Results 1 to 10 of about 3,364 (161)

Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis

Biomédica: revista del Instituto Nacional de Salud, 2023
Introduction. Drug resistance to azoles is a growing problem in the Candida genus. Objective. To analyze molecularly the genes responsible for fluconazole resistance in Candida tropicalis strains. Materials and methods. Nineteen strains, with and without
Ana Elisa Rojas, Leidy Yurany Cárdenas, María Camila García, Jorge Enrique Pérez   +3 more
doaj   +3 more sources

Overexpression of Both ERG11 and ABC2 Genes Might Be Responsible for Itraconazole Resistance in Clinical Isolates of Candida krusei. [PDF]

PLoS ONE, 2015
To study the main molecular mechanisms responsible for itraconazole resistance in clinical isolates of Candida krusei.The 14α-demethylases encoded by ERG11 gene in the 16 C.krusei clinical isolates were amplified by polymerase chain reaction (PCR), and ...
Xiaoyuan He, Mingfeng Zhao, Jinyan Chen, Rimao Wu, Jianlei Zhang, Rui Cui, Yanyu Jiang, Jie Chen, Xiaoli Cao, Yi Xing, Yuchen Zhang, Juanxia Meng, Qi Deng, Tao Sui   +13 more
doaj   +4 more sources

Spectrum and functional properties of ERG11 gene mutations in fluconazole-resistant Candida albicans strains isolated from HIV-infected patients

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Rationale. The low efficacy of azole antimycotics in treatment of Candida infections, especially in HIV-infected patients, is often associated with overexpression of the ERG11 gene in Candida spp., which results in increased production of ergosterol the
Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Alexander D. Voropaev, Yulia N. Urban, Mariam E. Suleimanova, Maxim S. Afanasiev, Elena V. Budanova, Elena A. Voropaeva   +7 more
doaj   +1 more source

Lack of Association between Fluconazole Susceptibility and ERG11 Nucleotide Polymorphisms in Cryptococcus neoformans Clinical Isolates from Uganda

Journal of Fungi, 2022
Fluconazole is the drug of choice for cryptococcal meningitis (CM) monoprophylaxis in resource-limited settings such as Uganda. Emerging fluconazole resistance linked to mutations in the Cryptococcus neoformansERG11 gene (CYP51) has been observed in ...
Priscilla Belbir Atim, David B. Meya, Elliot S. Gerlach, Dennis Muhanguzi, Allan Male, Benedict Kanamwanji, Kirsten Nielsen   +6 more
doaj   +1 more source

Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalis.

PLoS ONE, 2022
This study was designed to understand the molecular mechanisms of azole resistance in Candida tropicalis using genetic and bioinformatics approaches. Thirty-two azole-resistant and 10 azole-susceptible (S) clinical isolates of C.
Saikat Paul, Dipika Shaw, Himanshu Joshi, Shreya Singh, Arunaloke Chakrabarti, Shivaprakash M Rudramurthy, Anup K Ghosh   +6 more
doaj   +1 more source

Rapid detection of ERG11 polymorphism associated azole resistance in Candida tropicalis.

PLoS ONE, 2021
Increasing reports of azole resistance in Candida tropicalis, highlight the development of rapid resistance detection techniques. Nonsynonymous mutations in the lanosterol C14 alpha-demethylase (ERG11) gene is one of the predominant mechanisms of azole ...
Saikat Paul, Rajneesh Dadwal, Shreya Singh, Dipika Shaw, Arunaloke Chakrabarti, Shivaprakash M Rudramurthy, Anup K Ghosh   +6 more
doaj   +1 more source

Analysis of molecular resistance to azole and echinocandin in Candida species in patients with vulvovaginal candidiasis [PDF]

Current Medical Mycology, 2022
Background and Purpose: Vulvovaginal candidiasis (VVC) is considered the most common mucosal infection caused by Candida species. Azoles were considered the firstline treatment for VVC or recurrent vulvovaginal candidiasis (RVVC) in both healthy and ...
Ensieh Lotfali, Mahzad Erami, Mahsa Fattahi, Houshang Nemati, Zeinab Ghasemi, Elham Mahdavi   +5 more
doaj   +1 more source

Comparison of ERG11 gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata [PDF]

Biological Journal of Microorganism, 2018
Introduction:Diseases caused by opportunistic pathogen Candida albicans are usually treated with antifungal drugs, but treatment failure is not uncommon especially in profoundly immunocompromised hosts.
Alireza Khodavandi, Fahimeh Alizadeh, Zeynab Abrahe   +2 more
doaj   +1 more source

Characterization of ERG11 Gene in Drug-Resistant Candida Albicans Isolated from Iranian Cases of Recurrent Vulvovaginal Candidiasis [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2020
Background & Aims:  Candida albicans is the most common fungal pathogen of human infections. C. albicans is responsible for significant mucosal infections such as vulvovaginitis in women.
Kambiz Diba, Shahram Khademvatan, Kowsar Jaafari, Soudabe Abharian   +3 more
doaj  

Screening of fluconazole resistance-related genes in Trichosporon asahii with induced fluconazole resistance in vitro

Di-san junyi daxue xuebao, 2020
Objective To screen the genes associated with fluconazole resistance in Trichosporon asahii to facilitate mechanistic studies of fluconazole resistance and the development of new antifungal agents. Methods Three clinical isolates of fluconazole-sensitive
XIA Zhikuan1, XIA Zhikuan1, GUO Jing, ZHANG Dequan, LU Yong, AO Junhong, YANG Rongya   +6 more
doaj   +1 more source