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The Role of ERG11 Point Mutations in the Resistance of Candida albicans to Fluconazole in the Presence of Lactate

Pathogens, 2022
Candidiasis refers to both superficial and deep-tissue fungal infections often caused by Candida albicans. The treatment of choice for these infections is the use of azoles, such as fluconazole (FLC). However, the increased use of antifungal agents has led to the emergence of azole-resistant isolates of C. albicans. Thus, the development of alternative
Aneta K Urbanek, Zofia Łapińska, Daria Derkacz   +2 more
exaly   +5 more sources

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Association of T916C (Y257H) mutation inCandida albicans ERG11with fluconazole resistance

Mycoses, 2012
SummaryRepeated and prolonged use of fluconazole in treating candidosis leads to drug resistance. The aim of this study was to confirm the relationship between T916C (Y257H) mutation inCandida albicans ERG11and fluconazole resistance. We replaced one copy ofERG11withERG11containing the T916C mutation inC.
Jie, Zhao, Yonghao, Xu, Chunyang, Li
openaire   +4 more sources

Cloning and characterization of the lanosterol 14α-demethylase (ERG11) gene in Cryptococcus neoformans

Biochemical and Biophysical Research Communications, 2004
The ergosterol pathway in fungal pathogens is an attractive antimicrobial target because it is unique from the major sterol (cholesterol) producing pathway in humans. Lanosterol 14alpha-demethylase is the target for a major class of antifungals, the azoles. In this study we have isolated the gene for this enzyme from Cryptococcus neoformans.
S G, Revankar, J, Fu, M G, Rinaldi, S L, Kelly, D E, Kelly, D C, Lamb, S M, Keller, B L, Wickes   +7 more
openaire   +2 more sources

Implication of efflux pumps and ERG11 genes in resistance of clinical Trichosporon asahii isolates to fluconazole

Journal of Medical Microbiology, 2021
Introduction. Trichosporon asahii has been recognized as an opportunistic agent having a limited sensitivity to antifungal treatment. Hypothesis/Gap Statement. Molecular mechanisms of azole resistance have been rarely reported for Trichosproron asahii.
S, Abbes, H, Sellami, S, Neji, H, Trabelsi, F, Makni, A, Ayadi   +5 more
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Upregulation of the ERG11 gene in Candida krusei by azoles.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2012
Candida species are the agents of local and systemic opportunistic infections and have become a major cause of morbidity and mortality in the last few decades. Azole resistance in Candida krusei (C. krusei) species appears to be the result of gene alterations in relation to the ergosterol biosynthesis pathway, as well as efflux pumps.
M, Tavakoli, F, Zaini, M, Kordbacheh, M, Safara, R, Raoofian, M, Heidari   +5 more
openaire   +1 more source

[Analysis of ERG11 gene mutation in Candida albicans].

Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2007
To study the relationship between fluconazole (FCZ)-resistance of Candida albicans and the mutation of ERG11 gene encoding FCZ-targeted enzyme.Three strains of FCZ-susceptible and 10 FCZ-resistent C. albicans were isolated from the urethra, vagina, oropharynx, respiratory tract, prostate secretion and blood samples.
Ying-bin, Wang, Hong, Wang, Hui-yu, Guo, Yong-zhong, Zhao, Shen-qiu, Luo   +4 more
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The A395T Mutation in ERG11 Gene Confers Fluconazole Resistance in Candida tropicalis Causing Candidemia

Mycopathologia, 2014
The mechanism of fluconazole resistance in Candida tropicalis is still unclear. Recently, we isolated a fluconazole-resistant strain of C. tropicalis from the blood specimen of a patient with candidemia in China. In vitro antifungal susceptibility of the isolate was determined by using CLSI M27-A3 and E-test methods. The sequence of ERG11 gene was then
Jingwen Tan, Jinqing Zhang, Zhe Wan
exaly   +3 more sources

ERG11 mutations and upregulation in clinical itraconazole-resistant isolates of Candida krusei

Canadian Journal of Microbiology, 2016
To better understand the association between the ERG11 gene and drug resistance in Candida krusei, C. krusei strains were isolated from patients from January 2010 to May 2013. Susceptibility to 5-fluorocytosine (5-FC), amphotericin B (AMB), voriconazole (VRC), fluconazole (FLC), and itraconazole (ITR) were tested by broth microdilution method ...
Wenli, Feng, Jing, Yang, Yiru, Wang, Jinyu, Chen, Zhiqin, Xi, Zusha, Qiao   +5 more
openaire   +2 more sources

Variation in the erg11 Gene from Pneumocystis jirovecii.

2010
The erg11 gene codes for sterol 14-demethylase (14DM), a key enzyme in sterol biosynthesis and the target for triazole antimycotic drugs. Two sterol composition phenotypes have been described in patients with pneumonia caused by P. jirovecii; one phenotype has a much higher amount of lanosterol derivatives (C31 and C32 sterols) dominated by ...
SCOTT P. KEELY, JAMES R. STRINGER, CONTINI, Carlo, BETTINA LUNGREN, RONALD BRUBAKER, LAURA Q. JOHNSTON, EDNA S. KANESHIRO   +6 more
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The new mutation L321F in Candida albicans ERG11 gene may be associated with fluconazole resistance

Revista Iberoamericana de Micología, 2013
For many years fluconazole has been commonly used to treat Candida infections. However, the indiscriminate use of this antimycotic therapy has favored the emergence of resistant isolates. Mutations in the ERG11 gene have been described as one of the primary mechanisms of resistance in Candida species.In this study we investigated missense mutations in ...
Vagner, Oliveira Carvalho, Thelma S, Okay, Márcia S C, Melhem, Maria, Walderez Szeszs, Gilda M B, del Negro   +4 more
openaire   +2 more sources