Doxorubicin induces drug efflux pumps in Candida albicans [PDF]
, 2017 Candida albicans is one of the most important opportunistic fungal pathogens. It can cause serious fungal diseases in immunocompromised patients, including those with cancer. Treatment failures due to the emergence of drug-resistant C.
Coste, Alix T. +8 more
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Impact of Resistance to Fluconazole on Virulence and Morphological Aspects of Cryptococcus neoformans and Cryptococcus gattii Isolates [PDF]
, 2016 Cryptococcus spp. are responsible for around one million cases of meningitis every year. Fluconazole (FLU) is commonly used in the treatment of cryptococcosis, mainly in immunocompromised patients and the resistance is usually reported after long periods
Ana Cecilia Mesa-Arango +9 more
core +5 more sources
Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity [PDF]
, 2018 Inactivation of sterol Δ5,6-desaturase (Erg3p) in the prevalent fungal pathogen Candida albicans is one of several mechanisms that can confer resistance to the azole antifungal drugs.
Alspaugh, J. Andrew +10 more
core +2 more sources
Tipping the balance both ways: drug resistance and virulence in Candida glabrata [PDF]
, 2017 Among existing fungal pathogens, Candida glabrata is outstanding in its capacity to rapidly develop resistance to currently used antifungal agents. Resistance to the class of azoles, which are still widely used agents, varies in proportion (from 5 to 20%)
Bolotin-Fukuhara, Monique +2 more
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Molecular mechanisms of azole resistance in Candida bloodstream isolates
BMC Infectious Diseases, 2019 Background Antifungal resistance rates are increasing. We investigated the mechanisms of azole resistance of Candida spp. bloodstream isolates obtained from a surveillance study conducted between 2012 and 2015.
Jocelyn Qi-Min Teo +6 more
doaj +1 more source
The CgHaa1-dependent pathway mediates Candida glabrata response and tolerance to acetic acid thereby enhancing colonization of vaginal epithelium [PDF]
, 2014 To successfully colonize the vaginal tract Candida glabrata has to cope with various stresses including the presence of acetic acid at a low pH that is produced by the bacteria that co-colonize this niche. The genes/pathways involved in C.
Azeredo, Joana +9 more
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Role of ERG11 and MDR1 genes in cycloheximide and multidrug resistance in Candida species
Brazilian Journal of MicrobiologyCandida species are amongst the commensals of the mucosal surfaces of the human body which include the oral cavity, vagina, and intestinal mucosa. Fungal infections are on the rise worldwide. The overall burden of infections due to fungi is difficult to estimate because the majority of them remain undiagnosed.
Zill-e- Huma +5 more
openaire +2 more sources
O factor de trancrição NDT80 como regulator negativo da adesão e da formação de biofilme em Candida parapsilosis [PDF]
, 2014 Mestrado em Biologia Molecular e CelularC. parapsilosis infections incidence has been increasing for the past 20 years. Its caracteristics of adhering and forming biofilms are a critical factor for infection caused by this organism, affecting from ...
Gomes, Nuno Miguel Araújo da Cunha
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Mechanism of Action of a Novel Antifungal Compound [PDF]
, 2012 Opportunistic fungal infections have become problematic in recent years. There has been an emergence of new fungal pathogens, development of antifungal resistance, and increasing prevalence.
Ward, Amber
core +1 more source
Mecanismes d'acció dels antifúngics i resistència en llevats [PDF]
, 2005 Si bé s'ha avançat en la síntesi de nous antifúngics i se'n coneix el mode d'acció, els mecanismes moleculars de resistència encara són insuficientment coneguts, i afecten principalment els llevats i els azoles.
Alvarado Ramírez, Eidi +2 more
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