Results 1 to 10 of about 5,330 (202)

First detection of mutated ERG11 gene in vulvovaginal Candida albicans isolates at Ouagadougou/Burkina Faso [PDF]

BMC Infectious Diseases, 2022
Background Vulvovaginal candidiasis is an important cause of morbidity among women due to Candida species. In the last decades, resistance to azoles, first-line antifungals has increased.
Essi Etonam Dovo, Théodora Mahoukèdè Zohoncon, Sessi Frida Tovo, Serge Théophile Soubeiga, Isabelle Touwendpoulimdé Kiendrebeogo, Albert Théophane Yonli, Rogomenona Alice Ouedraogo, Amana Mètuor Dabire, Florencia Wendkuuni Djigma, Christelle Wendyam Nadembega, Marius Belemgnegre, Paul Ouedraogo, Dorcas Obiri-Yeboah, Jacques Simpore   +13 more
doaj   +4 more sources

Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species [PDF]

Memorias do Instituto Oswaldo Cruz, 2016
The azoles are the class of medications most commonly used to fight infections caused by Candida sp. Typically, resistance can be attributed to mutations in ERG11 gene (CYP51) which encodes the cytochrome P450 14α-demethylase, the primary target for the ...
Danielly Beraldo dos Santos Silva, Luana Mireli Carbonera Rodrigues, Adriana Araújo de Almeida, Kelly Mari Pires de Oliveira, Alexéia Barufatti Grisolia/   +4 more
doaj   +5 more sources

The A756T Mutation of the ERG11 Gene Associated With Resistance to Itraconazole in Candida Krusei Isolated From Mycotic Mastitis of Cows [PDF]

Frontiers in Veterinary Science, 2021
Candida krusei (C. krusei) has been recently recognized as an important pathogen involved in mycotic mastitis of cows. The phenotypic and molecular characteristics of 15 C.
Jun Du, Jun Du, Wenshuang Ma, Wenshuang Ma, Jiaqi Fan, Jiaqi Fan, Xiaoming Liu, Xiaoming Liu, Yujiong Wang, Yujiong Wang, Xuezhang Zhou, Xuezhang Zhou   +11 more
doaj   +2 more sources

Fluconazole resistance among Candida species with special emphasis on ERG11 gene mutations among Candida tropicalis [PDF]

Frontiers in Fungal Biology
IntroductionCandidiasis, an opportunistic fungal infection, is increasingly caused by non-albicans Candida species that show reduced fluconazole susceptibility, mainly due to ERG11 overexpression.
Vidyavathi B. Chitharagi, Gowthami S., Mahadevaiah Neelambike Sumana, Morubagal Raghavendra Rao, Sowmya G. S., Yogeesh D. Maheshwarappa   +5 more
doaj   +2 more sources

Pseudolaric Acid B Combats Drug-Resistant Candida albicans Infection via Dual-Action Mechanisms of Direct Antifungals and Vaginal Microbiota Restoration. [PDF]

Microb Biotechnol
We propose a novel therapeutic approach against fungal infection: Pseudolaric acid B directly eradicates C. albicans via Erg11 inhibition and uniquely, restores vaginal microecological homeostasis by promoting probiotic lactobacilli, addressing both the pathogen and the dysbiotic environment.
Shao T, Zhang Y, Xue B, Chu W.
europepmc   +2 more sources

Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates [PDF]

mBio
Fluconazole (FLC)-resistant Candidozyma auris isolates have reduced drug accumulation compared to azole-susceptible isolates. Of 119 C. auris isolates, 83 out of 87 resistant isolates (~95%) had extremely low fluconazole uptake, whereas 30 out of 32 ...
Brooke D. Esquivel, Amanda Santos, Jeffrey M. Rybak, Darian J. Santana, P. David Rogers, Theodore C. White   +5 more
doaj   +2 more sources

Standardization of polymerase chain reaction for detection of fluconazole resistance targeting Y132F mutation in ERG11 gene in Candida parapsilosis [PDF]

Current Medical Mycology
Background and Purpose: Candida parapsilosis is the third most commonly isolated species from candidemia patients admitted to Indian intensive care units.
Kanagasabapathi Karthika, Thayanidhi Premamalini, Thanneru Vijayakishore, Anupama Kindo   +3 more
doaj   +2 more sources

Azole Resistance in Candida parapsilosis From Patients With Burns in Mexico: A Genomic and Phylogenetic Analysis [PDF]

Mycoses
ABSTRACT Background Candida species are common causes of nosocomial infections. Candida parapsilosis has emerged as an important pathogen. Mortality rates associated with invasive C. parapsilosis infections range from 14.5% to 47%, with azole resistance estimated between 4% and 15%.
García‐Hernández M, Nuñez‐García L, Ortíz‐Álvarez J, Delaye‐Martínez M, Flores‐Huacuja M, Vazquez‐Olivares M, Espinosa‐Camacho L, Delgado‐Sapien G, Morales‐Espinosa M, Becerra‐Lobato N, Franco‐Cendejas R, Garza‐González E, Ostrosky‐Zeichner L, Chávez‐Heres T, Hernández‐Durán M, López‐Jácome L, Colín‐Castro C.   +16 more
europepmc   +2 more sources

Non‐albicans Candida in Vulvovaginal Candidiasis: Antifungal Resistance and Expression of ERG11, CDR1, CDR2, and MDR1 Genes [PDF]

MicrobiologyOpen
The rise in azole resistance among Nakaseomyces glabratus and Pichia kudriavzevii in recurrent vulvovaginal candidiasis presents a growing public health challenge. This study investigated the expression of antifungal resistance‐related genes (ERG11, CDR1,
Fatemeh Zahra Ranjbar Golafshani, Firoozeh Kermani, Soheila Abbaszadeh Godarzi, Saeid Mahdavi Omran   +3 more
doaj   +2 more sources

Emergence of Candida (Candidozyma) auris in Minas Gerais, Brazil: Genomic Surveillance to Guide Rapid Public Health Responses. [PDF]

Mycoses
ABSTRACT Background Candida (Candidozyma) auris is an emerging yeast that poses a significant global health threat due to its multidrug resistance and ability to cause healthcare‐associated outbreaks. Genomic surveillance is essential for monitoring spread, transmission and antifungal resistance.
Tomé LMR, Camargo DRA, Bastos RW, Dos Santos SCF, Guimarães NR, Pedroso SHSP, de Souza da Silva PE, Góes-Neto A, de Assis Figueredo LJ, da Côrte Castro G, Rodrigues AMRN, Cruzeiro FRS, Dutra NAC, Moura JBP, de Carvalho Pereira G, Faria CD, Giovanetti M, de Melo Iani FC, Alcantara LCJ, Adelino TÉR.   +19 more
europepmc   +2 more sources