Detection of ERG11 gene mutation in coding and non-coding regions of clinical Candida glabrata (Nakaseomyces glabratus) isolates from Pakistan. [PDF]
Access MicrobiolAzoles inhibit the cytochrome P450-dependent enzyme lanosterol 14α-demethylase (CYP51) that is encoded by the ERG11 gene. Azole resistance in Candida species arises through different mechanisms, like mutations in the ERG11 gene, ERG11 overexpression ...
Memon S +5 more
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The A756T Mutation of the ERG11 Gene Associated With Resistance to Itraconazole in Candida Krusei Isolated From Mycotic Mastitis of Cows [PDF]
Frontiers in Veterinary Science, 2021 Candida krusei (C. krusei) has been recently recognized as an important pathogen involved in mycotic mastitis of cows. The phenotypic and molecular characteristics of 15 C.
Jun Du +11 more
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First detection of mutated ERG11 gene in vulvovaginal Candida albicans isolates at Ouagadougou/Burkina Faso [PDF]
BMC Infectious Diseases, 2022 Background Vulvovaginal candidiasis is an important cause of morbidity among women due to Candida species. In the last decades, resistance to azoles, first-line antifungals has increased.
Essi Etonam Dovo +13 more
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Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species [PDF]
Memorias do Instituto Oswaldo Cruz, 2016 The azoles are the class of medications most commonly used to fight infections caused by Candida sp. Typically, resistance can be attributed to mutations in ERG11 gene (CYP51) which encodes the cytochrome P450 14α-demethylase, the primary target for the ...
Danielly Beraldo dos Santos Silva +4 more
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Fluconazole resistance among Candida species with special emphasis on ERG11 gene mutations among Candida tropicalis [PDF]
Frontiers in Fungal BiologyIntroductionCandidiasis, an opportunistic fungal infection, is increasingly caused by non-albicans Candida species that show reduced fluconazole susceptibility, mainly due to ERG11 overexpression.
Vidyavathi B. Chitharagi +5 more
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Phylogenetic and Structural Analysis of Miconazole Susceptibility in Malassezia pachydermatis Isolates From Dogs With Otitis Externa. [PDF]
Vet DermatolBackground: An increased number of dogs with unresolved yeast otitis externa (OE) after miconazole treatment was observed at a tertiary practice. Hypothesis/Objectives: To evaluate miconazole susceptibility in Malassezia pachydermatis isolates from canine OE.
Belcher CM +5 more
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Standardization of polymerase chain reaction for detection of fluconazole resistance targeting Y132F mutation in ERG11 gene in Candida parapsilosis [PDF]
Current Medical MycologyBackground and Purpose: Candida parapsilosis is the third most commonly isolated species from candidemia patients admitted to Indian intensive care units.
Kanagasabapathi Karthika +3 more
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Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates [PDF]
mBioFluconazole (FLC)-resistant Candidozyma auris isolates have reduced drug accumulation compared to azole-susceptible isolates. Of 119 C. auris isolates, 83 out of 87 resistant isolates (~95%) had extremely low fluconazole uptake, whereas 30 out of 32 ...
Brooke D. Esquivel +5 more
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Fluconazole-resistant Candida parapsilosis strains with a Y132F substitution in the ERG11 gene causing invasive infections in a neonatal unit, South Africa. [PDF]
Mycoses, 2020 Magobo RE, Lockhart SR, Govender NP.
europepmc +2 more sources
Non‐albicans Candida in Vulvovaginal Candidiasis: Antifungal Resistance and Expression of ERG11, CDR1, CDR2, and MDR1 Genes [PDF]
MicrobiologyOpenThe rise in azole resistance among Nakaseomyces glabratus and Pichia kudriavzevii in recurrent vulvovaginal candidiasis presents a growing public health challenge. This study investigated the expression of antifungal resistance‐related genes (ERG11, CDR1,
Fatemeh Zahra Ranjbar Golafshani +3 more
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