and detection of both common and rare pathogens. While Candida and Aspergillus species remain the leading causes of invasive fungal disease, increasing attention has ...
Narut Chancharussin, Anupop Jitmuang, Arunaloke Chakrabarti, Methee Chayakulkeeree   +3 more
wiley   +1 more source